Faculty 2016-07-07T15:14:03+00:00

Faculty

Florence M Hofman, PhD

Professor of Pathology

Pathology
HMR 2011 Zonal Ave
Health Sciences Campus
Los Angeles

+1 323 442 1153
hofman@usc.edu


Overview

Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.

Publications

. NEO212 Inhibits Migration and Invasion of Glioma Stem Cells Mol Cancer Ther. 2018 Mar; 17(3):625-637. View in: PubMed

. Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model J Neurosurg. 2018 Mar; 128(3):695-700. View in: PubMed

. Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram Int J Mol Sci. 2018 Jan 17; 19(1). View in: PubMed

. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells Cancer Lett. 2017 08 01; 400:161-174. View in: PubMed

. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression Oncotarget. 2016 Mar 22; 7(12):13842-53. View in: PubMed

. A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells Cancer Lett. 2016 Feb 28; 371(2):240-50. View in: PubMed

. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment Sci Rep. 2016 Feb 05; 6:20605. View in: PubMed

. Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and a6ß1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties Front Cell Neurosci. 2016; 10:284. View in: PubMed

. Tumor vasculature and glioma stem cells: Contributions to glioma progression Cancer Lett. 2016 10 01; 380(2):545-51. View in: PubMed

. Nanoparticle biointerfacing by platelet membrane cloaking Nature. 2015 Oct 01; 526(7571):118-21. View in: PubMed

. Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo J Biomed Sci. 2015 Aug 19; 22:71. View in: PubMed

. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity Vaccine. 2015 May 28; 33(23):2690-6. View in: PubMed

. A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo Cancer Lett. 2015 Mar 28; 358(2):144-151. View in: PubMed

. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals Neurosurg Focus. 2015 Mar; 38(3):E8. View in: PubMed

. Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors Neurosurg Focus. 2015 Mar; 38(3):E12. View in: PubMed

. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model Hum Gene Ther. 2015 Feb; 26(2):82-93. View in: PubMed

. Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report Perm J. 2015; 19(2):41-6. View in: PubMed

. Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy Neurosurg Focus. 2014 Dec; 37(6):E12. View in: PubMed

. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas Mol Cancer Ther. 2014 Aug; 13(8):2004-17. View in: PubMed

. Argonaute-2 promotes miR-18a entry in human brain endothelial cells J Am Heart Assoc. 2014 May 16; 3(3):e000968. View in: PubMed

. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo Mol Cancer Ther. 2014 May; 13(5):1181-93. View in: PubMed

. A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option J Neurooncol. 2014 Feb; 116(3):437-46. View in: PubMed

. MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function Stroke. 2014 Jan; 45(1):293-7. View in: PubMed

. Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas Front Oncol. 2014; 4:180. View in: PubMed

. ImmunohistochemistryCurr Protoc Immunol. 2013 Nov 18; 103:Unit 21. 4. View in: PubMed

. Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I PLoS One. 2013; 8(6):e65695. View in: PubMed

. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett. 2012 Dec 30; 326(2):143-54. View in: PubMed

. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors Cancer Lett. 2012 Dec 01; 325(1):63-71. View in: PubMed

. Perillyl alcohol for the treatment of temozolomide-resistant gliomas Mol Cancer Ther. 2012 Nov; 11(11):2462-72. View in: PubMed

. Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation Oncoimmunology. 2012 May 01; 1(3):298-305. View in: PubMed

. Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators J Clin Cell Immunol. 2012; Suppl 5:004. View in: PubMed

. Noscapine inhibits tumor growth in TMZ-resistant gliomas Cancer Lett. 2011 Dec 22; 312(2):245-52. View in: PubMed

. Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. View in: PubMed

. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis Cancer Res. 2011 Apr 15; 71(8):2848-57. View in: PubMed

. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models Cancer Lett. 2011 Mar 28; 302(2):100-8. View in: PubMed

. Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivoLaboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. View in: PubMed

. Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response Curr Pharm Des. 2011; 17(23):2428-38. View in: PubMed

. Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells Anticancer Agents Med Chem. 2010 Jul; 10(6):462-70. View in: PubMed

. Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature Mol Cancer Ther. 2010 Mar; 9(3):631-41. View in: PubMed

. Glioma-associated endothelial cells are chemoresistant to temozolomide J Neurooncol. 2009 Oct; 95(1):13-22. View in: PubMed

. Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress Cancer Lett. 2009 Sep 08; 282(1):87-97. View in: PubMed

. Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2 Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3275-82. View in: PubMed

. Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. View in: PubMed

. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells Mol Cancer Res. 2008 Aug; 6(8):1268-75. View in: PubMed

. Increased survivin expression confers chemoresistance to tumor-associated endothelial cells Am J Pathol. 2008 Aug; 173(2):575-85. View in: PubMed

. Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. View in: PubMed

. Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib Cancer Res. 2008 Feb 01; 68(3):843-51. View in: PubMed

. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development Cancer Res. 2008 Jan 15; 68(2):498-505. View in: PubMed

. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas Cancer Res. 2007 Oct 15; 67(20):9809-16. View in: PubMed

. Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib J Biomed Sci. 2007 Sep; 14(5):647-62. View in: PubMed

. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage J Virol. 2007 Jun; 81(11):5518-26. View in: PubMed

. Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion J Leukoc Biol. 2007 May; 81(5):1205-12. View in: PubMed

. Glioma-associated endothelial cells show evidence of replicative senescence Exp Cell Res. 2007 Apr 01; 313(6):1192-202. View in: PubMed

. Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas J Neurosurg. 2007 Mar; 106(3):455-62. View in: PubMed

. Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64. View in: PubMed

. Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo Mol Cancer. 2006 May 18; 5:19. View in: PubMed

. Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin Neurosurg Focus. 2006 Apr 15; 20(4):E20. View in: PubMed

. Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells Neurosurg Focus. 2006 Apr 15; 20(4):E26. View in: PubMed

. Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme Neurosurg Focus. 2006 Apr 15; 20(4):E22. View in: PubMed

. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib Blood. 2005 Dec 15; 106(13):4330-8. View in: PubMed

. Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells Cancer Res. 2005 Nov 15; 65(22):10347-54. View in: PubMed

. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. View in: PubMed

. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo Cancer Biol Ther. 2005 May; 4(5):571-82. View in: PubMed

. CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2 Exp Neurol. 2005 May; 193(1):1-18. View in: PubMed

. Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells J Neurosurg. 2005 Apr; 102(4):699-705. View in: PubMed

. Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide J Neuroimmunol. 2004 Aug; 153(1-2):183-9. View in: PubMed

. Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice Curr Eye Res. 2004 Aug-Sep; 29(2-3):145-51. View in: PubMed

. Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide J Neuroimmunol. 2003 Dec; 145(1-2):86-90. View in: PubMed

. A simple method for isolation and characterization of mouse brain microvascular endothelial cells J Neurosci Methods. 2003 Nov 30; 130(1):53-63. View in: PubMed

. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat Med. 2003 Jul; 9(7):907-13. View in: PubMed

. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. View in: PubMed

. ImmunohistochemistryCurr Protoc Immunol. 2002 Aug; Chapter 21:Unit 21. 4. View in: PubMed

. The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells Cancer Biol Ther. 2002 May-Jun; 1(3):268-76. View in: PubMed