{"id":309,"date":"2015-01-22T17:26:56","date_gmt":"2015-01-23T01:26:56","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-symposium-creates-scientific-synergy\/"},"modified":"2023-11-19T12:05:03","modified_gmt":"2023-11-19T20:05:03","slug":"usc-stem-cell-symposium-creates-scientific-synergy","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-symposium-creates-scientific-synergy\/","title":{"rendered":"USC Stem Cell Symposium creates scientific synergy"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC Stem Cell Symposium creates scientific synergy<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n January 22, 2015<\/span>\n <\/div>\n \n \n
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Fred H. Gage from the Salk Institute for Biological Sciences and the University of California, San Diego, delivered a brainy keynote address. (Photo by Cristy Lytal)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Provost Michael Quick convened the inaugural USC Stem Cell Symposium with a straightforward truth about the future of regenerative medicine: \u201cit will take a dedicated community of scholars across the disciplines to have maximum impact.\u201d
\nThe January 16 symposium brought together precisely such a community, with speakers hailing from USC\u2019s schools of medicine, dentistry, gerontology and engineering and from The Saban Research Institute of Children\u2019s Hospital Los Angeles (CHLA). Held at Aresty Auditorium at the Keck School of Medicine of USC, the event was hosted by USC Stem Cell (stemcell.usc.edu<\/em>), a collaborative and multidisciplinary effort bringing together more than 100 researchers and clinicians working to translate discoveries into cures.
\n<\/span>Andy McMahon, chair of the USC Stem Cell executive committee, shared his vision of engaging even more scholars from beyond the scientific realm: \u201cAn important part of the future is how USC Stem Cell is going to engage other schools \u2014\u00a0in business, in public policy, in law \u2014 as this area of medicine becomes increasingly more involved. So I\u2019m looking forward to a future that embraces many more schools than are currently represented.\u201d
\nMcMahon also unveiled two new opportunities for young scientists to engage in collaborative and creative research projects. The new USC Stem Cell Hearst Fellowship will support exceptional junior postdoctoral fellows pursuing stem cell research at USC. The USC Stem Cell Student\/Postdoc Collaborative Challenge Grant Program will provide $10,000 to one-year research projects bringing together students or postdocs in two or more labs.
\n\u201cParticularly, we\u2019re interested in interdisciplinary projects that bring people together across different areas of research that tend to have boundaries,\u201d said McMahon. \u201cThe idea is to stimulate new interdisciplinary research and with this, to enhance the student\u2019s or postdoc\u2019s ability to be a creative and independent scientist.\u201d
\nThe USC Stem Cell Regenerative Medicine Initiative (RMI) Awards have enabled additional multi-investigator research collaborations among USC-affiliated faculty members. The three winning teams presented their progress in developing stem cell-based strategies to treat certain forms of deafness, bone defects and pediatric leukemia.
\nOne of the day\u2019s highlights was the keynote address by Fred H. Gage, the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease at the Salk Institute for Biological Sciences and the University of California, San Diego. Gage introduced the concept of \u201cmobile elements,\u201d genetic material that that can move from one part of the genome to another. When these mobile elements insert into neural genes, they may potentially alter behavior, enhance genomic diversity and even speed evolution.
\nSeveral USC Stem Cell principal investigators also shared their most recent research:<\/p>\n

    \n
  • David Warburton from CHLA and the Keck School addressed lung development and disease, which can have both genetic and environmental causes, such as smoking or pollution. He also shared his work on infant mortality in Ulaanbaatar, Mongolia, which consistently tops the list of cities with the worst air pollution in the world.<\/li>\n
  • Paula Cannon from the Keck School talked about genetically modifying blood stem cells to cure HIV\/AIDS. Her approach is inspired by the \u201cBerlin patient,\u201d a man cured of both HIV and leukemia through a bone marrow transplant from a donor with a gene mutation that confers natural immunity to HIV. The first human clinical trials will take place in collaboration with the City of Hope and Sangamo BioSciences.<\/li>\n
  • Rong Lu from USC\u2019s stem cell research center discussed \u201cbarcoding\u201d individual blood stem cells by labeling them with a genetic marker. This allowed her to observe individual cells\u2019 contributions to forming blood, which could determine strategies for more effective blood transfusions or bone marrow transplants.<\/li>\n
  • Tracy Grikscheit \u2014\u00a0from Children\u2019s Hospital Los Angeles (CHLA), the Keck School and the USC Viterbi School of Engineering \u2014\u00a0explained her strategy for \u201cusing science to cure babies\u201d with injured or diseased intestine. Her approach is to take discarded human intestine from the operating room, break it up, and put it on a felt-like biodegradable tube in a special machine, to regrow into new intestine. Eventually, surgeons would reconnect this newly formed intestine to the patient\u2019s digestive tract.<\/li>\n
  • Senta Georgia from CHLA and the Keck School\u00a0has different plans for patients\u2019 intestines: inducing intestinal stem cells to make insulin by \u201cturning on\u201d key genes. The goal is to use these insulin-producing intestinal cells to treat diabetes.<\/li>\n
  • Valter Longo from the USC Davis School of Gerontology introduced his research on fasting, which inhibits the genes responsible for both aging and overall growth in response to protein. Clinical trials are currently underway at the USC Norris Comprehensive Cancer Center, Mayo Clinic and elsewhere to explore whether fasting can improve outcomes in patients receiving chemotherapy for lymphoma as well as breast, prostate and colorectal cancers. He\u2019s also conducting a clinical trial exploring whether a five-day fast can stimulate stem cell-based regeneration of multiple organ systems.<\/li>\n
  • Min Yu \u2014\u00a0from USC\u2019s stem cell research center and the USC Norris Comprehensive Cancer Center \u2014 recently isolated breast cancer cells circulating through patients\u2019 blood streams and kept these cells alive in petri dishes. She is using these cells to identify mutated cancer strains and the right drugs to target them \u2014\u00a0ushering in personalized treatments for breast cancer patients.<\/li>\n
  • Alan S. Wayne from CHLA and the Keck School talked about immunotherapy for patients with the most common form of childhood cancer, acute lymphoblastic leukemia, or ALL. In a recent clinical trial, his team trained patients\u2019 immune cells to recognize and attack leukemia, and two-thirds of the children experienced complete remission.<\/li>\n
  • Michael Bonaguidi from USC\u2019s stem cell research center described the potential of neural stem cells within the adult brain. These stem cells can generate more stem cells or form new neurons and supporting cells, offering a possible avenue for treating symptoms associated with Alzheimer\u2019s disease and other brain dysfunctions.<\/li>\n
  • Justin Ichida from USC\u2019s stem research cell center shared his progress in finding treatments for another fatal neurodegenerative disease: amyotrophic lateral sclerosis (ALS), or Lou Gehrig\u2019s disease. His lab is testing FDA-approved drugs on neurons formed by reprogramming skin cells from patients with ALS. Although these patient-derived neurons display the disease\u2019s signature degeneration, the Ichida lab has already found FDA-approved drugs that keep the neurons alive in the petri dishes \u2014 and might do the same in patients.<\/li>\n
  • Ruchi Bajpai \u2014\u00a0from the Ostrow School of Dentistry of USC and the Keck School \u2014\u00a0addressed why neural tube and craniofacial birth defects occur together in a congenital disorder known as CHARGE syndrome. She studies the genetics underlying this disease by differentiating stem cells into the so-called \u201cneural crest cells\u201d that form many parts of the brain and face.<\/li>\n
  • David Cobrinik from CHLA and the Keck School discussed the formation of a childhood eye tumor called retinoblastoma, which he studies by creating retinal tissue from human stem cells. This research elucidates how the mutation of a tumor-suppressing gene called RB1 can lead to the formation of retinoblastoma.<\/li>\n
  • Megan McCain from USC Viterbi and the Keck School\u00a0introduced the concept of a \u201cheart on a chip.\u201d To overcome the limitations of using laboratory animals or human cells in petri dishes to study human disease, McCain\u2019s laboratory engineers dynamic micro-scale mimics of human heart tissue.<\/li>\n
  • Cheng-Ming Chuong from the Keck School addressed two related topics: how feather stem cells enabled the evolution of birds, and how hair stem cells might enable the \u201cextinction\u201d of male pattern baldness. His research has demonstrated that by plucking 200 hairs in a specific pattern and density, he can induce 1,000 replacement hairs to grow.<\/li>\n
  • Yang Chai \u2014\u00a0director of the Center for Craniofacial Molecular Biology at the Ostrow School \u2014\u00a0explored stem cells that can maintain tooth growth and a possible way to help babies with fused skulls that can\u2019t grow normally. Chai\u2019s lab has found that the skull joints, known as sutures, contain a special population of stem cells that can help maintain and repair the skull.<\/li>\n<\/ul>\n

    At the end of the day, USC\u2019s stem cell scientists left the symposium informed and inspired to translate discoveries into cures.
    \n\u201cIt\u2019s fantastic to see the diversity of different research that\u2019s going on in the schools across USC,\u201d said McMahon. \u201cI very much look forward to meeting again next year.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":84,"featured_media":310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[436],"class_list":["post-309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nUSC Stem Cell Symposium creates scientific synergy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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