{"id":4525,"date":"2022-01-24T12:31:11","date_gmt":"2022-01-24T20:31:11","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/with-a-50-million-gift-usc-and-uc-san-diego-join-forces-in-alzheimers-research\/"},"modified":"2025-08-27T15:12:16","modified_gmt":"2025-08-27T22:12:16","slug":"with-a-50-million-gift-usc-and-uc-san-diego-join-forces-in-alzheimers-research","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/with-a-50-million-gift-usc-and-uc-san-diego-join-forces-in-alzheimers-research\/","title":{"rendered":"With a $50 Million Gift, USC and UC San Diego Join Forces in Alzheimer\u2019s Research"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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With a $50 Million Gift, USC and UC San Diego Join Forces in Alzheimer\u2019s Research<\/h1>\n\n\n<\/div>\n \n \n
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A transformative donation from the Epstein Family Foundation will accelerate Alzheimer\u2019s research at the two universities in a push to find better treatments and a cure<\/p>\n\n\n\n<\/div>\n \n

\n Leigh Hopper and Jade Griffin<\/span>\n \n January 24, 2022<\/span>\n <\/div>\n \n \n
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Alzheimer\u2019s disease has touched the family of Daniel and Phyllis Epstein: Dan\u2019s identical twin brother, David, suffered from Alzheimer\u2019s for 15 years and passed away recently as a result of the disease. (Photo\/Courtesy of Daniel and Phyllis Epstein)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n
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(Originally posted on USC News<\/a>)<\/em><\/p>\n

A joint gift to USC and the University of California, San Diego, totaling $50 million from the Epstein Family Foundation will drive Alzheimer\u2019s research and accelerate the search for treatments and a cure.<\/p>\n

The generous donation establishes the Epstein Family Alzheimer\u2019s Research Collaboration at USC and UC San Diego. The gift will be split evenly, with $25 million going to each institution. The funding will support existing research at each university and will spark new collaborative efforts to discover effective therapies for Alzheimer\u2019s disease.<\/p>\n

Alzheimer\u2019s disease is a progressive neurological disorder that affects more than 6 million Americans, according to the\u00a0Centers for Disease Control and Prevention. Experts have projected the number of Americans diagnosed with the disease will more than double to 13 million by 2060, barring breakthroughs that prevent, slow or cure the condition.<\/p>\n

This disease also has touched the family of Daniel \u201cDan\u201d and Phyllis Epstein: Dan\u2019s identical twin brother, David, suffered from Alzheimer\u2019s for 15 years and passed away recently as a result of the disease. With their gift, the Epsteins hope to drive research that can change the trajectory of the sobering statistics.<\/p>\n

\u201cWe experienced first-hand the significant challenges that come with the progression of Alzheimer\u2019s disease,\u201d said Dan Epstein. \u201cThe fact is that there are no viable treatments for this condition, so we are very pleased to serve as a catalyst in moving Alzheimer\u2019s research ahead and hopefully achieving something noteworthy in the not-too-distant future.\u201d<\/p>\n

Leveraging the strengths of both universities in the field of Alzheimer\u2019s research, the gift will help compress the time between study design, patient recruitment and clinical trials, in hopes of expediting the discovery of better treatments and, ultimately, a cure for Alzheimer\u2019s disease.<\/p>\n

\u201cWith this extraordinary gift, Dan and Phyllis Epstein are making a dramatic investment in a better future for perhaps millions of Americans coping with Alzheimer\u2019s disease and those at risk of developing the disease in the years to come,\u201d\u00a0USC President Carol L. Folt<\/a>\u00a0and\u00a0UC San Diego Chancellor Pradeep K. Khosla<\/a>\u00a0said in a joint statement.<\/p>\n

\u201cBy establishing this visionary collaboration between USC and UC San Diego, the Epsteins are forging a bond between two Alzheimer\u2019s research powerhouses that has the potential to transform the landscape of treatment for this devastating disease.\u201d<\/p>\n

\u2018One plus one equals three\u2019<\/h3>\n

In teaming up the institutions, Dan Epstein expressed his belief that the new collaboration can create something greater than the sum of its parts.<\/p>\n

\u201cWith the extraordinary talent at USC and UC San Diego, it seemed as though we could take one plus one and make it three with this collaboration,\u201d said Epstein. \u201cWhen researchers are interacting and sharing ideas, it can lead to new solutions that they might not have originally thought about. When two stellar universities are working together to achieve the same goal, great things will come out of it.\u201d<\/p>\n

Examples of the gift\u2019s impact include enabling USC\u2019s\u00a0Alzheimer\u2019s Therapeutic Research Institute<\/a>\u00a0\u2014 led by founding director Paul Aisen, professor of neurology at the Keck School of Medicine of USC \u2014 to work with the\u00a0USC Mark and Mary Stevens Neuroimaging and Informatics Institute<\/a>\u00a0to pair biological samples and brain images, enriching the research value of both and making those resources available to researchers around the world. Data are typically not linked with specimens because of the costs and the complexities of ensuring participant confidentiality.<\/p>\n

At UC San Diego, the funds will drive research led by the\u00a0Alzheimer\u2019s Disease Cooperative Study<\/a>\u00a0\u2014 under the leadership of Howard Feldman, dean of Alzheimer\u2019s Disease Research, professor of neurosciences at UC San Diego School of Medicine and a neurologist \u2014 and will catalyze Alzheimer\u2019s disease research efforts across the UC San Diego campus. The gift will support two primary areas of focus: gene therapy for Alzheimer\u2019s disease and a \u201cpowder for pennies\u201d (P4P) program, designed to expedite the testing of existing or repurposed drugs and natural products for its treatment.<\/p>\n

A priority of P4P will be the development and implementation of early phase \u201csmart\u201d clinical trials that more quickly assess the potential of investigated drugs and compounds. Promising compounds would then be forwarded to USC for phase III trials or larger-scale investigation.<\/p>\n

Beyond the Epstein\u2019s initial $50 million investment to establish the Epstein Family Alzheimer\u2019s Research Collaboration, the couple has challenged USC and UC San Diego to raise an additional $25 million each to support Alzheimer\u2019s research.<\/p>\n

\u201cIt is just a matter of time before most people will have someone in their families develop dementia or Alzheimer\u2019s, yet there are no viable treatments beyond temporary measures to delay the onset,\u201d said Epstein. \u201cIf, together, we can double our initial investment, just imagine the impact that we can have in creating real solutions for this condition.\u201d<\/p>\n

About the Epsteins<\/h3>\n

Dan Epstein is the founder of the ConAm Group, a nationwide apartment owner\/developer\/property management company headquartered in San Diego. He has had a distinguished career as a real estate entrepreneur. Phyllis Epstein is active in the community on many leadership boards, including the San Diego Symphony and the Lawrence Family Jewish Community Center.<\/p>\n

The Epsteins are longtime supporters of both USC and UC San Diego. Dan earned his bachelor\u2019s degree in engineering from the USC Viterbi School of Engineering in 1962 and has served as a\u00a0trustee of USC<\/a>\u00a0since 2002. He also is a member of the executive committee of the USC Lusk Center for Real Estate and chair of the advisory committee of the Daniel J. Epstein Department of Industrial and Systems Engineering. Phyllis Epstein, a graduate of UCLA, is a board member of the\u00a0USC Roski School of Art and Design<\/a>\u00a0and\u00a0USC Shoah Foundation \u2014 The Institute for Visual History and Education<\/a>. Both of their children graduated from USC.<\/p>\n

The couple has contributed substantial gifts including donations to establish the USC Epstein Family Alumni Center, the\u00a0USC Epstein Family Center for Sports Medicine<\/a>\u00a0and the Epstein Family Plaza at USC Viterbi.<\/p>\n

At UC San Diego, the Epsteins are members of the Chancellor\u2019s Executive Advisory Cabinet for the Campaign for UC San Diego, a universitywide comprehensive fundraising effort concluding June 30. Phyllis Epsteins is also a trustee of the UC San Diego Foundation and serves as the chair of the Donor Relations and Stewardship Committee. Dan Epsteins\u00a0is a trustee emeritus of the UC San Diego Foundation. Recently, the Epstein Family Amphitheater was named in honor of a $10 million gift, and they have established endowed faculty fellowships and chairs at the Rady School of Management, in addition to supporting the School of Global Policy and Strategy, Arts and Humanities, student scholarships and more.<\/p>\n

Alzheimer’s Research: How You Can Help:<\/h3>\n

To learn more about how you can make a difference in Alzheimer\u2019s disease research at the two universities:<\/p>\n

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\u2022 Visit\u00a0USC\u2019s Epstein Challenge website<\/a>.<\/p>\n<\/div>\n

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\u2022 Visit\u00a0UC San Diego\u2019s Epstein Challenge website<\/a>.<\/p>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":4526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[489,234,140,169,20,103],"class_list":["post-4525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-alzheimers-disease","tag-department-of-neurology","tag-impact-stories","tag-latest","tag-research","tag-alzheimers-therapeutic-research-institute"],"acf":[],"yoast_head":"\nWith a $50 Million Gift, USC and UC San Diego Join Forces in Alzheimer\u2019s Research<\/title>\n<meta name=\"robots\" content=\"index, follow, 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