{"id":8270,"date":"2024-11-20T08:00:00","date_gmt":"2024-11-20T16:00:00","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/?p=8270"},"modified":"2024-11-21T09:24:49","modified_gmt":"2024-11-21T17:24:49","slug":"6-million-grant-drives-potential-treatment-for-common-cause-of-vision-loss-toward-the-clinic","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/6-million-grant-drives-potential-treatment-for-common-cause-of-vision-loss-toward-the-clinic\/","title":{"rendered":"$6 million grant drives potential treatment for common cause of vision loss toward the clinic"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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$6 million grant drives potential treatment for common cause of vision loss toward the clinic<\/h1>\n\n\n<\/div>\n \n \n
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The California Institute for Regenerative Medicine has funded Keck School of Medicine of USC translational research advancing a therapy for dry age-related macular degeneration, one of the leading causes of blindness in older adults.<\/p>\n\n\n\n<\/div>\n \n

\n Wayne Lewis<\/span>\n \n November 20, 2024<\/span>\n <\/div>\n \n \n
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The California Institute for Regenerative Medicine<\/a> (CIRM), the state\u2019s stem cell agency, has awarded a two-year, $6 million grant to a team at the USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics and the USC Roski Eye Institute advancing a new treatment for one of the leading causes of blindness in older adults. The funding will enable the researchers to conduct preclinical studies needed before launching human trials.<\/span><\/p>\n

The investigators aim to accelerate progress in fighting dry age-related macular degeneration (AMD), which affects about 16 million people in the U.S. The disease is rooted in damage to the eye\u2019s retinal pigment epithelium (RPE), the cells that support the photoreceptors of the retina. RPE cells protect, feed, and restore the rods and cones that convert light into signals readable by the brain. Dry AMD, which typically manifests in people 50 and older, is currently incurable and can eventually render those suffering legally blind.<\/span><\/p>\n

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USC Ginsburg Institute researchers are culturing healthy retinal cells derived from stem cells and harnessing the biological factors they produce to create therapeutic injections to treat dry AMD. Photo\/Created with BioRender.com<\/figcaption><\/figure>\n

Treatment options are presently limited to well-established vitamin supplements and newly emerged immune-regulating treatments, both of which can only slow the progression of dry AMD. <\/span>The USC strategy supported by CIRM takes an entirely different approach \u2014 an injection containing a mixture of the restorative, anti-inflammatory and antioxidant compounds that are released by stem cell-derived healthy RPE.<\/span><\/p>\n

\u201cNothing that\u2019s currently out there halts or reverses the disease, and many patients end up progressing to blindness,\u201d said principal investigator Mark Humayun, MD, PhD, University Professor of Ophthalmology and Biomedical Engineering and holder of the <\/span>Keck School of Medicine of USC<\/span><\/a>\u2019s Cornelius J. Pings Chair in Biomedical Sciences. \u201cThere\u2019s a need for a new approach. If we can develop this injection and stop disease progression or actually improve vision, that would be amazing from a patient perspective.\u201d<\/span><\/p>\n

The RPE secretions were derived from another dry AMD treatment developed by Humayun and his colleagues. The original therapy, which will soon enter mid-stage clinical trials, is an implantable patch of RPE cells grown from stem cells that is being commercialized by Regenerative Patch Technologies. When the researchers found that the patch was helping retinal cells far beyond its borders, they started looking into the effects of the fluid released by the patch (i.e., the secretome).\u00a0<\/span><\/p>\n

CIRM support, beginning in 2010, enabled the patch to move from preclinical development to clinical trials. Building on that success, CIRM funding then allowed the team to carefully study the promising effects of the RPE secretome, resulting in the new CIRM grant meant to again bridge research from the laboratory to early-stage tests in humans.\u00a0<\/span><\/p>\n

\u201cCIRM has been incredibly important to this work,\u201d said Humayun, who is the co-director of the <\/span>USC Roski Eye Institute<\/span><\/a> and director of the <\/span>USC Ginsburg Institute for Biomedical Therapeutics<\/span><\/a>. \u201cAll of this was made possible by CIRM support. California is really leading the way in stem cell research for a host of health challenges thanks to California public investment.\u201d<\/span><\/p>\n

The forthcoming research funded by the stem cell agency gains momentum from other steps already taken to fast-track the new treatment for clinical trials. The investigators have had a series of preliminary discussions with the Food and Drug Administration (FDA) and have identified partner testing and manufacturing facilities certified to follow good practices regulated by the FDA.<\/span><\/p>\n

The new therapy is meant for intervention at earlier stages of dry AMD. It may play a complementary role with the patch, which addresses advanced dry AMD.<\/span><\/p>\n

\u201cEssentially, we get two shots on goal from the same product,\u201d Humayun said. \u201cIf we\u2019re successful, we can cover patients from A to Z in the continuum of their disease.\u201d<\/span><\/p>\n

He emphasizes the importance of another key ingredient \u2014 cross-disciplinary collaboration. Bioengineers from the <\/span>USC Viterbi School of Engineering<\/span><\/a> will be vital to the development of the patch, and Humayun will enlist USC Viterbi experts in artificial intelligence to maximize the healing potential of the secretome from stem cell-derived RPE.<\/span><\/p>\n

\u201cThere are so many combinations and permutations for the genetic knobs and levers we can use, it would take forever if you just tried them sequentially,\u201d he said. \u201cThe engineering input is critical. AI will help us better understand how to refine and improve this therapy. And as a \u2018school of schools,\u2019 USC provides a unique culture and environment for these types of interactions between disparate fields.\u201d<\/span><\/p>\n

Humayun, a recipient of the National Medal of Technology and Innovation, has already built an uncommon track record of success in improving care through his research. He is the lead inventor of the <\/span>Argus II<\/span><\/a> \u2014 also known as the \u201cartificial retina\u201d or the \u201cbionic eye\u201d \u2014 a device that has restored limited vision to hundreds who were previously blind since its FDA approval in 2013.\u00a0<\/span><\/p>\n

For this physician-researcher, the prospect of expanding the benefits he has created for patients is exciting on multiple fronts. He knows the toll of blindness all too well; his grandmother, who helped raise him, ultimately lost her sight.<\/span><\/p>\n

\u201cThere\u2019s no other feeling quite like when you are able to help restore sight to somebody who is blind,\u201d Humayun said. \u201cProfessionally, you can\u2019t ask for anything more. And on a personal note, it is deeply impactful for me given everything my grandmother meant to me.\u201d<\/span><\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":278,"featured_media":8271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[11,446,169,21,168,36],"class_list":["post-8270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-artificial-intelligence","tag-homepage","tag-latest","tag-ophthalmology","tag-roski-eye-institute","tag-stem-cell-research"],"acf":[],"yoast_head":"\n$6 million grant drives potential treatment for common cause of vision loss toward the clinic<\/title>\n<meta name=\"robots\" content=\"index, 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