{"id":860,"date":"2016-05-03T11:20:12","date_gmt":"2016-05-03T18:20:12","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-enter-the-conversation-about-crispr\/"},"modified":"2023-11-19T12:11:08","modified_gmt":"2023-11-19T20:11:08","slug":"usc-stem-cell-scientists-enter-the-conversation-about-crispr","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-enter-the-conversation-about-crispr\/","title":{"rendered":"USC Stem Cell scientists enter the conversation about CRISPR"},"content":{"rendered":"\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n  <div class=\"text-container\">\n              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Press Release<\/span>\n\n\n\n<\/div>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n      <h1>USC Stem Cell scientists enter the conversation about CRISPR<\/h1>\n\n\n<\/div>\n    \n    \n          <div class=\"meta\">\n                  <span class=\"author\">Zen Vuong<\/span>\n        \n                  <span class=\"date\">May 03, 2016<\/span>\n              <\/div>\n    \n              \n<div class=\"f--field f--embed\">\n\n    \n  <div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/keck.usc.edu\/news\/usc-stem-cell-scientists-enter-the-conversation-about-crispr\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fkeck.usc.edu%2Fnews%2Fusc-stem-cell-scientists-enter-the-conversation-about-crispr%2F\" title=\"Facebook\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg\" 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11.903 5 10.826c0-1.08.382-1.993 1.146-2.738L8.128 6.12C8.873 5.372 9.785 5 10.864 5c1.087 0 2.004.382 2.75 1.146l2.777 2.79c.75.747 1.12 1.66 1.12 2.737 0 1.105-.392 2.045-1.183 2.817l1.186 1.186c.774-.79 1.708-1.186 2.805-1.186 1.078 0 1.995.377 2.75 1.132l2.804 2.804c.754.755 1.13 1.672 1.13 2.75z\"\/><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div>\n\n\n<\/div>\n        \n  <\/div>\n\n  \n\n  <\/div><\/div>\n\r\n\r\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>CRISPR-Cas9 is a gene-editing technique that enables scientists to disable, replace or modify sections of DNA. It allows for\u00a0unprecedented\u00a0precision and speed in the field of genome editing. It has been used to create\u00a0<a href=\"http:\/\/www.nature.com\/news\/gene-edited-micropigs-to-be-sold-as-pets-at-chinese-institute-1.18448\" target=\"_blank\" rel=\"noopener\">micropigs to be sold as pets<\/a>\u00a0and to try to\u00a0<a href=\"http:\/\/www.pnas.org\/content\/111\/31\/11461.abstract\" target=\"_blank\" rel=\"noopener\">eradicate HIV infection in humans<\/a>.<br \/>\nThe scientific community is concerned about altering human embryos to create \u201cdesigner babies,\u201d but some USC Stem Cell experts say that in the United States, CRISPR-Cas9\u2019s use on plants and animals will make waves first. Should these edited organisms be labeled as genetically modified organisms (GMOs)? Questions about environmental consequences, the ethics of consent and public policy need to be addressed.<br \/>\nQi-Long Ying \u2014 associate professor of stem cell biology and regenerative medicine and director of the Chang Stem Cell Engineering Facility \u2014 has been using CRISPR-Cas9 on embryonic stem cells since 2013. Ying has used CRISPR-Cas9 on heritable stem cells in mice and rats. His research goal is to sustain a cell\u2019s ability to regenerate when needed.<br \/>\n\u201cThis technology is very powerful and has the potential to cure many genetic diseases,\u201d he said. \u201cI expect that CRIPSR-Cas9-based therapies will be in clinical trials in the next few years. But before all that, we need to do a lot of research, including in early human embryos.\u201d<br \/>\nAs scientists perform this research, Ying advises the utmost caution in employing this new gene-editing technique.<br \/>\n\u201cWe use the bacterial protein Cas9 to cut DNA; however, this protein may have unwanted functions in human cells,\u201d he said. \u201cIn some cases, DNA repair after a CRISPR-Cas9 cut is not perfect. The repaired DNA sequence could create a new protein that is harmful. Additionally, people think the chances of an off-target snip using CRISPR-Cas9 is extremely rare, but the probability of this happening is actually high. Just one off-target cut could cause big trouble.\u201d<br \/>\nUSC Stem Cell principal investigator Paula Cannon leads a research team that studies viruses, stem cells and gene therapy. Cannon has been working on the precursor to CRISPR-Cas9, \u201czinc-finger nuclease editing,\u201d for nine years. She is engaged in a clinical trial that edits DNA in the middle of the CCR5 gene in an effort to produce an HIV-resistant immune system.<br \/>\n\u201cThe December 2015 call for a moratorium on the use of CRISPR-Cas9 to make heritable changes to the human genome may not be enforceable or practical,\u201d she said. \u201cThe truth is that countries that do not have well-regulated research protocols could allow companies to exploit people\u2019s vanity or desperation and use this technology to engineer human embryos. In such situations, saying \u2018let\u2019s not do any germ line engineering\u2019 is too simplistic. We should instead continue to research how this could be done safely and understand more about the process, while recognizing that society currently does not condone the use of this technology.\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":60,"featured_media":862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[596,20,436],"class_list":["post-860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-immunology-and-immune-therapeutics","tag-research","tag-usc-stem-cell"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.6) - 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