{"id":5281,"date":"2023-11-16T18:40:01","date_gmt":"2023-11-17T02:40:01","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/measured-brain-activity-signals-chronic-pain-activity\/"},"modified":"2025-12-17T15:14:31","modified_gmt":"2025-12-17T23:14:31","slug":"measured-brain-activity-signals-chronic-pain-activity","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/measured-brain-activity-signals-chronic-pain-activity\/","title":{"rendered":"Measured brain activity signals chronic pain activity"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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Measured brain activity signals chronic pain activity<\/h1>\n\n\n<\/div>\n \n \n
\n Steven Richeimer, M.D.<\/span>\n \n November 16, 2023<\/span>\n <\/div>\n \n \n
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Concept of idea. Female silhouette with gears on pink background. Flat design, vector illustration.<\/p>\n<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

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Up until now, those in the medical community have largely had to rely upon a\u00a0patient\u2019s feedback\u00a0<\/a>when it comes to the details regarding chronic pain. The information they receive is subjective and potentially hampered if there are any communication limitations. There is hope that this will change with the news of a biomarker for chronic pain that researchers have discovered.<\/p>\n

Researchers set out to see if they could identify any biomarker that takes place during chronic pain. A biomarker provides objective information about what is happening in a cell or area of the body so that the data is something that can be measured accurately and consistently. Being able to identify a biomarker that is associated with chronic pain provides a signal and in-depth details to health professionals about the chronic pain episodes the person may be experiencing.<\/p>\n

This is an essential finding in the chronic pain field because the information may help clinicians and patients better manage chronic pain. The more we can understand about it, including the brain activity and signals, the better we will be in helping to bring about pain relief.<\/p><\/blockquote>\n

In the May 2023 issue of the journal\u00a0Nature Neuroscience, researchers published their study that was conducted in which they have identified a biomarker for chronic pain (1). To learn about it, they did a study that included four people who experienced refractory\u00a0n<\/a>europathic pain<\/a>\u00a0that was limited to one side for at least a year. The study involved long-term implantation of intracranial electrodes in two areas of the brain, including the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC). Three of the study participants had suffered from post-stroke pain, with the fourth experiencing phantom limb pain.<\/p>\n

Study participants recorded pain scores throughout the day, from 78 to 184 days. They also completed pain questionnaires. Using the information gathered, they could compare and identify signatures in brain activity with chronic pain episodes that differed from acute pain. They were able to identify that the patterns of activity differ between acute and chronic pain. With that information, they could make predictions about the chronic pain episodes.<\/p>\n

This is an essential finding in the chronic pain field because the information may help clinicians and patients better manage chronic pain. The more we can understand about it, including the brain activity and signals, the better we will be in helping to bring about pain relief. While the biomarkers have been lacking until this point, things are moving in the right direction. As more information becomes available about predicting chronic pain and being able to identify the biomarkers, the more hope there is for chronic pain relief.<\/p>\n

Earn an Online Postgraduate Degree in Pain Medicine<\/h3>\n

Like what you\u2019re learning? Consider enrolling in the Herman Ostrow School of Dentistry of USC\u2019s online, competency-based certificate or master\u2019s program in\u00a0Pain Medicine<\/a>\u00a0in partnership with the Keck School of Medicine of USC.<\/p>\n

Get More Information<\/a><\/p>\n

Sources<\/h3>\n

Nature Neuroscience.\u00a0First-in-human prediction of chronic pain state using intracranial neural biomarkers.<\/a>\u00a0May 2023.<\/p>\n

This\u00a0article\u00a0was originally published on Confronting Chronic Pain by Dr. Steven Richeimer,\u00a0Director Pain Medicine Master and Certificate<\/a>.<\/p>\n

The information and resources contained on this website are for informational purposes only and are not intended to assess, diagnose, or treat any medical and\/or mental health disease or condition. The use of this website does not imply nor establish any type of provider-client relationship. Furthermore, the information obtained from this site should not be considered a substitute for a thorough medical and\/or mental health evaluation by an appropriately credentialed and licensed professional. Commercial supporters are not involved in the content development or editorial process.<\/p>\n

Like what you\u2019re learning?\u00a0 Download a brochure for our\u00a0online, postgraduate pain medicine<\/a>\u00a0certificate or master\u2019s degree program in\u00a0partnership with the Keck School of Medicine of USC.<\/p>\n

Steven Richeimer, M.D.<\/a> is a renowned specialist on issues related to chronic pain. He is the chief of the Division of Pain Medicine at the University of Southern California. He has written or co-written a large number of scientific articles about pain medicine. He recently published an instructive book and guide for pain patients. Dr. Richeimer has given numerous lectures to medical and lay audiences throughout the U.S.<\/em><\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":5282,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[476,226,61,606,146,20,216],"class_list":["post-5281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-brain-health","tag-department-of-medicine","tag-education","tag-ostrow-school-of-dentistry-of-usc","tag-pain-medicine","tag-research","tag-research-in-60-seconds"],"acf":[],"yoast_head":"\nMeasured brain activity signals chronic pain activity<\/title>\n<meta name=\"robots\" content=\"index, follow, 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