{"id":8719,"date":"2025-03-24T13:30:44","date_gmt":"2025-03-24T20:30:44","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/?p=8719"},"modified":"2025-11-12T15:15:44","modified_gmt":"2025-11-12T23:15:44","slug":"two-usc-innovators-honored-by-the-national-academy-of-inventors","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/two-usc-innovators-honored-by-the-national-academy-of-inventors\/","title":{"rendered":"Two USC innovators honored by the National Academy of Inventors\u00a0"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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Two USC innovators honored by the National Academy of Inventors\u00a0<\/h1>\n\n\n<\/div>\n \n \n
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Harnessing the body\u2019s natural defenses, these researchers are advancing the future of immune-based treatments to develop breakthroughs in treating diseases ranging from rheumatoid arthritis and sepsis to cancer.<\/p>\n\n\n\n<\/div>\n \n

\n Stacia Pelletier<\/span>\n \n March 24, 2025<\/span>\n <\/div>\n \n \n
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From left: Preet Chaudhary, MD, PhD, professor of medicine and the Ronald H. Bloom Family Chair in Lymphoma Research, and Michael Selsted, MD, PhD, professor of pathology. Photos\/Ricardo Carrasco III<\/p>\n<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

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Two researchers from the Keck School of Medicine of USC have been elected as senior members of the National Academy of Inventors (NAI), an organization that recognizes inventors holding US patents and promotes academic technology and innovation to benefit society.\u00a0<\/span><\/p>\n

The newly elected senior members are <\/span>Preet Chaudhary, MD, PhD,<\/span><\/a> professor of medicine and the Ronald H. Bloom Family Chair in Lymphoma Research, and <\/span>Michael Selsted, MD, PhD<\/span><\/a>, professor of pathology.\u00a0<\/span><\/p>\n

\u201cProfessors Chaudhary and Selsted are nationally known for their entrepreneurial research, and I\u2019m thrilled to see them acknowledged with this significant honor,\u201d said Carolyn Meltzer, dean of the <\/span>Keck School of Medicine<\/span><\/a>. \u201cTheir discoveries are advancing our understanding and treatment of some of medicine\u2019s most challenging conditions. The clinical impact of their work is significant.\u201d<\/span><\/p>\n

Preet Chaudhary, MD, PhD\u00a0<\/b><\/h3>\n
\"Headshot
Preet Chaudhary, MD, PhD. Photo\/Richard Carrasco III<\/figcaption><\/figure>\n

Chaudhary\u2019s journey into medical innovation began early. As a PhD student in the 1990s, he received patents for his methodological work on drug resistance in cancer cells and the purification of hematopoietic stem cells, specialized cells in bone marrow that are essential for fighting infection and disease. As a postdoctoral fellow, he filed a patent describing a family of proteins involved in the immune response that became the most highly cited cancer-related patent application globally from 1993 to 2013.\u00a0<\/span><\/p>\n

Now a physician-scientist and chief of the Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases at the Keck School, Chaudhary holds 12 allowed\/issued US patents, 16 allowed\/issued international patents, and more than 120 pending applications. These are for next-generation treatments, genetically tailored for individual patients, that help a patient\u2019s own immune system target multiple types of cancer\u2014leukemias, lymphomas, multiple myeloma, and solid tumors. The overarching goal is to equip human immune cells to combat internal threats such as cancer in the same way they fend off external invaders such as viruses.\u00a0\u00a0<\/span><\/p>\n

\u201cThe human immune system evolved over millions of years to fight off foreign pathogens,\u201d Chaudhary says. \u201cWith these new technologies, we\u2019re learning how to redirect a person\u2019s immune system to fight cancer the same way.\u201d<\/span><\/p>\n

Preclinical and animal studies in the Chaudhary lab have yielded compelling results, with preparations for clinical trials underway. Chaudhary\u2019s latest research, called synthetic immune receptor (or SIR-T) therapy, adapts an existing immunotherapy treatment for blood cancers (chimeric antigen receptor or CAR-T therapy) for use in solid tumor cancers such as prostate, breast, and lung cancer. Supported by the California Institute for Regenerative Medicine and the US Department of Defense, this homegrown USC technology shows substantial promise, and it could hold potential for treating a range of cancers as well as certain autoimmune conditions.\u00a0<\/span><\/p>\n

Chaudhary approaches medical innovation both as a clinician and as a researcher. He recognizes the urgent need for new therapies to offer patients. <\/span><\/p>\n

\u201cLike many physicians of a certain generation, I was trained to look at cancer as mostly incurable, especially the solid tumors,\u201d he says. \u201cBut all that\u2019s changing. These technologies are set to revolutionize the treatment of cancer and other immune disorders within the next five to ten years.\u201d\u00a0<\/span><\/p>\n

Election as a senior member of the NAI is an added motivation to keep moving these discoveries forward, he says. <\/span><\/p>\n

\u201cIt\u2019s a validation of the work we\u2019ve been doing. I\u2019m deeply honored, and it\u2019s very encouraging.\u201d\u00a0<\/span><\/p>\n

Michael Selsted, MD, PhD<\/b><\/h3>\n
\"Headshot
Michael Selsted, MD, PhD. Photo\/Chris Shin<\/figcaption><\/figure>\n

Selsted, a physician-scientist and former chair of the department of pathology (2009-2024) at the Keck School of Medicine, has made pivotal contributions to the field of innate immunity, with innovations resulting in 60 US patents, 130 international patents, and another 80 pending applications. His research focuses on defensins, small proteins produced by mammals that act as a crucial first line of defense against infection and disease.\u00a0<\/span><\/p>\n

Selsted and his team were the first to identify and characterize theta defensins, a type of protein found only in old-world primates such as baboons and rhesus monkeys. In preclinical models, these proteins have proven highly effective in combating antibiotic-resistant infections and have remarkable anti-inflammatory properties. Their unique closed-loop structure makes these proteins extremely stable and sturdy, equipping them to combat a range of threats, from fungi and bacteria to cancer cells. Selsted and his collaborators are developing synthetic versions of theta defensin as drug candidates for treating rheumatoid arthritis, inflammatory bowel disease, sepsis, and cancer.\u00a0<\/span><\/p>\n

\u201cWe\u2019ve spent the last twenty years producing theta defensins synthetically in the lab and reengineering their structure to create novel drug candidates,\u201d Selsted says. \u201cThe work we are doing now is positioning us to pursue clinical trials for several clinical disorders.\u201d\u00a0<\/span><\/p>\n

His work on sepsis, funded by the Department of Defense, has shown strong promise for treating bacterial and fungal infections. Preclinical studies for treating cancer and inflammatory bowel disease are also yielding positive results.<\/span><\/p>\n

\u201cFor cancer, it turns out that our compounds work extremely well in combination with immune checkpoint inhibitors,\u201d Selsted says. \u201cThey could be used to make those inhibitors far more effective in cancer treatment.\u201d\u00a0<\/span><\/p>\n

For patients navigating rheumatoid arthritis, the news is equally encouraging. Selsted\u2019s team is preparing for Phase 2 clinical trials of a new injectable treatment.<\/span><\/p>\n

\u201cIf this compound does anything in humans like it does in rodents, it will be a notable breakthrough,\u201d he says. \u201cWe\u2019ve seen animals completely disabled by rheumatoid arthritis running around a week and a half after treatment initiation.\u201d\u00a0<\/span><\/p>\n

With his research continuously funded by the National Institutes of Health since 1986, Selsted views the NAI\u2019s recognition as a tribute to the science itself.<\/span><\/p>\n

\u201cI\u2019ve been privileged to contribute to the discovery and characterization of these important proteins over the course of my career,\u201d he says.\u00a0 \u201cAnd I sincerely believe that the best is yet to come.\u201d\u00a0<\/span><\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":278,"featured_media":8721,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[10,226,637,241,169,86,436],"class_list":["post-8719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-cancer","tag-department-of-medicine","tag-department-of-pathology","tag-faculty","tag-latest","tag-usc-norris-comprehensive-cancer-center","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nTwo USC innovators honored by the National Academy of Inventors\u00a0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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