CBG Faculty

Anat Erdreich-Epstein, MD, PhD
Anat Erdreich-Epstein, MD, PhD
Associate Professor of Pediatrics
CHL Mail Stop 57 Off Campus Los Angeles

SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors J Pathol. 2020 Jun 19. . View in PubMed

Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma PLoS One. 2019; 14(1):e0206394. . View in PubMed

GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis Sci Rep. 2019 09 25; 9(1):13902. . View in PubMed

Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution JCO Precis Oncol. 2019; 3. . View in PubMed

Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 Oncotarget. 2017 Aug 08; 8(32):52193-52210. . View in PubMed

PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NF? B. Sci Rep. 2017 04 11; 7(1):835.. View in PubMed

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors Cancer Cell. 2016 Dec 12; 30(6):891-908. . View in PubMed

Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 Oncotarget. 2016 Nov 16. . View in PubMed

Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature Cureus. 2016 Apr 25; 8(4):e585. . View in PubMed

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy Neuro Oncol. 2016 Jan; 18(1):126-31. . View in PubMed

CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study Oncotarget. 2016 12 13; 7(50):83701-83719. . View in PubMed

BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma PLoS One. 2016; 11(6):e0156907. . View in PubMed

Wnt pathway in atypical teratoid rhabdoid tumors Neuro Oncol. 2015 Apr; 17(4):526-35. . View in PubMed

Tumor-associated macrophages in SHH subgroup of medulloblastomas Clin Cancer Res. 2015 Mar 15; 21(6):1457-65. . View in PubMed

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target Oncotarget. 2015 Feb 20; 6(5):3165-77. . View in PubMed

Pediatric brain tumor cell lines J Cell Biochem. 2015 Feb; 116(2):218-24. . View in PubMed

The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity J Neuropathol Exp Neurol. 2015 Feb; 74(2):177-85. . View in PubMed

Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia Front Oncol. 2015; 5:191. . View in PubMed

Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas Cancer Res. 2014 Oct 01; 74(19):5435-5448. . View in PubMed

A retrospective analysis of recurrent intracranial ependymoma Pediatr Blood Cancer. 2014 Jul; 61(7):1195-201. . View in PubMed

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas Clin Cancer Res. 2014 Feb 15; 20(4):827-36. . View in PubMed

A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1 Neuro Oncol. 2014 Jan; 16(2):191-203. . View in PubMed

Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells Mol Cancer Res. 2012 Jun; 10(6):689-702. . View in PubMed

Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children's Hospital Los Angeles (CHLA) experience, 1991-2010 Pediatr Blood Cancer. 2012 Jun; 58(6):905-9. . View in PubMed

Novel cell lines established from pediatric brain tumors J Neurooncol. 2012 Apr; 107(2):269-80. . View in PubMed

Microdeletion del(22)(q122) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. BMC Med Genet. 2012 Mar 22; 13:19. . View in PubMed

c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins avß3 and avß5 PLoS One. 2012; 7(8):e42291. . View in PubMed

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro J Neuroinflammation. 2011 Nov 23; 8:162. . View in PubMed

Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen J Neurooncol. 2011 Jul; 103(3):673-80. . View in PubMed

Novel cancer vaccine based on genes of Salmonella pathogenicity island 2 Int J Cancer. 2010 Jun 01; 126(11):2622-34. . View in PubMed

c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin Blood. 2010 Apr 01; 115(13):2709-18. . View in PubMed

Nuclear factor IA is expressed in astrocytomas and is associated with improved survival Neuro Oncol. 2010 Feb; 12(2):122-32. . View in PubMed

High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome Cancer. 2009 Jul 01; 115(13):2956-63. . View in PubMed

Metabolism of orthotopic mouse brain tumor models Mol Imaging. 2009 Jul-Aug; 8(4):199-208. . View in PubMed

Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis Brain Behav Immun. 2007 May; 21(4):395-408. . View in PubMed

Progress in the treatment of childhood brain tumors: no room for complacency Pediatr Hematol Oncol. 2007 Jan-Feb; 24(1):79-84. . View in PubMed

Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation Genes Chromosomes Cancer. 2006 Feb; 45(2):169-81. . View in PubMed

Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways Blood. 2005 Jun 01; 105(11):4353-61. . View in PubMed

Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells Cancer Res. 2005 Feb 15; 65(4):1129-35. . View in PubMed

Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience J Pediatr Hematol Oncol. 2004 Jan; 26(1):31-4. . View in PubMed

Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors Lab Invest. 2003 Dec; 83(12):1787-98. . View in PubMed

Placenta growth factor activates monocytes and correlates with sickle cell disease severity Blood. 2003 Aug 15; 102(4):1506-14. . View in PubMed

Ceramide signaling in fenretinide-induced endothelial cell apoptosis J Biol Chem. 2002 Dec 20; 277(51):49531-7. . View in PubMed

Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):229-33. . View in PubMed

Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin Cancer Res. 2001 Jul 15; 61(14):5587-94. . View in PubMed

Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide Cancer Res. 2000 Feb 01; 60(3):712-21. . View in PubMed

High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase J Immunol. 1999 Dec 01; 163(11):6023-34. . View in PubMed

Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages J Leukoc Biol. 1999 Apr; 65(4):523-34. . View in PubMed

Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling Exp Cell Res. 1998 Dec 15; 245(2):330-42. . View in PubMed

Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression Growth Factors. 1998; 15(2):149-58. . View in PubMed

Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling Exp Cell Res. 1997 Dec 15; 237(2):288-95. . View in PubMed

Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome Am J Pediatr Hematol Oncol. 1992 Nov; 14(4):348-51. . View in PubMed

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