{"id":8742,"date":"2025-03-28T10:37:20","date_gmt":"2025-03-28T17:37:20","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/?p=8742"},"modified":"2025-03-28T10:43:57","modified_gmt":"2025-03-28T17:43:57","slug":"usc-researchers-present-their-findings-at-society-of-toxicology-annual-meeting","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-researchers-present-their-findings-at-society-of-toxicology-annual-meeting\/","title":{"rendered":"USC researchers present their findings at Society of Toxicology Annual Meeting"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Campus News<\/span>\n\n\n\n<\/div>\n \n \n
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USC researchers present their findings at Society of Toxicology Annual Meeting<\/h1>\n\n\n<\/div>\n \n \n
\n Bokie Muigai<\/span>\n \n March 28, 2025<\/span>\n <\/div>\n \n \n
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(Photo\/Jonathan Kay)<\/p>\n<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

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Last week, a group of researchers from the Department of Population and Public Health Sciences<\/a> at Keck School of Medicine of USC attended the Society of Toxicology (SOT) Annual Meeting in Orlando, Florida. The conference held from March 16-20, 2025, brought together toxicologists, epidemiologists, and practitioners from across the country to share the latest in toxicology research. Doctoral and postdoctoral trainees from the Center for Translational Exposomics Research<\/a> and Southern California Environmental Health Sciences Center<\/a> presented their findings on exposure to PFAS\u2014also known as forever chemicals\u2014which are linked to several adverse health outcomes ranging from disruptions of the nervous system to compromising liver health.<\/p>\n

Read about our researchers below.<\/p>\n

Carmen Jiawen Chen<\/strong><\/p>\n

\"smiling
(Photo\/Max Aung)<\/figcaption><\/figure>\n

Carmen Jiawen Chen is a fifth-year doctoral student in epidemiology program who presented her work at the conference. \u201cI thoroughly enjoyed attending the 2025 SOT Annual Conference!\u201d says Chen. \u201cConnecting with diverse talents in related fields was a highlight\u2014their knowledge of- and enthusiasm for environmental health inspired me. The career development symposium gave me valuable insights into different options of career paths and how to prepare for success after graduation. I am excited to apply these fresh ideas to my career later.\u201d<\/p>\n

Title of poster presentation:<\/strong> Mediating Role of Proteomics in the Association Between Per- and Polyfluoroalkyl Substance Exposure and Blood Pressure in Hispanic Youth<\/p>\n

Description:<\/strong> Chen\u2019s research evaluated associations between PAFS exposure and blood pressure in children and young adults\u2014possibly through certain proteins in the body. Through a cross-sectional study she found that higher PFAS levels were associated with elevated diastolic blood pressure, and identified a pro-inflammatory and pro-fibrotic protein called galectin-3 (LGALS3) as possibly an important link. These results suggest that reducing PFAS exposure or targeting the galectin-3\u2019s inflammatory pathway could help lower the risk of high blood pressure in youth.<\/p>\n

 <\/p>\n

Roselyn B. Tanghal<\/strong><\/p>\n

\"researcher
(Photo\/Max Aung)<\/figcaption><\/figure>\n

Roselyn B. Tanghal, is a second-year doctoral student in the epidemiology program who presented her research at the conference. \u201cThe Society of Toxicology Annual Meeting was a great opportunity to learn about toxicology and how ongoing toxicology research provides a foundation in examining the health impacts of PFAS exposure,\u201d says Tanghal.<\/p>\n

Title of poster presentation:<\/strong> Per- and Polyfluoroalkyl Substances Exposure and Risk of Liver Cancer: A Systematic Review<\/p>\n

Description:<\/strong> The global incidence and mortality rates of liver cancer are rising, highlighting the need to better understand emerging risk factors contributing to its development. Tanghal\u2019s research explored the relationship between PFAS exposure and liver cancer risk. She conducted a systematic review on animal and epidemiological studies to evaluate links between PFAS exposure and liver cancer risk. Her review found that some studies in animals and humans suggested a possible connection between PFAS exposure and liver cancer, but more research is needed to confirm the relationship.<\/p>\n

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Shiwen “Sherlock” Li<\/strong><\/p>\n

\"researcher
(Photo\/Max Aung)<\/figcaption><\/figure>\n

Shiwen “Sherlock” Li, a postdoctoral fellow in the Department of Population and Public Health Sciences.<\/p>\n

Title of poster presentation:<\/strong> Developmental exposure to perfluorooctanesulfonic acid (PFOS), altered gene expression in nucleus accumbens and prefrontal cortex and cognitive function in rats: a transcriptomic analysis<\/p>\n

Description:<\/strong> Differential gene expression is a process where various genes are activated in a cell, giving it a specific purpose that defines its function. Li\u2019s research looked at the differential gene expression in three key brain regions of rat\u2019s offspring exposed to PFOS during pregnancy. PFOS is a chemical within the PFAS family which recent studies have revealed is linked to neurodevelopmental and neurodegenerative diseases. Li found that PFOS exposure was linked to disruption in two regions of the brain he examined, the prefrontal cortex and nucleus accumbens. These regions are responsible for important brain functions such as decision making and reward system. The genes involved were related to important biological pathways associated with neurodegeneration.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":18,"featured_media":8743,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[7],"tags":[81,61,315],"class_list":["post-8742","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","tag-department-of-population-and-public-health-sciences","tag-education","tag-pphs-alumni"],"acf":[],"yoast_head":"\nUSC researchers present their findings at Society of Toxicology Annual Meeting<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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