{"id":4091,"date":"2021-06-24T12:39:39","date_gmt":"2021-06-24T19:39:39","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-researchers-share-discoveries-on-alzheimers-disease-and-discuss-strategies-to-fight-the-illness\/"},"modified":"2023-11-19T12:46:31","modified_gmt":"2023-11-19T20:46:31","slug":"usc-researchers-share-discoveries-on-alzheimers-disease-and-discuss-strategies-to-fight-the-illness","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-researchers-share-discoveries-on-alzheimers-disease-and-discuss-strategies-to-fight-the-illness\/","title":{"rendered":"USC researchers share discoveries on Alzheimer\u2019s disease and discuss strategies to fight the illness"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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USC researchers share discoveries on Alzheimer\u2019s disease and discuss strategies to fight the illness<\/h1>\n\n\n<\/div>\n \n \n
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A newly approved yet controversial drug, in particular, brings both hope and challenges for patients and clinicians.<\/p>\n\n\n\n<\/div>\n \n

\n Leigh Hopper and Jenesse Miller<\/span>\n \n June 24, 2021<\/span>\n <\/div>\n \n \n
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(Originally posted at USC News<\/a>.)<\/p>\n

A controversial new drug for Alzheimer\u2019s disease is raising tough questions: Who should take it? Who will pay for it? And how will we know how well it works? But that\u2019s not the only Alzheimer\u2019s news during Alzheimer\u2019s and Brain Awareness Month.<\/p>\n

Recent USC research shows that members of an isolated indigenous group in the Bolivian Amazon have healthier brains that age more slowly \u2014 possibly because of healthy diet and exercise. And another study finds that texted messages, tailored to African Americans, can increase knowledge about Alzheimer\u2019s in the Black community.<\/p>\n

More than 5 million Americans are living with the memory-erasing disease, and USC remains one of the top private institutions in federal funding for Alzheimer\u2019s research. Here\u2019s a look at some of the latest topics that USC researchers are studying.<\/p>\n

USC implementing the rollout of new Alzheimer\u2019s drug<\/strong><\/p>\n

Keck Medicine of USC<\/a>\u00a0is currently developing a screening criterion for patients best suited to try aducanumab, the new Alzheimer\u2019s drug that was\u00a0recently approved<\/a>\u00a0by the Food and Drug Administration. In clinical trials, the medication \u2014 which must be infused \u2014 was found to clear amyloid plaques in the brain.<\/p>\n

\u201cThe drug was tested on patients with mild cognitive impairment. Therefore, while the Food and Drug Administration has issued a broad authorization of aducanumab, we will work to designate a select patient population that may benefit from the therapy,\u201d said Krist Azizian, chief pharmacy officer at Keck Medicine of USC. \u201cWe will also create guidelines for monitoring and assessing patients during and post-treatment that includes brain imaging. Access to the medication will not be an issue for patients, as our health system has multiple infusion centers available to administer the drug.\u201d<\/p>\n

\u201cWe will also keep in mind,\u201d he added, \u201cthe fact that the FDA can ultimately remove aducanumab from the market pending additional data and verification of clinical benefit as part of the accelerated approval process.\u201d<\/p>\n

Bringing the Black community trusted, timely information on Alzheimer\u2019s<\/strong><\/p>\n

\u201cAfrican Americans still have the lowest level of basic knowledge about Alzheimer\u2019s, have few trusted sources of information for it and have the highest risk of the disease in the United States,\u201d said\u00a0Karen Lincoln<\/a>, an associate professor at the USC Suzanne Dworak-Peck School of Social Work.<\/p>\n

\u201cIncreasing Alzheimer\u2019s literacy among African Americans is crucial for increasing their awareness of their personal risk for the disease, improving care, reducing disparities and ultimately enhancing the quality of life of people diagnosed and their caregivers.\u201d<\/p>\n

Lincoln, who founded\u00a0Advocates for African American Elders<\/a>, draws insight from personal experience \u2014 her own mother\u2019s diagnosis with dementia. Despite her professional expertise, it took Lincoln several years to convince her family that something was wrong.<\/p>\n

Today, Lincoln focuses on tailored text messaging to educate the Black community about the disease. While the Alzheimer\u2019s Association might text reminders to engage in brain games such as Scrabble or Sudoku, Lincoln urges her community to play dominoes or try driving a different route to church.<\/p>\n

Amazon indigenous group\u2019s lifestyle may hold a key to slowing aging<\/strong><\/p>\n

USC researchers also look for clues to preventing Alzheimer\u2019s through studies and fieldwork around the globe. A\u00a0recent study<\/a>\u00a0of a physically active Amazonian population in Bolivia has revealed possible hints for staving off the disease.<\/p>\n

\u201cThe Tsimane people have provided us with an amazing natural experiment on the potentially detrimental effects of modern lifestyles on our health,\u201d said\u00a0Andrei Irimia<\/a>, an assistant professor of gerontology, neuroscience and biomedical engineering at the USC Leonard Davis School of Gerontology and the USC Viterbi School of Engineering.<\/p>\n

In his study of the Tsimane (pronounced\u00a0chee-MAH\u2019-nay<\/em>), Irimia has found that despite high levels of inflammation, these individuals are unique for their healthy brains that age more slowly.<\/p>\n

Although people in industrialized nations have access to modern medical care, they are more sedentary and eat a diet high in saturated fats. In contrast, the Tsimane have little or no access to health care but are extremely physically active and consume a high-fiber diet that includes vegetables, fish and lean meat.<\/p>\n

\u201cThese findings suggest that brain atrophy may be slowed substantially by the same lifestyle factors associated with very low risk of heart disease,\u201d Irimia said.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Keck Medicine of USC\u00a0is currently developing a screening criterion for patients best suited to try aducanumab, the new Alzheimer\u2019s drug that was\u00a0recently approved\u00a0by the FDA.<\/p>\n","protected":false},"author":131,"featured_media":4092,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[78],"class_list":["post-4091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-uncategorized"],"acf":[],"yoast_head":"\nUSC researchers share discoveries on Alzheimer\u2019s disease and discuss strategies to fight the illness<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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