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Louis Dubeau, MD, PhD

Professor of Pathology

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Phone +1 323 865 0720
Email ldubeau@usc.edu
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Overview

For many years, Dr. Dubeau has been a leading practitioner, educator and researcher in the field of ovarian cancer biology. A native of Canada, Dr. Dubeau first came to USC as a post-doctoral fellow at the Norris Comprehensive Cancer Center. During his time at USC, Dr. Dubeau has achieved the status of full professor, become director of the Molecular Diagnostics Laboratory at USC/Norris Comprehensive Cancer Center published numerous peer-reviewed articles for medical journals and lectured at medical conferences and seminars across the United States, Canada, United Kingdom, Hungary, Turkey and Greece. Dr. Dubeau is a renowned researcher and has been awarded over fourteen million dollars in research grants, many dealing with either ovarian cancer biology and genetics or with environmental issues such as exposure to and effects of air pollution. A devoted educator, Dr. Dubeau has mentored over fifty students, either as a member of their PhD advisory committee or by training doctoral and graduate students. Dr. Dubeau also has found time throughout his career to give lectures on health related subjects to area public school students.

Publications

  • Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis Cancers (Basel). 2024 Mar 18; 16(6). . View in PubMed
  • Neurotropism of SARS-CoV-2: A Pathological Examination of Neurosurgical Specimens Neurosurgery. 2024 02 01; 94(2):379-388. . View in PubMed
  • GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage Viruses. 2023 05 06; 15(5). . View in PubMed
  • Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract Cold Spring Harb Perspect Med. 2023 07 05; 13(7). . View in PubMed
  • Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women Genome Med. 2022 Jul 19; 14(1):76. . View in PubMed
  • Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women Genome Med. 2022 06 15; 14(1):64. . View in PubMed
  • Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis Oncogene. 2021 05; 40(20):3624-3632. . View in PubMed
  • A Phosphotyrosine Switch in Estrogen Receptor ß Is Required for Mouse Ovarian Function Front Cell Dev Biol. 2021; 9:649087. . View in PubMed
  • Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control Cancers (Basel). 2020 Feb 27; 12(3). . View in PubMed
  • First reported case of BRAF V600E mutation in T-cell prolymphocytic leukaemia Br J Haematol. 2020 10; 191(2):e52-e55. . View in PubMed
  • Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma Sci Rep. 2020 02 07; 10(1):2160. . View in PubMed
  • Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways Int J Cancer. 2018 12 01; 143(11):2932-2942. . View in PubMed
  • Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018; 13(10-11):1027-1038. . View in PubMed
  • Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 07 20; 10(1):98. . View in PubMed
  • Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer Oncotarget. 2017 Nov 28; 8(61):103543-103556. . View in PubMed
  • Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer Oncotarget. 2017 Jan 17; 8(3):3811-3825. . View in PubMed
  • GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed
  • Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed
  • Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice Sci Rep. 2017 02 01; 7:40919. . View in PubMed
  • Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development Oncotarget. 2016 Mar 22; 7(12):14885-97. . View in PubMed
  • Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution Nat Commun. 2016 05 24; 7:11620. . View in PubMed
  • HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer Genome Med. 2015 Oct 24; 7:108. . View in PubMed
  • EBioMedicine. 2015 Oct; 2(10):1331-9. . View in PubMed
  • A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State EBioMedicine. 2015 Oct; 2(10):1318-30. . View in PubMed
  • A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan Cell Metab. 2015 Jul 07; 22(1):86-99. . View in PubMed
  • Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications Transl Cancer Res. 2015 Feb; 4(1):3-13. . View in PubMed
  • Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent PLoS One. 2015; 10(10):e0139013. . View in PubMed
  • Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism PLoS Genet. 2014 Dec; 10(12):e1004789. . View in PubMed
  • NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas Mol Cancer Ther. 2014 Aug; 13(8):2004-17. . View in PubMed
  • Coming into focus: the nonovarian origins of ovarian cancer Ann Oncol. 2013 Nov; 24 Suppl 8:viii28-viii35. . View in PubMed
  • The sex hormone system in carriers of BRCA1/2 mutations: a case-control study Lancet Oncol. 2013 Nov; 14(12):1226-32. . View in PubMed
  • The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival Gynecol Oncol. 2013 Mar; 128(3):552-9. . View in PubMed
  • Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells Int J Cancer. 2012 Jun 01; 130(11):2495-504. . View in PubMed
  • Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs Lab Invest. 2012 Jun; 92(6):802-11. . View in PubMed
  • Pathological characteristics of BRCA-associated breast cancers in Hispanics Breast Cancer Res Treat. 2011 Nov; 130(1):281-9. . View in PubMed
  • BRCA genes: lessons learned from experimental and clinical cancer Ann Oncol. 2011 Jan; 22 Suppl 1:i7-10. . View in PubMed
  • Genome-scale screen for DNA methylation-based detection markers for ovarian cancer PLoS One. 2011; 6(12):e28141. . View in PubMed
  • Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis Cell Death Differ. 2010 Mar; 17(3):488-98. . View in PubMed
  • Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer Cancer Res. 2010 Jan 01; 70(1):221-8. . View in PubMed
  • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study Int J Cancer. 2009 Nov 01; 125(9):2214-8. . View in PubMed
  • Hemimethylation footprints of DNA demethylation in cancer Epigenetics. 2009 Apr 01; 4(3):165-75. . View in PubMed
  • The cell of origin of ovarian epithelial tumours Lancet Oncol. 2008 Dec; 9(12):1191-7. . View in PubMed
  • Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice Cancer Prev Res (Phila). 2008 Sep; 1(4):233-40. . View in PubMed
  • Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation J Biol Chem. 2008 Jul 11; 283(28):19184-91. . View in PubMed
  • Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development Cancer Res. 2008 Jan 15; 68(2):498-505. . View in PubMed
  • BRCA1-induced ovarian oncogenesis Adv Exp Med Biol. 2008; 622:89-97. . View in PubMed
  • Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas Br J Cancer. 2007 Jun 18; 96(12):1908-13. . View in PubMed
  • Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain Hum Mol Genet. 2007 May 15; 16(10):1133-42. . View in PubMed
  • The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome Br J Cancer. 2007 Apr 10; 96(7):1083-91. . View in PubMed
  • Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed
  • Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors Oncogene. 2006 Apr 27; 25(18):2636-45. . View in PubMed
  • TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8. . View in PubMed
  • Intercellular adhesion molecule-1 and childhood asthma Hum Genet. 2005 Sep; 117(5):476-84. . View in PubMed
  • Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer Genes Chromosomes Cancer. 2005 May; 43(1):11-24. . View in PubMed
  • A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others Cancer Biol Ther. 2005 Apr; 4(4):440-8. . View in PubMed
  • Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells Curr Biol. 2005 Mar 29; 15(6):561-5. . View in PubMed
  • Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors Hum Gene Ther. 2004 Jun; 15(6):553-61. . View in PubMed
  • Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy Clin Cancer Res. 2004 Apr 15; 10(8):2681-6. . View in PubMed
  • Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone Mol Carcinog. 2003 Dec; 38(4):160-9. . View in PubMed
  • Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells Cancer Res. 2003 Sep 15; 63(18):5813-20. . View in PubMed
  • The TATA-binding protein as a regulator of cellular transformation Cell Cycle. 2003 Sep-Oct; 2(5):442-4. . View in PubMed
  • Huntington disease expansion mutations in humans can occur before meiosis is completed Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. . View in PubMed
  • Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis Mol Cell Biol. 2003 May; 23(9):3043-51. . View in PubMed
  • Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages Cancer Res. 2002 Dec 15; 62(24):7207-12. . View in PubMed
  • p53: a key player in the telomere dynamics Cancer Biol Ther. 2002 Sep-Oct; 1(5):518-9. . View in PubMed
  • Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. . View in PubMed
  • Effect of reproductive hormones on ovarian epithelial tumors: IEffect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. . View in PubMed
  • Telomerase and malignant transformation Cancer Treat Res. 2002; 107:213-28. . View in PubMed
  • Collection of buccal cell DNA in seventh-grade children using water and a toothbrush Cancer Epidemiol Biomarkers Prev. 2001 Nov; 10(11):1227-30. . View in PubMed
  • The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes? Gynecol Oncol. 1999 Mar; 72(3):437-42.. View in PubMed
  • Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25 Oncogene. 1999 Feb 25; 18(8):1545-51. . View in PubMed
  • Satellite DNA hypomethylation vsoverall genomic hypomethylation in ovarian epithelial tumors of different malignant potential. Mutat Res. 1999 Jan 25; 423(1-2):91-101. . View in PubMed
  • Differences in p16 gene methylation and expression in benign and malignant ovarian tumors Gynecol Oncol. 1999 Jan; 72(1):87-92. . View in PubMed
  • Genetics and biology of gynecologic cancer Curr Opin Oncol. 1998 Sep; 10(5):439-46. . View in PubMed
  • Detection of ovarian cancer cells: comparison of a telomerase assay and cytologic examination J Natl Cancer Inst. 1998 Feb 04; 90(3):238-42. . View in PubMed
  • Telomerase and cancer management: silver bullet or fool’s gold? Gynecol Oncol. 1998 Feb; 68(2):143-4.. View in PubMed
  • Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases Gynecol Oncol. 1997 Dec; 67(3):277-84. . View in PubMed
  • Biology of ovarian cancer Curr Opin Oncol. 1997 Sep; 9(5):465-70. . View in PubMed
  • Telomerase activity in benign and malignant epithelial ovarian tumors J Natl Cancer Inst. 1997 Mar 19; 89(6):437-41. . View in PubMed
  • Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis Br J Cancer. 1997; 75(3):396-402. . View in PubMed
  • WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer Br J Cancer. 1996 Jun; 73(11):1398-400. . View in PubMed
  • Potential role of the inactivated X chromosome in ovarian epithelial tumor development J Natl Cancer Inst. 1996 Apr 17; 88(8):510-8. . View in PubMed
  • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas Int J Cancer. 1995 Aug 22; 64(4):280-5. . View in PubMed
  • Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas J Natl Cancer Inst. 1995 Aug 02; 87(15):1146-53. . View in PubMed
  • 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas Int J Oncol. 1994 Nov; 5(5):1043-8. . View in PubMed
  • Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression Cancer Res. 1994 Feb 01; 54(3):605-9. . View in PubMed
  • Histologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas Cancer Res. 1993 Sep 15; 53(18):4138-42. . View in PubMed
  • Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p155 in ovarian tumorigenesis. Int J Oncol. 1992 Jul; 1(2):215-9. . View in PubMed
  • Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification Cancer Res. 1991 Aug 01; 51(15):4045-51. . View in PubMed
  • C-myc proto-oncogene amplification detected by polymerase chain reaction in archival human ovarian carcinomas Am J Pathol. 1990 Sep; 137(3):653-8. . View in PubMed
  • Mechanisms of human bladder tumor invasion: role of protease cathepsin B J Urol. 1990 Sep; 144(3):798-804. . View in PubMed
  • Culture of human fetal ovarian epithelium in a chemically-defined, serum-free medium: a model for ovarian carcinogenesis Anticancer Res. 1990 Sep-Oct; 10(5A):1233-40. . View in PubMed
  • Rapid degradation of extracellular matrix proteins by normal human uroepithelial cells Cancer Res. 1990 Mar 15; 50(6):1897-904. . View in PubMed
  • Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas Oncogene. 1990 Feb; 5(2):219-23. . View in PubMed
  • Human decidua is a major source of renin J Clin Invest. 1989 Jun; 83(6):2085-92. . View in PubMed
  • Detection of ras point mutations by polymerase chain reaction using mutation-specific, inosine-containing oligonucleotide primers Biochem Biophys Res Commun. 1989 Apr 28; 160(2):441-7. . View in PubMed
  • Lymphocyte gene rearrangement studies in formalin-fixed, paraffin-embedded pathology specimens West J Med. 1988 Nov; 149(5):596. . View in PubMed
  • Differential regulation of plasminogen activators by epidermal growth factor in normal and neoplastic human urothelium Cancer Res. 1988 Oct 01; 48(19):5552-6. . View in PubMed
  • Studies on immunoglobulin gene rearrangement in formalin-fixed, paraffin-embedded pathology specimens Am J Pathol. 1988 Mar; 130(3):588-94. . View in PubMed
  • A new in vivo model to study invasion and metastasis of human bladder carcinoma Cancer Res. 1987 Dec 15; 47(24 Pt 1):6660-5. . View in PubMed
  • Growth of normal and neoplastic urothelium and response to epidermal growth factor in a defined serum-free medium Cancer Res. 1987 Apr 15; 47(8):2107-12. . View in PubMed
  • Southern blot analysis of DNA extracted from formalin-fixed pathology specimens Cancer Res. 1986 Jun; 46(6):2964-9. . View in PubMed
  • Long-term effects of pulmonary shrapnel injuryReport of a case with carcinoma and residual shrapnel tract. Arch Pathol Lab Med. 1984 May; 108(5):407-9. . View in PubMed
  • The mechanism of replication of phi X 174XVIII. Gene A and A* proteins of phi X 174 bind tightly to phi X 174 replicative form DNA. Biochim Biophys Acta. 1981 Mar 26; 653(1):52-60. . View in PubMed
  • The mechanism of replication of phiX174XVII. Purification and partial characterization of the gene A and A proteins. Can J Biochem. 1981 Feb; 59(2):106-15. . View in PubMed

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