Basic Research

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Making significant contributions to translational medicine

Research interests in the Department of Pathology can be divided into 5 main groups: development and regeneration, inherent and infectious disease, molecular and cellular immunology, neurological diseases and tumor biology.

Development and Regeneration

Kinji Asahina, PhD
Liver development, injury, and regeneration.

Cheng-Ming Chuong, MD, PhD
Development, regeneration, evolution and engineering of ectodermal organogenesis using hair, tooth and feather models.

Inherent and Infectious Disease

Ajay Perumbeti, MD, FAAP
Pediatric Transfusion Medicine, Pediatric Cellular Therapy, The Role of HLA-G in Erythropoiesis and Pediatric Disease.

Suraiya Rasheed, PhD
Biomarkers and protein-protein interaction pathways in cancer and viral (HIV) diseases.

Takeshi Saito, MD, PhD
Pathophysiology of viral hepatitis and liver biology.

Molecular and Cellular Immunology

Lee Ann Baxter-Lowe, PhD, d(ABHI)
Definition and clinical relevance of HLA polymorphism.

Alan Epstein, MD, PhD
Development of CAR T-cells for the immunotherapy of solid tumors.

André J. Ouellette, PhD
Defensins in innate and adaptive immune responses.

Neurological Diseases

David R Hinton, MD, FARVO
Pathogenesis of age-related macular degeneration and development of novel stem cell and neuroprotective therapies.

Carol Miller, MD
Cell and molecular biology of neurodegenerative diseases: Translational interfaces with bioengineering.

Tumor Biology

Shahab Azgharzadeh, MD
Next-Generation Sequencing of Relapsed Neuroblastoma. This study will generate and analyze data from tumor cells obtained from bone marrows of children with relapsed neuroblastoma to identify recurring mutations.

Philip Carpenter, MD
Relationship between tumor and surrounding normal tissue. Our projects include purifying Laminin 5 from lung tissue and meauring the effect of renal tumors on the adjacent tissue and if there are correlations between tumor characteristics and the effect on the tissue.

Louis Dubeau, MD, PhD
Biology, molecular genetics, and animal modeling of ovarian cancer.

Anat Erdreich-Epstein, MD, PhD
Molecular mechanisms of PID1-based sensitization of brain tumors to chemotherapy in mice.

Florence M. Hofman, PhD
Mechanisms of resistance and therapy for primary brain tumors and glioma stem cells.

Joseph Landolph, PhD
Molecular and cell biology of morphological and neoplastic cell transformation induced by carcinogenic nickel compounds and chromium (VI) compounds.