CBG Faculty

Steve Kay

Steve Kay

University and Provost Professor of Neurology, Biomedical Engineering and Biological Sciences, Director of Convergent Bioscience;Co-Director of the USC Norris Center for Cancer Drug Development
KAM 500 Health Sciences Campus Los Angeles

An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in MammalsCell Chem Biol. 2020 Sep 17; 27(9):1192-1198. e5. . View in PubMed

Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues Int J Mol Sci. 2020 Sep 03; 21(17). . View in PubMed

Changes in ambient temperature are the prevailing cue in determining Brachypodium distachyon diurnal gene regulation . 2020 Feb 28. . View in PubMed

A mobile ELF4 delivers circadian temperature information from shoots to roots Nat Plants. 2020 04; 6(4):416-426. . View in PubMed

COP1 destabilizes DELLA proteins in Arabidopsis Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13792-13799. . View in PubMed

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth Sci Adv. 2019 01; 5(1):eaau9060. . View in PubMed

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation Nat Commun. 2019 09 02; 10(1):3916. . View in PubMed

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Ia and d J Med Chem. 2019 02 28; 62(4):1989-1998. . View in PubMed

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11528-11536. . View in PubMed

Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins Plant Physiol. 2018 07; 177(3):1170-1186. . View in PubMed

Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis Nat Genet. 2017 Oct; 49(10):1546-1552. . View in PubMed

A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies J Vis Exp. 2017 07 24; (125). . View in PubMed

Arabidopsis B-BOX32 interacts with CONSTANS-LIKE3 to regulate flowering Proc Natl Acad Sci U S A. 2017 01 03; 114(1):172-177. . View in PubMed

Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes PLoS One. 2017; 12(1):e0169923. . View in PubMed

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBa Degradation Cell. 2016 Jun 16; 165(7):1644-1657. . View in PubMed

Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities Arthritis Care Res (Hoboken). 2016 07; 68(7):1012-20. . View in PubMed

Cultivated tomato clock runs slow Nat Genet. 2016 Jan; 48(1):8-9. . View in PubMed

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock ChemMedChem. 2015 Sep; 10(9):1489-97. . View in PubMed

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Angew Chem Int Ed Engl. 2015 Jun 08; 54(24):7193-7. . View in PubMed

A parametric classification rule based on the exponentially embedded family IEEE Trans Neural Netw Learn Syst. 2015 Feb; 26(2):367-77. . View in PubMed

An Arabidopsis gene regulatory network for secondary cell wall synthesis Nature. 2015 Jan 29; 517(7536):571-5. . View in PubMed

Control of plant stem cell function by conserved interacting transcriptional regulators Nature. 2015 Jan 15; 517(7534):377-80. . View in PubMed

A genome-scale resource for the functional characterization of Arabidopsis transcription factors Cell Rep. 2014 Jul 24; 8(2):622-32. . View in PubMed

Daily changes in temperature, not the circadian clock, regulate growth rate in Brachypodium distachyon PLoS One. 2014; 9(6):e100072. . View in PubMed

BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Plant Cell. 2013 Apr; 25(4):1228-42. . View in PubMed

Circadian surprise--it's not all about transcription Science. 2012 Oct 19; 338(6105):338-40. . View in PubMed

CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17129-34. . View in PubMed

Complexity in the wiring and regulation of plant circadian networks Curr Biol. 2012 Aug 21; 22(16):R648-57. . View in PubMed

Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3167-72. . View in PubMed

Cell-autonomous hepatic circadian clock regulates polyamine synthesis . 2012 Feb 01; 11(3):422-3. . View in PubMed

[Circadian clocks and photoperiodism] Fukuoka Igaku Zasshi. 2012 Feb; 103(2):29-34. . View in PubMed

ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock Plant Signal Behav. 2012 Feb; 7(2):170-3. . View in PubMed

Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18560-5. . View in PubMed

A small molecule modulates circadian rhythms through phosphorylation of the period protein Angew Chem Int Ed Engl. 2011 Nov 04; 50(45):10608-11. . View in PubMed

Enhanced Y1H assays for Arabidopsis Nat Methods. 2011 Oct 30; 8(12):1053-5. . View in PubMed

Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Plant J. 2011 Mar; 65(6):991-1000. . View in PubMed

Clocks not winding down: unravelling circadian networks Nat Rev Mol Cell Biol. 2010 Nov; 11(11):764-76. . View in PubMed

Emergence of noise-induced oscillations in the central circadian pacemaker PLoS Biol. 2010 Oct 12; 8(10):e1000513. . View in PubMed

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis Nat Med. 2010 Oct; 16(10):1152-6. . View in PubMed

Climate change and the integrity of science Science. 2010 May 07; 328(5979):689-90. . View in PubMed

An expanding universe of circadian networks in higher plants Trends Plant Sci. 2010 May; 15(5):259-65. . View in PubMed

Circadian control of global gene expression patterns Annu Rev Genet. 2010; 44:419-44. . View in PubMed

A genome-wide RNAi screen for modifiers of the circadian clock in human cells Cell. 2009 Oct 02; 139(1):199-210. . View in PubMed

A model of the cell-autonomous mammalian circadian clock Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11107-12. . View in PubMed

Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways Plant Physiol. 2009 Jun; 150(2):858-78. . View in PubMed

A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock Science. 2009 Mar 13; 323(5920):1481-5. . View in PubMed

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2097-103. . View in PubMed

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. . View in PubMed

A morning-specific phytohormone gene expression program underlying rhythmic plant growth PLoS Biol. 2008 Sep 16; 6(9):e225. . View in PubMed

[Molecular mechanism by which plant determines flowering timing with circadian clock] Tanpakushitsu Kakusan Koso. 2008 May; 53(6):739-46. . View in PubMed

Circadian rhythmsDaily watch on metabolism. Science. 2007 Dec 14; 318(5857):1730-1. . View in PubMed

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP J Biol Chem. 2007 Oct 26; 282(43):31349-57. . View in PubMed

Exploring spatiotemporal organization of SCN circuits Cold Spring Harb Symp Quant Biol. 2007; 72:527-41. . View in PubMed

A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Plant Cell. 2006 Nov; 18(11):2919-28. . View in PubMed

Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock Plant Cell. 2006 Oct; 18(10):2506-16. . View in PubMed

A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9 Mol Syst Biol. 2006; 2:58. . View in PubMed

Circadian rhythms lit up in Chlamydomonas Genome Biol. 2006; 7(4):215. . View in PubMed

Bioluminescence imaging in living organisms Curr Opin Biotechnol. 2005 Feb; 16(1):73-8. . View in PubMed

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression Curr Biol. 2004 Dec 29; 14(24):2289-95. . View in PubMed

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock Neuron. 2004 Aug 19; 43(4):527-37. . View in PubMed

A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription FEBS Lett. 2003 Dec 04; 555(2):341-5. . View in PubMed

A genomic analysis of the shade avoidance response in Arabidopsis Plant Physiol. 2003 Dec; 133(4):1617-29. . View in PubMed

Circadian clocks in daily and seasonal control of development Science. 2003 Jul 18; 301(5631):326-8. . View in PubMed

DNA arrays: applications and implications for circadian biology J Biol Rhythms. 2003 Apr; 18(2):96-105. . View in PubMed

Circadian light input in plants, flies and mammals Novartis Found Symp. 2003; 253:73-82; discussion 82-8102-9281-4. . View in PubMed

Circadian transcriptional output in the SCN and liver of the mouse Novartis Found Symp. 2003; 253:171-80; discussion 52-5102-9180-3 passim. . View in PubMed

Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis Plant Cell. 2003 Jan; 15(1):223-36. . View in PubMed

Divergent perspectives on GM food Nat Biotechnol. 2002 Dec; 20(12):1195-6; author reply 1197. . View in PubMed

Circadian rhythms from flies to human Nature. 2002 May 16; 417(6886):329-35. . View in PubMed

Coordinated transcription of key pathways in the mouse by the circadian clock Cell. 2002 May 03; 109(3):307-20. . View in PubMed

Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis Curr Biol. 2002 Apr 30; 12(9):757-61. . View in PubMed

A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock Mol Cell Neurosci. 2002 Apr; 19(4):501-14. . View in PubMed

A role for LKP2 in the circadian clock of Arabidopsis Plant Cell. 2001 Dec; 13(12):2659-70. . View in PubMed

A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes Cell. 2001 Aug 24; 106(4):413-5. . View in PubMed

ELF3 modulates resetting of the circadian clock in Arabidopsis Plant Cell. 2001 Jun; 13(6):1305-15. . View in PubMed

Analysis of the function of two circadian-regulated CONSTANS-LIKE genes Plant J. 2001 Apr; 26(1):15-22. . View in PubMed

Circadian photoperception Annu Rev Physiol. 2001; 63:677-94. . View in PubMed

Cryptochromes are required for phytochrome signaling to the circadian clock but not for rhythmicity Plant Cell. 2000 Dec; 12(12):2499-2510. . View in PubMed

Circadian rhythm genetics: from flies to mice to humans Nat Genet. 2000 Sep; 26(1):23-7. . View in PubMed

Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog Science. 2000 Aug 04; 289(5480):768-71. . View in PubMed

Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene Science. 1999 Sep 03; 285(5433):1579-82. . View in PubMed

A patient preference study comparing raltitrexed ('Tomudex') and bolus or infusional 5-fluorouracil regimens in advanced colorectal cancer: influence of side-effects and administration attributes Eur J Cancer Care (Engl). 1999 Sep; 8(3):154-61. . View in PubMed

Cryptochromes--bringing the blues to circadian rhythms Trends Cell Biol. 1999 Aug; 9(8):295-8. . View in PubMed

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim Science. 1998 Jun 05; 280(5369):1599-603. . View in PubMed

An Arabidopsis mutant hypersensitive to red and far-red light signals Plant Cell. 1998 Jun; 10(6):889-904. . View in PubMed

Attenuation of phytochrome A and B signaling pathways by the Arabidopsis circadian clock Plant Cell. 1997 Oct; 9(10):1727-43. . View in PubMed

Coordination of Plant Metabolism and Development by the Circadian Clock Plant Cell. 1997 Jul; 9(7):1235-1244. . View in PubMed

As time PASses: the first mammalian clock gene Science. 1997 May 16; 276(5315):1093. . View in PubMed

Conditional circadian dysfunction of the Arabidopsis early-flowering 3 mutant Science. 1996 Nov 01; 274(5288):790-2. . View in PubMed

Circadian clock mutants in Arabidopsis identified by luciferase imaging Science. 1995 Feb 24; 267(5201):1161-3. . View in PubMed

Circadian clock- and phytochrome-regulated transcription is conferred by a 78 bp cis-acting domain of the Arabidopsis CAB2 promoter Plant J. 1994 Oct; 6(4):457-70. . View in PubMed

A novel circadian phenotype based on firefly luciferase expression in transgenic plants Plant Cell. 1992 Sep; 4(9):1075-87. . View in PubMed

Characterization of a gene encoding a DNA binding protein with specificity for a light-responsive element Plant Cell. 1992 Jul; 4(7):839-49. . View in PubMed

Circadian Control of cab Gene Transcription and mRNA Accumulation in Arabidopsis Plant Cell. 1991 May; 3(5):541-550. . View in PubMed

A 268 bp upstream sequence mediates the circadian clock-regulated transcription of the wheat Cab-1 gene in transgenic plants Plant Mol Biol. 1990 Dec; 15(6):921-32. . View in PubMed

Differential expression of two related organ-specific genes in pea Plant Mol Biol. 1990 May; 14(5):765-74. . View in PubMed

Cloning and sequencing of protochlorophyllide reductase Biochem J. 1990 Feb 01; 265(3):789-98. . View in PubMed

Donor-specific IgG antibody and the chronic rejection of human renal allografts Surgery. 1975 Jul; 78(1):14-21. . View in PubMed

Congenital mesoblastic nephroma and its recurrence Arch Pathol. 1973 Jul; 96(1):66-70. . View in PubMed

Cervical dysplasia and cancer developing in women on immunosuppression therapy for renal homotransplantation Cancer. 1970 Nov; 26(5):1048-52. . View in PubMed

Dr. Steve Kay currently serves as the Director of the MESH (Medicine, Engineering, Sciences, and Humanities) Academy, the Director of the USC Michelson Center for Convergent Bioscience, and is a Provost Professor of Neurology, Biomedical Engineering and Biological Sciences at the Keck School of Medicine of USC. He held the position as the 21st dean of the USC Dornsife College of Letters, Arts and Sciences from 2012 to 2015.

Dr. Kay is one of the world’s top experts on the genetics and genomics of circadian rhythms. Having published more than 200 papers, he was named by Thomson Reuters as one of “The World’s Most Influential Scientific Minds” from 2014 to 2017 and has been cited in Science magazine’s “Breakthroughs of the Year” three times since 1997. In 2008, Dr. Kay was elected as a member of the National Academy of Sciences. In 2009 he was elected as a fellow of the American Association for the Advancement of Science, and in 2011 he was awarded the American Society of Plant Biologists’ 2011 Martin Gibbs Medal for his pioneering work in plant sciences. To learn more about the Kay Laboratory and current research visit https://kaylab.usc.edu/

Dr. Kay received his PhD and DSc from the University of Bristol, United Kingdom. Prior to joining USC in 2012, Dr. Kay served as dean of biological sciences at the University of California, San Diego. He also has held faculty positions at The Rockefeller University, University of Virginia and The Scripps Research Institute, as well as served as the VP of discovery research at the Genomics Institute of the Novartis Research Foundation, where he focused on using high throughput technologies to push novel development candidates into the Novartis clinical pipeline. Dr. Kay served as president of The Scripps Research Institute from 2015 to 2016. In addition, he has founded several biotechnology companies.
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