{"id":620,"date":"2016-02-05T13:59:19","date_gmt":"2016-02-05T21:59:19","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/keck-school-researchers-discover-gene-that-protects-women-from-heart-disease\/"},"modified":"2023-11-19T12:09:19","modified_gmt":"2023-11-19T20:09:19","slug":"keck-school-researchers-discover-gene-that-protects-women-from-heart-disease","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/keck-school-researchers-discover-gene-that-protects-women-from-heart-disease\/","title":{"rendered":"Keck School researchers discover gene that protects women from heart disease"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Keck School researchers discover gene that protects women from heart disease<\/h1>\n\n\n<\/div>\n \n \n
\n \u00a0Zen Vuong<\/span>\n \n February 05, 2016<\/span>\n <\/div>\n \n \n
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The study represents one of the first female-specific genetic associations for heart disease.<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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USC researchers have identified a gene variant that decreases the risk of heart disease \u2014 but only among women.
\nHooman Allayee, PhD, senior author of the study and associate professor of preventive medicine at the Keck School of Medicine of USC, said scientists have known that heart disease affects men and women differently, but what causes the difference has not been entirely clear. This new finding may shed light on that mystery.
\n\u201cThe study represents one of the first female-specific genetic associations for heart disease,\u201d Allayee said. \u201cWomen who carried a variant of the CPS1 gene had about a 12 percent decreased risk for heart disease. But the same variant had no protective effect on men when it came to coronary artery disease.\u201d
\nThe study was published online Jan. 29 in the journal Nature Communications<\/em>.
\nHeart disease is the No. 1 cause of death for both men and women in the United States, according to the Centers for Disease Control and Prevention. Men comprised more than half of the deaths due to heart disease in 2009.
\nAbout half the population carries either one or two copies of the CPS1 variant, Allayee said.
\nThe gene variant may control levels of certain metabolites found in blood. Metabolites are small molecules that cells can produce. Of the metabolites analyzed, the CPS1 variant had an especially strong effect on raising glycine levels, said Jaana Hartiala, PhD, lead author and a postdoctoral researcher at Keck Medicine of USC.
\nPrevious research has shown that glycine, an amino acid, can decrease inflammation in cells that line heart arteries and in immune cells that infiltrate the artery wall, Hartiala said.
\n\u201cInflammation in these two types of cells can promote the buildup of cholesterol-containing deposits in arteries, so the glycine-raising properties of CPS1 may explain why it protects against heart disease,\u201d she said. \u201cScientists know of at least 50 genes associated with heart disease in both men and women. Since many more genes must be involved, our results suggest that doing separate genetic studies in men and women could help scientists identify some of the other genes.\u201d
\nAllayee chimed in.
\n\u201cWe still don\u2019t know why the protective effect of CPS1 on heart disease is specific to only women,\u201d he said. \u201cIt could be glycine, but it also could be something else that has not been identified yet. Nevertheless, understanding this novel mechanism could pave the way for developing therapies that might be particularly beneficial to women.\u201d
\nThe researchers performed two genetic studies. The initial discovery was made in 6,092 men and 2,576 women from the Cleveland Clinic. The female-specific association of the CPS1 variant with heart disease was then confirmed in a second sample of 26,905 women and 26,772 men.
\nResearchers from the Cleveland Clinic, the University of Ottawa Heart Institute and the University of L\u00fcbeck contributed to the study. The research was supported by grants from the National Institutes of Health, the American Heart Association and Foundation Leducq.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":60,"featured_media":621,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[81,57,20],"class_list":["post-620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-population-and-public-health-sciences","tag-recent","tag-research"],"acf":[],"yoast_head":"\nKeck School researchers discover gene that protects women from heart disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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