{"id":35,"date":"2023-08-16T00:28:01","date_gmt":"2023-08-16T00:28:01","guid":{"rendered":"https:\/\/keck.usc.edu\/otolaryngology\/?page_id=35"},"modified":"2025-01-14T16:28:36","modified_gmt":"2025-01-14T16:28:36","slug":"labs","status":"publish","type":"page","link":"https:\/\/keck.usc.edu\/otolaryngology\/research-old\/labs\/","title":{"rendered":"Labs"},"content":{"rendered":"\n\n\n\n\n    \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--hero-primary horizontal-navigation\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--hero-primary\"\n    \n      >\n\n    \n  \n  <div class=\"inner-wrapper has-horizontal-nav\">\n\n          <div class=\"title-wrapper\">\n\n                  <div class=\"eyebrow-container\">\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/\" >USC Caruso Department of Otolaryngology<\/a>\n\n\n\n<\/div>\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/research\/\" >Research<\/a>\n\n\n\n<\/div>\n                      <\/div>\n        \n                      \n<div class=\"f--field f--page-title has-stripe\">\n\n    \n      <h1>Labs<\/h1>\n\n\n<\/div>\n        \n              <\/div>\n    \n              \n<div class=\"f--field f--link eyebrow-link\">\n\n    \n    \n  \n\n<a\n  class=\"link \"\n  href=\"https:\/\/www.keckmedicine.org\/services\/ear-nose-and-throat-care\/\"\n    >\n        Are you a patient?\n    <\/a>\n\n\n<\/div>\n    \n    \n      \n              <div class=\"horizontal-nav\">\n                      <div class=\"horizontal-menu-container\">\n              <button class=\"expand-menu\">\n                                  In This Section\n                                <svg class=\"menu\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\"\n                  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class=\"link-arrow-wrapper\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/training-education\/medical-student-education\/\" >Medical Student Education<\/a>\n\n      <button class=\"expand-children has-submenu arrow-toggle\" aria-expanded=\"false\" aria-haspopup=\"true\" aria-label=\"Display Submenu for Medical Student Education\">\n        <svg height=\"35\" viewBox=\"0 0 35 35\" width=\"35\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n          <path d=\"m17.5 20.2142857 6.2142857-6.2142857 1.2857143 1.2857143-7.5 7.5-7.5-7.5 1.2857143-1.2857143z\" fill=\"#000\" fill-rule=\"evenodd\"\/>\n        <\/svg>\n      <\/button>\n    <\/div>\n  \n      <div class=\"submenus-wrapper\">\n      <div class=\"submenus-wrapper-inner\">\n        <ul class=\"submenu\" aria-hidden=\"true\">\n                      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-235\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/training-education\/medical-student-education\/sub-internship-program\/\" >Sub-Internship Program<\/a>\n  \n  \n<\/li>\n                      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-239\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/training-education\/medical-student-education\/clinician-scientist-training-program-cstp-for-medical-students\/\" >CSTP for Medical Students<\/a>\n  \n  \n<\/li>\n                  <\/ul>\n      <\/div>\n    <\/div>\n  \n<\/li>\n                      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-474\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/training-education\/externship-program\/\" >Externship Program<\/a>\n  \n  \n<\/li>\n                  <\/ul>\n      <\/div>\n    <\/div>\n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-26\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/patient-care\/\" >Patient Care<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-250\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/faculty\/\" >Faculty<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\"has-submenu menu-item menu-item-type-post_type menu-item-object-page menu-item-27 menu-item-has-children\">\n      <div class=\"link-arrow-wrapper\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/support\/\" >Support<\/a>\n\n      <button class=\"expand-children has-submenu arrow-toggle\" aria-expanded=\"false\" aria-haspopup=\"true\" aria-label=\"Display Submenu for Support\">\n        <svg height=\"35\" viewBox=\"0 0 35 35\" width=\"35\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n          <path d=\"m17.5 20.2142857 6.2142857-6.2142857 1.2857143 1.2857143-7.5 7.5-7.5-7.5 1.2857143-1.2857143z\" fill=\"#000\" fill-rule=\"evenodd\"\/>\n        <\/svg>\n      <\/button>\n    <\/div>\n  \n      <div class=\"submenus-wrapper\">\n      <div class=\"submenus-wrapper-inner\">\n        <ul class=\"submenu\" aria-hidden=\"true\">\n                      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-244\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/support\/endowments\/\" >Endowments<\/a>\n  \n  \n<\/li>\n                  <\/ul>\n      <\/div>\n    <\/div>\n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-28\">\n      <a href=\"https:\/\/keck.usc.edu\/otolaryngology\/contact\/\" >Contact<\/a>\n  \n  \n<\/li>\n\n    \n      <\/ul><!-- m--menu -->\n<\/nav>\n\n            <\/div>\n                  <\/div>\n        <\/div>\n\n\n  <\/div><\/div>\n\n\n\n                                    \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--editorial-cards \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--editorial-cards\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n    \n          <div class=\"cards-container\">\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/oghalailab.usc.edu\/\"\n      target=\"_blank\"      aria-label=\"The Oghalai Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/OghalaiLab-320x180.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/OghalaiLab-768x432.png 768w,https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/OghalaiLab-320x180.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"The sensory tissues of the inner ear. This image was taken from a living mouse using a special imaging technique called dynamic optical coherence microscopy. It shows the sensory hair cells (inner hair cells, IHCs; outer hair cells, OHCs) that detect sound and the auditory nerve fibers that carry the sound information to the brain. It also shows the nerves that come from the brain and regulate the inner ear (medial olivocochlear [MOC] efferents). Photo Credit: John Oghalai.\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>John S. Oghalai, MD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/oghalailab.usc.edu\/\" target=\"_blank\">\n                    \n                      The Oghalai Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Oghalai lab at the Zilkha Neurogenetics Institute seeks to better understand the fundamental changes in cochlear function that underlie progressive hearing loss and to develop novel techniques to treat this problem before it leads to deafness. Clinically, our ultimate goal is to improve human health not only by caring for our patients expertly, but also by advancing our scientific knowledge base so that all physicians can treat disease more effectively.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/abdalab\/\"\n      target=\"_blank\"      aria-label=\"The Abdala Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AbdalaLab-320px-320x180.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AbdalaLab-320px-1280x720.png 1280w,https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AbdalaLab-320px-768x432.png 768w,https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AbdalaLab-320px-320x180.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"A high-resolution DPOAE (distortion product otoacoustic emission) Level Series, which researchers measure in the Abdala Lab on human subjects with and without hearing loss. (Photo Credit: Carolina Abdala)\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Carolina Abdala, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/abdalab\/\" target=\"_blank\">\n                    \n                      The Abdala Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Abdala Lab, within the USC Caruso Department of Otolaryngology, studies natural changes in cochlear mechanics throughout the arc of the human lifespan. This research aims to provide a normative framework, but also to explore the mechanisms driving such change. Recent work is focused on the potential development and application of a combined reflection (SFOAE) and distortion (DPOAE) OAE protocol to understand and describe underlying deficits, not just detect and label sensorineural hearing loss.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/kalluri-pielab\"\n      target=\"_blank\"      aria-label=\"The Kalluri Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/KalluriLab-320px.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/KalluriLab-320px.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Sensory hair cells and neurons. Photo Credit: Radha Kalluri.\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Radha Kalluri, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/kalluri-pielab\" target=\"_blank\">\n                    \n                      The Kalluri Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Kalluri Lab at the Zilkha Neurogentic Institute, led by Radha Kalluri, PhD, assistant professor of otolaryngology, explores the cochlea, an elegant hydromechanical structure in the ear, that which works to separate sounds of different frequencies and maps them onto a different place on the sensory epithelium. Specialized sensory cells that provide feedback forces to actively amplify local mechanical resonances refine this frequency-place map within the cochlea. Research is focused on understanding the biophysical mechanisms by which the auditory periphery parses frequency and intensity information, and how these functions degrade with hearing loss.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/www.mechanicsofhearing.org\/apg\/\"\n      target=\"_blank\"      aria-label=\"The  Auditory Physics Group\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AuditoryPhysicsGroup-320x180.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AuditoryPhysicsGroup-768x432.png 768w,https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/AuditoryPhysicsGroup-320x180.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Analogy between laser and cochlear amplifiers. Photo credit: Christopher Shera\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Christopher Shera, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/www.mechanicsofhearing.org\/apg\/\" target=\"_blank\">\n                    \n                      The  Auditory Physics Group\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Auditory Physics Group in the Caruso Department of Otolaryngology works to solve fundamental problems in the mechanics and physiology of the auditory system. Current interests of the group include comparative cochlear mechanics, cochlear nonlinearity and amplification, middle-ear mechanics, and otoacoustic emissions.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"http:\/\/www.applegatelab.org\/\"\n      target=\"_blank\"      aria-label=\"The Applegate Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/ApplegateResearchGroup.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/ApplegateResearchGroup.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Left) Technician imaging the ear of a volunteer with a prototype Optical Coherence Tomography (OCT) otoscope. Right) An otoscope image and OCT cross-sections of a patient presenting with a retraction pocket, illustrating the depth of the retraction and its contact points with the incus and cochlear promontory. (Photo Credit: Applegate Research Group)\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Brian Applegate, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"http:\/\/www.applegatelab.org\/\" target=\"_blank\">\n                    \n                      The Applegate Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease. Our primary application area is functional imaging of the middle and inner ear. We are working toward advanced diagnostics for patient care as well as advanced imaging systems for probing the fundamental mechanics of the ear.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/bionicearlab\"\n      target=\"_blank\"      aria-label=\"The Goldsworthy Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/BionicEarLab.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/BionicEarLab.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Postdoctoral scholar Samantha O\u2019Connell and Research Technician Julianne Papadopoulos prepare to measure Dr. Ray Goldsworthy\u2019s brain activity in response to music. Photo Credit: Kristin Brokaw.\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Raymond Goldsworthy, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/bionicearlab\" target=\"_blank\">\n                    \n                      The Goldsworthy Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Bionic Ear Lab in the Caruso Department of Otolaryngology explores ways of improving hearing for cochlear implant recipients. A focus of the lab is to optimize stimulation timing to provide better musical pitch and refined spatial hearing for cochlear implant users. Our lab emphasizes the importance of auditory training and neural plasticity in achieving optimal outcomes.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/gnedevalab\/\"\n      target=\"_blank\"      aria-label=\"The Gnedeva Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/OC.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/OC.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Inside the cochlea in the inner ear, the Organ of Corti contains hair cells (stained cyan blue) that turn incoming sound waves into nerve signals for the brain. The loss of hair cells is considered one of the primary causes of sensorineural deafness. The Keck School of Medicine of USC\u2019s Gnedeva Lab is researching how to stimulate the remaining supporting cells (stained red) to regenerate lost hair cells and restore hearing. (Photo Credit: Ksenia Gnedeva)\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Ksenia Gnedeva, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/gnedevalab\/\" target=\"_blank\">\n                    \n                      The Gnedeva Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>In the Gnedeva Lab at the Zilkha Neurogenetic Institute, we investigate how the mechanical microenvironment controls sensory organ development and directs tissue repair after damage. Although the focus of our research is on hearing and balance restoration, we are interested in the common mechanisms that suppress regeneration in the specialized sensory tissues.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/deweylab\"\n      target=\"_blank\"      aria-label=\"The Dewey Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/DeweyLab.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/DeweyLab.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Cross-sectional image of the live mouse cochlea obtained with optical coherence tomography. Using this technique, we can image through the cochlear bone and visualize the interior fluid-filled spaces as well as the sensory organ of Corti. It also allows us to measure how the organ of Corti vibrates in response to sound, which is a critical aspect of auditory sensation. (Photo Credit: James Dewey)\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>James Dewey, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/deweylab\" target=\"_blank\">\n                    \n                      The Dewey Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>The Dewey Lab at the Zilkha Neurogenetic Institute examines how structures within the inner ear vibrate in response to sound, how these vibrations are amplified by sensory hair cells, and how this amplification process leads to emission of sound from the ear. The overarching aims of this research are to understand the mechanisms underlying sensitive, normal hearing, and to improve how we detect and diagnose common forms of hearing loss.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n        \n          <div class=\"card\">\n\n            \n                                            \n                  \n<div class=\"f--field f--image\">\n\n    \n        <a\n      href=\"https:\/\/sites.usc.edu\/charaziaklab\"\n      target=\"_blank\"      aria-label=\"The Charaziak Lab\"                >\n  \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/CharaziakLab-320px.png\"\n          data-srcset=\"https:\/\/keck.usc.edu\/otolaryngology\/wp-content\/uploads\/sites\/26\/2025\/01\/CharaziakLab-320px.png 320w\"          data-sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"          class=\"lazyload\"\n        \n                alt=\"Karolina Charaziak, Ph.D. in her research lab. (Photo Credit: Chris Shinn)\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n      <\/a>\n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                  \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Karolina Charaziak, PhD<\/span>\n\n\n\n<\/div>\n              \n                                              <span class=\"card-title\">\n                                          <a href=\"https:\/\/sites.usc.edu\/charaziaklab\" target=\"_blank\">\n                    \n                      The Charaziak Lab\n\n                                          <\/a>\n                                      <\/span>\n              \n                                  \n<div class=\"f--field f--description\">\n\n    \n  <p>Research at the Charaziak lab is focused on understanding how the cochlea of the inner ear processes sounds. We utilize approaches that combine both direct (e.g., intracochlear vibrometry) and indirect (e.g., otoacoustic emissions) measurements of cochlear responses in animals with theoretical modeling. Joint intracochlear and otoacoustic emission (OAE) studies informed by theoretical models are crucial for improving the power of OAE-based diagnostics in humans, where the cochlea cannot be accessed for a direct study.<\/p>\n\n\n\n<\/div>\n                          <\/div>\n\n\n          <\/div>\n              <\/div>\n      <\/div>\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":14,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-35","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Labs - USC Caruso Department of Otolaryngology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/otolaryngology\/research-old\/labs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Labs\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/otolaryngology\/research-old\/labs\/\" \/>\n<meta property=\"og:site_name\" content=\"USC Caruso Department of Otolaryngology\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-14T16:28:36+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/research-old\\\/labs\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/research-old\\\/labs\\\/\",\"name\":\"Labs - USC Caruso Department of Otolaryngology\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/#website\"},\"datePublished\":\"2023-08-16T00:28:01+00:00\",\"dateModified\":\"2025-01-14T16:28:36+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/research-old\\\/labs\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/research-old\\\/labs\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/research-old\\\/labs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/keck.usc.edu\\\/otolaryngology\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research &#8211; 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