{"id":3944,"date":"2021-03-30T10:15:39","date_gmt":"2021-03-30T17:15:39","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/"},"modified":"2023-11-19T12:45:04","modified_gmt":"2023-11-19T20:45:04","slug":"usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/","title":{"rendered":"USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
\n\n \n

USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n March 30, 2021<\/span>\n <\/div>\n \n \n
\n\n \n
<\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/g><\/svg><\/span><\/a><\/svg><\/span><\/a><\/div>
<\/div><\/div>\n\n\n<\/div>\n \n <\/div>\n\n \n
\n\n \n \n \n
\n \n \n \n \n \n\n \n
From left, Andy McMahon, Lisa Rutledge, Helena Bugacov and Alex Guo hold an impromptu lab meeting. (Photo\/Christina Gandolfo)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n

(Originally posted at USC Stem Cell<\/a>.)<\/p>\n

Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study in the journal\u00a0eLife<\/em><\/a>\u00a0from Andy McMahon\u2019s laboratory in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC, former graduate student Alex Quiyu Guo and a team of scientists demonstrate the importance of a molecule called \u03b2-catenin in striking this balance.<\/p>\n

\u03b2-catenin is a key driver at the end of a complex signaling cascade known as the Wnt pathway. Wnt signaling plays critical roles in the embryonic development of multiple organs including the kidneys. By partnering with other Wnt pathway molecules, \u03b2-catenin controls the activity of hundreds to thousands of genes within the cell.<\/p>\n

The new study builds on the McMahon Lab\u2019s previous discovery that Wnt\/\u03b2-catenin can initiate progenitor cells to execute a lengthy and highly orchestrated program of forming structures in the kidney called nephrons. A healthy human kidney contains a million nephrons that balance body fluids and remove soluble waste products. Too few nephrons results in kidney disease.<\/p>\n

Previous studies from the UT Southwestern Medical Center laboratory of Thomas Carroll, a former postdoctoral trainee in the McMahon Lab, suggested that Wnt\/\u03b2-catenin signaling plays opposing roles in ensuring the proper number of nephrons: promoting progenitor maintenance and self-renewal, and stimulating progenitor cell differentiation.<\/p>\n

\u201cIt sounded like Wnt\/\u03b2-catenin is doing two things\u2014both maintenance and differentiation\u2014that seem to be opposite operations,\u201d said Guo. \u201cTherefore, the hypothesis was that different levels of Wnt\/\u03b2-catenin can dictate different fates of the nephron progenitors: when it\u2019s low, it works on maintenance; when it\u2019s high, it directs differentiation.\u201d<\/p>\n

In 2015, it became more possible to test this hypothesis when Leif Oxburgh, a scientist at the Rogosin Institute in New York and a co-author of the\u00a0eLife\u00a0<\/em>study, developed a system for growing large numbers of nephron progenitor cells, or NPCs, in a Petri dish.<\/p>\n

Relying on this game-changing new system, Guo and his collaborators grew NPCs, added different levels of a chemical that activates \u03b2-catenin, and saw their hypothesis play out in the Petri dishes.<\/p>\n

They observed that high levels of \u03b2-catenin triggered a \u201cswitch\u201d in part of the Wnt pathway that relies on another family of transcription factors known as TCF\/LEF. There are two types of TCF\/LEF transcription factors: one type inhibits genes related to differentiation, and the other activates these genes. In response to high levels of \u03b2-catenin, the \u201cactivating\u201d members of TCF\/LEF switched places with the \u201cinhibiting\u201d members, effectively taking charge. This \u201cswitch\u201d triggered NPCs to differentiate into more specialized types of kidney cells.<\/p>\n

When they looked at low levels of \u03b2-catenin, they saw NPCs self-renewing and maintaining their populations, as expected. However, they were surprised to learn that \u03b2-catenin was not engaged with any of the known genes related to self-renewal and maintenance.<\/p>\n

\u201c\u03b2-catenin does something,\u201d said Guo. \u201cThat is for sure. But how it does it is kind of mysterious right now.\u201d<\/p>\n

After publishing these results in\u00a0eLife<\/em>, Guo earned his PhD from USC, and began his postdoctoral training at UCLA. Helena Bugacov, a current PhD student in the McMahon Lab and a co-author of the\u00a0eLife\u00a0<\/em>study, is now taking the lead in continuing the project\u2014which has implications far beyond the kidney field, due to the broad role of\u00a0Wnt<\/em>\u00a0throughout the body.<\/p>\n

\u201cUnderstanding how Wnt regulates these two very distinct cell outcomes of self-renewal and differentiation, which is very important for kidney development, is also important for understanding the development of other organs and adult stem cells, as Wnt signaling plays important roles in almost all developmental systems,\u201d said Bugacov. \u201cThere is also a lot of attention from cancer researchers, as this process can go awry in cancer. Many therapeutics are trying to target this process.\u201d<\/p>\n

She added, \u201cThe more we know about things, the better we can inform work on developing human kidney organoid cultures, which can be more readily used to understand problems in human health, regeneration and development.\u201d<\/p>\n

Additional co-authors of the\u00a0eLife<\/em>\u00a0study include: Albert Kim, Andrew Ransick, Xi Chen, and Nils Lindstrom from USC; Aaron Brown from the Maine Medical Center Research Institute; and Bin Li and Bing Ren from the University of California, San Diego. The research was supported by federal funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant number R01 DK054364).<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":84,"featured_media":3946,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[78],"class_list":["post-3944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-uncategorized"],"acf":[],"yoast_head":"\nUSC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-30T17:15:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-19T20:45:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1402\" \/>\n\t<meta property=\"og:image:height\" content=\"1054\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cristy Lytal\u00a0\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\"},\"author\":{\"name\":\"Cristy Lytal\u00a0\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/d069582f631be687afcb7867ff7ebdb8\"},\"headline\":\"USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells\",\"datePublished\":\"2021-03-30T17:15:39+00:00\",\"dateModified\":\"2023-11-19T20:45:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\"},\"wordCount\":13,\"publisher\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg\",\"articleSection\":[\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\",\"url\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\",\"name\":\"USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells\",\"isPartOf\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg\",\"datePublished\":\"2021-03-30T17:15:39+00:00\",\"dateModified\":\"2023-11-19T20:45:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage\",\"url\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg\",\"contentUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg\",\"width\":1402,\"height\":1054,\"caption\":\"Andy McMahon\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/keck.usc.edu\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#website\",\"url\":\"https:\/\/keck.usc.edu\/news\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/keck.usc.edu\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#organization\",\"name\":\"Keck School of Medicine of USC\",\"alternateName\":\"Keck School of Medicine\",\"url\":\"https:\/\/keck.usc.edu\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg\",\"contentUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg\",\"width\":696,\"height\":696,\"caption\":\"Keck School of Medicine of USC\"},\"image\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/KECKschoolUSC\/\",\"https:\/\/x.com\/KeckSchool_USC\",\"https:\/\/www.linkedin.com\/school\/keckschoolusc\/\",\"https:\/\/www.instagram.com\/KeckSchoolUSC\/\",\"https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA\",\"https:\/\/www.tiktok.com\/@keckschoolusc\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/d069582f631be687afcb7867ff7ebdb8\",\"name\":\"Cristy Lytal\u00a0\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"caption\":\"Cristy Lytal\u00a0\"},\"url\":\"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/","og_locale":"en_US","og_type":"article","og_title":"USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells","og_url":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/KECKschoolUSC\/","article_published_time":"2021-03-30T17:15:39+00:00","article_modified_time":"2023-11-19T20:45:04+00:00","og_image":[{"width":1402,"height":1054,"url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg","type":"image\/jpeg"}],"author":"Cristy Lytal\u00a0","twitter_card":"summary_large_image","twitter_creator":"@KeckSchool_USC","twitter_site":"@KeckSchool_USC","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#article","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/"},"author":{"name":"Cristy Lytal\u00a0","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/d069582f631be687afcb7867ff7ebdb8"},"headline":"USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells","datePublished":"2021-03-30T17:15:39+00:00","dateModified":"2023-11-19T20:45:04+00:00","mainEntityOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/"},"wordCount":13,"publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg","articleSection":["Press Release"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/","url":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/","name":"USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg","datePublished":"2021-03-30T17:15:39+00:00","dateModified":"2023-11-19T20:45:04+00:00","breadcrumb":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#primaryimage","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al.jpg","width":1402,"height":1054,"caption":"Andy McMahon"},{"@type":"BreadcrumbList","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-study-identifies-molecular-switch-that-turns-precursors-into-kidney-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/keck.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"USC Stem Cell study identifies molecular ‘switch’ that turns precursors into kidney cells"}]},{"@type":"WebSite","@id":"https:\/\/keck.usc.edu\/news\/#website","url":"https:\/\/keck.usc.edu\/news\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/keck.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/keck.usc.edu\/news\/#organization","name":"Keck School of Medicine of USC","alternateName":"Keck School of Medicine","url":"https:\/\/keck.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","width":696,"height":696,"caption":"Keck School of Medicine of USC"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/KECKschoolUSC\/","https:\/\/x.com\/KeckSchool_USC","https:\/\/www.linkedin.com\/school\/keckschoolusc\/","https:\/\/www.instagram.com\/KeckSchoolUSC\/","https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA","https:\/\/www.tiktok.com\/@keckschoolusc"]},{"@type":"Person","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/d069582f631be687afcb7867ff7ebdb8","name":"Cristy Lytal\u00a0","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","caption":"Cristy Lytal\u00a0"},"url":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"}]}},"author_meta":{"display_name":"Cristy Lytal\u00a0","author_link":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"},"featured_img":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/McMahon-et-al-300x226.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Press Release<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Press Release<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Uncategorized<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Uncategorized<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 5 years ago","modified":"Updated 2 years ago"},"absolute_dates":{"created":"Posted on March 30, 2021","modified":"Updated on November 19, 2023"},"absolute_dates_time":{"created":"Posted on March 30, 2021 10:15 am","modified":"Updated on November 19, 2023 12:45 pm"},"featured_img_caption":"Andy McMahon","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/3944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=3944"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/3944\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/3946"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=3944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=3944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=3944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}