CBG Faculty

Hormone-Independent Sexual Dimorphism in the Regulation of Bone Resorption by Krox20 J Bone Miner Res. 2019 12; 34(12):2277-2286. . View in PubMed

Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells J Steroid Biochem Mol Biol. 2018 10; 183:10-17. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed

Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms J Cell Physiol. 2017 Dec; 232(12):3798-3807. . View in PubMed

Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer . 2017 Feb 16; 16(4):312-318. . View in PubMed

Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation J Cell Physiol. 2017 01; 232(1):145-53. . View in PubMed

High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer J Pharmacol Exp Ther. 2016 Nov; 359(2):256-261. . View in PubMed

RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer Nat Commun. 2016 Feb 26; 7:10751. . View in PubMed

Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase Mol Cell. 2016 05 19; 62(4):507-19. . View in PubMed

Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis Int J Cancer. 2015 Aug 15; 137(4):797-809. . View in PubMed

Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association Bone. 2015 Jun; 75:96-104. . View in PubMed

Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line J Cell Physiol. 2015 Feb; 230(2):237-41. . View in PubMed

Glucocorticoid-Induced Osteoporosis Adv Exp Med Biol. 2015; 872:179-215. . View in PubMed

Dependence of castration-resistant prostate cancer (CRPC) stem cells on CRPC-associated fibroblasts J Cell Physiol. 2014 Sep; 229(9):1170-6. . View in PubMed

Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness Cancer Res. 2014 May 15; 74(10):2857-68. . View in PubMed

Runx1-mediated regulation of osteoclast differentiation and function Mol Endocrinol. 2014 Apr; 28(4):546-53. . View in PubMed

Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner PLoS One. 2014; 8(6):e62361. . View in PubMed

Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells J Cell Biochem. 2014 Jan; 115(1):27-33. . View in PubMed

Contextual effect of repression of bone morphogenetic protein activity in prostate cancer Endocr Relat Cancer. 2013 Dec; 20(6):861-74. . View in PubMed

The RUNX family in breast cancer: relationships with estrogen signaling Oncogene. 2013 Apr 25; 32(17):2121-30. . View in PubMed

Estrogen receptor-a is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2 J Bone Miner Res. 2013 Feb; 28(2):291-301. . View in PubMed

Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription J Cell Biochem. 2012 Jul; 113(7):2406-14. . View in PubMed

Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs Lab Invest. 2012 Jun; 92(6):802-11. . View in PubMed

An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice Dis Model Mech. 2012 May; 5(3):366-74. . View in PubMed

Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation J Cell Physiol. 2012 May; 227(5):2276-82. . View in PubMed

Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells Osteoporos Int. 2012 Apr; 23(4):1399-413. . View in PubMed

Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion Nucleic Acids Res. 2012 Apr; 40(8):3538-47. . View in PubMed

Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness Clin Cancer Res. 2012 Feb 01; 18(3):901-11. . View in PubMed

Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells Mol Cell Biol. 2011 Dec; 31(23):4648-62. . View in PubMed

Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6288-93. . View in PubMed

Developmentally regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin A transcription in primary osteoblast cultures J Cell Physiol. 2011 Apr; 226(4):991-8. . View in PubMed

CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts J Bone Miner Res. 2011 Feb; 26(2):308-16. . View in PubMed

Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2 Breast Cancer Res. 2011; 13(6):R127. . View in PubMed

Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass Blood. 2010 Nov 11; 116(19):3964-71. . View in PubMed

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis Mol Cancer. 2010 Sep 23; 9:258. . View in PubMed

Regulation of adult bone turnover by sex steroids J Cell Physiol. 2010 Aug; 224(2):305-10. . View in PubMed

Androgen receptor responsive enhancers are flanked by consistently-positioned H3-acetylated nucleosomes . 2010 Jun 01; 9(11):2249-50. . View in PubMed

A systematic approach to understand the functional consequences of non-protein coding risk regions . 2010 Jan 15; 9(2):256-9. . View in PubMed

Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway Biochem Biophys Res Commun. 2009 Sep 25; 387(3):558-63. . View in PubMed

Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA Mol Endocrinol. 2009 Aug; 23(8):1203-14. . View in PubMed

Functional enhancers at the gene-poor 8q24 cancer-linked locus PLoS Genet. 2009 Aug; 5(8):e1000597. . View in PubMed

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer Nat Genet. 2009 Aug; 41(8):882-4. . View in PubMed

Location, location, (ChIP-)location! Mapping chromatin landscapes one immunoprecipitation at a time J Cell Biochem. 2009 May 01; 107(1):1-5. . View in PubMed

Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions Prostate. 2009 Mar 01; 69(4):392-400. . View in PubMed

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner PLoS One. 2009; 4(5):e5438. . View in PubMed

Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer Endocrinology. 2008 Dec; 149(12):5984-95. . View in PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 . 2008 Nov; 295(5):C1141-50. . View in PubMed

Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation J Cell Biochem. 2008 Nov 01; 105(4):965-70. . View in PubMed

BMP-2 vsBMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization. Growth Factors. 2008 Aug; 26(4):226-37. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures J Cell Biochem. 2008 Apr 15; 103(6):1938-51. . View in PubMed

Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity PLoS One. 2008; 3(11):e3645. . View in PubMed

Identification of transcription factor target genes by ChIP display Methods Mol Biol. 2008; 455:177-90. . View in PubMed

A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer Cancer Res. 2008 Jan 01; 68(1):198-205. . View in PubMed

Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2 J Cell Biochem. 2007 Dec 15; 102(6):1458-71. . View in PubMed

Androgen receptor-mediated repression of novel target genes Prostate. 2007 Sep 15; 67(13):1371-83. . View in PubMed

A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells J Biol Chem. 2007 Jun 29; 282(26):18676-85. . View in PubMed

Identification of novel androgen receptor target genes in prostate cancer Mol Cancer. 2007 Jun 06; 6:39. . View in PubMed

Peripheral cannabinoid receptor, CB2, regulates bone mass Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):696-701. . View in PubMed

ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells J Biol Chem. 2005 Nov 11; 280(45):37495-502. . View in PubMed

Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells Cancer Res. 2005 Jul 01; 65(13):5769-77. . View in PubMed

Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer Arthritis Rheum. 2005 Mar; 52(3):929-39. . View in PubMed

Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner J Biol Chem. 2005 Jan 21; 280(3):2388-94. . View in PubMed

Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo Nucleic Acids Res. 2005; 33(4):1298-308. . View in PubMed

Gene expression profiling of glucocorticoid-inhibited osteoblasts J Mol Endocrinol. 2004 Aug; 33(1):175-93. . View in PubMed

ChIP Display: novel method for identification of genomic targets of transcription factors Nucleic Acids Res. 2004 Jul 13; 32(12):e104. . View in PubMed

Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2 J Biol Chem. 2003 Nov 07; 278(45):44995-5003. . View in PubMed

Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures J Bone Miner Res. 2003 Jul; 18(7):1186-97. . View in PubMed

Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis Crit Rev Eukaryot Gene Expr. 2003; 13(2-4):221-35. . View in PubMed

Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta J Biol Chem. 2002 May 17; 277(20):18191-7. . View in PubMed

Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro J Orthop Res. 2000 Sep; 18(5):721-7. . View in PubMed

Glucocorticoids inhibit developmental stage-specific osteoblast cell cycleDissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem. 2000 Jun 30; 275(26):19992-20001. . View in PubMed

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7294-9. . View in PubMed

Biosynthesis of osteogenic growth peptide via alternative translational initiation at AUG85 of histone H4 mRNA J Biol Chem. 1999 May 14; 274(20):14474-81. . View in PubMed

Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice J Exp Med. 1999 Feb 15; 189(4):729-34. . View in PubMed

Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo Biochemistry. 1999 Jan 26; 38(4):1338-45. . View in PubMed

AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation Endocrinology. 1999 Jan; 140(1):63-70. . View in PubMed

Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression Mol Endocrinol. 1997 Oct; 11(11):1681-94. . View in PubMed

Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: inhibition by proliferating osteoblasts and osteosarcoma cells J Cell Biochem. 1997 Aug 01; 66(2):141-52. . View in PubMed

Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression Endocrinology. 1997 May; 138(5):2117-27. . View in PubMed

Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex Endocrinology. 1997 May; 138(5):2109-16. . View in PubMed

YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):121-6. . View in PubMed

Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells J Cell Biochem. 1996 Nov 01; 63(2):221-8. . View in PubMed

Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site Endocrinology. 1996 May; 137(5):1991-2000. . View in PubMed

Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain Endocrinology. 1996 Mar; 137(3):1080-88. . View in PubMed

Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E Cancer Res. 1995 Nov 01; 55(21):5019-24. . View in PubMed

Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene Biochemistry. 1995 Jun 13; 34(23):7648-58. . View in PubMed

A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: promoter and cell type requirements Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10923-7. . View in PubMed

The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III Biochem J. 1994 Mar 01; 298 ( Pt 2):409-14. . View in PubMed

Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene Biochemistry. 1993 Dec 14; 32(49):13636-43. . View in PubMed

The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III J Biol Chem. 1988 Jun 15; 263(17):8491-7. . View in PubMed

Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats J Lipid Res. 1988 Apr; 29(4):431-41. . View in PubMed