{"id":673,"date":"2016-03-09T11:10:27","date_gmt":"2016-03-09T19:10:27","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/study-antidepressants-may-fight-brain-cancer\/"},"modified":"2023-11-19T12:09:54","modified_gmt":"2023-11-19T20:09:54","slug":"study-antidepressants-may-fight-brain-cancer","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/study-antidepressants-may-fight-brain-cancer\/","title":{"rendered":"Study: Antidepressants may fight brain cancer"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Study: Antidepressants may fight brain cancer<\/h1>\n\n\n<\/div>\n \n \n
\n Michele Keller<\/span>\n \n March 09, 2016<\/span>\n <\/div>\n \n \n
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An illustration depicts the makeup of the antidepressant\/MAO-A inhibitor Clorgiline.<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Antidepressants can shrink and stunt cancerous brain tumors that are otherwise difficult to treat, an international team of researchers has found.
\nUSC School of Pharmacy researchers who led the study on mice found that the drugs stifle the growth of brain cancer, glioma or glioblastoma by suppressing the enzyme monoamine oxidase A, which affects the release of emotional brain chemicals such as dopamine and serotonin.
\n\u201cUntil now, patients diagnosed with these drug-resistant tumors have had no treatment options,\u201d said University Professor Jean Chen Shih at the USC School of Pharmacy and the Keck School of Medicine of USC. \u201cAntidepressants could be a potential treatment, slowing down the cancer growth and extending the lives of patients.\u201d
\nGlioblastoma, the most aggressive form of malignant brain tumor, usually becomes resistant to standard treatments, at which point there are no further treatment options. An estimated 13,000 Americans die from brain cancer each year, according to the National Cancer Institute. The median age of a patient diagnosed with glioblastoma is 64. Patients live an additional 14 months on average after diagnosis.
\nTypically, brain cancer is treated with TMZ \u2014 temozolomide \u2014 an oral drug that attacks the DNA of the tumor cells. Some tumors become resistant to TMZ.
\nShih and her collaborators found that the MAO-A inhibitors reduce cell proliferation and increase immune response. Their study was published on Feb. 9 in the journal Oncotarget.
\n\u201cOur data identified the MAO-A inhibitors as potential novel stand-alone drugs or as a combination therapy with a low dose of the current treatment, TMZ, thus reducing the toxicity of TMZ,\u201d said Shih, who is also the director of the USC-Taiwan Center for Translational Research. \u201cWe hope to do a clinical study in the near future to learn if this finding in animals will be applicable in humans.\u201d
\nThe study builds upon prior research that showed antidepressants can also reduce prostate cancer progression and metastasis.
\nShih, who has spent decades studying the enzyme and brain development, collaborated with Florence Hofman and Thomas Chen of the Keck School of Medicine, two experts in glioma research.
\nOther School of Pharmacy faculty members involved in the study were Kevin Chen, a molecular biologist, and Bogdan Olenyuk, an expert in chemistry synthesis, as well as Keck School of Medicine Professor Susan Groshen.
\nThe study was funded by the Daniel Tsai Family Fund, the USC-Taiwan Center for Translational Research and the National Institutes for Health (RO1 MH39085).<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":144,"featured_media":674,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[589,20],"class_list":["post-673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-neurological-surgery","tag-research"],"acf":[],"yoast_head":"\nStudy: Antidepressants may fight brain cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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