CBG Faculty

Radiation Treatment, ATM, BRCA1/2, and CHEK2*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer J Natl Cancer Inst. 2020 Dec 14; 112(12):1275-1279. . View in PubMed

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults Environ Int. 2020 Dec; 145:106091. . View in PubMed

Incorporating prior knowledge into regularized regression Bioinformatics. 2020 Sep 11. . View in PubMed

A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits Bioinformatics. 2020 02 01; 36(3):842-850. . View in PubMed

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity Environ Int. 2019 09; 130:104935. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed

Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer JAMA Netw Open. 2019 09 04; 2(9):e1912259. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Re: Kheifets et al(2017): Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. Cancer Causes Control. 2018 07; 29(7):609-610. . View in PubMed

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic FactorsGastroenterology. 2018 06; 154(8):2152-2164. e19. . View in PubMed

Cancer Epidemiol Biomarkers Prev. 2018 05; 27(5):531-540. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 05 20; 36(15):1513-1520. . View in PubMed

Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort Am J Clin Nutr. 2018 07 01; 108(1):117-126. . View in PubMed

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases Am J Epidemiol. 2017 Oct 01; 186(7):753-761. . View in PubMed

Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions Am J Epidemiol. 2017 Oct 01; 186(7):771-777. . View in PubMed

Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health Annu Rev Public Health. 2017 Mar 20; 38:279-294. . View in PubMed

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies Cancer Epidemiol Biomarkers Prev. 2017 09; 26(9):1370-1380. . View in PubMed

Estimating the Effect of Targeted Screening Strategies: An Application to Colonoscopy and Colorectal Cancer Epidemiology. 2017 07; 28(4):470-478. . View in PubMed

Inclusion of biological knowledge in a Bayesian shrinkage model for joint estimation of SNP effects Genet Epidemiol. 2017 05; 41(4):320-331. . View in PubMed

Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study J Natl Cancer Inst. 2017 10 01; 109(10). . View in PubMed

GWASeq: targeted re-sequencing follow up to GWAS BMC Genomics. 2016 Mar 03; 17:176. . View in PubMed

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study Toxicol Sci. 2015 Nov; 148(1):89-100. . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed

A model to determine colorectal cancer risk using common genetic susceptibility lociGastroenterology. 2015 Jun; 148(7):1330-9. e14. . View in PubMed

Complex pedigrees in the sequencing era: to track transmissions or decorrelate? Genet Epidemiol. 2014 Sep; 38 Suppl 1:S29-36.. View in PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai Int J Cancer. 2014 Jul 15; 135(2):335-47. . View in PubMed

A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. . View in PubMed

Invited commentary: is it time to retire the "pack-years" variable? Maybe not! Am J Epidemiol. 2014 Feb 01; 179(3):299-302.. View in PubMed

Measurement Error in Spatial Exposure Models: Study Design Implications Environmetrics. 2013 Dec 01; 24(8):518-520. . View in PubMed

Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. . View in PubMed

Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report Eur J Cancer. 2013 Sep; 49(14):2979-85. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

Meta-analysis identifies four new loci associated with testicular germ cell tumor Nat Genet. 2013 Jun; 45(6):680-5. . View in PubMed

Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2013 Feb 01; 31(4):433-9. . View in PubMed

A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk Int J Genomics. 2013; 2013:406217. . View in PubMed

Analysis and optimal design for association studies using next-generation sequencing with case-control pools Genet Epidemiol. 2012 Dec; 36(8):870-81. . View in PubMed

Reproductive status at first diagnosis influences risk of radiation-induced second primary contralateral breast cancer in the WECARE study Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84(4):917-24. . View in PubMed

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships Hum Genet. 2012 Oct; 131(10):1565-89. . View in PubMed

Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans Int J Epidemiol. 2012 Jun; 41(3):686-704. . View in PubMed

Genetic epidemiology with a capital E: where will we be in another 10 years? Genet Epidemiol. 2012 Apr; 36(3):179-82.. View in PubMed

A review of cancer in US. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. . View in PubMed

Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9. . View in PubMed

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 PLoS One. 2012; 7(5):e38175. . View in PubMed

Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches Hum Hered. 2012; 74(2):83-96. . View in PubMed

Some surprising twists on the road to discovering the contribution of rare variants to complex diseases Hum Hered. 2012; 74(3-4):113-7. . View in PubMed

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases Genet Epidemiol. 2012 Jan; 36(1):22-35. . View in PubMed

Incorporating model uncertainty in detecting rare variants: the Bayesian risk index Genet Epidemiol. 2011 Nov; 35(7):638-49. . View in PubMed

Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types Carcinogenesis. 2011 Aug; 32(8):1238-43. . View in PubMed

Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling Genet Epidemiol. 2011 Jul; 35(5):389-97. . View in PubMed

Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed

Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study Breast Cancer Res. 2011; 13(6):R114. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2 J Clin Oncol. 2010 May 10; 28(14):2404-10. . View in PubMed

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study J Natl Cancer Inst. 2010 Apr 07; 102(7):475-83. . View in PubMed

Gene--environment-wide association studies: emerging approaches Nat Rev Genet. 2010 Apr; 11(4):259-72. . View in PubMed

Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study Hum Mutat. 2010 Mar; 31(3):E1200-40. . View in PubMed

Complex system approaches to genetic analysis Bayesian approaches Adv Genet. 2010; 72:47-71. . View in PubMed

Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies Annu Rev Public Health. 2010; 31:21-36. . View in PubMed

Methodological Issues in Multistage Genome-wide Association Studies Stat Sci. 2009 Nov 01; 24(4):414-429. . View in PubMed

Gene-trait similarity regression for multimarker-based association analysis Biometrics. 2009 Sep; 65(3):822-32. . View in PubMed

Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer Biometrics. 2009 Jun; 65(2):599-608. . View in PubMed

Genome-wide association studies for discrete traits Genet Epidemiol. 2009; 33 Suppl 1:S8-12. . View in PubMed

Approaches to complex pathways in molecular epidemiology: summary of a special conference of the American Association for Cancer Research Cancer Res. 2008 Dec 15; 68(24):10028-30. . View in PubMed

Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1021-30. . View in PubMed

Design considerations in a sib-pair study of linkage for susceptibility loci in cancer BMC Med Genet. 2008 Jul 10; 9:64. . View in PubMed

Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study J Natl Cancer Inst. 2008 Jan 02; 100(1):32-40. . View in PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed

Multistage sampling for latent variable models Lifetime Data Anal. 2007 Dec; 13(4):565-81. . View in PubMed

Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty Health Phys. 2007 Oct; 93(4):326-7; author reply 327-8. . View in PubMed

Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al Ann Epidemiol. 2007 Jul; 17(7):511-3. . View in PubMed

Dissecting effects of complex mixtures: who's afraid of informative priors? Epidemiology. 2007 Mar; 18(2):186-90.. View in PubMed

Bayesian model averaging in time-series studies of air pollution and mortality J Toxicol Environ Health A. 2007 Feb 01; 70(3-4):311-5. . View in PubMed

Bayesian hierarchical modeling of means and covariances of gene expression data within families BMC Proc. 2007; 1 Suppl 1:S111. . View in PubMed

Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15 Genet Epidemiol. 2007; 31 Suppl 1:S96-102. . View in PubMed

An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna Eur J Hum Genet. 2006 Dec; 14(12):1238-9. . View in PubMed

BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50 Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1863-70. . View in PubMed

High-volume "-omics" technologies and the future of molecular epidemiology Epidemiology. 2006 Sep; 17(5):490-1. . View in PubMed

No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1565-7. . View in PubMed

Optimal two-stage genotyping designs for genome-wide association scans Genet Epidemiol. 2006 May; 30(4):356-68. . View in PubMed

Are we ready for genome-wide association studies? Cancer Epidemiol Biomarkers Prev. 2006 Apr; 15(4):595-8.. View in PubMed

Recent developments in genomewide association scans: a workshop summary and review Am J Hum Genet. 2005 Sep; 77(3):337-45. . View in PubMed

Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study Radiat Res. 2005 Jun; 163(6):698-9. . View in PubMed

BRCA1 variants in a family study of African-American and Latina women Hum Genet. 2005 May; 116(6):497-506. . View in PubMed

A three-level model for binary time-series data: the effects of air pollution on school absences in the Southern California Children's Health Study Stat Med. 2005 Apr 15; 24(7):1103-15. . View in PubMed

Breast cancer risks for BRCA1/2 carriers Science. 2004 Dec 24; 306(5705):2187-91; author reply 2187-91. . View in PubMed

Lung cancer etiology: independent and joint effects of genetics, tobacco, and arsenic JAMA. 2004 Dec 22; 292(24):3026-9. . View in PubMed

Case-sibling gene-association studies for diseases with variable age at onset Stat Med. 2004 Dec 15; 23(23):3697-712. . View in PubMed

SNPs, haplotypes, and cancer: applications in molecular epidemiology Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):681-7. . View in PubMed

Commentary: the concept of 'Mendelian Randomization' Int J Epidemiol. 2004 Feb; 33(1):21-5. . View in PubMed

Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits BMC Genet. 2003 Dec 31; 4 Suppl 1:S3. . View in PubMed

Segregation and linkage analysis for longitudinal measurements of a quantitative trait BMC Genet. 2003 Dec 31; 4 Suppl 1:S21. . View in PubMed

Bayesian modeling of complex metabolic pathways Hum Hered. 2003; 56(1-3):83-93. . View in PubMed

Bayesian spatial modeling of haplotype associations Hum Hered. 2003; 56(1-3):32-40. . View in PubMed

Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals Hum Hered. 2003; 55(4):179-90. . View in PubMed

Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):505-12.. View in PubMed

A two-stage model for multiple time series data of counts Biostatistics. 2002 Mar; 3(1):21-32. . View in PubMed

Genetic epidemiology with a capital "E" Genet Epidemiol. 2000 Dec; 19(4):289-300. . View in PubMed