Hematopathology Fellowship

Program Overview

The USC Department of Pathology offers a one-year ACGME- accredited fellowship program in hematopathology, with comprehensive training in morphologic interpretation of bone marrow and lymph node specimens, laboratory hematology, flow cytometric immunophenotyping, immunohistochemistry, molecular hematopathology, special coagulation testing and laboratory management. Fellows are exposed to a wide variety of practice settings and case material, with expanded opportunities for scholarly activity, and are required to participate in research projects, conference presentations, and teaching activities.


Board certified or board eligible in anatomic and/or clinical pathology; eligible for medical licensure in California; and, prior to interviews, submit CAP Fellowship Application; Curriculum Vitae; Personal Statement; three Letters of Recommendation

Types and Numbers of Appointments

Three positions for the 1-year fellowship are available.


As of 2014-15, we are excited to announce significant expansion of the curriculum, incorporating three 4-month rotations at three different sites, in three diverse practice settings: LAC+USC Medical Center (large County hospital with highly diverse patient population), Children’s Hospital Los Angeles (pediatric hematopathology), and USC Norris Cancer Hospital (tertiary care center). These restructured rotations allow our fellows to be exposed to a wide variety of practice settings and case material, with expanded opportunities for scholarly activity. In particular, four months of dedicated pediatric hematopathology at a top tier Children’s Hospital is a highly unique training experience. Training at all sites emphasizes development of problem solving skills.

Los Angeles County + USC (LAC+USC) Medical Center

  • Largest healthcare provider in Los Angeles and one of the largest public hospitals in the U.S., with highly diverse patient population.
  • Rotation provides comprehensive training in the various morphologic and laboratory-based techniques of hematology-hematopathology to attain the knowledge, skills and attitudes to practice competently and independently.
  • Under faculty supervision, fellows are provided increasing independence and graded responsibility for work-up of cases, primary decision-making on use of ancillary testing, and junior attending-level sign-out duty with residents on the hematopathology service.
  • Fellows can obtain the necessary hands-on experience to become competent diagnosticians as well as learn the value of contemporary analytical methods, the cost associated with these tools and their limitations.

Children’s Hospital Los Angeles (CHLA)

  • Nationally recognized and a member of the Children’s Oncology group (COG) cooperative of pediatric cancer research centers.
  • CHLA performs approximately 800 bone marrow aspirates, 300 bone marrow biopsies, 100 lymph node biopsies, and 2000 cerebrospinal fluid cytologies with approximately 120 new cases of acute leukemia (lymphoid and myeloid) per year, 40 new cases of lymphoma (non-Hodgkin and Hodgkin) per year, and a multitude of non-neoplastic acquired and congenital hematopathology conditions (bone marrow failure syndromes, congenital cytopenias, autoimmune disease, hemoglobinopathies, thalassemia syndromes, and others). In addition
    to standard coagulation assays, CHLA offers more specialized coagulation assays.
  • CHLA has large hemophilia treatment and research programs as well as clinical and laboratory expertise with other congenital coagulation disorders.
  • CHLA has a new Center for Personalized Medicine which will be a next-generation sequencing center funded by a new $50 million dollar grant to the Department of Pathology.

USC Norris Cancer Hospital

  • Tertiary care facility with an active and growing program in hematologic malignancies and stem cell transplantation.
  • Emphasis on ancillary testing, including flow cytometry and molecular assays for minimal residual disease, cytogenetics, FISH, and molecular tests (single gene and mutation panels by next generation sequencing approaches) for case material at USC Norris/Keck Hospitals as well as those sent to USC from external clients in consultation.
  • Fellow is integrated into the laboratory administration, daily quality control and pathologist oversight of the Norris Clinical Hematology Laboratory.


Program Director

Imran N. Siddiqi, MD, PhD

Teaching Staff

LAC+USC Medical Center
Russell K. Brynes, MD, Chief, Hematopathology Service, Co-Director, Core Laboratory, Director, Special Hematology
Imran N. Siddiqi, MD, PhD, Program Director Hematopathology Fellowship, Attending Staff, Hematopathology
Darryl Shibata, MD, Attending Staff, Hematopathology
Maria Vergara-Lluri, MD, Attending Staff, Hematopathology

Children’s Hospital Los Angeles
Paul Pattengale, MD, Medical Director, Clinical Laboratory, Chief of Research and Education, Hematopathologist
Matthew Oberley, MD, Hematopathologist
Sam Wu, MD, Director of Cytogenetics
Maurice O’Gorman, PhD, Chief of Laboratory Medicine, Director, Flow Cytometry Laboratory
Richard Ko, MD, Director of Coagulation

USC Norris Cancer Medical Center
Imran N. Siddiqi, MD, PhD, Hematology Laboratory Director, Attending Staff, Hematopathology
Russell K. Brynes, MD, Attending Staff, Chief, Hematopathology Service
Darryl Shibata, MD, Attending Staff, Hematopathology


For more information, please contact:

Maria Guerra (mrg@usc.edu), Program Coordinator or Imran Siddiqi, MD, Program Director (isiddiqi@usc.edu)
Department of Pathology
1200 North State Street CT A7E
Los Angeles, CA 90033
Office: (323) 409-7150
Fax: (323) 441-8193