CBG Faculty

David Wesley Craig

David Wesley Craig

Professor of Translational Genomics;Co-Director, Institute of Translational Genomics
Department of Translational Genomics
1450 Biggy Street Health Sciences Campus Los Angeles

Congenital myasthenic syndrome caused by a frameshift insertion mutation in GFPT1 Neurol Genet. 2020 Aug; 6(4):e468. . View in PubMed

miEAA 20: integrating multi-species microRNA enrichment analysis and workflow management systems. Nucleic Acids Res. 2020 07 02; 48(W1):W521-W528. . View in PubMed

Activity of Various Essential Oils Against Clinical Dermatophytes of Microsporum and Trichophyton Front Cell Infect Microbiol. 2020; 10:545913. . View in PubMed

Compound heterozygous mutations in SNAP29 is associated with Pelizaeus-Merzbacher-like disorder (PMLD) Hum Genet. 2019 Dec; 138(11-12):1409-1417. . View in PubMed

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 Sep; 51(9):1423-1424. . View in PubMed

Adolescent Tobacco Use and Misperceptions of Social Norms Across Schools in the United States J Stud Alcohol Drugs. 2019 11; 80(6):659-668. . View in PubMed

E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases Invest New Drugs. 2019 08; 37(4):636-645. . View in PubMed

Genome-wide association study identifies 30 loci associated with bipolar disorder Nat Genet. 2019 05; 51(5):793-803. . View in PubMed

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 03; 51(3):414-430. . View in PubMed

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder Neuropsychopharmacology. 2019 02; 44(3):620-628. . View in PubMed

Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder Eur Neuropsychopharmacol. 2019 01; 29(1):156-170. . View in PubMed

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome Neuronal Signal. 2018 Sep; 2(3):NS20180141. . View in PubMed

Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations Sci Rep. 2018 Apr 25; 8(1):6771. . View in PubMed

A novel FBXO28 frameshift mutation in a child with developmental delay, dysmorphic features, and intractable epilepsy: A second gene that may contribute to the 1q41-q42 deletion phenotype . 2018 07; 176(7):1549-1558. . View in PubMed

Accuracy of Estimated Blood Alcohol Concentration Norms From College Student Drinking Survey Data: Verification Using Matched Late-Night Breath Measurements J Stud Alcohol Drugs. 2018 05; 79(3):455-464. . View in PubMed

Misperceived norms and personal sugar-sweetened beverage consumption and fruit and vegetable intake among students in the United States Appetite. 2018 10 01; 129:82-93. . View in PubMed

Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum Oncotarget. 2017 Nov 21; 8(59):99237-99244. . View in PubMed

Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases PLoS Genet. 2017 Nov; 13(11):e1007087. . View in PubMed

Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer Clin Cancer Res. 2017 Aug 15; 23(16):4919-4928. . View in PubMed

A de novo splice site mutation in CASK causes FG syndrome-4 and congenital nystagmus . 2017 Mar; 173(3):611-617. . View in PubMed

A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits Neurol Genet. 2017 Feb; 3(1):e129. . View in PubMed

Exploring genome-wide DNA methylation patterns in Aicardi syndrome Epigenomics. 2017 11; 9(11):1373-1386. . View in PubMed

Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib Clin Genitourin Cancer. 2017 08; 15(4):e727-e734. . View in PubMed

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma Genome Res. 2017 04; 27(4):524-532. . View in PubMed

A population-specific reference panel empowers genetic studies of Anabaptist populations Sci Rep. 2017 07 20; 7(1):6079. . View in PubMed

A method to reduce ancestry related germline false positives in tumor only somatic variant calling BMC Med Genomics. 2017 10 19; 10(1):61. . View in PubMed

A prospective pilot study of genome-wide exome and transcriptome profiling in patients with small cell lung cancer progressing after first-line therapy PLoS One. 2017; 12(6):e0179170. . View in PubMed

Case Report: Novel mutations in TBC1D24 are associated with autosomal dominant tonic-clonic and myoclonic epilepsy and recessive Parkinsonism, psychosis, and intellectual disability F1000Res. 2017; 6:553. . View in PubMed

Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies BMC Cancer. 2017 01 05; 17(1):17. . View in PubMed

An International Standard for holotranscobalamin (holoTC): international collaborative study to assign a holoTC value to the International Standard for vitamin B12 and serum folate Clin Chem Lab Med. 2016 Sep 01; 54(9):1467-72. . View in PubMed

A de novo missense mutation in ZMYND11 is associated with global developmental delay, seizures, and hypotonia Cold Spring Harb Mol Case Stud. 2016 Sep; 2(5):a000851. . View in PubMed

Efficacy of Topical Treatments for Chrysaora chinensis Species: A Human Model in Comparison with an In Vitro Model Wilderness Environ Med. 2016 Mar; 27(1):25-38. . View in PubMed

Dystonia in ATP2B3-associated X-linked spinocerebellar ataxia Mov Disord. 2016 11; 31(11):1752-1753. . View in PubMed

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers Sci Rep. 2016 12 23; 6(1):25. . View in PubMed

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder Hum Mol Genet. 2016 08 01; 25(15):3383-3394. . View in PubMed

Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease Am J Geriatr Psychiatry. 2015 Dec; 23(12):1290-1296. . View in PubMed

Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort Brain Imaging Behav. 2012 Mar; 6(1):1-15. . View in PubMed

Germline mutations in HOXB13 and prostate-cancer risk N Engl J Med. 2012 Jan 12; 366(2):141-9. . View in PubMed

Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability Genome Med. 2012; 4(7):56. . View in PubMed

Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing PLoS One. 2012; 7(10):e43192. . View in PubMed

Deep clonal profiling of formalin fixed paraffin embedded clinical samples PLoS One. 2012; 7(11):e50586. . View in PubMed

Induction of pluripotent stem cells from autopsy donor-derived somatic cells Neurosci Lett. 2011 Sep 20; 502(3):219-24. . View in PubMed

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 Nat Genet. 2011 Sep 18; 43(10):977-83. . View in PubMed

Demographic history and rare allele sharing among human populations Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11983-8. . View in PubMed

Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes PLoS Genet. 2011 Jun; 7(6):e1002134. . View in PubMed

Autism and increased paternal age related changes in global levels of gene expression regulation PLoS One. 2011 Feb 17; 6(2):e16715. . View in PubMed

Mapping copy number variation by population-scale genome sequencing Nature. 2011 Feb 03; 470(7332):59-65. . View in PubMed

Introduction to genetic epidemiology Optometry. 2011 Feb; 82(2):83-91. . View in PubMed

Accuracy of CNV Detection from GWAS Data PLoS One. 2011 Jan 13; 6(1):e14511. . View in PubMed

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort Neurology. 2011 Jan 04; 76(1):69-79. . View in PubMed

Microarray-based genome-wide association studies using pooled DNA Methods Mol Biol. 2011; 700:49-60. . View in PubMed

Exonic DNA sequencing of ERBB4 in bipolar disorder PLoS One. 2011; 6(5):e20242. . View in PubMed

Assessing and managing risk when sharing aggregate genetic variant data Nat Rev Genet. 2011 09 16; 12(10):730-6. . View in PubMed

Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors Genome Res. 2011 Jan; 21(1):47-55. . View in PubMed

Bar-coded, multiplexed sequencing of targeted DNA regions using the Illumina Genome Analyzer Methods Mol Biol. 2011; 700:89-104. . View in PubMed

Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study Int J Alzheimers Dis. 2011; 2011:729478. . View in PubMed

Decreased serum arylesterase activity in autism spectrum disorders Psychiatry Res. 2010 Dec 30; 180(2-3):105-13. . View in PubMed

Misperceptions of peer norms as a risk factor for sugar-sweetened beverage consumption among secondary school students J Am Diet Assoc. 2010 Dec; 110(12):1916-21. . View in PubMed

Diversity of human copy number variation and multicopy genes Science. 2010 Oct 29; 330(6004):641-6. . View in PubMed

A map of human genome variation from population-scale sequencing Nature. 2010 Oct 28; 467(7319):1061-73. . View in PubMed

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals Hum Mol Genet. 2010 Aug 15; 19(16):3295-301. . View in PubMed

Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease Neuroimage. 2010 Jun; 51(2):542-54. . View in PubMed

Evidence for an association between KIBRA and late-onset Alzheimer's disease Neurobiol Aging. 2010 Jun; 31(6):901-9. . View in PubMed

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8404-9. . View in PubMed

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans Alzheimers Dement. 2010 May; 6(3):265-73. . View in PubMed

Genetic control of individual differences in gene-specific methylation in human brain Am J Hum Genet. 2010 Mar 12; 86(3):411-9. . View in PubMed

Cerebellar telomere length and psychiatric disorders Behav Genet. 2010 Mar; 40(2):250-4. . View in PubMed

Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes Diabet Med. 2009 Nov; 26(11):1090-8. . View in PubMed

Genetic variants at 6p2133 are associated with susceptibility to follicular lymphoma. Nat Genet. 2009 Aug; 41(8):873-5. . View in PubMed

Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis Arch Neurol. 2009 Aug; 66(8):972-8. . View in PubMed

Genetic control of human brain transcript expression in Alzheimer disease Am J Hum Genet. 2009 Apr; 84(4):445-58. . View in PubMed

A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis Am J Hum Genet. 2009 Mar; 84(3):328-38. . View in PubMed

GRM7 variants confer susceptibility to age-related hearing impairment Hum Mol Genet. 2009 Feb 15; 18(4):785-96. . View in PubMed

A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets J Neurochem. 2009 Jan; 108(2):341-9. . View in PubMed

Identification of genetic variants using bar-coded multiplexed sequencing Nat Methods. 2008 Oct; 5(10):887-93. . View in PubMed

Common sequence variants on 20q1122 confer melanoma susceptibility. Nat Genet. 2008 Jul; 40(7):838-40. . View in PubMed

Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q131 and 14q12. Mol Psychiatry. 2008 May; 13(5):522-30. . View in PubMed

Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus Am J Hum Genet. 2008 Feb; 82(2):366-74. . View in PubMed

Identification of a novel risk locus for multiple sclerosis at 13q313 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS One. 2008; 3(10):e3490. . View in PubMed

A survey of genetic human cortical gene expression Nat Genet. 2007 Dec; 39(12):1494-9. . View in PubMed

Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance Hum Mol Genet. 2007 Jun 15; 16(12):1469-77. . View in PubMed

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers Neuron. 2007 Jun 07; 54(5):713-20. . View in PubMed

Chromosomal abnormality at 6p251-25. 3 identifies a susceptibility locus for hypothalamic hamartoma associated with epilepsy. Epilepsy Res. 2007 Jun; 75(1):70-3. . View in PubMed

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease J Clin Psychiatry. 2007 Apr; 68(4):613-8. . View in PubMed

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms Am J Hum Genet. 2007 Apr; 80(4):769-78. . View in PubMed

Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study Diabetes. 2007 Apr; 56(4):975-83. . View in PubMed

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies Am J Hum Genet. 2007 Jan; 80(1):126-39. . View in PubMed

Common Kibra alleles are associated with human memory performance Science. 2006 Oct 20; 314(5798):475-8. . View in PubMed

High-density single nucleotide polymorphism screen in a large multiplex neural tube defect family refines linkage to loci at 7p211-pter and 2q33. 1-q35. Birth Defects Res A Clin Mol Teratol. 2006 Jun; 76(6):499-505. . View in PubMed

Genome-wide SNP arrays as a diagnostic tool: clinical description, genetic mapping, and molecular characterization of Salla disease in an Old Order Mennonite population . 2005 Oct 15; 138A(3):262-7. . View in PubMed

Identification of disease causing loci using an array-based genotyping approach on pooled DNA BMC Genomics. 2005 Sep 30; 6:138. . View in PubMed

Applications of whole-genome high-density SNP genotyping Expert Rev Mol Diagn. 2005 Mar; 5(2):159-70. . View in PubMed

Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11689-94. . View in PubMed

A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's disease Int J Geriatr Psychiatry. 2003 Nov; 18(11):1037-42. . View in PubMed

Identifying unfolding intermediates of FN-III(10) by steered molecular dynamics J Mol Biol. 2002 Nov 08; 323(5):939-50. . View in PubMed

A structural model for force regulated integrin binding to fibronectin's RGD-synergy site Matrix Biol. 2002 Mar; 21(2):139-47. . View in PubMed

Comparison of the early stages of forced unfolding for fibronectin type III modules Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5590-5. . View in PubMed

Fluorescence-based enzymatic assay by capillary electrophoresis laser-induced fluorescence detection for the determination of a few beta-galactosidase molecules Anal Biochem. 1995 Mar 20; 226(1):147-53. . View in PubMed

Adolescents' cognitions and attributions for academic cheating: a cross-national study J Psychol. 1993 Nov; 127(6):585-602. . View in PubMed

Human kidney preservation by intracellular electrolyte flush followed by cold storage for over 24 hours Transplantation. 1981 Dec; 32(6):485-7. . View in PubMed

David Craig serves as Vice-Chair of USC's new Department of Translational Genomics ( http://dtg.usc.edu ) within the USC Keck School of Medicine. Dr. Craig's expertise is in genomics, bioinformatics, and data analysis of high-throughput genomics data. His laboratory consists of both a wet-lab and dry-lab. Within his group, lab personnel have the opportunity to either specialize or become dual trained in bioinformatics and molecular biology.

His group pioneered cost-effective GWAS methods leading to genetic associations reported in Science, Nature Genetics, and New England Journal of Medicine. His publications include some of the most significant papers addressing the challenges of data sharing and data privacy (Homer et al, PLOS Genetics 2008). Since 2006, his group has been developing tools based on NGS beginning with publishing one of the first papers for targeted variant calling in humans (Craig et al Nature Methods, 2008). In the past 8 years, his group has published and collaborated on over 60 NGS publications balanced between the wet and dry-labs. During this time, he has served in several international genomics projects including as PI on a U01 responsible for developing bioinformatic pipelines for the Phase I and Phase II portions of the 1000 Genomes Project.

With collaborators, his group was among the first to implement NGS in molecular profiling for cancer patient treatment recommendations in a feasibility study in metastatic triple negative breast cancer (Craig et al., Mol Cancer Ther. 2013). Building upon this and other efforts his group developed an end-to-end platform for personalized medicine, NGS data management, analysis, and clinical genomic interpretation following CAP/CLIA guidelines. Within this framework, they completed analytical validation for integrated RNA/DNA analysis of tumor/normal sets. Community resources from these efforts included include a collaborative release of COLO829 tumor/normal sequencing reference sets. He also was a founding scientific director for TGen's Center for Rare Childhood Disorders - a research clinic enrolling over 1000 individuals into a study developing integrative RNA/DNA approaches for identifying the germline genetic basis of disease.

Dr. Craig's laboratory has openings for post-doctoral fellows and graduate students, and can be reached at davidwcr at symbol usc.edu.
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