{"id":4084,"date":"2021-06-15T08:34:17","date_gmt":"2021-06-15T15:34:17","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/"},"modified":"2023-11-19T12:46:26","modified_gmt":"2023-11-19T20:46:26","slug":"usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/","title":{"rendered":"USC Stem Cell scientists make big progress in building mini-kidneys"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
\n\n \n

USC Stem Cell scientists make big progress in building mini-kidneys<\/h1>\n\n\n<\/div>\n \n \n
\n\n \n

The organoids, which resemble a kidney\u2019s uretic buds, provide a way to study kidney disease that could lead to new treatments and regenerative approaches for patients.<\/p>\n\n\n\n<\/div>\n \n

\n Cristy Lytal<\/span>\n \n June 15, 2021<\/span>\n <\/div>\n \n \n
\n\n \n
<\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/g><\/svg><\/span><\/a><\/svg><\/span><\/a><\/div>
<\/div><\/div>\n\n\n<\/div>\n \n <\/div>\n\n \n
\n\n \n \n \n
\n \n \n \n \n \n\n \n
Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney\u2019s collecting duct system. (Image by Zipeng Zeng\/Li Lab)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n

(Originally posted at\u00a0USC Stem Cell<\/a>.)<\/p>\n

A team of scientists at the Keck School of Medicine of USC<\/a> has created what could be a key building block for assembling a synthetic kidney. In a new study in Nature Communications<\/em><\/a>, Zhongwei Li and his colleagues describe how they can generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system that helps maintain the body\u2019s fluid and pH balance by concentrating and transporting urine.<\/p>\n

\u201cOur progress in creating new types of kidney organoids provides powerful tools for not only understanding development and disease, but also finding new treatments and regenerative approaches for patients,\u201d said Li, the study\u2019s corresponding author and an assistant professor of medicine, and of stem cell biology and regenerative medicine.<\/p>\n

Creating the building blocks<\/strong><\/p>\n

The first authors of the study, PhD student Zipeng Zeng and postdoc Biao Huang, and the team started with a population of what are known as ureteric bud progenitor cells, or UPCs, that play an important role in early kidney development. Using first mouse and then human UPCs, the scientists were able to develop cocktails of molecules that encourage the cells to form organoids resembling uretic buds\u2014the branching tubes that eventually give rise to the collecting duct system. The scientists also succeeded in finding a different cocktail to induce human stem cells to develop into ureteric bud organoids.<\/p>\n

An additional molecular cocktail pushed ureteric bud organoids\u2014grown from either mouse UPCs or human stem cells\u2014to reliably develop into even more mature and complex collecting duct organoids.<\/p>\n

The human and mouse ureteric bud organoids can also be genetically engineered to harbor mutations that cause disease in patients, providing better models for understanding kidney problems, as well as for screening potential therapeutic drugs. As one example, the scientists knocked out a gene to create an organoid model of congenital anomalies of the kidney and urinary tract, known as CAKUT.<\/p>\n

In addition to serving as models of disease, ureteric bud organoids could also prove to be an essential ingredient in the recipe for a synthetic kidney. To explore this possibility, the scientists combined mouse ureteric bud organoids with a second population of mouse cells: the progenitor cells that form nephrons, which are the filtering units of the kidney. After inserting the tip of a lab-grown ureteric bud into a clump of NPCs, the team observed the growth of an extensive network of branching tubes reminiscent of a collecting duct system, fused with rudimentary nephrons.<\/p>\n

\u201cOur engineered mouse kidney established a connection between nephron and collecting duct\u2014an essential milestone towards building a functional organ in the future,\u201d said Li.<\/p>\n

About the Study<\/strong><\/p>\n

The project brought together scientists from the USC\/UKRO Kidney Research Center<\/a>, Li\u2019s primary affiliation; the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC<\/a>; the departments of Medicine, and Stem Cell Biology and Regenerative Medicine; and the divisions of Nephrology and Hypertension, and Maternal Fetal Medicine. Additional authors include Riana K. Parvez, Yidan Li, Jyunhao Chen, Ariel C. Vonk, Matthew E. Thornton, Tadrushi Patel, Elisabeth A. Rutledge, Albert D. Kim, Jingying Yu, Brendan H. Grubbs, Jill A. McMahon, N\u00faria M. Pastor-Soler, Kenneth R. Hallows and Andrew P. McMahon.<\/p>\n

Twenty percent of this work was supported by federal funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant DK054364 and F31 fellowship DK107216). The remainder of the support came from departmental startup funding, UKRO foundation support, a USC Stem Cell Challenge Award, and the California Institute for Regenerative Medicine (CIRM) Bridges Program.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

“Our progress in creating new types of kidney organoids provides powerful tools for not only understanding development and disease, but also finding new treatments.”<\/p>\n","protected":false},"author":84,"featured_media":4085,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[56,169,20,436],"class_list":["post-4084","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-featured","tag-latest","tag-research","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nUSC Stem Cell scientists make big progress in building mini-kidneys<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USC Stem Cell scientists make big progress in building mini-kidneys\" \/>\n<meta property=\"og:description\" content=\""Our progress in creating new types of kidney organoids provides powerful tools for not only understanding development and disease, but also finding new treatments."\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-15T15:34:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-19T20:46:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cristy Lytal\u00a0\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/\"},\"author\":{\"name\":\"Cristy Lytal\u00a0\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/9af9659d177a1ffc2f67e5940d535394\"},\"headline\":\"USC Stem Cell scientists make big progress in building mini-kidneys\",\"datePublished\":\"2021-06-15T15:34:17+00:00\",\"dateModified\":\"2023-11-19T20:46:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/\"},\"wordCount\":10,\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/Featured-Image2.jpg\",\"keywords\":[\"Featured\",\"Latest\",\"Research\",\"USC Stem Cell\"],\"articleSection\":[\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/\",\"name\":\"USC Stem Cell scientists make big progress in building mini-kidneys\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/Featured-Image2.jpg\",\"datePublished\":\"2021-06-15T15:34:17+00:00\",\"dateModified\":\"2023-11-19T20:46:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#primaryimage\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/Featured-Image2.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/Featured-Image2.jpg\",\"width\":1200,\"height\":675,\"caption\":\"Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney\u2019s collecting duct system. (Image by Zipeng Zeng\\\/Li Lab)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"USC Stem Cell scientists make big progress in building mini-kidneys\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\",\"name\":\"Keck School of Medicine of USC\",\"alternateName\":\"Keck School of Medicine\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"width\":696,\"height\":696,\"caption\":\"Keck School of Medicine of USC\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/KECKschoolUSC\\\/\",\"https:\\\/\\\/x.com\\\/KeckSchool_USC\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/keckschoolusc\\\/\",\"https:\\\/\\\/www.instagram.com\\\/KeckSchoolUSC\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCpL1E1W5ZTfkc5iihwLSFEA\",\"https:\\\/\\\/www.tiktok.com\\\/@keckschoolusc\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/9af9659d177a1ffc2f67e5940d535394\",\"name\":\"Cristy Lytal\u00a0\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"caption\":\"Cristy Lytal\u00a0\"},\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/author\\\/cristy_lytal\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"USC Stem Cell scientists make big progress in building mini-kidneys","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/","og_locale":"en_US","og_type":"article","og_title":"USC Stem Cell scientists make big progress in building mini-kidneys","og_description":"\"Our progress in creating new types of kidney organoids provides powerful tools for not only understanding development and disease, but also finding new treatments.\"","og_url":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/KECKschoolUSC\/","article_published_time":"2021-06-15T15:34:17+00:00","article_modified_time":"2023-11-19T20:46:26+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg","type":"image\/jpeg"}],"author":"Cristy Lytal\u00a0","twitter_card":"summary_large_image","twitter_creator":"@KeckSchool_USC","twitter_site":"@KeckSchool_USC","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#article","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/"},"author":{"name":"Cristy Lytal\u00a0","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/9af9659d177a1ffc2f67e5940d535394"},"headline":"USC Stem Cell scientists make big progress in building mini-kidneys","datePublished":"2021-06-15T15:34:17+00:00","dateModified":"2023-11-19T20:46:26+00:00","mainEntityOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/"},"wordCount":10,"publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg","keywords":["Featured","Latest","Research","USC Stem Cell"],"articleSection":["Press Release"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/","url":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/","name":"USC Stem Cell scientists make big progress in building mini-kidneys","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#primaryimage"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg","datePublished":"2021-06-15T15:34:17+00:00","dateModified":"2023-11-19T20:46:26+00:00","breadcrumb":{"@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#primaryimage","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2.jpg","width":1200,"height":675,"caption":"Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney\u2019s collecting duct system. (Image by Zipeng Zeng\/Li Lab)"},{"@type":"BreadcrumbList","@id":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-make-big-progress-in-building-mini-kidneys\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/keck.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"USC Stem Cell scientists make big progress in building mini-kidneys"}]},{"@type":"WebSite","@id":"https:\/\/keck.usc.edu\/news\/#website","url":"https:\/\/keck.usc.edu\/news\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/keck.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/keck.usc.edu\/news\/#organization","name":"Keck School of Medicine of USC","alternateName":"Keck School of Medicine","url":"https:\/\/keck.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","width":696,"height":696,"caption":"Keck School of Medicine of USC"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/KECKschoolUSC\/","https:\/\/x.com\/KeckSchool_USC","https:\/\/www.linkedin.com\/school\/keckschoolusc\/","https:\/\/www.instagram.com\/KeckSchoolUSC\/","https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA","https:\/\/www.tiktok.com\/@keckschoolusc"]},{"@type":"Person","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/9af9659d177a1ffc2f67e5940d535394","name":"Cristy Lytal\u00a0","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","caption":"Cristy Lytal\u00a0"},"url":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"}]}},"author_meta":{"display_name":"Cristy Lytal\u00a0","author_link":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"},"featured_img":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Featured-Image2-300x169.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Press Release<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Press Release<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Featured<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Latest<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Research<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">USC Stem Cell<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Featured<\/span>","<span class=\"advgb-post-tax-term\">Latest<\/span>","<span class=\"advgb-post-tax-term\">Research<\/span>","<span class=\"advgb-post-tax-term\">USC Stem Cell<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 5 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on June 15, 2021","modified":"Updated on November 19, 2023"},"absolute_dates_time":{"created":"Posted on June 15, 2021 8:34 am","modified":"Updated on November 19, 2023 12:46 pm"},"featured_img_caption":"Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney\u2019s collecting duct system. (Image by Zipeng Zeng\/Li Lab)","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/4084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=4084"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/4084\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/4085"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=4084"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=4084"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=4084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}