CBG Faculty

Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code Trends Biochem Sci. 2020 Jun; 45(6):497-510. . View in PubMed

Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3052-3061. . View in PubMed

Aberrant expression of SETD1A promotes survival and migration of estrogen receptor a-positive breast cancer cells Int J Cancer. 2018 12 01; 143(11):2871-2883. . View in PubMed

Different chromatin and DNA sequence characteristics define glucocorticoid receptor binding sites that are blocked or not blocked by coregulator Hic-5 PLoS One. 2018; 13(5):e0196965. . View in PubMed

Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death Cell Death Dis. 2018 10 10; 9(10):1038. . View in PubMed

A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP . 2017 08; 18(8):1442-1459. . View in PubMed

Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes J Biol Chem. 2017 06 02; 292(22):9320-9334. . View in PubMed

Positive regulation of ß-catenin-PROX1 signaling axis by DBC1 in colon cancer progression Oncogene. 2016 06 30; 35(26):3410-8. . View in PubMed

Identifying differential transcription factor binding in ChIP-seq Front Genet. 2015; 6:169. . View in PubMed

Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes Genome Biol. 2014 Jul 31; 15(7):418. . View in PubMed

Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway J Biol Chem. 2014 Jun 13; 289(24):17078-86. . View in PubMed

Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. . View in PubMed

Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression Nucleic Acids Res. 2014 Feb; 42(4):2245-56. . View in PubMed

Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators Nucl Recept Signal. 2014; 12:e002. . View in PubMed

Aberrant BAF57 signaling facilitates prometastatic phenotypes Clin Cancer Res. 2013 May 15; 19(10):2657-67. . View in PubMed

cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1 Endocrinology. 2013 Apr; 154(4):1513-27. . View in PubMed

G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19673-8. . View in PubMed

Functional interplay between p53 acetylation and H12 phosphorylation in p53-regulated transcription. Oncogene. 2012 Sep 27; 31(39):4290-301. . View in PubMed

Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription J Cell Biochem. 2012 Jul; 113(7):2406-14. . View in PubMed

Gene-specific patterns of coregulator requirements by estrogen receptor-a in breast cancer cells Mol Endocrinol. 2012 Jun; 26(6):955-66. . View in PubMed

Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells Epigenetics Chromatin. 2012 Jan 27; 5(1):3. . View in PubMed

A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation J Biol Chem. 2011 Dec 09; 286(49):41963-71. . View in PubMed

Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. . View in PubMed

Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor a activity and co-activator synergy Nucleic Acids Res. 2011 Sep 01; 39(16):6932-43. . View in PubMed

A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression Mol Cancer Res. 2011 May; 9(5):660-70. . View in PubMed

Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation Genes Dev. 2011 Jan 15; 25(2):176-88. . View in PubMed

A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation Chembiochem. 2010 Jun 14; 11(9):1219-23. . View in PubMed

Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I J Biol Chem. 2009 Oct 23; 284(43):29298-309. . View in PubMed

Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation Mol Endocrinol. 2009 Apr; 23(4):425-33. . View in PubMed

Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer Endocrinology. 2008 Dec; 149(12):5984-95. . View in PubMed

CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes Mol Cell. 2008 Aug 22; 31(4):510-9. . View in PubMed

Inhibition of cyclin D1 gene transcription by Brg-1 . 2008 Mar 01; 7(5):647-55. . View in PubMed

Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation BMC Mol Biol. 2008 Jan 25; 9:12. . View in PubMed

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization Biochemistry. 2006 Oct 03; 45(39):11727-36. . View in PubMed

Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors J Biol Chem. 2006 Mar 31; 281(13):8476-85. . View in PubMed

Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1 J Biol Chem. 2006 Feb 10; 281(6):3389-97. . View in PubMed

A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation J Am Chem Soc. 2006 Feb 01; 128(4):1092-3. . View in PubMed

Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription Nucleic Acids Res. 2006; 34(18):5052-9. . View in PubMed

Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA Nucleic Acids Res. 2006; 34(9):2736-50. . View in PubMed

GAC63, a GRIP1-dependent nuclear receptor coactivator Mol Cell Biol. 2005 Jul; 25(14):5965-72. . View in PubMed

Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing Am J Pathol. 2005 Jul; 167(1):59-69. . View in PubMed

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation Genes Dev. 2005 Jun 15; 19(12):1466-73. . View in PubMed

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3611-6. . View in PubMed

Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication J Virol. 2004 Dec; 78(23):13325-34. . View in PubMed

Human PAD4 regulates histone arginine methylation levels via demethylimination Science. 2004 Oct 08; 306(5694):279-83. . View in PubMed

Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation J Cell Biochem. 2004 Jul 01; 92(4):810-9. . View in PubMed

Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity Mol Cell Biol. 2004 Mar; 24(5):2103-17. . View in PubMed

CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators Mol Cell. 2003 Dec; 12(6):1537-49. . View in PubMed

Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1Coactivator-associated arginine methyltransferase. J Biol Chem. 2002 Nov 22; 277(47):44623-30. . View in PubMed

Effect of reproductive hormones on ovarian epithelial tumors: IEffect on cell cycle activity. . 2002 May-Jun; 1(3):300-6. . View in PubMed

Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter Curr Biol. 2001 Dec 11; 11(24):1981-5. . View in PubMed

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1 Curr Biol. 2001 Jun 26; 11(12):996-1000. . View in PubMed

Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity J Biol Chem. 2001 Jun 22; 276(25):22177-82. . View in PubMed

Methylation of histone H3 by coactivator-associated arginine methyltransferase 1 Biochemistry. 2001 May 15; 40(19):5747-56. . View in PubMed

Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 Oncogene. 2001 Apr 19; 20(17):2134-43. . View in PubMed

Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor Cancer Res. 2000 Nov 01; 60(21):5946-9. . View in PubMed

Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix Mol Biol Cell. 2000 Jun; 11(6):2007-18. . View in PubMed

Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors Mol Cell Biol. 2000 Mar; 20(5):1855-67. . View in PubMed

Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length Hum Mol Genet. 2000 Jan 22; 9(2):267-74. . View in PubMed

Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation Biochem Soc Trans. 2000; 28(4):415-8. . View in PubMed

Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 Mol Endocrinol. 1999 Dec; 13(12):2151-62. . View in PubMed

Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1 Mol Cell Biol. 1999 Oct; 19(10):6509-22. . View in PubMed

Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins Mol Cell Biol. 1999 Sep; 19(9):6164-73. . View in PubMed

Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 J Biol Chem. 1999 Aug 06; 274(32):22618-26. . View in PubMed

Regulation of transcription by a protein methyltransferase Science. 1999 Jun 25; 284(5423):2174-7. . View in PubMed

An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors J Biol Chem. 1999 Feb 05; 274(6):3496-502. . View in PubMed

Estrogen receptor activation function 1 works by binding p160 coactivator proteins Mol Endocrinol. 1998 Oct; 12(10):1605-18. . View in PubMed

Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology J Biol Chem. 1998 Mar 20; 273(12):6679-88. . View in PubMed

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities Mol Endocrinol. 1998 Feb; 12(2):302-13. . View in PubMed

Identification of amino acids in the tau 2-region of the mouse glucocorticoid receptor that contribute to hormone binding and transcriptional activation Mol Endocrinol. 1997 Nov; 11(12):1795-805. . View in PubMed

Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis Mamm Genome. 1997 Aug; 8(8):620-1. . View in PubMed

Expression of a defective mouse mammary tumor virus envelope glycoprotein precursor which binds stably to GRP78 within the lumen of the endoplasmic reticulum is associated with decreased glucocorticoid-induced apoptosis in mouse lymphoma cells Cell Death Differ. 1997 May; 4(4):283-8. . View in PubMed

GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors Mol Cell Biol. 1997 May; 17(5):2735-44. . View in PubMed

A functional MRI study of mental image generation Neuropsychologia. 1997 May; 35(5):725-30. . View in PubMed

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4948-52. . View in PubMed

A somatic cell genetic method for identification of untargeted mutations in the glucocorticoid receptor that cause hormone binding deficiencies Mol Endocrinol. 1995 Jul; 9(7):826-37. . View in PubMed

Growth inhibition of androgen-insensitive human prostate carcinoma cells by a 19-norsteroid derivative agent, mifepristone Prostate. 1995 Apr; 26(4):194-204. . View in PubMed

Genetic analysis of the N-terminal end of the glucocorticoid receptor hormone binding domain J Steroid Biochem Mol Biol. 1994 Oct; 51(1-2):11-9. . View in PubMed

Abnormal processing of a recombinant feline leukemia virus envelope polyprotein and its interference with subgroup C virus infection Virology. 1994 Jul; 202(1):329-38. . View in PubMed

Phenylalanine-780 near the C-terminus of the mouse glucocorticoid receptor is important for ligand binding affinity and specificity Mol Endocrinol. 1994 Apr; 8(4):422-30. . View in PubMed

Relationship between defective mouse mammary tumor virus envelope glycoprotein synthesis and GRP78 synthesis in glucocorticoid-treated mouse lymphoma cellsEvidence for translational control of GRP78 synthesis. J Biol Chem. 1993 Apr 05; 268(10):7482-8. . View in PubMed

Maturation of mouse mammary tumor virus envelope protein is blocked by a specific point mutation Virology. 1992 Jul; 189(1):393-6. . View in PubMed

A novel intermediate in processing of murine leukemia virus envelope glycoproteinsProteolytic cleavage in the late Golgi region. J Biol Chem. 1992 Apr 05; 267(10):7060-5. . View in PubMed

Cellular and viral components that mediate glucocorticoid-regulated processing of retroviral envelope proteins Cell Biophys. 1991 Oct-Dec; 19(1-3):93-108. . View in PubMed

Characterization of oligosaccharide chains on mouse mammary tumor virus envelope proteins and the implications for the mechanism of their glucocorticoid regulated processing Mol Endocrinol. 1990 May; 4(5):749-57. . View in PubMed

Glucocorticoid-dependent maturation of mouse mammary tumor virus glycoproteins in mouse lymphoma cells: isolation of variants with constitutive viral protein maturation and normal glucocorticoid receptor function Mol Endocrinol. 1990 Feb; 4(2):341-8. . View in PubMed

A role for divalent cations in specifying the start site for transcription from chromatin templates in vitro J Biol Chem. 1988 Jul 05; 263(19):9550-6. . View in PubMed

Optimized reaction conditions and specific inhibitors for initiation of transcription by RNA polymerase II in nuclei from cultured mammalian cells J Biol Chem. 1988 Mar 05; 263(7):3513-20. . View in PubMed

Glucocorticoid-resistant lymphoma cell variants that contain functional glucocorticoid receptors Mol Cell Biol. 1987 Dec; 7(12):4211-7. . View in PubMed

Mouse lymphoma cell variants with genetically dominant alterations in the maturation of viral glycoproteins Mol Endocrinol. 1987 Jul; 1(7):491-9. . View in PubMed

Glucocorticoid-dependent maturation of viral proteins in mouse lymphoma cells: isolation of defective and hormone-independent cell variants Somat Cell Mol Genet. 1987 Mar; 13(2):131-43. . View in PubMed

Hormonal regulation of transcription of rDNA: use of nucleoside thiotriphosphates to measure initiation in isolated nuclei Nucleic Acids Res. 1984 Nov 12; 12(21):8115-28. . View in PubMed

Asymmetric transcription of mouse mammary tumor virus genes in vivo and in vitro J Virol. 1984 Apr; 50(1):60-5. . View in PubMed

Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants Mol Cell Biol. 1984 Mar; 4(3):449-53. . View in PubMed

Immunological selection of variant mouse lymphoid cells with altered glucocorticoid responsiveness Mol Cell Biol. 1983 Jul; 3(7):1310-6. . View in PubMed

Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei J Biol Chem. 1983 Mar 10; 258(5):2802-7. . View in PubMed

Isolation of recombinant bacteriophage containing male-specific mouse DNA Mol Gen Genet. 1983; 190(1):80-4. . View in PubMed

A comparison of nucleoside (beta-S)triphosphates and nucleoside (gamma-S)triphosphates as suitable substrates for measuring transcription initiation in preparations of cell nuclei Nucleic Acids Res. 1982 Dec 20; 10(24):8311-22. . View in PubMed

Initiation of protein synthesis in vitro by a clostridial systemI. Specificity in the translation of natural messenger ribonucleic acids. J Biol Chem. 1973 May 10; 248(9):3209-15. . View in PubMed

Initiation of protein synthesis in vitro by a clostridial systemII. The roles of initiation factors and salt-washed ribosomes in determining specificity in the translation of natural messenger ribonucleic acids. J Biol Chem. 1973 May 10; 248(9):3216-9. . View in PubMed