{"id":2924,"date":"2019-08-07T16:17:07","date_gmt":"2019-08-07T23:17:07","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-researchers-receive-12-5-million-grant-for-craniofacial-research-data-sharing-endeavor\/"},"modified":"2023-11-26T08:28:58","modified_gmt":"2023-11-26T16:28:58","slug":"usc-researchers-receive-12-5-million-grant-for-craniofacial-research-data-sharing-endeavor","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-researchers-receive-12-5-million-grant-for-craniofacial-research-data-sharing-endeavor\/","title":{"rendered":"USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor"},"content":{"rendered":"\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n  <div class=\"text-container\">\n              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Press Release<\/span>\n\n\n\n<\/div>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n      <h1>USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor<\/h1>\n\n\n<\/div>\n    \n    \n          <div class=\"meta\">\n        \n                  <span class=\"date\">August 07, 2019<\/span>\n              <\/div>\n    \n              \n<div class=\"f--field f--embed\">\n\n    \n  <div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/keck.usc.edu\/news\/usc-researchers-receive-12-5-million-grant-for-craniofacial-research-data-sharing-endeavor\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fkeck.usc.edu%2Fnews%2Fusc-researchers-receive-12-5-million-grant-for-craniofacial-research-data-sharing-endeavor%2F\" title=\"Facebook\" 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1.99-1.146 2.736l-1.982 1.968c-.745.75-1.658 1.12-2.736 1.12-1.087 0-2.004-.38-2.75-1.143l-2.777-2.79c-.75-.747-1.12-1.66-1.12-2.737 0-1.106.392-2.046 1.183-2.818l-1.186-1.185c-.774.79-1.708 1.186-2.805 1.186-1.078 0-1.995-.376-2.75-1.13l-2.803-2.81C5.377 12.82 5 11.903 5 10.826c0-1.08.382-1.993 1.146-2.738L8.128 6.12C8.873 5.372 9.785 5 10.864 5c1.087 0 2.004.382 2.75 1.146l2.777 2.79c.75.747 1.12 1.66 1.12 2.737 0 1.105-.392 2.045-1.183 2.817l1.186 1.186c.774-.79 1.708-1.186 2.805-1.186 1.078 0 1.995.377 2.75 1.132l2.804 2.804c.754.755 1.13 1.672 1.13 2.75z\"\/><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div>\n\n\n<\/div>\n        \n  <\/div>\n\n  \n\n  <\/div><\/div>\n\r\n\r\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Nearly half of all birth defects involve the face and skull and, for the most part, scientists remain unclear as to why most occur. To better serve families at risk for these conditions, scientists need a comprehensive and systematic understanding of how the faces of healthy children form and what goes wrong to cause common malformations, such as cleft lip and palate.<\/p>\n<p>With this in mind, the National Institute of Dental and Craniofacial Research (NIDCR) launched FaceBase, a central repository for craniofacial datasets and tools meant to advance craniofacial science by fostering cooperation and collaboration around the globe. Since 2014, USC scientists have been developing FaceBase\u2019s central data hub. That team just received a $12.5 million NIDCR grant to continue the development and expansion of FaceBase into its third phase.<\/p>\n<figure id=\"attachment_119367\" aria-describedby=\"caption-attachment-119367\" style=\"width: 390px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-400 wp-image-119367\" src=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Chai_kesselman2.jpg\" alt=\"\" width=\"400\" height=\"222\" \/><figcaption id=\"caption-attachment-119367\" class=\"wp-caption-text\">USC scientists Yang Chai (left), a practicing dentist, and Carl Kesselman, a data scientist. (Photos by Phil Channing and Damon Casarez)<\/figcaption><\/figure>\n<p>The project\u2019s principal investigators are <a href=\"https:\/\/viterbi.usc.edu\/directory\/faculty\/Kesselman\/Carl\" target=\"_blank\" rel=\"noopener noreferrer\">Carl Kesselman<\/a>, professor at the USC Viterbi School of Engineering Department of Computer Science and director of the Biomedical Data Center at USC\u2019s Information Sciences Institute, and <a href=\"https:\/\/dent-web10.usc.edu\/ccmb\/faculty_detail.asp?RS=1\" target=\"_blank\" rel=\"noopener noreferrer\">Yang Chai<\/a>, associate dean of research for the Herman Ostrow School of Dentistry of USC and director of the Center of Craniofacial and Molecular Biology.<\/p>\n<p>\u201cWe are very excited and honored to serve as the hub for FaceBase III,\u201d said Chai, who is also a professor of stem cell biology and regenerative medicine at the <a href=\"https:\/\/keck.usc.edu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"click here to open Keck School of Medicine of USC\">Keck School of Medicine of USC<\/a>. \u201cThis NIDCR supported Craniofacial Development and Dysmorphology Data Management and Integration Hub will continue to develop towards a comprehensive resource for researchers around the globe and highlights the leadership provided by interdisciplinary researchers at USC to bring oral and craniofacial research to the next level of excellence.\u201d<\/p>\n<p><div class=\"video-embed\"><iframe loading=\"lazy\" id=\"player_1\" class=\"vidframe\" style=\"height: 366.188px; border: 0;\" title=\"Fly-Through of Mouse Skull\" src=\"https:\/\/www.youtube.com\/embed\/tKD5P3tqb6o?controls=1&amp;showinfo=0&amp;rel=0&amp;hd=1&amp;enablejsapi=1&amp;wmode=opaque\" width=\"640\" height=\"360\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div>\n<\/p>\n<p><em> (A fly-through inside a mouse skull, to help better understand craniofacial structures. Video courtesy of FaceBase.)<\/em><\/p>\n<p>The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of craniofacial development and dysmorphologies, or birth defects, and to disseminate these datasets to the wider craniofacial research community.<\/p>\n<p>Craniofacial conditions, a broad term used to describe any disease, defect, or trauma resulting in the malformation of the head and face, affects approximately\u00a0<a href=\"https:\/\/childrensnational.org\/choose-childrens\/conditions-and-treatments\/genetic-disorders-and-birth-defects\/craniofacial-disorder\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">600,000 people in the United States,<\/a>according to Children\u2019s National Health System.<\/p>\n<p>Cleft lip and palate are amongst the most common of all birth defects. In fact, The Center for Disease Control and Prevention recently estimated that in the United States, about 2,650 babies are born with a cleft palate and 4,440 are born with a cleft lip, which can lead to problems with feeding and speaking.<\/p>\n<p>\u201cThis ongoing research represents an ongoing and fruitful collaboration in multi-disciplinary bioscience between the Viterbi School of Engineering and the Herman Ostrow School of Dentistry,\u201d said Kesselman, who is also director of the Center for Discovery Informatics in the\u00a0<a href=\"https:\/\/michelson.usc.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">USC Michelson Center for Convergent Bioscience<\/a>.<\/p>\n<p>\u201cWe\u2019re looking at really challenging problems, which cannot be solved by a single group or individual\u2019s expertise. Together, we can better develop and apply advanced computer science and information management techniques to solve problems in cranio-facial dysmorphia that would otherwise be inaccessible.\u201d<\/p>\n<p>FaceBase launched in 2009, with research focused on the middle region of the face and the genetics related to developmental disorders. The data collected from these projects created an unprecedented, freely available resource for the scientific community. Since then, projects have expanded to include other regions of the face and skull.<\/p>\n<p>This third phase aims to continue work on the data repository, motivate craniofacial researchers around the globe to share their own research data and foster a community of active users through outreach activities and dissemination of new features and available data sets. Past FaceBase contributors have included researchers from more than 24 universities nationwide.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2925,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[436],"class_list":["post-2924","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-usc-stem-cell"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor<\/title>\n<meta name=\"robots\" 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