Faculty 2016-07-07T15:09:12+00:00

Faculty

Heinz-Josef Lenz, MD

Professor of Medicine;J. Terrence Lanni Chair in Gastrointestinal Cancer Research;Co-Director, USC Center for Molecular Pathway and Drug Discovery

Medicine
NOR 3456
Health Sciences Campus
Los Angeles

+1 323 865 3967
lenz@usc.edu


Overview

Heinz-Josef Lenz, M.D., FACP, is the Associate Director for Clinical Research and Co-Leader of the Gastrointestinal Cancers Program at the USC Norris Comprehensive Cancer Center. Dr. Lenz is Professor of Medicine and Preventive Medicine, Section Head of GI Oncology in the Division of Medical Oncology and Co-Director of the Colorectal Center at the Keck School of Medicine of the University of Southern California.

Dr. Lenz received his medical degree from Johannes-Gutenberg Universität in Mainz, Germany, in 1985. He completed a residency in Hematology and Oncology at the University Hospital Tübingen in Germany, a clerkship in Oncology at George Washington University in Washington, DC, and a clerkship in Hematology at Beth Israel Hospital of Harvard Medical School in Boston, Massachusetts. He served subsequent fellowships in Biochemistry and Molecular Biology at the USC Norris Comprehensive Cancer Center.

An active researcher, Dr. Lenz focuses on topics including the regulation of gene expression involved in drug resistance, patients at high risk of developing colorectal cancer, and determination of carcinogenesis, methods of early detection, and better surveillance of these cancers. He is a member of several professional societies, including the American Association for Cancer Research, the American Gastroenterology Association, and the National Society of Genetic Counselors. He also serves on the National Advisory Board of a number of professional organizations. Dr. Lenz is the author of numerous peer-reviewed publications and invited papers, reviews, and editorials. He also serves as Co-Chair of the GI Committee and Correlative Science Committee for SWOG. He is a member of the NCI Task Force for Gastroesophageal Cancer, the NCI Steering Committee and the NCI Translational Science Committee. In addition to having an NCI-funded laboratory, he was a recipient of the ASCO Young Investigator Award, the ASCO Career Development Award, and the STOP Cancer Career Development Award. He has been listed in the Best Doctors’ database (www.bestdoctors.com) since 2003.

As Associate Director for Clinical Research, Dr. Lenz oversees the programmatic activities of the Gastrointestinal Cancers, Genitourinary Cancers, Women’s Cancers, and Leukemia and Lymphoma Programs.

Publications

. Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer Pharmacogenomics J. 2018 Jun 21. View in: PubMed

. Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2018 Jun 16. View in: PubMed

. Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types Biochem Biophys Res Commun. 2018 Jun 07; 500(3):621-625. View in: PubMed

. Identification of a Genomic Region Between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance) Clin Cancer Res. 2018 Jun 05. View in: PubMed

. Comparative Molecular Analyses of Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, and Gastric Adenocarcinoma Oncologist. 2018 Jun 04. View in: PubMed

. A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer Am J Clin Oncol. 2018 May 18. View in: PubMed

. Association Between Height and Clinical Outcome in Metastatic Colorectal Cancer Patients Enrolled Onto a Randomized Phase 3 Clinical Trial: Data From the FIRE-3 Study Clin Colorectal Cancer. 2018 May 10. View in: PubMed

. A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma Cancer Chemother Pharmacol. 2018 May; 81(5):957-963. View in: PubMed

. Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers Mol Cancer Res. 2018 May; 16(5):805-812. View in: PubMed

. Andecaliximab/GS-5745 alone and combined with mFOLFOX6 in advanced gastric and gastroesophageal junction adenocarcinoma: Results from a phase 1 study Clin Cancer Res. 2018 Apr 24. View in: PubMed

. A phase 1 dose-escalation study of veliparib with bimonthly FOLFIRI in patients with advanced solid tumours Br J Cancer. 2018 Apr; 118(7):938-946. View in: PubMed

. Outlooks on Epstein-Barr virus associated gastric cancer Cancer Treat Rev. 2018 Mar 31; 66:15-22. View in: PubMed

. Differentiation Therapy Targeting the ß-Catenin/CBP Interaction in Pancreatic Cancer Cancers (Basel). 2018 Mar 29; 10(4). View in: PubMed

. Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study Clin Colorectal Cancer. 2018 Mar 14. View in: PubMed

. Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer J Clin Oncol. 2018 Mar 10; 36(8):773-779. View in: PubMed

. The role of tumor angiogenesis as a therapeutic target in colorectal cancer Expert Rev Anticancer Ther. 2018 Mar; 18(3):251-266. View in: PubMed

. Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713 Clin Colorectal Cancer. 2018 Mar; 17(1):e121-e125. View in: PubMed

. Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib Clin Colorectal Cancer. 2018 Feb 27. View in: PubMed

. A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab Clin Cancer Res. 2018 Feb 15; 24(4):784-793. View in: PubMed

. Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation Cancer Treat Rev. 2018 Feb; 63:48-60. View in: PubMed

. Colorectal cancer in 2017: Practice-changing updates in the adjuvant and metastatic setting Nat Rev Clin Oncol. 2018 Feb; 15(2):77-78. View in: PubMed

. The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer Eur J Cancer. 2018 Feb; 90:63-72. View in: PubMed

. CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy Cancer Treat Rev. 2018 Feb; 63:40-47. View in: PubMed

. First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors Invest New Drugs. 2018 Jan 29. View in: PubMed

. NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients PLoS One. 2018; 13(3):e0193640. View in: PubMed

. Determination of an optimal response cut-off able to predict progression-free survival in patients with well-differentiated advanced pancreatic neuroendocrine tumours treated with sunitinib: an alternative to the current RECIST-defined response Br J Cancer. 2018 Jan; 118(2):181-188. View in: PubMed

. Outlook: Immunotherapy in Gastrointestinal Carcinoma - Innovative Strategies Oncol Res Treat. 2018; 41(5):313-315. View in: PubMed

. Trends in colorectal cancer mortality in hispanics: a SEER analysis Oncotarget. 2017 Dec 12; 8(65):108771-108777. View in: PubMed

. Molecular Landscape and Treatment Options for Patients with Metastatic Colorectal Cancer Indian J Surg Oncol. 2017 Dec; 8(4):580-590. View in: PubMed

. Randomized study of etirinotecan pegol versus irinotecan as second-line treatment for metastatic colorectal cancer Cancer Chemother Pharmacol. 2017 Dec; 80(6):1161-1169. View in: PubMed

. Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer Cancer. 2017 Nov 15; 123(22):4506-4514. View in: PubMed

. Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers Oncotarget. 2017 Oct 17; 8(49):86356-86368. View in: PubMed

. DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer Cancer. 2017 Oct 01; 123(19):3732-3743. View in: PubMed

. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study Lancet Oncol. 2017 Sep; 18(9):1182-1191. View in: PubMed

. Mindfulness practice reduces cortisol blunting during chemotherapy: A randomized controlled study of colorectal cancer patients Cancer. 2017 Aug 15; 123(16):3088-3096. View in: PubMed

. Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers Clin Cancer Res. 2017 Jul 15; 23(14):3657-3666. View in: PubMed

. New perspectives for colorectal cancer Oncotarget. 2017 Jun 27; 8(26):41782-41783. View in: PubMed

. What We Know About Stage II and III Colon Cancer: It's Still Not Enough Target Oncol. 2017 Jun; 12(3):265-275. View in: PubMed

. What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers? J Cell Commun Signal. 2017 Mar; 11(1):79-87. View in: PubMed

. Colorectal cancer: epigenetic alterations and their clinical implications Biochim Biophys Acta. 2017 12; 1868(2):439-448. View in: PubMed

. Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer Eur J Cancer. 2017 11; 86:197-206. View in: PubMed

. Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes Eur J Cancer. 2017 10; 84:69-80. View in: PubMed

. A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer Cancer Discov. 2017 06; 7(6):610-619. View in: PubMed

. Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials Eur J Cancer. 2017 05; 77:13-20. View in: PubMed

. A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803 Oncologist. 2017 01; 22(1):107-114. View in: PubMed

. Comparative effectiveness of screening strategies for colorectal cancer Cancer. 2017 05 01; 123(9):1516-1527. View in: PubMed

. Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer Int J Cancer. 2017 09 15; 141(6):1222-1230. View in: PubMed

. Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial JAMA. 2017 06 20; 317(23):2392-2401. View in: PubMed

. Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial Int J Cancer. 2017 07 15; 141(2):383-392. View in: PubMed

. Metastatic Colorectal Cancer in Hispanics: Treatment Outcomes in a Treated Population Clin Colorectal Cancer. 2016 Dec; 15(4):e221-e227. View in: PubMed

. An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma Clin Cancer Res. 2016 Nov 01; 22(21):5204-5210. View in: PubMed

. Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials JAMA Oncol. 2016 Oct 10. View in: PubMed

. Impact of sex, age, and ethnicity/race on the survival of patients with rectal cancer in the United States from 1988 to 2012 Oncotarget. 2016 Aug 16; 7(33):53668-53678. View in: PubMed

. Molecular Pathways: Cachexia Signaling-A Targeted Approach to Cancer Treatment Clin Cancer Res. 2016 Aug 15; 22(16):3999-4004. View in: PubMed

. Novel therapeutics in metastatic colorectal cancer: molecular insights and pharmacogenomic implications Expert Rev Clin Pharmacol. 2016 Aug; 9(8):1091-108. View in: PubMed

. Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy Clin Cancer Res. 2016 Jul 01; 22(13):3218-26. View in: PubMed

. The safety of monoclonal antibodies for treatment of colorectal cancer Expert Opin Drug Saf. 2016 Jun; 15(6):799-808. View in: PubMed

. Biomarker in Colorectal Cancer Cancer J. 2016 May-Jun; 22(3):156-64. View in: PubMed

. Understanding the FOLFOXIRI-regimen to optimize treatment for metastatic colorectal cancer Crit Rev Oncol Hematol. 2016 Apr; 100:117-26. View in: PubMed

. Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer Oncologist. 2016 Feb; 21(2):172-7. View in: PubMed

. Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database J Clin Oncol. 2016 Jan 10; 34(2):144-50. View in: PubMed

. Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Mol Cancer Ther. 2016 11; 15(11):2814-2821. View in: PubMed

. A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer Mol Cancer Ther. 2016 09; 15(9):2251-8. View in: PubMed

. Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab Mol Cancer Ther. 2016 07; 15(7):1740-5. View in: PubMed

. Genome-wide association study of colorectal cancer in Hispanics Carcinogenesis. 2016 06; 37(6):547-556. View in: PubMed

. TWIST1 Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy Mol Cancer Ther. 2016 06; 15(6):1405-11. View in: PubMed

. Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand? Nat Rev Gastroenterol Hepatol. 2016 05; 13(5):258-9. View in: PubMed

. ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016 ESMO Open. 2016; 1(5):e000097. View in: PubMed

. Combined assessment of EGFR-related molecules to predict outcome of 1st-line cetuximab-containing chemotherapy for metastatic colorectal cancer Cancer Biol Ther. 2016 07 02; 17(7):751-9. View in: PubMed

. CDX2 as a Prognostic Biomarker in Colon Cancer N Engl J Med. 2016 06 02; 374(22):2183. View in: PubMed

. A novel antimetabolite: TAS-102 for metastatic colorectal cancer Expert Rev Clin Pharmacol. 2016; 9(3):355-65. View in: PubMed

. Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer J Clin Oncol. 2015 Dec 20; 33(36):4284-92. View in: PubMed

. Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor Clin Cancer Res. 2015 Nov 15; 21(22):5002-7. View in: PubMed

. Pharmacodynamics (PD) and pharmacokinetics (PK) of E7389 (eribulin, halichondrin B analog) during a phase I trial in patients with advanced solid tumors: a California Cancer Consortium trial Cancer Chemother Pharmacol. 2015 Nov; 76(5):897-907. View in: PubMed

. Integrin beta-3 genetic variants and risk of venous thromboembolism in colorectal cancer patients Thromb Res. 2015 Nov; 136(5):865-9. View in: PubMed

. TAS-102, a novel antitumor agent: a review of the mechanism of action Cancer Treat Rev. 2015 Nov; 41(9):777-83. View in: PubMed

. Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer Mol Cancer Ther. 2015 Oct; 14(10):2374-81. View in: PubMed

. Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach Mol Cancer Ther. 2015 Oct; 14(10):2401-8. View in: PubMed

. Response J Natl Cancer Inst. 2015 Sep; 107(9). View in: PubMed

. Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial Lancet Oncol. 2015 Aug; 16(8):937-48. View in: PubMed

. Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness Sci Rep. 2015 Jun 08; 5:11207. View in: PubMed

. Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases Cancer. 2015 Jun 01; 121(11):1898-905. View in: PubMed

. FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study Gut. 2015 Jun; 64(6):921-8. View in: PubMed

. Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results Int J Clin Oncol. 2015 Jun; 20(3):518-24. View in: PubMed

. Randomized trial of TAS-102 for refractory metastatic colorectal cancer N Engl J Med. 2015 May 14; 372(20):1909-19. View in: PubMed

. IL-33 activates tumor stroma to promote intestinal polyposis Proc Natl Acad Sci U S A. 2015 May 12; 112(19):E2487-96. View in: PubMed

. Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors J Clin Oncol. 2015 May 10; 33(14):1551-6. View in: PubMed

. Pharmacogenomics of fluorouracil -based chemotherapy toxicity Expert Opin Drug Metab Toxicol. 2015 May; 11(5):811-21. View in: PubMed

. Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation Clin Cancer Res. 2015 Apr 01; 21(7):1583-90. View in: PubMed

. Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network Curr Treat Options Oncol. 2015 Apr; 16(4):17. View in: PubMed

. Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). 2015 Mar; 29(3):183-4; 186. View in: PubMed

. Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer J Clin Oncol. 2015 Mar 01; 33(7):692-700. View in: PubMed

. A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine Cancer Chemother Pharmacol. 2015 Mar; 75(3):537-46. View in: PubMed

. Primary tumor location as a prognostic factor in metastatic colorectal cancer J Natl Cancer Inst. 2015 Mar; 107(3). View in: PubMed

. Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): personalized medicine at work Hematol Oncol Clin North Am. 2015 Feb; 29(1):43-60. View in: PubMed

. Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer Pharmacogenet Genomics. 2015 Jan; 25(1):30-7. View in: PubMed

. Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients Pharmacogenet Genomics. 2014 Dec; 24(12):588-96. View in: PubMed

. Impact of sex on the survival of patients with hepatocellular carcinoma: a Surveillance, Epidemiology, and End Results analysis Cancer. 2014 Dec 01; 120(23):3707-16. View in: PubMed

. Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent Pharmacogenet Genomics. 2014 Nov; 24(11):539-47. View in: PubMed

. Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304) Cancer. 2014 Nov 01; 120(21):3329-3337. View in: PubMed

. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727) Cancer. 2014 Oct 01; 120(19):2980-5. View in: PubMed

. So much effort, so little progress? J Natl Cancer Inst. 2014 Oct; 106(10). View in: PubMed

. A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy Clin Cancer Res. 2014 Sep 01; 20(17):4499-4510. View in: PubMed

. Safely targeting cancer stem cells via selective catenin coactivator antagonism Cancer Sci. 2014 Sep; 105(9):1087-92. View in: PubMed

. A randomized, phase II study of the anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody robatumumab (SCH 717454) in patients with advanced colorectal cancer Cancer Med. 2014 Aug; 3(4):988-97. View in: PubMed

. Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer Invest New Drugs. 2014 Aug; 32(4):682-90. View in: PubMed

. CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development Int J Cancer. 2014 Jul 01; 135(1):232-7. View in: PubMed

. ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer Cell Rep. 2014 Jun 26; 7(6):1940-55. View in: PubMed

. The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin ß1 Sci Signal. 2014 Jun 17; 7(330):ra58. View in: PubMed

. Molecular pathways: turning proteasomal protein degradation into a unique treatment approach Clin Cancer Res. 2014 Jun 15; 20(12):3064-70. View in: PubMed

. The potential of targeting Wnt/ß-catenin in colon cancer Expert Opin Ther Targets. 2014 Jun; 18(6):611-5. View in: PubMed

. Panitumumab safety for treating colorectal cancer Expert Opin Drug Saf. 2014 Jun; 13(6):843-51. View in: PubMed

. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy Nat Rev Clin Oncol. 2014 May; 11(5):282-98. View in: PubMed

. Panitumumab : leading to better overall survival in metastatic colorectal cancer? Expert Opin Biol Ther. 2014 Apr; 14(4):535-48. View in: PubMed

. Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients Invest New Drugs. 2014 Feb; 32(1):113-22. View in: PubMed

. Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy Mol Cancer Ther. 2014 Feb; 13(2):528-39. View in: PubMed

. Testing for RAS mutations in patients with metastatic colorectal cancer Clin Adv Hematol Oncol. 2014 Jan; 12(1):48-9. View in: PubMed

. A small cog in a big wheel: PIK3CA mutations in colorectal cancer J Natl Cancer Inst. 2013 Dec 04; 105(23):1775-6. View in: PubMed

. Timeliness of adjuvant chemotherapy for stage III adenocarcinoma of the colon: a measure of quality of care Clin Colorectal Cancer. 2013 Dec; 12(4):275-9. View in: PubMed

. RAS mutations in colorectal cancer N Engl J Med. 2013 Nov 28; 369(22):2159. View in: PubMed

. Protein kinase inhibitors in metastatic colorectal cancer Let's pick patients, tumors, and kinase inhibitors to piece the puzzle together! Expert Opin Pharmacother. 2013 Nov; 14(16):2203-20. View in: PubMed

. Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle Pharmacogenomics. 2013 Nov; 14(14):1671-4. View in: PubMed

. Molecular pathways: Estrogen pathway in colorectal cancer Clin Cancer Res. 2013 Nov 01; 19(21):5842-8. View in: PubMed

. Listening in on difficult conversations: an observational, multi-center investigation of real-time conversations in medical oncology BMC Cancer. 2013 Oct 04; 13:455. View in: PubMed

. SWOG S0353: Phase II trial of intravesical gemcitabine in patients with nonmuscle invasive bladder cancer and recurrence after 2 prior courses of intravesical bacillus Calmette-Guérin J Urol. 2013 Oct; 190(4):1200-4. View in: PubMed

. Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States Mol Cancer Ther. 2013 Oct; 12(10):2261-72. View in: PubMed

. Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation Cancer. 2013 Aug 15; 119(16):3043-51. View in: PubMed

. Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer Invest New Drugs. 2013 Aug; 31(4):845-57. View in: PubMed

. Phase I study of pazopanib in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study Clin Cancer Res. 2013 Jul 01; 19(13):3631-9. View in: PubMed

. A phase I trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors Cancer Chemother Pharmacol. 2013 Jul; 72(1):85-91. View in: PubMed

. MicroRNA-21 in colorectal cancer: "Just another brick in the wall"? J Natl Cancer Inst. 2013 Jun 19; 105(12):840-1. View in: PubMed

. Markers of response for the antiangiogenic agent bevacizumab J Clin Oncol. 2013 Mar 20; 31(9):1219-30. View in: PubMed

. Reply to JZhang et al. J Clin Oncol. 2013 Feb 20; 31(6):816-7. View in: PubMed

. Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement HPB (Oxford). 2013 Feb; 15(2):106-15. View in: PubMed

. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial Lancet. 2013 Jan 26; 381(9863):303-12. View in: PubMed

. Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration Angiogenesis. 2013 Jan; 16(1):29-44. View in: PubMed

. Assessing the in vivo efficacy of biologic antiangiogenic therapies Cancer Chemother Pharmacol. 2013 Jan; 71(1):1-12. View in: PubMed

. Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab PLoS One. 2013; 8(7):e66774. View in: PubMed

. Angiogenesis-related agents in esophageal cancer Expert Opin Biol Ther. 2012 Oct; 12(10):1335-45. View in: PubMed

. Targeted therapies: Cetuximab dosing by rash--is the scaling of EVEREST meaningful? Nat Rev Clin Oncol. 2012 Oct; 9(10):554-6. View in: PubMed

. Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer Clin Cancer Res. 2012 Oct 01; 18(19):5412-26. View in: PubMed

. A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma Invest New Drugs. 2012 Aug; 30(4):1597-606. View in: PubMed

. SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinoma Invest New Drugs. 2012 Aug; 30(4):1646-51. View in: PubMed

. Influence of sex on the survival of patients with esophageal cancer J Clin Oncol. 2012 Jun 20; 30(18):2265-72. View in: PubMed

. The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models Mol Cancer Ther. 2012 Jun; 11(6):1353-64. View in: PubMed

. Explaining the unexplainable: EGFR antibodies in colorectal cancer J Clin Oncol. 2012 May 20; 30(15):1735-7. View in: PubMed

. Targeting IL-8 in colorectal cancer Expert Opin Ther Targets. 2012 May; 16(5):491-7. View in: PubMed

. Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414) J Thorac Oncol. 2012 May; 7(5):906-12. View in: PubMed

. Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study Invest New Drugs. 2012 Apr; 30(2):723-8. View in: PubMed

. LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome Breast Cancer Res Treat. 2012 Apr; 132(2):537-44. View in: PubMed

. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas Clin Cancer Res. 2012 Mar 15; 18(6):1726-34. View in: PubMed

. Pancreatic cancer: medical management (novel chemotherapeutics) Gastroenterol Clin North Am. 2012 Mar; 41(1):189-209. View in: PubMed

. A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study Cancer Chemother Pharmacol. 2012 Mar; 69(3):835-43. View in: PubMed

. Pharmacogenomics and metastatic colorectal cancer: current knowledge and perspectives Scand J Gastroenterol. 2012 Mar; 47(3):325-39. View in: PubMed

. Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer Mol Cancer Ther. 2012 Mar; 11(3):616-28. View in: PubMed

. Cancer dormancy: a model of early dissemination and late cancer recurrence Clin Cancer Res. 2012 Feb 01; 18(3):645-53. View in: PubMed

. "HER majesty's a pretty nice girl but she changes from day to day" J Clin Oncol. 2012 Feb 01; 30(4):465-6; author reply 466-7. View in: PubMed

. A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer Mol Cancer Ther. 2012 Jan; 11(1):119-31. View in: PubMed

. S0356: a phase II clinical and prospective molecular trial with oxaliplatin, fluorouracil, and external-beam radiation therapy before surgery for patients with esophageal adenocarcinoma J Clin Oncol. 2011 Dec 01; 29(34):4555-60. View in: PubMed

. Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study Cancer Chemother Pharmacol. 2011 Dec; 68(6):1439-47. View in: PubMed

. A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma: Southwest Oncology Group study S0202 Cancer Chemother Pharmacol. 2011 Dec; 68(6):1595-602. View in: PubMed

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Awards

Western Society of Clinical Investigation: Outstanding Investigator Award, 2016

The WunderGlo Foundation: 1st Annual Cancer Warrior Award, 2012

USC: Bob Chandler Courage Award, 2003

2003 Annual Retreat on Cancer Research: The Gallo Award, 2003

Conquer Cancer Foundation: ASCO Career Development Award, 1995-1998

Conquer Cancer Foundation: ASCO Young Investigator Award, 1994