Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging Neuron. 2023 Oct 04; 111(19):3131-3132. . View in PubMed

Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2023 Oct 03; 14(1):6151. . View in PubMed

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice Cell Rep. 2023 Aug 29; 42(8):113050. . View in PubMed

Magnetic resonance imaging of white matter response to diesel exhaust particles Res Sq. 2023 Jul 18. . View in PubMed

Analysis of brain edema in RHAPSODY Int J Stroke. 2023 Jul 16; 17474930231187268. . View in PubMed

Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2023 May; 617(7961):E12. . View in PubMed

Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRß, a marker of blood brain barrier breakdown, in older adults Res Sq. 2023 Mar 07. . View in PubMed

Correction: Anti-malaria drug artesunate prevents development of amyloid-ß pathology in mice by upregulating PICALM at the blood-brain barrier Mol Neurodegener. 2023 Feb 24; 18(1):14. . View in PubMed

The small HDL particle hypothesis of Alzheimer's disease Alzheimers Dement. 2023 02; 19(2):391-404. . View in PubMed

Anti-malaria drug artesunate prevents development of amyloid-ß pathology in mice by upregulating PICALM at the blood-brain barrier Mol Neurodegener. 2023 01 27; 18(1):7. . View in PubMed

PIKFYVE inhibition mitigates disease in models of diverse forms of ALSCell. 2023 02 16; 186(4):786-802. e28. . View in PubMed

Characterization of spastic paraplegia in a family with a novel PSEN1 mutation Brain Commun. 2023; 5(2):fcad030. . View in PubMed

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias Alzheimers Dement. 2022 Dec 08. . View in PubMed

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2022 Nov 03; 17(1):71. . View in PubMed

Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease Nat Cardiovasc Res. 2022 Feb; 1(2):108-115. . View in PubMed

Brain barriers and their potential role in migraine pathophysiology J Headache Pain. 2022 Jan 26; 23(1):16. . View in PubMed

Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging J Cereb Blood Flow Metab. 2022 10; 42(10):1813-1826. . View in PubMed

Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions Geroscience. 2022 06; 44(3):1339-1351. . View in PubMed

How the brain regulates its own immune system Nat Neurosci. 2022 05; 25(5):532-534. . View in PubMed

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice Front Neurosci. 2022; 16:841916. . View in PubMed

A single-cell atlas of the normal and malformed human brain vasculature Science. 2022 03 04; 375(6584):eabi7377. . View in PubMed

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C J Exp Med. 2022 01 03; 219(1). . View in PubMed

A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice J Exp Med. 2022 11 07; 219(11). . View in PubMed

Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119. . View in PubMed

Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling Front Cell Neurosci. 2022; 16:1078919. . View in PubMed

Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 Jul; 1(7):624. . View in PubMed

Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques Spinal Cord. 2021 Jun; 59(6):596-612. . View in PubMed

Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen Headache. 2021 Mar; 61(3):536-545. . View in PubMed

Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure" J Magn Reson Imaging. 2021 11; 54(5):1527-1528. . View in PubMed

Reply to: Rethink the classical view of cerebrospinal fluid production Nat Rev Neurol. 2021 09; 17(9):590-591. . View in PubMed

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model Environ Health Perspect. 2021 08; 129(8):87006. . View in PubMed

APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 06; 1(6):506-520. . View in PubMed

Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults Brain Behav Immun. 2021 05; 94:299-307. . View in PubMed

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease Transl Stroke Res. 2021 02; 12(1):15-30. . View in PubMed

Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion Front Immunol. 2021; 12:785519. . View in PubMed

Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma? Cell Rep Med. 2021 12 21; 2(12):100481.. View in PubMed

Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed

Microglia have a grip on brain microvasculature Nat Commun. 2021 09 06; 12(1):5290. . View in PubMed

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A J Exp Med. 2021 04 05; 218(4). . View in PubMed

Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Front Neurol. 2021; 12:593582. . View in PubMed

Acetylated tau: A missing link between head injury and dementia Med (N Y). 2021 06 11; 2(6):637-639. . View in PubMed

On the intersection between systemic infection, brain vascular dysfunction and dementia Brain. 2021 07 28; 144(6):1629-1631. . View in PubMed

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop Alzheimers Dement. 2020 12; 16(12):1714-1733. . View in PubMed

3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke. 2020 07; 51(7):2236-2239. . View in PubMed

A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed

Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature Lab Anim (NY). 2020 06; 49(6):175-176. . View in PubMed

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed

Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease Neurobiol Dis. 2020 03; 136:104745. . View in PubMed

Perivascular spaces in the brain: anatomy, physiology and pathology Nat Rev Neurol. 2020 03; 16(3):137-153. . View in PubMed

APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.. View in PubMed

Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-a in APOE4 carriers Neurobiol Aging. 2020 02; 86:112-122. . View in PubMed

Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort Front Neurosci. 2020; 14:571480. . View in PubMed

Endothelial Tip Cell Finds Its Way with Piezo1 Neuron. 2020 10 14; 108(1):5-7. . View in PubMed

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(5):e0232785. . View in PubMed

Therapeutic TVs for Crossing Barriers in the Brain Cell. 2020 07 23; 182(2):267-269. . View in PubMed

Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid J Neurosci. 2020 10 28; 40(44):8573-8586. . View in PubMed

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo Front Aging Neurosci. 2020; 12:108. . View in PubMed

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling Front Cell Neurosci. 2020; 14:27. . View in PubMed

Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(7):e0236379. . View in PubMed

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy Alzheimers Dement (Amst). 2020; 12(1):e12053. . View in PubMed

Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto Int J Stroke. 2019 Sep 22; 1747493019871915. . View in PubMed

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 12; 15(12):1568-1575. . View in PubMed

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 07; 22(7):1089-1098. . View in PubMed

Preventing dementia by preventing stroke: The Berlin Manifesto Alzheimers Dement. 2019 07; 15(7):961-984. . View in PubMed

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. . View in PubMed

Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits Trends Mol Med. 2019 02; 25(2):74-76. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke Ann Neurol. 2019 01; 85(1):125-136. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med. 2019 02 04; 216(2):279-293. . View in PubMed

Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 01 01; 99(1):21-78. . View in PubMed

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H255-H263. . View in PubMed

Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model PLoS One. 2019; 14(5):e0216726. . View in PubMed

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in MiceCell Rep. 2019 04 09; 27(2):549-560. e6. . View in PubMed

Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed

Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular ReprogrammingCell Stem Cell. 2019 10 03; 25(4):486-500. e9. . View in PubMed

The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 10; 21(10):1318-1331. . View in PubMed

A lymphatic waste-disposal system implicated in Alzheimer's disease Nature. 2018 08; 560(7717):172-174. . View in PubMed

Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. . View in PubMed

In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain Nat Protoc. 2018 06; 13(6):1377-1402. . View in PubMed

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 03; 14(3):133-150. . View in PubMed

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed

Understanding the role of the perivascular space in cerebral small vessel disease Cardiovasc Res. 2018 09 01; 114(11):1462-1473. . View in PubMed

Neuropharmacology. 2018 05 15; 134(Pt B):293-301. . View in PubMed

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed

Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol Neurosurgery. 2018 06 01; 82(6):770-780. . View in PubMed

Activated protein C, protease activated receptor 1, and neuroprotection Blood. 2018 07 12; 132(2):159-169. . View in PubMed

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood. 2018 03 15; 131(11):1163-1171. . View in PubMed

Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed

NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface Fluids Barriers CNS. 2017 May 01; 14(1):12. . View in PubMed

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain Nat Neurosci. 2017 Mar; 20(3):406-416. . View in PubMed

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed

Remote control of BBB: A tale of exosomes and microRNA Cell Res. 2017 07; 27(7):849-850. . View in PubMed

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed

Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. . View in PubMed

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thromb Res. 2016 May; 141 Suppl 2:S62-4. . View in PubMed

Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed

Brain imaging of neurovascular dysfunction in Alzheimer's disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed

Clearance systems in the brain--implications for Alzheimer diseaser Nat Rev Neurol. 2016 Apr; 12(4):248. . View in PubMed

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. . View in PubMed

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nat Med. 2016 09; 22(9):1050-5. . View in PubMed

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 05; 1862(5):887-900. . View in PubMed

Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed

Neurovascular and Immuno-Imaging: From Mechanisms to TherapiesProceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. . View in PubMed

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy Cell Stem Cell. 2016 11 03; 19(5):663-671. . View in PubMed

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. . View in PubMed

Pericytes of the neurovascular unit: key functions and signaling pathways Nat Neurosci. 2016 05 26; 19(6):771-83. . View in PubMed

Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed

Establishment and Dysfunction of the Blood-Brain Barrier Cell. 2015 Nov 19; 163(5):1064-1078. . View in PubMed

Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed

Clearance systems in the brain-implications for Alzheimer disease Nat Rev Neurol. 2015 Aug; 11(8):457-70. . View in PubMed

Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease Alzheimers Dement. 2015 Jun; 11(6):710-7. . View in PubMed

Activated protein C: biased for translation Blood. 2015 May 07; 125(19):2898-907. . View in PubMed

Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed

7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Front Cell Neurosci. 2015; 9:344. . View in PubMed

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed

Cytoprotective-selective activated protein C therapy for ischaemic stroke Thromb Haemost. 2014 Nov; 112(5):883-92. . View in PubMed

Nat Commun. 2014 Sep 05; 5:4820. . View in PubMed

Recommendations of the Alzheimer's disease-related dementias conference Neurology. 2014 Aug 26; 83(9):851-60. . View in PubMed

The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed

Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30.. View in PubMed

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke. 2013 Dec; 44(12):3529-36. . View in PubMed

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity J Thromb Haemost. 2013 Nov; 11(11):2059-62. . View in PubMed

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. . View in PubMed

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed

Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease Brain Pathol. 2013 May; 23(3):303-10. . View in PubMed

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Res. 2013 Apr 24; 1507:97-104. . View in PubMed

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway J Neurosci. 2013 Apr 03; 33(14):6181-90. . View in PubMed

A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4.. View in PubMed

Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol. 2013 Apr; 70(4):440-4. . View in PubMed

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Curr Pharm Des. 2013; 19(42):7479-85. . View in PubMed

Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed

Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis Acta Neuropathol. 2013 Jan; 125(1):111-20. . View in PubMed

Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed

Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. . View in PubMed

Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. . View in PubMed

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke. 2012 Sep; 43(9):2444-9. . View in PubMed

Hypertension induces brain ß-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature Hypertension. 2012 Jul; 60(1):188-97. . View in PubMed

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2012 May 16; 485(7399):512-6. . View in PubMed

Protein C anticoagulant and cytoprotective pathways Int J Hematol. 2012 Apr; 95(4):333-45. . View in PubMed

A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease J Clin Invest. 2012 Apr; 122(4):1377-92. . View in PubMed

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Curr Pharm Des. 2012; 18(27):4215-22. . View in PubMed

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. . View in PubMed

Central nervous system pericytes in health and disease Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. . View in PubMed

From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels J Neurosci Res. 2011 Jul; 89(7):967-8. . View in PubMed

Microhemorrhages: undetectable but clinically meaningful the question persists Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. . View in PubMed

Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends Neurosci. 2011 Apr; 34(4):198-209. . View in PubMed

Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch Dev Cell. 2011 Mar 15; 20(3):279-80. . View in PubMed

Methamphetamine causes sustained depression in cerebral blood flow Brain Res. 2011 Feb 10; 1373:91-100. . View in PubMed

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Mol Neurodegener. 2011 Feb 03; 6:13. . View in PubMed

Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease J Alzheimers Dis. 2011; 24(1):25-34. . View in PubMed

Neurodegeneration and the neurovascular unit Nat Med. 2010 Dec; 16(12):1370-1. . View in PubMed

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain J Neurochem. 2010 Dec; 115(5):1077-89. . View in PubMed

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region J Neurosci. 2010 Nov 17; 30(46):15521-34. . View in PubMed

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron. 2010 Nov 04; 68(3):409-27. . View in PubMed

Pericyte constriction after stroke: the jury is still out Nat Med. 2010 Sep; 16(9):959; author reply 960. . View in PubMed

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling Mol Neurodegener. 2010 Aug 25; 5:32. . View in PubMed

Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact Brain Res. 2010 Aug 06; 1347:125-31. . View in PubMed

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor Blood. 2010 Jun 10; 115(23):4963-72. . View in PubMed

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice Brain Res. 2010 Mar 04; 1317:218-26. . View in PubMed

Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. . View in PubMed

Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica. 2009 Dec; 94(12):1721-31. . View in PubMed

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J Clin Invest. 2009 Nov; 119(11):3437-49. . View in PubMed

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease Acta Neuropathol. 2009 Jul; 118(1):103-13. . View in PubMed

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity Stroke. 2009 May; 40(5):1864-9. . View in PubMed

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity J Neurochem. 2009 Apr; 109(1):116-24. . View in PubMed

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Eur J Neurosci. 2009 Mar; 29(6):1119-30. . View in PubMed

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. . View in PubMed

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells Nat Cell Biol. 2009 Feb; 11(2):143-53. . View in PubMed

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. . View in PubMed

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain J Clin Invest. 2008 Dec; 118(12):4002-13. . View in PubMed

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 J Neurosci. 2008 Nov 26; 28(48):12788-97. . View in PubMed

Myocardin is sufficient for a smooth muscle-like contractile phenotype Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. . View in PubMed

New therapeutic targets in the neurovascular pathway in Alzheimer's disease Neurotherapeutics. 2008 Jul; 5(3):409-14. . View in PubMed

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat Neurosci. 2008 Apr; 11(4):420-2. . View in PubMed

Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71. . View in PubMed

The blood-brain barrier in health and chronic neurodegenerative disorders Neuron. 2008 Jan 24; 57(2):178-201. . View in PubMed

The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease Curr Pharm Des. 2008; 14(16):1601-5. . View in PubMed

Clearance of amyloid-beta by circulating lipoprotein receptors Nat Med. 2007 Sep; 13(9):1029-31. . View in PubMed

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. . View in PubMed

The cytoprotective protein C pathway Blood. 2007 Apr 15; 109(8):3161-72. . View in PubMed

Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Curr Alzheimer Res. 2007 Apr; 4(2):191-7. . View in PubMed

Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7.. View in PubMed

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease Ann N Y Acad Sci. 2007 Feb; 1097:40-50. . View in PubMed

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. . View in PubMed

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nat Med. 2006 Nov; 12(11):1278-85. . View in PubMed

Remodeling after stroke Nat Med. 2006 Apr; 12(4):390-1. . View in PubMed

The promise of protein C Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. . View in PubMed

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J Neurosci. 2005 Dec 14; 25(50):11495-503. . View in PubMed

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model J Clin Invest. 2005 Nov; 115(11):3285-90. . View in PubMed

Functional recovery after embolic stroke in rodents by activated protein C Ann Neurol. 2005 Sep; 58(3):474-7. . View in PubMed

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. . View in PubMed

Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1 Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. . View in PubMed

Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci. 2005 Apr; 28(4):202-8. . View in PubMed

Neurovascular pathways and Alzheimer amyloid beta-peptide Brain Pathol. 2005 Jan; 15(1):78-83. . View in PubMed

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nat Med. 2004 Dec; 10(12):1379-83. . View in PubMed

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. . View in PubMed

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. . View in PubMed

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron. 2004 Aug 05; 43(3):333-44. . View in PubMed

Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes Neurotoxicology. 2004 Jun; 25(4):605-16. . View in PubMed

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor J Biol Chem. 2004 May 07; 279(19):20296-306. . View in PubMed

Activated protein C and ischemic stroke Crit Care Med. 2004 May; 32(5 Suppl):S247-53. . View in PubMed

Clearing amyloid through the blood-brain barrier J Neurochem. 2004 May; 89(4):807-11. . View in PubMed

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron. 2004 Feb 19; 41(4):563-72. . View in PubMed

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain J Neurochem. 2004 Feb; 88(4):813-20. . View in PubMed

A simple method for isolation and characterization of mouse brain microvascular endothelial cells J Neurosci Methods. 2003 Nov 30; 130(1):53-63. . View in PubMed

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat Med. 2003 Jul; 9(7):907-13. . View in PubMed

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood. 2003 Jun 15; 101(12):4797-801. . View in PubMed

Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. . View in PubMed

Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation. 2003 Apr 08; 107(13):1791-6. . View in PubMed

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med. 2003 Mar; 9(3):338-42. . View in PubMed

Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. . View in PubMed

Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. . View in PubMed

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke Semin Hematol. 2002 Jul; 39(3):197-205. . View in PubMed

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions Vascul Pharmacol. 2002 Jun; 38(6):303-13. . View in PubMed

Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy J Drug Target. 2002 Jun; 10(4):359-68. . View in PubMed

The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease J Alzheimers Dis. 2002 Jun; 4(3):217-23. . View in PubMed

Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures J Neuroimmunol. 2001 May 01; 116(1):62-73. . View in PubMed

Lower cognitive performance of older football players possessing apolipoprotein E epsilon4 Neurosurgery. 2001 May; 48(5):1196-7. . View in PubMed

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation. 2001 Apr 03; 103(13):1799-805. . View in PubMed

Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist Neurosurgery. 2001 Jan; 48(1):151-7. . View in PubMed

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1 Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81. . View in PubMed

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier J Clin Invest. 2000 Dec; 106(12):1489-99. . View in PubMed

Apolipoprotein J (clusterin) and Alzheimer's disease Microsc Res Tech. 2000 Aug 15; 50(4):305-15. . View in PubMed

Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. . View in PubMed

Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9.. View in PubMed

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides Biochem J. 2000 Jun 01; 348 Pt 2:359-65. . View in PubMed

Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. . View in PubMed

Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier Endocrinology. 2000 Apr; 141(4):1434-41. . View in PubMed

Functional and structural properties of lipid-associated apolipoprotein J (clusterin) Biochem J. 1999 Dec 01; 344 Pt 2:375-83. . View in PubMed

Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. . View in PubMed

Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. . View in PubMed

Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions Neurosci Lett. 1999 Sep 10; 272(2):127-30. . View in PubMed

Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers Pharm Res. 1999 Sep; 16(9):1360-5. . View in PubMed

Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus Exp Neurol. 1999 May; 157(1):194-201. . View in PubMed

Corneal transport of circulating glutathione in normal and galactosemic guinea pigs Cornea. 1999 May; 18(3):321-7. . View in PubMed

Rat brain capillary thrombomodulin: structure and function Thromb Res. 1998 Dec 01; 92(5):213-9. . View in PubMed

Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. . View in PubMed

Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain Neurosurgery. 1998 Oct; 43(4):909-13. . View in PubMed

Strategies to circumvent vascular barriers of the central nervous system Neurosurgery. 1998 Oct; 43(4):877-8. . View in PubMed

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. . View in PubMed

Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction Thromb Res. 1998 Aug 15; 91(4):191-7. . View in PubMed

Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy Hum Gene Ther. 1998 May 01; 9(7):989-95. . View in PubMed

Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy J Neurochem. 1998 Jan; 70(1):210-5. . View in PubMed

Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. . View in PubMed

Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model J Neurosurg. 1997 Nov; 87(5):731-7. . View in PubMed

Thrombomodulin expression in bovine brain capillariesAnticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. . View in PubMed

Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta J Neurochem. 1997 Nov; 69(5):1995-2004. . View in PubMed

Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection Neurosurg Focus. 1997 Jun 15; 2(6):e5. . View in PubMed

Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Exp Eye Res. 1997 Apr; 64(4):615-26. . View in PubMed

Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs Curr Eye Res. 1997 Apr; 16(4):365-71. . View in PubMed

Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. . View in PubMed

Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. . View in PubMed

Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. . View in PubMed

Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir Pharm Res. 1997 Jan; 14(1):80-5. . View in PubMed

Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology Neurobiol Dis. 1997; 4(1):23-6. . View in PubMed

Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. . View in PubMed

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. . View in PubMed

Evidence for the existence of a sodium-dependent glutathione (GSH) transporterExpression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. . View in PubMed

Brain capillary tissue plasminogen activator in a diabetes stroke model Stroke. 1996 Apr; 27(4):712-9. . View in PubMed

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. . View in PubMed

Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine Pharm Res. 1996 Feb; 13(2):290-5. . View in PubMed

Cellular uptake and transport of methylprednisolone at the blood-brain barrier Neurosurgery. 1996 Feb; 38(2):348-54. . View in PubMed

Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations Exp Eye Res. 1996 Jan; 62(1):29-37. . View in PubMed

Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier Life Sci. 1996; 59(18):1483-97. . View in PubMed

Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier Neurosurgery. 1995 Nov; 37(5):955-61. . View in PubMed

RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. . View in PubMed

Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier Pharm Res. 1995 Oct; 12(10):1395-406. . View in PubMed

Molecular characterization of a reduced glutathione transporter in the lens Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. . View in PubMed

Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. . View in PubMed

Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. . View in PubMed

Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. . View in PubMed

Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Exp Eye Res. 1994 Oct; 59(4):487-96. . View in PubMed

Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. . View in PubMed

Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. . View in PubMed

Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. . View in PubMed

Blood-brain barrier transport of circulating Alzheimer's amyloid beta Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. . View in PubMed

The blood-brain barrier in vitro: recent progress Neurochem Int. 1993 Dec; 23(6):523. . View in PubMed

Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus J Biol Chem. 1993 Apr 15; 268(11):8019-25. . View in PubMed

Metaphit-induced audiogenic seizures in mice: IIStudies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. . View in PubMed

Metaphit-induced audiogenic seizures in mice: IPharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. . View in PubMed

Blood-brain transport of vasopressin Adv Exp Med Biol. 1993; 331:143-7. . View in PubMed

Expression of Na,K-ATPase at the blood-brain interface Adv Exp Med Biol. 1993; 331:55-60. . View in PubMed

Differential brain penetration of cerebroprotective drugs Adv Exp Med Biol. 1993; 331:117-20. . View in PubMed

A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs Exp Eye Res. 1993 Jan; 56(1):45-50. . View in PubMed

Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier Brain Res. 1992 Sep 11; 590(1-2):213-8. . View in PubMed

An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids Exp Eye Res. 1992 Mar; 54(3):471-7. . View in PubMed

Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse NIDA Res Monogr. 1992; 120:26-42. . View in PubMed

Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents Epilepsia. 1991 Nov-Dec; 32(6):783-90. . View in PubMed

Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. . View in PubMed

Kinetics of circulating vasopressin uptake by choroid plexus Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. . View in PubMed

The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta Agents Actions Suppl. 1991; 33:283-7. . View in PubMed

Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A J Neurochem. 1990 Oct; 55(4):1222-30. . View in PubMed

Kinetics of arginine-vasopressin uptake at the blood-brain barrier Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. . View in PubMed

Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. . View in PubMed

Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep Endocrinol Exp. 1990 Mar; 24(1-2):29-36. . View in PubMed

Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers Endocrinol Exp. 1990 Mar; 24(1-2):9-17. . View in PubMed

A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig Exp Neurol. 1990 Mar; 107(3):263-70. . View in PubMed

Immunoneurology: a serum protein afferent limb to the CNS Adv Exp Med Biol. 1990; 274:345-70. . View in PubMed

Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain J Neurol Sci. 1989 Dec; 94(1-3):41-50. . View in PubMed

Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain J Neurochem. 1989 Nov; 53(5):1333-40. . View in PubMed

Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. . View in PubMed

Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig Metab Brain Dis. 1989 Mar; 4(1):33-40. . View in PubMed

Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain Peptides. 1989 Mar-Apr; 10(2):249-54. . View in PubMed

Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs Metab Brain Dis. 1989 Mar; 4(1):9-15. . View in PubMed

Neutral amino acid uptake by the isolated perfused sheep choroid plexus J Physiol. 1989 Jan; 408:31-43. . View in PubMed

Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain J Neurochem. 1988 Jul; 51(1):252-7. . View in PubMed

Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier Peptides. 1988 May-Jun; 9(3):533-8. . View in PubMed

Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. . View in PubMed

Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism Regul Pept. 1988 Jan; 20(1):33-44. . View in PubMed

The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid Exp Neurol. 1987 Nov; 98(2):436-52. . View in PubMed

Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain J Neurochem. 1987 Jul; 49(1):310-5. . View in PubMed

Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid J Neurochem. 1986 May; 46(5):1444-51. . View in PubMed

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone Brain Res. 1985 Dec 09; 358(1-2):191-9. . View in PubMed

Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. . View in PubMed

Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine) Brain Res. 1985 Jun 10; 336(1):125-32. . View in PubMed

Blood-brain barrier permeability to dipeptides and their constituent amino acids Brain Res. 1983 Jul 18; 271(1):65-71. . View in PubMed

Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart Br J Pharmacol. 1982 Jul; 76(3):483-9. . View in PubMed