{"id":484,"date":"2015-10-09T12:50:41","date_gmt":"2015-10-09T19:50:41","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/stem-cell-researcher-min-yu-receives-the-nihs-new-innovator-award\/"},"modified":"2023-11-19T12:07:37","modified_gmt":"2023-11-19T20:07:37","slug":"stem-cell-researcher-min-yu-receives-the-nihs-new-innovator-award","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/stem-cell-researcher-min-yu-receives-the-nihs-new-innovator-award\/","title":{"rendered":"Stem cell researcher Min Yu receives the NIH\u2019s New Innovator Award"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Stem cell researcher Min Yu receives the NIH\u2019s New Innovator Award<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n October 09, 2015<\/span>\n <\/div>\n \n \n
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As a winner of the NIH Director\u2019s New Innovator Award, USC Stem Cell principal investigator Min Yu will strive to develop individualized medicine targeting rare and deadly breast cancer stem cells. The five-year, $2.475 million award is part of the High-Risk, High-Reward Research program supported by the NIH Common Fund.
\nThis year\u2019s New Innovator Awards support 41 unusually creative early-career investigators. The New Innovator Awards are unique in deemphasizing preliminary data and instead focusing on the creativity of the investigators, the innovation of the research approaches and the potential of the projects to have significant impact on important health problems.
\n\u201cThis program has consistently produced research that revolutionized scientific fields by giving investigators the freedom to take risks and explore potentially groundbreaking concepts,\u201d said NIH Director Francis S. Collins. \u201cWe look forward to the remarkable advances in biomedical research that the 2015 awardees will make.\u201d
\nYu\u2019s New Innovator project tackles one of the biggest challenges for treating breast cancer: targeting rare metastatic cancer stem cells (CSCs) in a constantly evolving tumor unique to each patient.
\nCSCs are thought to be a highly metastatic subset of the broader population of tumor cells that enter a patient\u2019s blood circulation. Therefore, Yu will first obtain these circulating tumor cells from patient blood samples, expand the number of these cells in the laboratory, and pinpoint the most metastatic of these cells \u2014 the dangerous and deadly CSCs \u2014 by evaluating their ability to form tumors in mice.
\nShe\u2019ll perform studies to reveal the CSCs\u2019 unique molecular properties and biomarkers, which are expected to vary among samples obtained from different patients. She will then test if CSCs with certain properties or biomarkers respond best to certain drugs \u2014 which could eventually inform clinicians about individualized treatment regimens for targeting CSCs in breast cancer patients.
\n\u201cBreast cancer occurs in one in eight women in the United States and leads to 40,000 deaths annually,\u201d said Yu. \u201cI believe that we can help these patients by targeting CSCs, the most important cells for sustaining tumor growth.\u201d
\nYu has devoted herself to advancing patient care for more than 15 years. Born and raised in the city of Qingdao in northeast China, Yu earned her MD at Shandong Medical University and completed a master\u2019s degree in neurology at Peking University Health Science Center.
\nAfter working with patients with incurable neurological diseases, Yu recognized the need to find new treatments through medical research. She joined the PhD program in genetics at SUNY Stony Brook University and Cold Spring Harbor Laboratory, where she developed her interest in breast cancer in the laboratory of Senthil Muthuswamy. She pursued postdoctoral training in the laboratory of Daniel A. Haber at Massachusetts General Hospital, Harvard Medical School, where she characterized circulating tumor cells isolated from the blood of cancer patients.
\nIn 2014, Yu became an assistant professor in the Department of Stem Cell Biology and Regenerative Medicine and a member of the USC Norris Comprehensive Cancer Center, where her laboratory is located in close proximity to the patients and clinicians who play a key role in advancing the translational aspects of her research.
\nUSC Norris\u2019 Director Stephen B. Gruber, who enabled this synergy, called Yu \u201ca bright, innovative researcher with an exceptional track record, intriguing and clinically relevant research program, and strong drive to succeed.\u201d He added, \u201cHer proposal bridges innovative basic research and translational oncology to address critical questions about cancer stem cells, and could have a huge impact on the treatment of cancer patients worldwide.\u201d
\nIn addition to the NIH Director\u2019s New Innovator Award, Yu has received the NCI Transition Career Development Award (K22), the STOP CANCER Research Career Development Award, the Pew-Stewart Scholar for Cancer Research award, and the Donald E. and Delia B. Baxter Foundation faculty fellowship.
\n\u201cThe New Innovator Award recognizes Min\u2019s exceptional creativity in pursuing individualized, stem cell-targeted treatments for breast cancer patients,\u201d said Andy McMahon, chair of the Department of Stem Cell Biology and Regenerative Medicine. \u201cSince her arrival at USC, Min has amply demonstrated this creativity \u2014 along with every other quality required to succeed in the challenging and critically important field of cancer research.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n 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