{"id":3903,"date":"2021-03-05T17:19:43","date_gmt":"2021-03-06T01:19:43","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/for-usc-scientist-xi-chen-a-chicken-is-more-than-just-an-eggs-way-of-making-another-egg\/"},"modified":"2023-11-19T12:44:42","modified_gmt":"2023-11-19T20:44:42","slug":"for-usc-scientist-xi-chen-a-chicken-is-more-than-just-an-eggs-way-of-making-another-egg","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/for-usc-scientist-xi-chen-a-chicken-is-more-than-just-an-eggs-way-of-making-another-egg\/","title":{"rendered":"For USC scientist Xi Chen, a chicken is more than just an egg\u2019s way of making another egg"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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For USC scientist Xi Chen, a chicken is more than just an egg\u2019s way of making another egg<\/h1>\n\n\n<\/div>\n \n \n
\n Isabelle Osterholt<\/span>\n \n March 05, 2021<\/span>\n <\/div>\n \n \n
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Xi Chen (Photo courtesy of Xi Chen)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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(Originally posted at USC Stem Cell<\/a>.)<\/p>\n

USC postdoctoral researcher Xi Chen knows that you have to break a few eggs in order to grow chicken stem cells. His work on maintaining embryonic stem cells (ESC) from chicken eggs provides insight into stem cell pluripotency and evolutionary developmental biology.<\/p>\n

\u201cThe choice of beginning with fertilized chicken eggs was critical to the success of my research because they are easy to get from a farm. It took more than 5,000 fertilized eggs to develop an optimal environment for maintaining chicken ESCs [in the lab],\u201d said Chen, who works in\u00a0Qi-Long Ying\u2019s lab<\/a>\u00a0in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.<\/p>\n

Chen hopes that his research will lead to applications in other avian species such as quail or geese. Quail ESCs could be useful in the lab due to their shorter maturation times and smaller size compared with chicken ESCs. Further applications could extend to developing laboratory-generated food lines. In addition, comparing ESCs from a variety of birds could shed light on their biological diversity, and create future potential for reviving extinct or repopulating endangered species.<\/p>\n

Chen originally intended to work in a clinical laboratory at a large hospital, and studied medicine at Shanghai Jiao Tong University. But after running the same lab tests day after day as an intern, he yearned for an opportunity to explore other areas of science.<\/p>\n

After completing his undergraduate degree, he earned an MS in biochemistry from George Washington University in Washington, DC. This led him to apply to PhD programs, which is how he came to USC.<\/p>\n

\u201cI looked at many universities,\u201d he said, \u201cbut USC offered a highly-supportive program that encouraged doctoral students to seek their areas of interest.\u201d<\/p>\n

After completing lab rotations in immunology, pharmacology, and stem cell biology, Chen found his fit in Ying\u2019s lab.<\/p>\n

Chen initially focused on using a then-novel gene editing technology, CRISPR, to deactivate genes, known as GSK3 genes, in mouse ESCs. He then published\u00a0research in the journal\u00a0Developmental Cell<\/em><\/a>\u00a0about the role of two forms of GSK3 on ESC maintenance and differentiation. In 2019, he presented this research at the meeting of the\u00a0International Society for Stem Cell Research (ISSCR)<\/a>, hosted by USC Stem Cell at the Los Angeles Convention Center.<\/p>\n

This early success inspired him to pursue a much riskier project: developing on a method for maintaining chicken ESCs in their undifferentiated self-renewing state. Chen presented his research on avian ESCs at the 2020 ISSCR meeting, which was virtual due to the pandemic.<\/p>\n

\u201cPresenting at the ISSCR two years in a row was both exciting and an honor for me,\u201d he said.<\/p>\n

In fall 2020, Chen received his PhD and is continuing his work on chicken ESCs as a postdoc in the Ying Lab.<\/p>\n

\u201cXi Chen is a smart, creative, hardworking, and driven young scientist,\u201d said Ying, who is a professor of stem cell biology and regenerative medicine, and integrative anatomical sciences at the Keck School of Medicine of USC. \u201cHe has a great potential to become a leader in the stem cell and regenerative medicine field.\u201d<\/p>\n

Chen enjoys life in Los Angeles\u2014with its ocean breezes that remind him of home, and authentic Chinese food offering many regional dishes that aren\u2019t available in his native Shanghai. He\u2019s even found time to go fishing for lobster, a favorite seafood in his hometown. But he devotes most of his time to the lab.<\/p>\n

\u201cI want to develop my chicken-egg ESC lines further to expand the research,\u201d said Chen. \u201cThis topic is my baby.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":109,"featured_media":3905,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[78],"class_list":["post-3903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-uncategorized"],"acf":[],"yoast_head":"\nFor USC scientist Xi Chen, a chicken is more than just an egg\u2019s way of making another egg<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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