{"id":506,"date":"2015-11-02T10:16:02","date_gmt":"2015-11-02T18:16:02","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/"},"modified":"2023-11-19T12:07:53","modified_gmt":"2023-11-19T20:07:53","slug":"a-prkci-gene-keeps-stem-cells-in-check","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/","title":{"rendered":"A Prkci gene keeps stem cells in check"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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A Prkci gene keeps stem cells in check<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n November 02, 2015<\/span>\n <\/div>\n \n \n
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The gene Prkci promotes the generation of differentiated cells (red). However if Prkci activity is reduced or absent, neural stem cells (green) are promoted. (Image by In Kyoung Mah)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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When it comes to stem cells, too much of a good thing isn\u2019t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body.
\nIn a\u00a0paper published in\u00a0Stem Cell Reports<\/em><\/a>, USC researcher In Kyoung Mah from the lab of Francesca Mariani and colleagues at the University of California, San Diego, (UCSD) describe a key gene in maintaining this critical balance between producing too many and too few stem cells. Called Prkci, the gene influences whether stem cells self-renew to produce more stem cells, or differentiate into more specialized cell types, such as blood or nerves.
\n<\/span>In their experiments, the team grew mouse embryonic stem cells, which lacked Prkci, into embryo-like structures in the laboratory. Without Prkci, the stem cells favored self-renewal, generating large numbers of stem cells and, subsequently, an abundance of secondary structures.
\nUpon closer inspection, the stem cells lacking Prkci had many activated genes typical of stem cells, and some activated genes typical of neural, cardiac and blood-forming cells. Therefore, the loss of Prkci can also encourage stem cells to differentiate into the progenitor cells that form neurons, heart muscle and blood.
\nPrkci achieves these effects by activating or deactivating a well-known group of interacting genes that are part of the \u201cNotch signaling pathway.\u201d In the absence of Prkci, the Notch pathway produces a protein that signals to stem cells to make more stem cells. In the presence of Prkci, the Notch pathway remains silent, and stem cells differentiate into specific cell types.
\nThese findings have implications for developing patient therapies. Even though Prkci can be active in certain skin cancers, inhibiting it might lead to unintended consequences, such as tumor overgrowth. However, for patients with certain injuries or diseases, it could be therapeutic to use small molecule inhibitors to block the activity of Prkci, thus boosting stem cell production.
\n\u201cWe expect that our findings will be applicable in diverse contexts and make it possible to easily generate stem cells that have typically been difficult to generate,\u201d said Francesca Mariani, principal investigator at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.
\nAdditional co-authors on the study include Rachel Soloff and Stephen Hedrick from UCSD, and the research was supported by USC and the Robert E. and May R. Wright Foundation.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":84,"featured_media":507,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[20,17],"class_list":["post-506","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-research","tag-stem-cell"],"acf":[],"yoast_head":"\nA Prkci gene keeps stem cells in check<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Prkci gene keeps stem cells in check\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-11-02T18:16:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-19T20:07:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/prcki.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cristy Lytal\u00a0\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\"},\"author\":{\"name\":\"Cristy Lytal\u00a0\",\"@id\":\"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/d069582f631be687afcb7867ff7ebdb8\"},\"headline\":\"A Prkci gene keeps stem cells in check\",\"datePublished\":\"2015-11-02T18:16:02+00:00\",\"dateModified\":\"2023-11-19T20:07:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\"},\"wordCount\":8,\"publisher\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/prcki.jpg\",\"keywords\":[\"Research\",\"Stem Cell\"],\"articleSection\":[\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\",\"url\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\",\"name\":\"A Prkci gene keeps stem cells in check\",\"isPartOf\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/prcki.jpg\",\"datePublished\":\"2015-11-02T18:16:02+00:00\",\"dateModified\":\"2023-11-19T20:07:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/keck.usc.edu\/news\/a-prkci-gene-keeps-stem-cells-in-check\/#primaryimage\",\"url\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/prcki.jpg\",\"contentUrl\":\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/prcki.jpg\",\"width\":600,\"height\":447,\"caption\":\"The gene Prkci promotes the generation of differentiated cells (red). 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