{"id":319,"date":"2014-12-01T17:47:38","date_gmt":"2014-12-02T01:47:38","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-hosts-california-stem-cell-agencys-tenth-birthday-bash\/"},"modified":"2023-11-19T12:05:16","modified_gmt":"2023-11-19T20:05:16","slug":"usc-hosts-california-stem-cell-agencys-tenth-birthday-bash","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-hosts-california-stem-cell-agencys-tenth-birthday-bash\/","title":{"rendered":"USC hosts California stem cell agency\u2019s tenth birthday bash"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC hosts California stem cell agency\u2019s tenth birthday bash<\/h1>\n\n\n<\/div>\n \n \n
\n Kevin McCormack and Cristy Lytal<\/span>\n \n December 01, 2014<\/span>\n <\/div>\n \n \n
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Stem cells won the heart of clinical trial participant Fred Lesikar. (Photo by Cristy Lytal)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Few 10 year olds have brought 10 potential medical treatments into clinical trials. The California Institute for Regenerative Medicine (CIRM), however, is a truly exceptional 10 year old.
\nIn 2004, the people of California created CIRM to dispense $3 billion in voter-approved dollars to fund stem cell research in the state. Progress has been impressive. This year alone, 10 CIRM-funded projects, including ones based at USC, are expected to be approved for clinical trials.
\nTo celebrate this milestone, CIRM held a press day on November 20 at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC. This contemporary, state-of-the-art research facility would not exist without funding from CIRM, noted Carmen A. Puliafito, dean of the Keck School of Medicine of USC.
\nPuliafito added: \u201cWith this funding, our researchers and researchers in 11 other facilities throughout the state gained dedicated space to hunt for cures for some of the most pernicious diseases in the world, including heart disease, stroke, cancer, diabetes, Alzheimer\u2019s disease and Parkinson\u2019s disease.\u201d
\nA distinguished panel of speakers joined Puliafito in highlighting CIRM\u2019s decade of accomplishments.
\nJonathan Thomas, chairman of CIRM\u2019s governing board, called the stem cell agency\u2019s first 10 years \u201ca most exciting and historical time in medical research.\u201d
\nDhruv Sareen, a research scientist at the Regenerative Medicine Institute and director of the iPSC Core Facility at Cedars-Sinai, praised CIRM for creating a whole new industry in the state: \u201cWhat Silicon Valley has done for technology, CIRM is doing for stem cell research in California.\u201d
\nOne beneficiary of this new industry is ViaCyte, a San Diego-based company now in clinical trials with a small, implantable device containing stem cells to treat type 1 diabetes.
\n\u201cIn 2008, it was extremely hard for a small biotech company to get funding for the kind of work we were doing,\u201d said ViaCyte\u2019s Eugene Brandon. \u201cWithout that support, without that funding from CIRM, I don\u2019t know where this work would be today.\u201d
\nAnother biotech company, Sangamo BioSciences, is collaborating on a CIRM-funded HIV\/AIDS clinical trial with principal investigator John Zaia, chair of virology at the Beckman Research Institute of the City of Hope.
\nAt the event, Zaia credited CIRM with creating a \u201cclimate of research that is relatively product- and milestone-driven.\u201d
\nCIRM supported this clinical trial from its inception by providing $14.6 million to fund the early-stage development of a technique for genetically modifying blood-forming stem cells to cure HIV\/AIDS, pioneered by Zaia, David DiGiusto from City of Hope, scientists at Sangamo BioSciences and Paula Cannon, associate professor of Molecular Microbiology and Immunology, Pediatrics, and Biochemistry and Molecular Biology at the Keck School.
\nAs the head of USC\u2019s department, research center and university-wide initiative in stem cell biology and regenerative medicine, Andy McMahon underscored the importance of this HIV\/AIDS trial. He also mentioned other USC-led clinical trials exploring stem cell-related treatments for Alzheimer\u2019s disease, the dry form of age-related macular degeneration, knee osteoarthritis and immune damage due to chemotherapy.
\n\u201cI\u2019m personally very excited and hopeful about the future of stem cell research in California,\u201d he said. \u201cThe public support of our work through Proposition 71 has enabled our own researchers to spearhead important new research programs and to develop new therapeutic approaches. But as important, CIRM funding has brought together powerful, cross-institutional teams that have united research around the goals of regenerative medicine to treat a host of diseases affecting humanity.\u201d
\nA few CIRM-supported clinical trials have already benefitted patients. Gay Crooks, professor and co-director of the Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research at UCLA, shared news of one such success.
\n\u201cDr. Donald Kohn, through the Mattel Children\u2019s Hospital at UCLA, has brought cures to 18 children who have a lethal form of immune deficiency, otherwise known as \u2018bubble baby\u2019 disease, through correcting the genes in the stem cells of these children,\u201d said Crooks. \u201cThese trials were absolutely supported by CIRM, which was critically important to bringing them to fruition.\u201d
\nKohn is using the same approach to develop a clinical trial addressing sickle cell disease.
\nFred Lesikar from Menifee, Calif., shared his personal story of suffering a massive heart attack and leaving the hospital a diminished person, unable to do most basic things. Months later, he enrolled in a clinical trial, in which researchers harvested cells from his heart, coaxed them to grow, and returned them into his heart again \u2014 which seems to have improved function and reduced scar tissue in the damaged organ.
\n\u201cIt\u2019s not just patients who benefit from these treatments, families do, too,\u201d said Lesikar. \u201cIt changes the life of the patient and the lives of all those around them. I feel like I\u2019m back to normal, and I\u2019m so grateful for CIRM and Cedars-Sinai for helping me get here.\u201d
\nThe Cedars-Sinai-based team behind the approach is now conducting a much larger, CIRM-funded clinical trial.
\nThe last word was left to Bob Klein, who led the drive to create CIRM.
\n\u201cThe genius of the people of this state is reflected in their commitment to this cause,\u201d he said, \u201cand we should all be eternally grateful for their vision in supporting research that will save and transform people\u2019s lives.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":123,"featured_media":320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[20,17],"class_list":["post-319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-research","tag-stem-cell"],"acf":[],"yoast_head":"\nUSC hosts California stem cell agency\u2019s tenth birthday bash<\/title>\n<meta name=\"robots\" content=\"index, follow, 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