{"id":8123,"date":"2024-10-14T11:42:23","date_gmt":"2024-10-14T18:42:23","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/?p=8123"},"modified":"2024-10-15T13:48:38","modified_gmt":"2024-10-15T20:48:38","slug":"chuck-murry-stem-cell-science-for-healing-the-heart","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/chuck-murry-stem-cell-science-for-healing-the-heart\/","title":{"rendered":"Chuck Murry | Stem cell science for healing the heart"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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Chuck Murry | Stem cell science for healing the heart<\/h1>\n\n\n<\/div>\n \n \n
\n Wayne Lewis<\/span>\n \n October 14, 2024<\/span>\n <\/div>\n \n \n
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A stem cell innovator focusing on repairing the heart, Chuck Murry (second from right) shares his expertise in biomedical science. (Photo\/Steve Cohn)<\/p>\n<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

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Success in Chuck Murry\u2019s<\/a> vision for regenerating heart tissue to restore function after a heart attack would look like a radical shift in the medical landscape. Ironically enough, he chalks up his start in studying the vital organ to chance.<\/p>\n

When he was a third-year medical student at Duke University looking for a research lab, his first choice in oncology was unavailable. Of the options remaining, he signed on not out of interest in the subject matter but rather because he liked the professor. Truth was, he didn\u2019t originally see a future in basic science. Then he made an essential contribution to a finding that changed the way cellular damage from heart attacks was understood.<\/p>\n

\u201cIt\u2019s thrilling to be the first in humanity to see or realize something,\u201d said Murry, who is also chair of stem cell biology and regenerative medicine at the Keck School of Medicine<\/a>. \u201cChance gave me the opportunity. What I didn\u2019t expect was that I would fall in love with research the way I did.\u201d<\/p>\n

The turning point rerouted him to pursue a PhD, complemented afterward with the completion of his medical degree. Transitioning to the faculty at the University of Washington, he perhaps picked up another assist from chance: His research lab and the field of stem cell science started up at right about the same time around the turn of the millennium.<\/p>\n

\u201cThe open question was, if you want to fix the heart, where are we ever going to get the heart muscle cells,\u201d Murry said. \u201cI figured making more cells was probably something that would remain unsolved until the next generation took the reins. When stem cells came out, we could see, \u2018Okay, now we have a source.\u2019 So we pivoted.\u201d<\/p>\n

Early on, some in his orbit counseled him to reconsider his approach.<\/p>\n

\u201cWell-intentioned people gave me the tough-love talk,\u2019\u201d he said. \u201cThey said, \u2018Chuck, we think you\u2019re throwing away your career.\u2019 But I couldn\u2019t let go of it. Or it wouldn\u2019t let go of me.\u201d<\/p>\n

Over nearly a quarter-century, Murry has steadfastly pursued the goal of coaxing stem cells to develop into heart muscle and combining graft cells with a damaged host to form a functioning biological pump.<\/p>\n

\u201cAcross my career, I\u2019m proudest of taking heart regeneration to the point where we could make it work in an animal that predicts what might happen in a human. <\/span>I feel a sense of urgency. I think patients are waiting, and science is ready for this to move.\u201d<\/span><\/p>\n

Chuck Murry<\/em><\/p><\/blockquote>\n

Often, a leap forward led to a new obstacle. The researchers meet each setback with resolve and hard work. Most recently, his team found that, in late preclinical work, new tissue was beating to a different rhythm than its host and causing the heart to race.<\/p>\n

\u201cI believe it will work,\u201d Murry said. \u201cWhen something like this arrhythmia problem came up, I just thought rationally, there\u2019s going to be a way to solve this. I can see in my mind that, according to all the rules of science that I know, this should work. What\u2019s mostly changed is that people have gradually started to share that belief.\u201d<\/p>\n

Indeed, he and his colleagues reported earlier this year that, by deftly using gene editing to manipulate four specific spots in the genome, they had reversed damage from heart attack in rhesus monkeys while cutting down on arrhythmias by 95%.<\/p>\n

\u201cAcross my career, I\u2019m proudest of taking heart regeneration to the point where we could make it work in an animal that predicts what might happen in a human,\u201d Murry said.<\/p>\n

\u201cI think it put a flag in the sand that said, \u2018Come on, people! This can work. Let\u2019s get it done.\u2019 I feel a sense of urgency. I think patients are waiting, and science is ready for this to move.\u201d<\/p>\n

Importantly, that sense of urgency is counterbalanced by prudence. Murry\u2019s team functionally put on hold its efforts to move heart regeneration into the clinic for years to concentrate on eliminating the mistimed heartbeats.<\/p>\n

\u201cI wouldn\u2019t have done this in my mother at that point,\u201d Murry said. \u201cMy internal compass has always been, if you wouldn\u2019t have done it in your mom, you\u2019re not ready to do this in someone else\u2019s loved one.\u201d<\/p>\n

He takes that mix of drive and discernment to his leadership at USC Stem Cell as well. He aims to build on current strengths in basic science to form an interdisciplinary team accelerating research to clinical trials. Murry wants to make USC\u2019s medical school a destination for addressing the most debilitating health challenges, from heart disease to arthritis, blindness and beyond.<\/p>\n

\u201cUSC Stem Cell is a gem of a program, and the excellence in basic science is a foundation for taking it to the next level,\u201d he said. \u201cI\u2019d like to begin studies in humans. We will do it ethically, responsibly and as safely as possible. Meanwhile, the dual focus on knowledge and service to society will make for a great training environment.\u201d<\/p>\n

Having joined USC in fall 2024, Murry is working with his USC Stem Cell colleagues and medical school leadership to define opportunities to grow the program. One certain thing is that teamwork will be essential.<\/p>\n

\u201cWe\u2019re going to have to convene a whole community of physicians, scientists and engineers to execute on this vision,\u201d he said. \u201cIt\u2019s way too big for any one person, or any one department even, to accomplish. When we collaborate, we go further, faster.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":278,"featured_media":8124,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[7],"tags":[241,17,436],"class_list":["post-8123","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","tag-faculty","tag-stem-cell","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nChuck Murry | Stem cell science for healing the heart<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/chuck-murry-stem-cell-science-for-healing-the-heart\/\" 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