{"id":863,"date":"2016-05-03T11:32:15","date_gmt":"2016-05-03T18:32:15","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-study-paves-path-to-a-cure-for-chronic-hbv-infection\/"},"modified":"2023-11-19T12:11:10","modified_gmt":"2023-11-19T20:11:10","slug":"usc-study-paves-path-to-a-cure-for-chronic-hbv-infection","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-study-paves-path-to-a-cure-for-chronic-hbv-infection\/","title":{"rendered":"USC study paves path to a cure for chronic HBV infection"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC study paves path to a cure for chronic HBV infection<\/h1>\n\n\n<\/div>\n \n \n
\n Zen Vuong<\/span>\n \n May 03, 2016<\/span>\n <\/div>\n \n \n
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\"ParentChild_BW.104228\"The infection has been cured in mice by removing “traitors” residing in liver\u2019s immune cells.<\/em>
\nChronic hepatitis B infection, a lifetime disease with no effective cure, could one day be cleared from a person\u2019s system with a series of shots, according to a new USC study.
\nMost healthy adults infected with HBV will develop protective immunity, healing their own bodies within a few months. But children who acquired the virus from their mothers are unable to scrub HBV from their systems. Instead these individuals are fated to live with the virus for the rest of their lives.
\nAbout 1.1 million people in the United States have chronic HBV infection, reported the Centers for Disease Control and Prevention in 2013. USC is devoted to attacking today\u2019s \u201cwicked problems,\u201d which include infectious diseases.
\n\u201cHepatic macrophages\u201d \u2014 liver immune cells that eliminate foreign substances and toxins like a garbage disposal system \u2014 could be the target of future treatment, said Jing-hsiung James Ou, a professor of molecular microbiology and immunology<\/a> at the Keck School of Medicine of USC.
\n\u201cMaternal viral antigens teach the offspring\u2019s hepatic macrophages to suppress foot soldier white blood cells called CTLs,\u201d said Ou, senior author of the article published May 3 in Immunity<\/em>, a Cell journal. \u201cTherefore, when babies are exposed to the virus, the baby\u2019s \u2018garbage disposal units\u2019 will suppress its own immune system from fighting off the infection. We were able to deplete macrophages in a mouse model, activate CTLs and clear the virus.\u201d
\nThe study paves a path to curing chronic HBV infection, Ou said. His research unveils the function of HBV e antigen, which was previously a mystery, Ou added.
\nIn a mouse model, the experimental group came from mothers with HBV, whereas the control group came from mothers without HBV. Scientists introduced HBV-inducing DNA into offspring mouse liver to produce HBV.
\nMeasurements taken throughout the 28-week experiment found that the test group\u2019s hepatic macrophages turned against their foot soldier CTLs. In other words, white blood cells in the offspring of HBV-positive mice were weakened because of renegades within the ranks.
\nTo remove macrophages that prevented the immune system from eliminating HBV infection, Ou and his colleagues injected the test group with a drug that slays these traitors. Researchers performed the procedure two days before and once every five days after HBV DNA was administered. In total, researchers dispensed the drugs four times.
\nThe drug removed macrophages and restored normal CTL white blood cell activity, leading to HBV clearance after about four weeks. Ou said he will further his research in animal studies, which is essential to ensure the safety of the drug before the initiation of clinical trials.
\n\u201cThis study opens doors,\u201d he said. \u201cIn the future, clinical treatment for chronic HBV infection may last merely one month rather than a lifetime.\u201d
\nThe study was supported by National Institutes of Health grants (DK100257 and CA177337) and a research grant from the L.K. Whittier Foundation.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":60,"featured_media":864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[90,20],"class_list":["post-863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-molecular-microbiology-and-immunology","tag-research"],"acf":[],"yoast_head":"\nUSC study paves path to a cure for chronic HBV infection<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-study-paves-path-to-a-cure-for-chronic-hbv-infection\/\" \/>\n<meta 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