{"id":8119,"date":"2024-10-14T11:40:31","date_gmt":"2024-10-14T18:40:31","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/?p=8119"},"modified":"2024-10-14T15:17:06","modified_gmt":"2024-10-14T22:17:06","slug":"hussein-yassine-a-fresh-approach-to-alzheimers-prevention","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/","title":{"rendered":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n Campus News<\/span>\n\n\n\n<\/div>\n \n \n
\n\n \n

Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention<\/h1>\n\n\n<\/div>\n \n \n
\n Wayne Lewis<\/span>\n \n October 14, 2024<\/span>\n <\/div>\n \n \n
\n\n \n
<\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/g><\/svg><\/span><\/a><\/svg><\/span><\/a><\/div>
<\/div><\/div>\n\n\n<\/div>\n \n <\/div>\n\n \n
\n\n \n \n \n
\n \n \n \n \n \n\n \n

Hussein Yassine, MD, professor of neurology and department of physiology and neuroscience, and director of the Center for Personalized Brain Health (Photo\/Richard Carrasco)<\/p>\n<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

\n\n \n
\n \n
\n\n \n

Endocrinologist Hussein Yassine<\/a>\u2019s, MD, own ambitious drive to prevent Alzheimer\u2019s disease began with a mystery.<\/p>\n

It turns out that the strongest genetic risk factor for Alzheimer\u2019s disease is a variant called APOE \u03b54, carried by about half of disease patients. Having two copies of the variant can multiply risk by as much as 12 times, as that spot in the genome codes for a protein that plays an important role in transporting cholesterol. How the APOE gene and the \u03b54 variant relate to the brain had been poorly understood in the past.<\/p>\n

Studying cholesterol \u2014 and particularly the high-density lipoprotein (HDL) commonly called \u201cgood cholesterol\u201d \u2014 has been an area of expertise for Yassine. The key connection between Alzheimer\u2019s and the science of lipids was provided by his mentor and friend Helena Chui, MD, USC\u2019s Raymond and Betty McCarron Chair in Neurology, who approached Yassine back in 2013.<\/p>\n

\u201cShe told me, \u2018As neurologists, we don\u2019t know enough about what APOE \u03b54 does and how it functions,\u2019\u201d Yassine said. \u201c\u2018Given that you study apoE proteins in blood, would you be interested in looking at what it does in the brain?\u2019 I told her I\u2019d give it a shot.\u201d<\/p>\n

Embracing that challenge led to a series of discoveries. By using cerebrospinal fluid samples from the Alzheimer\u2019s Disease Research Center<\/a> at USC, Yassine is drawing the link between APOE \u03b54 and Alzheimer\u2019s into focus. The team found a protective association between small HDL particles in CSF and less Alzheimer\u2019s pathology.<\/a><\/p>\n

\u201cWe think there is a real chance to push back this disease if we can start intervening 20 years before it manifests. We\u2019re going to provide personalized interventions while patients are asymptomatic, with a high promise that they\u2019ll benefit later on.\u201d<\/p>\n

Hussein Yassine<\/em><\/p><\/blockquote>\n

Clues that small HDL plays a protective role in neurological health have led to a drug discovery program with one agent, a peptide, designed to increase brain small HDL that is now moving into clinical trials. The Yassine Lab is also looking at mechanisms of brain inflammation. Collaborating with experts across disciplines such as USC computational biologists and pharmacists, Yassine and collaborators discovered a new compound with possible protective effects that blocks an enzyme known as cPLA2, overactivated in APOE \u03b54 carriers, that breaks down omega-3 fatty acids and drives inflammation in the brain.<\/p>\n

Venturing into relatively unknown areas of research, he emphasizes diligence and rigor.<\/p>\n

His research trainees conduct numerous experiments using different lab models to confirm that the group is zeroing in on the right biochemical signal. In developing the enzyme-blocker, the researchers have screened billions of molecules and repeatedly refined candidates. The upside is a current compound that is 100 times more potent than what they found at first.<\/p>\n

\u201cThere\u2019s a huge responsibility before somebody calls their research a breakthrough,\u201d Yassine said. \u201cThe biology that we do in the lab, I meet with extreme skepticism. We repeat any preliminary findings to confirm their validity.\u201d<\/p>\n

Drug discovery is just one arm of a multipronged program<\/a> at the USC Center for Personalized Brain Health<\/a>, which Yassine launched in 2023 as founding director. He and his colleagues interrogate the basic biology of APOE \u03b54 and Alzheimer\u2019s in search of new markers for the disease. They apply contemporary technology for early detection of problems with brain function that precede telltale memory lapses. They also create new biomedical imaging techniques to identify changes in the brain before midlife that can be used to predict dementia risk as an older adult.<\/p>\n

Yassine is particularly excited about the patient-facing side of the Center for Personalized Brain Health. At the recently opened Prevention Clinic at Keck Medicine, patients can obtain genetic testing and evaluations of function in the brain, blood lipids, metabolism and blood vessels. These details lead to tailored guidance for synergistically reducing their individual risks of Alzheimer\u2019s and dementia.<\/p>\n

The clinic is the first of its kind in Alzheimer\u2019s care. Already, patients are traveling from as far afield as the East Coast to gain advice for prevention.<\/p>\n

\u201cWe think there is a real chance to push back this disease if we can start intervening 20 years before it manifests,\u201d Yassine said. \u201cThere are certain things that you can do to decrease dementia risk, and we have the opportunity to give the best protocols we have, whether it\u2019s about exercise, diet, sleep, blood pressure, cholesterol or diabetes. We\u2019re going to provide personalized interventions while patients are asymptomatic, with a high promise that they\u2019ll benefit later on.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":278,"featured_media":8120,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[7],"tags":[489,234,241,633],"class_list":["post-8119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","tag-alzheimers-disease","tag-department-of-neurology","tag-faculty","tag-usc-center-for-personalized-brain-health"],"acf":[],"yoast_head":"\nHussein Yassine | A fresh approach to Alzheimer\u2019s prevention<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-14T18:40:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-14T22:17:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"sheilaro\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/\"},\"author\":{\"name\":\"sheilaro\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/e82dc048d2c960e661893c9fca68c083\"},\"headline\":\"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention\",\"datePublished\":\"2024-10-14T18:40:31+00:00\",\"dateModified\":\"2024-10-14T22:17:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/\"},\"wordCount\":9,\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2024\\\/10\\\/Hussein.png\",\"keywords\":[\"Alzheimer\u2019s Disease\",\"Department of Neurology\",\"Faculty\",\"USC Center for Personalized Brain Health\"],\"articleSection\":[\"Campus News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/\",\"name\":\"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2024\\\/10\\\/Hussein.png\",\"datePublished\":\"2024-10-14T18:40:31+00:00\",\"dateModified\":\"2024-10-14T22:17:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#primaryimage\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2024\\\/10\\\/Hussein.png\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2024\\\/10\\\/Hussein.png\",\"width\":1920,\"height\":1080,\"caption\":\"Hussein Yassine, MD, professor of neurology and department of physiology and neuroscience, and director of the Center for Personalized Brain Health (Photo\\\/Richard Carrasco)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\",\"name\":\"Keck School of Medicine of USC\",\"alternateName\":\"Keck School of Medicine\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"width\":696,\"height\":696,\"caption\":\"Keck School of Medicine of USC\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/KECKschoolUSC\\\/\",\"https:\\\/\\\/x.com\\\/KeckSchool_USC\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/keckschoolusc\\\/\",\"https:\\\/\\\/www.instagram.com\\\/KeckSchoolUSC\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCpL1E1W5ZTfkc5iihwLSFEA\",\"https:\\\/\\\/www.tiktok.com\\\/@keckschoolusc\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/e82dc048d2c960e661893c9fca68c083\",\"name\":\"sheilaro\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g\",\"caption\":\"sheilaro\"},\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/author\\\/sheilaro\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/","og_locale":"en_US","og_type":"article","og_title":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention","og_url":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/KECKschoolUSC\/","article_published_time":"2024-10-14T18:40:31+00:00","article_modified_time":"2024-10-14T22:17:06+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png","type":"image\/png"}],"author":"sheilaro","twitter_card":"summary_large_image","twitter_creator":"@KeckSchool_USC","twitter_site":"@KeckSchool_USC","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#article","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/"},"author":{"name":"sheilaro","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/e82dc048d2c960e661893c9fca68c083"},"headline":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention","datePublished":"2024-10-14T18:40:31+00:00","dateModified":"2024-10-14T22:17:06+00:00","mainEntityOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/"},"wordCount":9,"publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png","keywords":["Alzheimer\u2019s Disease","Department of Neurology","Faculty","USC Center for Personalized Brain Health"],"articleSection":["Campus News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/","url":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/","name":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#primaryimage"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png","datePublished":"2024-10-14T18:40:31+00:00","dateModified":"2024-10-14T22:17:06+00:00","breadcrumb":{"@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#primaryimage","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein.png","width":1920,"height":1080,"caption":"Hussein Yassine, MD, professor of neurology and department of physiology and neuroscience, and director of the Center for Personalized Brain Health (Photo\/Richard Carrasco)"},{"@type":"BreadcrumbList","@id":"https:\/\/keck.usc.edu\/news\/hussein-yassine-a-fresh-approach-to-alzheimers-prevention\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/keck.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"Hussein Yassine | A fresh approach to Alzheimer\u2019s prevention"}]},{"@type":"WebSite","@id":"https:\/\/keck.usc.edu\/news\/#website","url":"https:\/\/keck.usc.edu\/news\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/keck.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/keck.usc.edu\/news\/#organization","name":"Keck School of Medicine of USC","alternateName":"Keck School of Medicine","url":"https:\/\/keck.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","width":696,"height":696,"caption":"Keck School of Medicine of USC"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/KECKschoolUSC\/","https:\/\/x.com\/KeckSchool_USC","https:\/\/www.linkedin.com\/school\/keckschoolusc\/","https:\/\/www.instagram.com\/KeckSchoolUSC\/","https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA","https:\/\/www.tiktok.com\/@keckschoolusc"]},{"@type":"Person","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/e82dc048d2c960e661893c9fca68c083","name":"sheilaro","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e6ee2a99be1484274d7e4e496f703f2e5bfcafe3adef93ca272b453f95bd9c0c?s=96&d=mm&r=g","caption":"sheilaro"},"url":"https:\/\/keck.usc.edu\/news\/author\/sheilaro\/"}]}},"author_meta":{"display_name":"sheilaro","author_link":"https:\/\/keck.usc.edu\/news\/author\/sheilaro\/"},"featured_img":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2024\/10\/Hussein-300x169.png","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/campus-news\/\" class=\"advgb-post-tax-term\">Campus News<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Campus News<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/campus-news\/\" class=\"advgb-post-tax-term\">Alzheimer\u2019s Disease<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/campus-news\/\" class=\"advgb-post-tax-term\">Department of Neurology<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/campus-news\/\" class=\"advgb-post-tax-term\">Faculty<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/campus-news\/\" class=\"advgb-post-tax-term\">USC Center for Personalized Brain Health<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Alzheimer\u2019s Disease<\/span>","<span class=\"advgb-post-tax-term\">Department of Neurology<\/span>","<span class=\"advgb-post-tax-term\">Faculty<\/span>","<span class=\"advgb-post-tax-term\">USC Center for Personalized Brain Health<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 2 years ago","modified":"Updated 2 years ago"},"absolute_dates":{"created":"Posted on October 14, 2024","modified":"Updated on October 14, 2024"},"absolute_dates_time":{"created":"Posted on October 14, 2024 11:40 am","modified":"Updated on October 14, 2024 3:17 pm"},"featured_img_caption":"Hussein Yassine, MD, professor of neurology and department of physiology and neuroscience, and director of the Center for Personalized Brain Health (Photo\/Richard Carrasco)","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/8119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/278"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=8119"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/8119\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/8120"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=8119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=8119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=8119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}