CBG Faculty

David V. Conti, PhD
David V. Conti, PhD
Professor of Preventive Medicine
Center for Genetic Epidemiology
SSB 202 2001 N. Soto Street Health Sciences Campus Los Angeles
My research is aimed at elucidating the genetic contribution of complex diseases from population-based samples, and is comprised of both applied genetic epidemiologic studies and development of statistical methods. Presently, my applied work focuses on elucidating the genetic contribution of candidate genes within the dopamine and serotonin pathways and their role in smoking initation, progression, and cessation. My research in statistical methodology concentrates on the use of hierarchical modeling and Bayes model averaging as a general framework for the analysis of multiple genetic polymorphisms in genes involved in numerous pathways impacting disease.

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Jul; 138(7):789-791. . View in PubMed

Alterations in folate-dependent one-carbon metabolism as colon cell transition from normal to cancerous J Nutr Biochem. 2019 Jul; 69:1-9. . View in PubMed

Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL Sci Rep. 2019 Jun 28; 9(1):9371. . View in PubMed

A genome-wide association study of prostate cancer in Latinos Int J Cancer. 2019 Jun 21. . View in PubMed

Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study Int J Epidemiol. 2019 Apr 21. . View in PubMed

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Apr; 138(4):307-326. . View in PubMed

Epstein-Barr virus load is higher in long-term Hodgkin lymphoma survivors compared to their unaffected twins and unrelated controls Br J Haematol. 2019 Apr; 185(2):377-380. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 Apr 01; 188(4):760-767. . View in PubMed

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2019 Apr; 120(8):867. . View in PubMed

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2019 Mar 06. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 Mar; 143(3):957-969. . View in PubMed

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Feb 28. . View in PubMed

Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel Eur Urol. 2019 Feb 15. . View in PubMed

Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2019 Feb 11; 15(1):21-29. . View in PubMed

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2019 Feb; 51(2):363. . View in PubMed

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin Leuk Lymphoma. 2019 Jan 22; 1-9. . View in PubMed

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2019 Jan 17; 10(1):382. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 Jan 10. . View in PubMed

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2019 Jan 08. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2019 02 11; 15(1):21-29. . View in PubMed

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study Cancer Epidemiol Biomarkers Prev. 2019 Jan; 28(1):208-216. . View in PubMed

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2019 01 17; 10(1):382. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 Jan; 51(1):76-87. . View in PubMed

Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2018 Dec 05. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2018 Dec 03. . View in PubMed

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study Cancer Epidemiol Biomarkers Prev. 2018 Oct 23. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2018 Sep 07. . View in PubMed

Epstein-Barr virus load is higher in long-term Hodgkin lymphoma survivors compared to their unaffected twins and unrelated controls Br J Haematol. 2018 Aug 16. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 Jul; 50(7):928-936. . View in PubMed

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants Nat Commun. 2018 Jun 11; 9(1):2256. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 Jun 11. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 May 20; 36(15):1513-1520. . View in PubMed

Genetic risk of prostate cancer in Ugandan men Prostate. 2018 Apr; 78(5):370-376. . View in PubMed

Genetic risk of prostate cancer in Ugandan men Prostate. 2018 04; 78(5):370-376. . View in PubMed

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants Nat Commun. 2018 06 11; 9(1):2256. . View in PubMed

Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort Front Cardiovasc Med. 2018; 5:19. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1016-1026. . View in PubMed

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium PLoS Genet. 2017 Apr; 13(4):e1006719. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun. 2016 Apr 07; 7:10979. . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer Cancer Epidemiol. 2016 10; 44:1-4. . View in PubMed

Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries Nicotine Tob Res. 2016 09; 18(9):1837-1844. . View in PubMed

Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed

Genome-wide association study of colorectal cancer in Hispanics Carcinogenesis. 2016 06; 37(6):547-556. . View in PubMed

Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants PLoS One. 2016; 11(7):e0157521. . View in PubMed

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Cancer Res. 2016 09 01; 76(17):5103-14. . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population J Clin Oncol. 2015 Sep 10; 33(26):2901-7. . View in PubMed

Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed

Generalizability of established prostate cancer risk variants in men of African ancestry Int J Cancer. 2015 Mar 01; 136(5):1210-7. . View in PubMed

Enlight: web-based integration of GWAS results with biological annotations Bioinformatics. 2015 Jan 15; 31(2):275-6. . View in PubMed

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD Am J Psychiatry. 2015 Jan; 172(1):82-93. . View in PubMed

Genetic ancestry influences asthma susceptibility and lung function among Latinos J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. . View in PubMed

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption PLoS One. 2015; 10(7):e0126113. . View in PubMed

A novel colorectal cancer risk locus at 4q322 identified from an international genome-wide association study. Carcinogenesis. 2014 Nov; 35(11):2512-9. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

Gender difference in interactions between MAOA promoter uVNTR polymorphism and negative familial stressors on body mass index among Chinese adolescents Pediatr Obes. 2014 Oct; 9(5):e80-90. . View in PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer Nat Genet. 2014 Oct; 46(10):1103-9. . View in PubMed

Genome-wide interaction study of smoking and bladder cancer risk Carcinogenesis. 2014 Aug; 35(8):1737-44. . View in PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai Int J Cancer. 2014 Jul 15; 135(2):335-47. . View in PubMed

A meta-analysis of Hodgkin lymphoma reveals 19p133 TCF3 as a novel susceptibility locus. Nat Commun. 2014 Jun 12; 5:3856. . View in PubMed

A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. . View in PubMed

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer Hum Mol Genet. 2013 Dec 15; 22(24):5075-82. . View in PubMed

Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2037-46. . View in PubMed

A scalable, knowledge-based analysis framework for genetic association studies BMC Bioinformatics. 2013 Oct 23; 14:312. . View in PubMed

Genome-wide association study of obsessive-compulsive disorder Mol Psychiatry. 2013 Jul; 18(7):788-98. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

Biomarkers for smoking cessation Clin Pharmacol Ther. 2013 Jun; 93(6):526-38. . View in PubMed

Genome-wide association study of Tourette's syndrome Mol Psychiatry. 2013 Jun; 18(6):721-8. . View in PubMed

Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):937-45. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry PLoS One. 2013; 8(4):e60464. . View in PubMed

Gender-stratified gene and gene-treatment interactions in smoking cessation Pharmacogenomics J. 2012 Dec; 12(6):521-32. . View in PubMed

Analysis and optimal design for association studies using next-generation sequencing with case-control pools Genet Epidemiol. 2012 Dec; 36(8):870-81. . View in PubMed

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers Pharmacogenet Genomics. 2012 Jul; 22(7):551-4. . View in PubMed

Cigarette smoking and subtypes of bladder cancer Int J Cancer. 2012 Feb 15; 130(4):896-901. . View in PubMed

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p2132. Blood. 2012 Jan 12; 119(2):469-75. . View in PubMed

Genome-wide search for gene-gene interactions in colorectal cancer PLoS One. 2012; 7(12):e52535. . View in PubMed

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk Hum Mol Genet. 2011 Jun 01; 20(11):2263-72. . View in PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease Hum Genet. 2011 Jun; 129(6):617-27. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):758-66. . View in PubMed

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study Carcinogenesis. 2011 Feb; 32(2):197-202. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry Carcinogenesis. 2010 Aug; 31(8):1412-6. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1812-21. . View in PubMed

A polytomous conditional likelihood approach for combining matched and unmatched case-control studies Stat Med. 2010 Apr 30; 29(9):1004-13. . View in PubMed

Genes involved with folate uptake and distribution and their association with colorectal cancer risk Cancer Causes Control. 2010 Apr; 21(4):597-608. . View in PubMed

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence Cancer Res. 2010 Feb 15; 70(4):1496-504. . View in PubMed

Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2):525-36. . View in PubMed

Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry Cancer Epidemiol Biomarkers Prev. 2010 Jan; 19(1):89-100. . View in PubMed

Complex system approaches to genetic analysis Bayesian approaches Adv Genet. 2010; 72:47-71. . View in PubMed

Dopamine genes and nicotine dependence in treatment-seeking and community smokers Neuropsychopharmacology. 2009 Sep; 34(10):2252-64. . View in PubMed

Effect of tidal volume in children with acute hypoxemic respiratory failure Intensive Care Med. 2009 Aug; 35(8):1428-37. . View in PubMed

A systems biology network model for genetic association studies of nicotine addiction and treatment Pharmacogenet Genomics. 2009 Jul; 19(7):538-51. . View in PubMed

Detecting gene-environment interactions using a combined case-only and case-control approach Am J Epidemiol. 2009 Feb 15; 169(4):497-504. . View in PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. . View in PubMed

DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2363-72. . View in PubMed

Alcohol consumption and risk of bladder cancer in Los Angeles County Int J Cancer. 2007 Aug 15; 121(4):839-45. . View in PubMed

Age-related smoking progression among adolescents in China J Adolesc Health. 2006 Nov; 39(5):686-93. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort J Clin Endocrinol Metab. 2005 Apr; 90(4):2198-204. . View in PubMed

A survey of current Bayesian gene mapping methods Hum Genomics. 2004 Aug; 1(5):371-4. . View in PubMed

Genetic dissection of complex traits with chromosome substitution strains of mice Science. 2004 Apr 16; 304(5669):445-8. . View in PubMed

Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2 Eur J Hum Genet. 2004 Apr; 12(4):321-32. . View in PubMed

Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR Prostate. 2004 Apr 01; 59(1):69-76. . View in PubMed

Commentary: the concept of 'Mendelian Randomization' Int J Epidemiol. 2004 Feb; 33(1):21-5. . View in PubMed

DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):23-9. . View in PubMed

Comparison of missing data approaches in linkage analysis BMC Genet. 2003 Dec 31; 4 Suppl 1:S44. . View in PubMed

CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):928-32. . View in PubMed

Bayesian modeling of complex metabolic pathways Hum Hered. 2003; 56(1-3):83-93. . View in PubMed

Bayesian spatial modeling of haplotype associations Hum Hered. 2003; 56(1-3):32-40. . View in PubMed

Genomewide scan for prostate cancer-aggressiveness loci Am J Hum Genet. 2000 Jul; 67(1):92-9. . View in PubMed

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