Joseph Leo Wiemels, PhD

Professor of Population and Public Health Sciences

Director of the PhD Program in Epidemiology

Websites

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Overview

The causes of most human cancers are unclear, but appear to be related to miscues in normal tissue developmental pathways, mutations (genetic and epigenetic) in critical genes caused by errors, infection, and chemicals, and a failure of recognition and removal of tumors by the immune system. Dr. Wiemels studies these factors as potential causes of hematopoietic and brain tumors. Large population-based studies of human cancer in California populations form a basis for examining the origin of these cancers, with a focus on future prevention. This type of research is highly collaborative, and Dr. Wiemels works with several epidemiologists, geneticists, clinicians, biologists, and statisticians.

Publications

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children Cell Genom. 2024 Mar 22; 100526. . View in PubMed
Association between county-level socioeconomic status and the incidence of and surgical treatment for pituitary adenoma J Neurosurg. 2024 Mar 01; 140(3):724-734. . View in PubMed
Effect of parental adverse childhood experiences on intergenerational DNA methylation signatures from peripheral blood mononuclear cells and buccal mucosa Transl Psychiatry. 2024 Feb 12; 14(1):89. . View in PubMed
Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population Haematologica. 2024 Jan 11. . View in PubMed
Backtracking to the future: unraveling the origins of childhood leukemia Leukemia. 2024 02; 38(2):416-419. . View in PubMed
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation Commun Biol. 2024 01 09; 7(1):66. . View in PubMed
Maternal prenatal use of alcohol, tobacco, and illicit drugs and associations with childhood cancer subtypes Cancer Epidemiol Biomarkers Prev. 2023 Dec 19. . View in PubMed
Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1 Haematologica. 2023 Dec 01; 108(12):3480-3484. . View in PubMed
Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients Haematologica. 2023 Oct 26. . View in PubMed
Birth characteristics and risk of Ewing sarcoma Cancer Causes Control. 2023 Oct; 34(10):837-843. . View in PubMed
Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in Latinos HGG Adv. 2023 Sep 13; 100239. . View in PubMed
Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001-2015 Cancer Causes Control. 2023 Sep; 34(9):757-768. . View in PubMed
Effect of Parental Adverse Childhood Experiences on Intergenerational DNA Methylation Signatures Res Sq. 2023 Jun 26. . View in PubMed
Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in Latinos medRxiv. 2023 Jun 12. . View in PubMed
High Ambient Temperature in Pregnancy and Risk of Childhood Acute Lymphoblastic Leukemia medRxiv. 2023 May 19. . View in PubMed
One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns Cancers (Basel). 2023 Feb 05; 15(4). . View in PubMed
Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia Am J Obstet Gynecol MFM. 2023 09; 5(9):101058. . View in PubMed
Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome Thyroid. 2023 01; 33(1):53-62. . View in PubMed
Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma Neuro Oncol. 2023 06 02; 25(6):1047-1057. . View in PubMed
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Clin Epigenetics. 2023 09 11; 15(1):148. . View in PubMed
Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):292-294. . View in PubMed
Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark JAMA Netw Open. 2023 02 01; 6(2):e230133. . View in PubMed
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2023 12 01; 32(12):1707-1715. . View in PubMed
Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers Sci Rep. 2023 01 11; 13(1):583. . View in PubMed
Does Cytomegalovirus Play a Role in Pediatric Lymphoblastic Leukemogenesis? JAMA Netw Open. 2023 01 03; 6(1):e2250226.. View in PubMed
Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p213 risk locus. Neuro Oncol. 2023 09 05; 25(9):1709-1720. . View in PubMed
Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control Genome Biol. 2023 01 12; 24(1):2. . View in PubMed
Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children Int J Cancer. 2023 03 01; 152(5):845-853. . View in PubMed
Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood Clin Epigenetics. 2022 Dec 01; 14(1):158. . View in PubMed
DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia Nat Commun. 2022 Oct 14; 13(1):6077. . View in PubMed
Correction to: Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts Int J Epidemiol. 2022 Jun 13; 51(3):1037. . View in PubMed
Variant to function mapping at single-cell resolution through network propagation bioRxiv. 2022 Jan 24. . View in PubMed
Variant to function mapping at single-cell resolution through network propagation Nat Biotechnol. 2022 11; 40(11):1644-1653. . View in PubMed
Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children PLoS Genet. 2022 09; 18(9):e1010388. . View in PubMed
Accelerated epigenetic aging in newborns with Down syndrome Aging Cell. 2022 07; 21(7):e13652. . View in PubMed
Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure Biotechniques. 2022 04; 72(4):121-133. . View in PubMed
Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia Leukemia. 2022 03; 36(3):865-868. . View in PubMed
Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California Int J Hyg Environ Health. 2022 01; 239:113881. . View in PubMed
Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac045. . View in PubMed
Birth characteristics and risk of meningioma in a population-based study in California Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac173. . View in PubMed
Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls Am J Clin Nutr. 2022 12 19; 116(6):1553-1564. . View in PubMed
Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia Hum Mol Genet. 2022 10 28; 31(21):3741-3756. . View in PubMed
Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case-Control Study Cancer Epidemiol Biomarkers Prev. 2022 09 02; 31(9):1788-1795. . View in PubMed
Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL Blood Adv. 2022 06 28; 6(12):3756-3766. . View in PubMed
Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children Haematologica. 2022 09 01; 107(9):2266-2270. . View in PubMed
Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome Blood Adv. 2022 07 26; 6(14):4132-4136. . View in PubMed
Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts Int J Epidemiol. 2022 06 13; 51(3):769-777. . View in PubMed
Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia Blood Adv. 2022 01 08; 6(3):854-865. . View in PubMed
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis Am J Hematol. 2022 06 01; 97(6):E198-E201. . View in PubMed
Epigenetic dysregulation in meningiomas Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac084. . View in PubMed
Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac044. . View in PubMed
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination Cell Rep. 2021 Jul 27; 36(4):109475. . View in PubMed
Mode of Delivery, Birth Characteristics, and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study Cancer Epidemiol Biomarkers Prev. 2021 12; 30(12):2286-2293. . View in PubMed
Low CtBP2 expression is associated with a stem cell-like signature and adverse clinical outcome in childhood B-cell lymphoblastic leukemia Leukemia. 2021 09; 35(9):2684-2687. . View in PubMed
Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525. . View in PubMed
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1526-1535. . View in PubMed
Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California Thyroid. 2021 04; 31(4):596-606. . View in PubMed
Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016 Am J Epidemiol. 2021 04 06; 190(4):519-527. . View in PubMed
Pediatric Acute Promyelocytic Leukemia: Epidemiology, Molecular Features, and Importance of GST-Theta 1 in Chemotherapy Response and Outcome Front Oncol. 2021; 11:642744. . View in PubMed
Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia Am J Hum Genet. 2021 10 07; 108(10):1823-1835. . View in PubMed
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination Cell Rep. 2021 06 29; 35(13):109302. . View in PubMed
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. . View in PubMed
Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites Elife. 2021 06 22; 10. . View in PubMed
Socioeconomic status and childhood central nervous system tumors in California Cancer Causes Control. 2021 Jan; 32(1):27-39. . View in PubMed
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis Nat Commun. 2021 02 05; 12(1):821. . View in PubMed
Outdoor artificial light at night and risk of non-Hodgkin lymphoma among women in the California Teachers Study cohort Cancer Epidemiol. 2020 12; 69:101811. . View in PubMed
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome Nat Cancer. 2020 11; 1(11):1066-1081. . View in PubMed
Birth Characteristics and Risk of Early-Onset Synovial Sarcoma Cancer Epidemiol Biomarkers Prev. 2020 06; 29(6):1162-1167. . View in PubMed
Spatial-Temporal Cluster Analysis of Childhood Cancer in California Epidemiology. 2020 03; 31(2):214-223. . View in PubMed
Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysisJ Pediatr. 2020 02; 217:98-109. e8. . View in PubMed
Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population Bone. 2020 01; 130:115070. . View in PubMed
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma Acta Neuropathol Commun. 2020 10 28; 8(1):173. . View in PubMed
Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. . View in PubMed
History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System Am J Epidemiol. 2020 10 01; 189(10):1076-1085. . View in PubMed
Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia Blood Adv. 2020 02 25; 4(4):672-675. . View in PubMed
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age Genome Med. 2020 03 02; 12(1):25. . View in PubMed
Germline cancer predisposition variants and pediatric glioma: a population-based study in California Neuro Oncol. 2020 06 09; 22(6):864-874. . View in PubMed
European genetic ancestry associated with risk of childhood ependymoma Neuro Oncol. 2020 11 26; 22(11):1637-1646. . View in PubMed
Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C Neuro Oncol. 2020 11 26; 22(11):1602-1613. . View in PubMed
Brain tumor disparities: From biology to social determinants – The 2019 Brain Tumor Epidemiology Consortium meeting report Clin Neuropathol. 2019 Nov/Dec; 38(6):297-305. . View in PubMed
Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study Neurooncol Adv. 2019 May-Dec; 1(1):vdz031. . View in PubMed
Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk J Neurooncol. 2019 May; 142(3):479-487. . View in PubMed
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology Haematologica. 2019 11; 104(11):e514-e516. . View in PubMed
Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome Leukemia. 2019 11; 33(11):2746-2751. . View in PubMed
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children Genes Chromosomes Cancer. 2019 10; 58(10):723-730. . View in PubMed
Early Infection with Cytomegalovirus and Risk of Childhood Hematologic Malignancies Cancer Epidemiol Biomarkers Prev. 2019 06; 28(6):1024-1027. . View in PubMed
Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk Epigenetics. 2019 02; 14(2):198-213. . View in PubMed
Germline genetic landscape of pediatric central nervous system tumors Neuro Oncol. 2019 11 04; 21(11):1376-1388. . View in PubMed
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome Blood. 2019 10 10; 134(15):1227-1237. . View in PubMed
Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort Neuro Oncol. 2019 03 18; 21(4):498-507. . View in PubMed
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight Nat Commun. 2019 04 23; 10(1):1893. . View in PubMed
Using germline variants to estimate glioma and subtype risks Neuro Oncol. 2019 03 18; 21(4):451-461. . View in PubMed
Mendelian randomization provides support for obesity as a risk factor for meningioma Sci Rep. 2019 01 22; 9(1):309. . View in PubMed
Advancing brain tumor epidemiology – multi-level integration and international collaboration: The 2018 Brain Tumor Epidemiology Consortium meeting report Clin Neuropathol. 2018 Nov/Dec; 37(6):254-261. . View in PubMed
An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016 Pediatr Hematol Oncol. 2018 Mar; 35(2):95-110. . View in PubMed
Allergies and Childhood Acute Lymphoblastic Leukemia: A Case-Control Study and Meta-analysis Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1142-1150. . View in PubMed
Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1151-1158. . View in PubMed
Herpesvirus Infection in Infants with Gastroschisis Epidemiology. 2018 07; 29(4):571-573. . View in PubMed
Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT) Cancer Epidemiol Biomarkers Prev. 2018 04; 27(4):488-495. . View in PubMed
A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology Haematologica. 2018 01; 103(1):e29-e31. . View in PubMed
Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia Cancer Res. 2018 09 15; 78(18):5458-5463. . View in PubMed
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium Int J Epidemiol. 2018 02 01; 47(1):22-23u. . View in PubMed
Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers Environ Health. 2018 05 02; 17(1):43. . View in PubMed
Genome-wide association analysis identifies a meningioma risk locus at 11p155. Neuro Oncol. 2018 10 09; 20(11):1485-1493. . View in PubMed
BMI1 enhancer polymorphism underlies chromosome 10p1231 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 12 01; 143(11):2647-2658. . View in PubMed
Genetic determinants of childhood and adult height associated with osteosarcoma risk Cancer. 2018 09 15; 124(18):3742-3752. . View in PubMed
To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Front Genet. 2018; 9:298. . View in PubMed
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q2421. Nat Commun. 2018 01 18; 9(1):286. . View in PubMed
Roadmap for investigating epigenome deregulation and environmental origins of cancer Int J Cancer. 2018 03 01; 142(5):874-882. . View in PubMed
Quality of life after surgery for intracranial meningioma Cancer. 2018 Jan 01; 124(1):161-166. . View in PubMed
Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma J Neurooncol. 2017 Nov; 135(2):237-244. . View in PubMed
Brain tumor epidemiology in the era of precision medicine: The 2017 Brain Tumor Epidemiology Consortium meeting report Clin Neuropathol. 2017 Nov/Dec; 36(6):255-263. . View in PubMed
Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California Am J Epidemiol. 2017 Oct 01; 186(7):843-856. . View in PubMed
Trends in childhood leukemia incidence over two decades from 1992 to 2013 Int J Cancer. 2017 Mar 01; 140(5):1000-1008. . View in PubMed
Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT Acta Neuropathol. 2017 06; 133(6):1001-1016. . View in PubMed
Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents Pediatr Blood Cancer. 2017 06; 64(6). . View in PubMed
Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children’s Environmental Health Studies: The Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group Environ Health Perspect. 2017 04; 125(4):511-526. . View in PubMed
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia Blood. 2017 03 23; 129(12):1680-1684. . View in PubMed
Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival Clin Epigenetics. 2017; 9:10. . View in PubMed
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium Hum Mol Genet. 2017 10 15; 26(20):4067-4085. . View in PubMed
Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California Am J Epidemiol. 2017 01 15; 185(2):96-105. . View in PubMed
Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Res. 2017 04 01; 77(7):1674-1683. . View in PubMed
Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures Environ Health. 2017 06 23; 16(1):70. . View in PubMed
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Oncotarget. 2016 Nov 08; 7(45):72733-72745. . View in PubMed
Childhood Leukemia: A Preventable Disease Pediatrics. 2016 Nov; 138(Suppl 1):S45-S55. . View in PubMed
Childhood Leukemia and Primary Prevention Curr Probl Pediatr Adolesc Health Care. 2016 Oct; 46(10):317-352. . View in PubMed
Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report Clin Neuropathol. 2016 Sep-Oct; 35(5):280-6. . View in PubMed
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome Crit Care. 2016 May 23; 20(1):151. . View in PubMed
Stressful exit from the womb and risk of childhood leukaemia Lancet Haematol. 2016 Apr; 3(4):e155-6. . View in PubMed
Understanding inherited genetic risk of adult glioma – a review Neurooncol Pract. 2016 Mar; 3(1):10-16. . View in PubMed
Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites Nucleic Acids Res. 2016 Feb 18; 44(3):1105-17. . View in PubMed
Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California Ann Epidemiol. 2016 Feb; 26(2):141-145. . View in PubMed
Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California Eur J Cancer. 2016 12; 69:19-27. . View in PubMed
Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia Arch Med Res. 2016 11; 47(8):677-683. . View in PubMed
Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates Epigenetics. 2016 09; 11(9):664-673. . View in PubMed
Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. . View in PubMed
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers Carcinogenesis. 2016 06; 37(6):576-582. . View in PubMed
A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros Leukemia. 2016 05; 30(5):1194-7. . View in PubMed
Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics Cancer Epidemiol Biomarkers Prev. 2016 05; 25(5):815-22. . View in PubMed
Evolving evidence on tumor and germline genetic classification of gliomas: implications for etiology and survival studies Clin Neuropathol. 2016 Jan-Feb; 35(1):31-8. . View in PubMed
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk Oncotarget. 2015 Dec 15; 6(40):42468-77. . View in PubMed
New insights into childhood leukemia etiology Eur J Epidemiol. 2015 Dec; 30(12):1225-7. . View in PubMed
A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution Cancer Res. 2015 Nov 15; 75(22):4884-94. . View in PubMed
Telomere maintenance and the etiology of adult glioma Neuro Oncol. 2015 Nov; 17(11):1445-52. . View in PubMed
Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time Int J Cancer. 2015 Aug 15; 137(4):826-36. . View in PubMed
What causes leukemia? Pediatr Blood Cancer. 2015 Jul; 62(7):1123-4.. View in PubMed
Whole-genome fingerprint of the DNA methylome during human B cell differentiation Nat Genet. 2015 Jul; 47(7):746-56. . View in PubMed
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors N Engl J Med. 2015 Jun 25; 372(26):2499-508. . View in PubMed
Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011 Blood. 2015 May 07; 125(19):3033-4. . View in PubMed
Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children Cancer Causes Control. 2015 Apr; 26(4):609-19. . View in PubMed
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. . View in PubMed
Global characteristics of childhood acute promyelocytic leukemia Blood Rev. 2015 Mar; 29(2):101-25. . View in PubMed
Excess winter deaths caused by cardiovascular diseases are associated with both mild winter temperature and socio-economic inequalities in the US. Int J Cardiol. 2015; 187:642-4. . View in PubMed
Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes Epigenetics. 2015; 10(12):1166-76. . View in PubMed
Survival and low-grade glioma: the emergence of genetic information Neurosurg Focus. 2015 Jan; 38(1):E6. . View in PubMed
Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA PLoS One. 2015; 10(11):e0143343. . View in PubMed
Brain Tumor Epidemiology – A Hub within Multidisciplinary Neuro-oncologyReport on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clin Neuropathol. 2015 Jan-Feb; 34(1):40-6. . View in PubMed
Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies BMC Genet. 2014 Dec 10; 15:130. . View in PubMed
PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia Int J Cancer. 2014 Sep 01; 135(5):1101-9. . View in PubMed
Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia Am J Hematol. 2014 Jul; 89(7):721-5. . View in PubMed
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk Nat Genet. 2014 Jul; 46(7):731-5. . View in PubMed
Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1414-20. . View in PubMed
Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk Int J Cancer. 2014 May 01; 134(9):2199-210. . View in PubMed
Mode of delivery and risk of childhood leukemia Cancer Epidemiol Biomarkers Prev. 2014 May; 23(5):876-81. . View in PubMed
The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia Blood. 2014 Apr 17; 123(16):2497-503. . View in PubMed
Endogenous and exogenous hormone exposure and the risk of meningioma in men J Neurosurg. 2014 Apr; 120(4):820-6. . View in PubMed
Cancer cluster investigations: review of the past and proposals for the future Int J Environ Res Public Health. 2014 Jan 28; 11(2):1479-99. . View in PubMed
Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein PLoS One. 2014; 9(2):e87602. . View in PubMed
Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children Leukemia. 2013 Dec; 27(12):2416-9. . View in PubMed
GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL Blood. 2013 Nov 07; 122(19):3385-7. . View in PubMed
Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics Cancer Causes Control. 2013 Oct; 24(10):1789-95. . View in PubMed
Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype Cancer Epidemiol Biomarkers Prev. 2013 Sep; 22(9):1600-11. . View in PubMed
Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype Blood. 2013 Jun 06; 121(23):4808-9. . View in PubMed
Blood levels of folate at birth and risk of childhood leukemia Cancer Epidemiol Biomarkers Prev. 2013 Jun; 22(6):1088-94. . View in PubMed
Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology Neuro Oncol. 2013 May; 15(5):535-41. . View in PubMed
Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females J Neurosurg. 2013 Mar; 118(3):649-56. . View in PubMed
Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies Genet Epidemiol. 2013 Feb; 37(2):222-8. . View in PubMed
Dental x-rays and risk of meningioma: response to DrsCalnon, Jorgensen, and White. Cancer. 2013 Jan 15; 119(2):465-6. . View in PubMed
Assessment of autoantibodies to meningioma in a population-based study Am J Epidemiol. 2013 Jan 01; 177(1):75-83. . View in PubMed
SNP association mapping across the extended major histocompatibility complex and risk of B-cell precursor acute lymphoblastic leukemia in children PLoS One. 2013; 8(8):e72557. . View in PubMed
Genome-wide association study of glioma and meta-analysis Hum Genet. 2012 Dec; 131(12):1877-88. . View in PubMed
Epigenetic biomarkers of T-cells in human glioma Epigenetics. 2012 Dec 01; 7(12):1391-402. . View in PubMed
A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network Nucleic Acids Res. 2012 Dec; 40(22):11339-51. . View in PubMed
Allergy and risk of childhood acute lymphoblastic leukemia: a population-based and record-based study Am J Epidemiol. 2012 Dec 01; 176(11):970-8. . View in PubMed
Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study Cancer. 2012 Nov 01; 118(21):5384-94. . View in PubMed
HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk Blood. 2012 Oct 11; 120(15):3039-47. . View in PubMed
A low-frequency variant at 8q2421 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet. 2012 Oct; 44(10):1122-5. . View in PubMed
Dental x-rays and risk of meningioma Cancer. 2012 Sep 15; 118(18):4530-7. . View in PubMed
Occurrence of ²¹°Po and biological effects of low-level exposure: the need for research Environ Health Perspect. 2012 Sep; 120(9):1230-7. . View in PubMed
Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia Cancer Causes Control. 2012 Sep; 23(9):1577-85. . View in PubMed
Medically diagnosed infections and risk of childhood leukaemia: a population-based case-control study Int J Epidemiol. 2012 Aug; 41(4):1050-9. . View in PubMed
Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia Cancer Causes Control. 2012 Aug; 23(8):1367-75. . View in PubMed
Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling Epigenetics. 2012 Jun 01; 7(6):559-66. . View in PubMed
Cigarette smoking and risk of meningioma: the effect of gender Cancer Epidemiol Biomarkers Prev. 2012 Jun; 21(6):943-50. . View in PubMed
SSBP2 variants are associated with survival in glioblastoma patients Clin Cancer Res. 2012 Jun 01; 18(11):3154-62. . View in PubMed
Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology Chem Biol Interact. 2012 Apr 05; 196(3):102-9. . View in PubMed
Perspectives on the causes of childhood leukemia Chem Biol Interact. 2012 Apr 05; 196(3):59-67. . View in PubMed
Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia BMC Cancer. 2012 Jan 06; 12:9. . View in PubMed
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia Cancer Causes Control. 2011 Dec; 22(12):1721-30. . View in PubMed
History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia Epigenetics. 2011 Dec; 6(12):1436-43. . View in PubMed
Family and personal medical history and risk of meningioma J Neurosurg. 2011 Dec; 115(6):1072-7. . View in PubMed
Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study Cancer Epidemiol Biomarkers Prev. 2011 Nov; 20(11):2377-83. . View in PubMed
Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls Int J Cancer. 2011 Oct 15; 129(8):1932-9. . View in PubMed
Matching on Race and Ethnicity in Case-Control Studies as a Means of Control for Population Stratification Epidemiology (Sunnyvale). 2011 Sep 29; 1:101. . View in PubMed
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia Cancer Causes Control. 2011 Sep; 22(9):1243-58. . View in PubMed
Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking Am J Epidemiol. 2011 Sep 01; 174(5):574-81. . View in PubMed
Profound deficit of IL10 at birth in children who develop childhood acute lymphoblastic leukemia Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1736-40. . View in PubMed
Early life exposure to infections and risk of childhood acute lymphoblastic leukemia Int J Cancer. 2011 Apr 01; 128(7):1632-43. . View in PubMed
DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression Neuro Oncol. 2011 Mar; 13(3):280-9. . View in PubMed
DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma J Natl Cancer Inst. 2011 Jan 19; 103(2):143-53. . View in PubMed
Molecular pathogenesis of secondary acute promyelocytic leukemia Mediterr J Hematol Infect Dis. 2011; 3(1):e2011045. . View in PubMed
Distinct germ line polymorphisms underlie glioma morphologic heterogeneity Cancer Genet. 2011 Jan; 204(1):13-8. . View in PubMed
TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a Blood. 2010 Dec 02; 116(23):4885-93. . View in PubMed
Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia Blood Cells Mol Dis. 2010 Oct 15; 45(3):186-91. . View in PubMed
Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma Cancer Res. 2010 Oct 01; 70(19):7534-42. . View in PubMed
FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia BMC Cancer. 2010 Sep 27; 10:513. . View in PubMed
Epidemiology and etiology of meningioma J Neurooncol. 2010 Sep; 99(3):307-14. . View in PubMed
Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2152-63. . View in PubMed
Identification of methylated genes associated with aggressive bladder cancer PLoS One. 2010 Aug 23; 5(8):e12334. . View in PubMed
Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci Genes Chromosomes Cancer. 2010 Aug; 49(8):726-32. . View in PubMed
Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake PLoS Genet. 2010 Jul 29; 6(7):e1001043. . View in PubMed
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia Blood. 2010 Jan 14; 115(2):326-30. . View in PubMed
Copy number variation has little impact on bead-array-based measures of DNA methylation Bioinformatics. 2009 Aug 15; 25(16):1999-2005. . View in PubMed
IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era Int J Cancer. 2009 Aug 01; 125(3):680-7. . View in PubMed
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context PLoS Genet. 2009 Aug; 5(8):e1000602. . View in PubMed
Maternal immunoglobulin E and childhood leukemia Cancer Epidemiol Biomarkers Prev. 2009 Aug; 18(8):2221-7. . View in PubMed
Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles Cancer Res. 2009 Aug 01; 69(15):6315-21. . View in PubMed
4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia Anesthesiology. 2009 May; 110(5):1086-91. . View in PubMed
Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma Carcinogenesis. 2009 Mar; 30(3):416-22. . View in PubMed
Allergies and childhood leukemia Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):99-104. . View in PubMed
Infection and pediatric acute lymphoblastic leukemia Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):117-20. . View in PubMed
SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system Nucleic Acids Res. 2009 Jan; 37(Database issue):D803-9. . View in PubMed
Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia Environ Health Perspect. 2009 Jan; 117(1):133-9. . View in PubMed
Backtracking of leukemic clones to birth Methods Mol Biol. 2009; 538:7-27. . View in PubMed
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis Am J Epidemiol. 2008 Dec 01; 168(11):1221-32. . View in PubMed
Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally Cancer Res. 2008 Dec 01; 68(23):9935-44. . View in PubMed
Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium Cancer. 2008 Oct 01; 113(7 Suppl):1953-68. . View in PubMed
Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions BMC Bioinformatics. 2008 Sep 09; 9:365. . View in PubMed
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests Cancer Epidemiol Biomarkers Prev. 2008 Jun; 17(6):1368-73. . View in PubMed
Chromosomal translocations in childhood leukemia: natural history, mechanisms, and epidemiology J Natl Cancer Inst Monogr. 2008; (39):87-90. . View in PubMed
Epidemiology of brain tumors Neurol Clin. 2007 Nov; 25(4):867-90vii. . View in PubMed
DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1686-90. . View in PubMed
Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer. 2007 Aug 01; 110(3):471-6.. View in PubMed
MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1172-7. . View in PubMed
Allergy-related polymorphisms influence glioma status and serum IgE levels Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1229-35. . View in PubMed
Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2533-6. . View in PubMed
Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways Intensive Care Med. 2006 Sep; 32(9):1293-303. . View in PubMed
Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California Cancer Epidemiol Biomarkers Prev. 2006 Mar; 15(3):578-81. . View in PubMed
Epidemiology of intracranial meningioma Neurosurgery. 2005 Dec; 57(6):1088-95; discussion 1088-95. . View in PubMed
ERCC1 and ERCC2 polymorphisms and adult glioma Neuro Oncol. 2005 Oct; 7(4):495-507. . View in PubMed
Molecular biomarkers for the study of childhood leukemia Toxicol Appl Pharmacol. 2005 Aug 07; 206(2):237-45. . View in PubMed
Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia Cancer Epidemiol Biomarkers Prev. 2005 Aug; 14(8):1928-34. . View in PubMed
History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls Am J Epidemiol. 2005 May 15; 161(10):929-38. . View in PubMed
DNA topoisomerase II in therapy-related acute promyelocytic leukemia N Engl J Med. 2005 Apr 14; 352(15):1529-38. . View in PubMed
Reduced immunoglobulin E and allergy among adults with glioma compared with controls Cancer Res. 2004 Nov 15; 64(22):8468-73. . View in PubMed
Protracted postnatal natural histories in childhood leukemia Genes Chromosomes Cancer. 2004 Apr; 39(4):335-40. . View in PubMed
Hypermethylation of the 5′ CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia Cancer Res. 2004 Mar 15; 64(6):2000-6. . View in PubMed
Leukemia in twins: lessons in natural history Blood. 2003 Oct 01; 102(7):2321-33. . View in PubMed
Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16) Blood. 2003 Jun 01; 101(11):4640-1. . View in PubMed
Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California Genes Chromosomes Cancer. 2003 May; 37(1):36-43. . View in PubMed
TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia Leuk Res. 2003 Feb; 27(2):155-64. . View in PubMed
Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia Genes Chromosomes Cancer. 2003 Feb; 36(2):175-88. . View in PubMed
Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemiaPolymerase chain reaction. J Pediatr Hematol Oncol. 2003 Feb; 25(2):103-8. . View in PubMed
Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15101-6. . View in PubMed
In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia Blood. 2002 May 15; 99(10):3801-5. . View in PubMed
History of allergies among adults with glioma and controls Int J Cancer. 2002 Apr 01; 98(4):609-15. . View in PubMed

Joseph Leo Wiemels, PhD

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