{"id":4887,"date":"2022-11-15T08:00:40","date_gmt":"2022-11-15T16:00:40","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/it-takes-two-research-synergy-links-l-a-biomedical-pillars\/"},"modified":"2023-11-28T09:22:05","modified_gmt":"2023-11-28T17:22:05","slug":"it-takes-two-research-synergy-links-l-a-biomedical-pillars","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/it-takes-two-research-synergy-links-l-a-biomedical-pillars\/","title":{"rendered":"It takes two: Research synergy links L.A. biomedical pillars"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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It takes two: Research synergy links L.A. biomedical pillars<\/h1>\n\n\n<\/div>\n \n \n
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Team science takes on a new dimension with Children\u2019s Hospital Los\u00a0Angeles and the Keck School of Medicine of USC<\/p>\n\n\n\n<\/div>\n \n

\n Wayne Lewis<\/span>\n \n November 15, 2022<\/span>\n <\/div>\n \n \n
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Connecting CHLA and the Keck School of Medicine opens the way for researchers to find complementary resources and interdisciplinary teammates across both. (Photo: USC\/CHLA)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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For the Keck School of Medicine of USC and Children’s Hospital Los Angeles, there’s no shortage of common ground.<\/p>\n

With robust collaboration, the two L.A. medical mainstays are united by nearly 60 research programs supported by external grants, the lion\u2019s share from the National Institutes of Health and other federal funders. Projects foster therapeutic advances, patient care innovation and community wellness. These include major efforts that tackle some of the most challenging problems in human health \u2014 battling cancer, manufacturing the latest cell therapies to fight incurable disease, boosting COVID-19 vaccination rates in underrepresented L.A. communities and preventing obesity in Latino youth.<\/p>\n

The institutions share a commitment to conducting leading-edge biomedical investigations, improving health outcomes for underserved populations and speeding new advances from the proverbial lab bench to the patient\u2019s bedside.<\/p>\n

The tightly knit alliance benefits health for people of all ages. Connecting CHLA and the Keck School of Medicine opens the way for researchers to find complementary resources and interdisciplinary teammates across both.<\/p>\n

\u201cWhen one investigator at one site has a burning question, they can cross over to seek expertise in how to approach that question,\u201d said Pat Levitt, PhD, chief scientific officer, vice president and director of the Saban Research Institute and Simms\/Mann Chair in Developmental Neurogenetics at CHLA, who is also W.M. Keck Provost Professor in Neurogenetics at USC. \u201cIt\u2019s a natural bridge, for instance, from CHLA\u2019s disease-focused basic and translational research to the Keck School of Medicine\u2019s fundamental work on understanding disease processes.\u201d<\/p>\n

The faculty at CHLA, which ranks among the nation\u2019s top 10 children\u2019s hospitals, all hold appointments at the Keck School of Medicine, which is home to eight departments that rank top 10 in NIH funding in their fields. Together, the two research and academic powerhouses \u2014 independent of each other \u2014 make a bigger difference than either could make alone.<\/p>\n

Both institutions play vital roles serving the diverse L.A. community. CHLA is a safety net pediatric hospital, with 70% of patients on subsidized healthcare or lacking insurance. Faculty from the Keck School of Medicine staff Los Angeles County + USC Medical Center, the largest single provider of health care in the county. As such, both institutions emphasize studies to address the health challenges of communities that are underserved and experience disparities in outcomes.<\/p>\n

Several initiatives backed by federal grants exemplify a partnership with impact exceeding the sum of its parts.<\/p>\n

Fighting cancer across the lifespan<\/strong><\/p>\n

USC Norris Comprehensive Cancer Center stands among the original eight such centers to receive the National Cancer Institute\u2019s highest designation in 1971, and remains an innovative leader in the cancer field. The USC Norris $34 million Cancer Center Support Grant from the NCI supports cutting-edge cancer research and collaborations that span USC and CHLA.<\/p>\n

Like many other diseases, cancer is understood to find its roots early along in development \u2014 as far back as the womb. So fully integrating oncology research between the two institutions has been a priority.<\/p>\n

\u201cTo really understand cancer and other disorders of humankind, we have to think about developmental biology,\u201d said Alan Wayne, M.D., director of Children\u2019s Hospital Los Angeles Cancer & Blood Disease Institute and associate director for pediatric oncology at USC Norris Comprehensive Cancer Center. \u201cIn that regard, the kind of close collaboration you see between basic, translational, population and clinical scientists across campuses \u2014 and across the age span \u2014 is going to make a tremendous difference.\u201d<\/p>\n

Innovative therapies, innovative infrastructure<\/strong><\/p>\n

Wayne\u2019s own research pushes forward CAR T cell therapy, a groundbreaking strategy that enhances the patients\u2019 own immune cells to target cancer. These investigations \u2014 and many others across USC and CHLA \u2014 will get a boost from another joint venture: establishing a state-of-the-art facility for manufacturing such cellular treatments.<\/p>\n

CHLA and the Keck School of Medicine (in partnership with Keck Medicine of USC and USC Norris cancer center) are on the cusp of opening a current good manufacturing practice facility for cellular treatments, part of the joint USC\/CHLA Translational Cell Therapy Program.<\/p>\n

\u201cCells have evolved for a million and a half years,\u201d said Tom Buchanan, M.D., the Keck School of Medicine\u2019s Bernard J. Hanley Chair in Medicine and vice dean of research. \u201cIt makes sense to take advantage of that evolution to fix things, so we\u2019re setting up one sophisticated facility where people can use the same basic methodologies and work with each other, while targeting an array of diseases.\u201d<\/p>\n

The capacity to make treatments will accelerate translation of research into clinical trials. In addition to CAR T cells, potential products could be engineered tissue to address blindness, bone and cartilage injury, gastrointestinal disorders and even diabetes.<\/p>\n

\u201cThese therapies have the potential to reverse, and in some cases prevent, conditions that have been considered irreversible,\u201d Wayne said. \u201cThe facility is expected to have a massive impact.\u201d<\/p>\n

The drive from scientific discovery to health solution<\/strong><\/p>\n

Supporting the sort of studies that would be the testing grounds for cellular therapies are an important aspect of the Southern California Clinical and Translational Science Institute (SC CTSI). Backed by a $50\u00a0million NIH grant, the collaboration bands together the Keck School of Medicine, CHLA and the L.A. County Department of Health Services.<\/p>\n

\u201cClinical trials are important across all populations,\u201d said Buchanan, director of SC CTSI. \u201cIt\u2019s crucial that we move from findings to real-world impact.\u201d<\/p>\n

The institute focuses on turning science into health solutions for the city\u2019s diverse communities by providing researchers with funding, expertise, training and facilities. It provides backing for studies designed to benefit everyone from infants to elders, testing everything from treatment protocols to care delivery improvements to community interventions.<\/p>\n

Health equity is often an area of concentration. Take, for example, the CTSI-associated Consortium for Pediatric Cellular Immunotherapy. Through the consortium, a CHLA-Keck School of Medicine contingent led by Wayne joins forces with four other leading biomedical centers. Part of its agenda is to expand access to the newest treatments, and increase clinical trial participation, among children in underserved communities.<\/p>\n

Promoting protection in those hardest-hit by the pandemic<\/strong><\/p>\n

SC CTSI also launched a multimedia initiative that brought scientifically sound, culturally grounded messages to people in certain majority Latino and Black neighborhoods. VaccinateLA, a joint project of CHLA and the Keck School of Medicine funded by the W. M. Keck Foundation, made a major impact in East and South L.A.<\/p>\n

Respectively, Latino and Black people in zip codes where VaccinateLA was active had immunization rates of 82% and 78%, compared to 66% and 58% in similar populations countywide.<\/p>\n

Outreach from CHLA pediatricians was essential in reaching parents worried about their kids, according to VaccinateLA co-leader Lourdes Baezconde-Garbanati, PhD, MPH, the Keck School of Medicine\u2019s associate dean for community initiatives and the SC CTSI\u2019s associate director for community outreach and engagement.<\/p>\n

\u201cCHLA has been a major catalyst, and really important to our credibility in the communities we focus on,\u201d she said.<\/p>\n

A vision for healthy adulthood among Latinos, starting in childhood<\/strong><\/p>\n

Baezconde-Garbanati, a tenured professor of population and public health sciences at the Keck School of Medicine, also co-leads a regional initiative dedicated to making a difference in Hispanic health tomorrow, by laying the foundation with today\u2019s youth.<\/p>\n

The recently established Southern California Center for Chronic Health Disparities in Latino Families and Children was initiated by co-leader Michael Goran, PhD, program director for diabetes and obesity at CHLA\u2019s Saban Research Institute and professor of pediatrics at the Keck School of Medicine.<\/p>\n

The community-engaged, obesity-fighting project is funded by a $24.5\u00a0million award from the NIH. It has already shown dividends, growing into a wider consortium encompassing all of Southern California.<\/p>\n

As with other collaborations between CHLA and the Keck School of Medicine, the power of that teamwork seems to add together one and one to make so much more than two.<\/p>\n

\u201cWe\u2019ve been able to kind of merge our worlds and bring a lot of different resources,\u201d Baezconde-Garbanati said. \u201cThis has created something that just would not have existed with any one of us going it alone.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":163,"featured_media":4888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[612,169],"class_list":["post-4887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-community","tag-latest"],"acf":[],"yoast_head":"\nIt takes two: Research synergy links L.A. biomedical pillars<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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