CBG Faculty

Florence M Hofman, PhD
Florence M Hofman, PhD
Professor of Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles
Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.

Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models J Neurosurg. 2019 Mar 15; 1-9. . View in PubMed

NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma Cancer Lett. 2019 Feb 01; 442:170-180. . View in PubMed

The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator Of Cell Death Through The Death Receptor Pathway Mol Cancer Ther. 2019 Jan 15. . View in PubMed

NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo Oncotarget. 2018 Dec 11; 9(97):37026-37041. . View in PubMed

Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo Cancers (Basel). 2018 Sep 28; 10(10). . View in PubMed

Therapeutic Immunization against Glioblastoma Int J Mol Sci. 2018 Aug 27; 19(9). . View in PubMed

NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion Oncoscience. 2018 May; 5(5-6):148-149. . View in PubMed

Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model J Neurosurg. 2018 Mar; 128(3):695-700. . View in PubMed

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram Int J Mol Sci. 2018 Jan 17; 19(1). . View in PubMed

NEO212 Inhibits Migration and Invasion of Glioma Stem Cells Mol Cancer Ther. 2018 03; 17(3):625-637. . View in PubMed

Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts CNS Oncol. 2018 07 01; 7(3):CNS22. . View in PubMed

A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells Cancer Lett. 2017 08 01; 400:161-174. . View in PubMed

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression Oncotarget. 2016 Mar 22; 7(12):13842-53. . View in PubMed

A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells Cancer Lett. 2016 Feb 28; 371(2):240-50. . View in PubMed

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment Sci Rep. 2016 Feb 05; 6:20605. . View in PubMed

Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and a6ß1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties Front Cell Neurosci. 2016; 10:284. . View in PubMed

Tumor vasculature and glioma stem cells: Contributions to glioma progression Cancer Lett. 2016 10 01; 380(2):545-51. . View in PubMed

Nanoparticle biointerfacing by platelet membrane cloaking Nature. 2015 Oct 01; 526(7571):118-21. . View in PubMed

Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo J Biomed Sci. 2015 Aug 19; 22:71. . View in PubMed

First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity Vaccine. 2015 May 28; 33(23):2690-6. . View in PubMed

A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo Cancer Lett. 2015 Mar 28; 358(2):144-151. . View in PubMed

Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors Neurosurg Focus. 2015 Mar; 38(3):E12. . View in PubMed

Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals Neurosurg Focus. 2015 Mar; 38(3):E8. . View in PubMed

Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model Hum Gene Ther. 2015 Feb; 26(2):82-93. . View in PubMed

Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report Perm J. 2015; 19(2):41-6. . View in PubMed

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy Neurosurg Focus. 2014 Dec; 37(6):E12. . View in PubMed

NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas Mol Cancer Ther. 2014 Aug; 13(8):2004-17. . View in PubMed

Argonaute-2 promotes miR-18a entry in human brain endothelial cells J Am Heart Assoc. 2014 May 16; 3(3):e000968. . View in PubMed

A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo Mol Cancer Ther. 2014 May; 13(5):1181-93. . View in PubMed

A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option J Neurooncol. 2014 Feb; 116(3):437-46. . View in PubMed

Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas Front Oncol. 2014; 4:180. . View in PubMed

MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function Stroke. 2014 Jan; 45(1):293-7. . View in PubMed

ImmunohistochemistryCurr Protoc Immunol. 2013 Nov 18; 103:Unit 21. 4. . View in PubMed

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I PLoS One. 2013; 8(6):e65695. . View in PubMed

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett. 2012 Dec 30; 326(2):143-54. . View in PubMed

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors Cancer Lett. 2012 Dec 01; 325(1):63-71. . View in PubMed

Perillyl alcohol for the treatment of temozolomide-resistant gliomas Mol Cancer Ther. 2012 Nov; 11(11):2462-72. . View in PubMed

Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation Oncoimmunology. 2012 May 01; 1(3):298-305. . View in PubMed

Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators J Clin Cell Immunol. 2012; Suppl 5:004. . View in PubMed

Noscapine inhibits tumor growth in TMZ-resistant gliomas Cancer Lett. 2011 Dec 22; 312(2):245-52. . View in PubMed

Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. . View in PubMed

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis Cancer Res. 2011 Apr 15; 71(8):2848-57. . View in PubMed

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models Cancer Lett. 2011 Mar 28; 302(2):100-8. . View in PubMed

Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivoLaboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. . View in PubMed

Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response Curr Pharm Des. 2011; 17(23):2428-38. . View in PubMed

Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells Anticancer Agents Med Chem. 2010 Jul; 10(6):462-70. . View in PubMed

Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature Mol Cancer Ther. 2010 Mar; 9(3):631-41. . View in PubMed

Glioma-associated endothelial cells are chemoresistant to temozolomide J Neurooncol. 2009 Oct; 95(1):13-22. . View in PubMed

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress Cancer Lett. 2009 Sep 08; 282(1):87-97. . View in PubMed

Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2 Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3275-82. . View in PubMed

Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. . View in PubMed

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells Mol Cancer Res. 2008 Aug; 6(8):1268-75. . View in PubMed

Increased survivin expression confers chemoresistance to tumor-associated endothelial cells Am J Pathol. 2008 Aug; 173(2):575-85. . View in PubMed

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. . View in PubMed

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib Cancer Res. 2008 Feb 01; 68(3):843-51. . View in PubMed

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development Cancer Res. 2008 Jan 15; 68(2):498-505. . View in PubMed

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas Cancer Res. 2007 Oct 15; 67(20):9809-16. . View in PubMed

Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib J Biomed Sci. 2007 Sep; 14(5):647-62. . View in PubMed

Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage J Virol. 2007 Jun; 81(11):5518-26. . View in PubMed

Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion J Leukoc Biol. 2007 May; 81(5):1205-12. . View in PubMed

Glioma-associated endothelial cells show evidence of replicative senescence Exp Cell Res. 2007 Apr 01; 313(6):1192-202. . View in PubMed

Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas J Neurosurg. 2007 Mar; 106(3):455-62. . View in PubMed

Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64. . View in PubMed

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo Mol Cancer. 2006 May 18; 5:19. . View in PubMed

Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme Neurosurg Focus. 2006 Apr 15; 20(4):E22. . View in PubMed

Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin Neurosurg Focus. 2006 Apr 15; 20(4):E20. . View in PubMed

Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells Neurosurg Focus. 2006 Apr 15; 20(4):E26. . View in PubMed

Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib Blood. 2005 Dec 15; 106(13):4330-8. . View in PubMed

Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells Cancer Res. 2005 Nov 15; 65(22):10347-54. . View in PubMed

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. . View in PubMed

CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2 Exp Neurol. 2005 May; 193(1):1-18. . View in PubMed

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo Cancer Biol Ther. 2005 May; 4(5):571-82. . View in PubMed

Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells J Neurosurg. 2005 Apr; 102(4):699-705. . View in PubMed

Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice Curr Eye Res. 2004 Aug-Sep; 29(2-3):145-51. . View in PubMed

Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide J Neuroimmunol. 2004 Aug; 153(1-2):183-9. . View in PubMed

Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide J Neuroimmunol. 2003 Dec; 145(1-2):86-90. . View in PubMed

A simple method for isolation and characterization of mouse brain microvascular endothelial cells J Neurosci Methods. 2003 Nov 30; 130(1):53-63. . View in PubMed

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat Med. 2003 Jul; 9(7):907-13. . View in PubMed

Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. . View in PubMed

ImmunohistochemistryCurr Protoc Immunol. 2002 Aug; Chapter 21:Unit 21. 4. . View in PubMed

The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells Cancer Biol Ther. 2002 May-Jun; 1(3):268-76. . View in PubMed

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