CBG Faculty

Duncan Campbell Thomas

Duncan Campbell Thomas

Professor of Preventive Medicine;Verna R. Richter Chair in Cancer Research
Preventive Medicine
SSB 202 2001 N. Soto Street Health Sciences Campus Los Angeles

Radiation Treatment, ATM, BRCA1/2, and CHEK2*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer J Natl Cancer Inst. 2020 Dec 14; 112(12):1275-1279. . View in PubMed

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults Environ Int. 2020 Dec; 145:106091. . View in PubMed

Incorporating prior knowledge into regularized regression Bioinformatics. 2020 Sep 11. . View in PubMed

A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits Bioinformatics. 2020 02 01; 36(3):842-850. . View in PubMed

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity Environ Int. 2019 09; 130:104935. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed

Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer JAMA Netw Open. 2019 09 04; 2(9):e1912259. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Re: Kheifets et al(2017): Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. Cancer Causes Control. 2018 07; 29(7):609-610. . View in PubMed

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic FactorsGastroenterology. 2018 06; 154(8):2152-2164. e19. . View in PubMed

Cancer Epidemiol Biomarkers Prev. 2018 05; 27(5):531-540. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 05 20; 36(15):1513-1520. . View in PubMed

Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort Am J Clin Nutr. 2018 07 01; 108(1):117-126. . View in PubMed

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases Am J Epidemiol. 2017 Oct 01; 186(7):753-761. . View in PubMed

Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions Am J Epidemiol. 2017 Oct 01; 186(7):771-777. . View in PubMed

Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health Annu Rev Public Health. 2017 Mar 20; 38:279-294. . View in PubMed

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies Cancer Epidemiol Biomarkers Prev. 2017 09; 26(9):1370-1380. . View in PubMed

Estimating the Effect of Targeted Screening Strategies: An Application to Colonoscopy and Colorectal Cancer Epidemiology. 2017 07; 28(4):470-478. . View in PubMed

Inclusion of biological knowledge in a Bayesian shrinkage model for joint estimation of SNP effects Genet Epidemiol. 2017 05; 41(4):320-331. . View in PubMed

Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study J Natl Cancer Inst. 2017 10 01; 109(10). . View in PubMed

GWASeq: targeted re-sequencing follow up to GWAS BMC Genomics. 2016 Mar 03; 17:176. . View in PubMed

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study Toxicol Sci. 2015 Nov; 148(1):89-100. . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed

A model to determine colorectal cancer risk using common genetic susceptibility lociGastroenterology. 2015 Jun; 148(7):1330-9. e14. . View in PubMed

Complex pedigrees in the sequencing era: to track transmissions or decorrelate? Genet Epidemiol. 2014 Sep; 38 Suppl 1:S29-36.. View in PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai Int J Cancer. 2014 Jul 15; 135(2):335-47. . View in PubMed

A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. . View in PubMed

Invited commentary: is it time to retire the "pack-years" variable? Maybe not! Am J Epidemiol. 2014 Feb 01; 179(3):299-302.. View in PubMed

Measurement Error in Spatial Exposure Models: Study Design Implications Environmetrics. 2013 Dec 01; 24(8):518-520. . View in PubMed

Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. . View in PubMed

Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report Eur J Cancer. 2013 Sep; 49(14):2979-85. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

Meta-analysis identifies four new loci associated with testicular germ cell tumor Nat Genet. 2013 Jun; 45(6):680-5. . View in PubMed

Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2013 Feb 01; 31(4):433-9. . View in PubMed

A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk Int J Genomics. 2013; 2013:406217. . View in PubMed

Analysis and optimal design for association studies using next-generation sequencing with case-control pools Genet Epidemiol. 2012 Dec; 36(8):870-81. . View in PubMed

Reproductive status at first diagnosis influences risk of radiation-induced second primary contralateral breast cancer in the WECARE study Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84(4):917-24. . View in PubMed

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships Hum Genet. 2012 Oct; 131(10):1565-89. . View in PubMed

Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans Int J Epidemiol. 2012 Jun; 41(3):686-704. . View in PubMed

Genetic epidemiology with a capital E: where will we be in another 10 years? Genet Epidemiol. 2012 Apr; 36(3):179-82.. View in PubMed

A review of cancer in US. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. . View in PubMed

Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9. . View in PubMed

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 PLoS One. 2012; 7(5):e38175. . View in PubMed

Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches Hum Hered. 2012; 74(2):83-96. . View in PubMed

Some surprising twists on the road to discovering the contribution of rare variants to complex diseases Hum Hered. 2012; 74(3-4):113-7. . View in PubMed

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases Genet Epidemiol. 2012 Jan; 36(1):22-35. . View in PubMed

Incorporating model uncertainty in detecting rare variants: the Bayesian risk index Genet Epidemiol. 2011 Nov; 35(7):638-49. . View in PubMed

Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types Carcinogenesis. 2011 Aug; 32(8):1238-43. . View in PubMed

Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling Genet Epidemiol. 2011 Jul; 35(5):389-97. . View in PubMed

Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed

Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study Breast Cancer Res. 2011; 13(6):R114. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2 J Clin Oncol. 2010 May 10; 28(14):2404-10. . View in PubMed

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study J Natl Cancer Inst. 2010 Apr 07; 102(7):475-83. . View in PubMed

Gene--environment-wide association studies: emerging approaches Nat Rev Genet. 2010 Apr; 11(4):259-72. . View in PubMed

Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study Hum Mutat. 2010 Mar; 31(3):E1200-40. . View in PubMed

Complex system approaches to genetic analysis Bayesian approaches Adv Genet. 2010; 72:47-71. . View in PubMed

Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies Annu Rev Public Health. 2010; 31:21-36. . View in PubMed

Methodological Issues in Multistage Genome-wide Association Studies Stat Sci. 2009 Nov 01; 24(4):414-429. . View in PubMed

Gene-trait similarity regression for multimarker-based association analysis Biometrics. 2009 Sep; 65(3):822-32. . View in PubMed

Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer Biometrics. 2009 Jun; 65(2):599-608. . View in PubMed

Genome-wide association studies for discrete traits Genet Epidemiol. 2009; 33 Suppl 1:S8-12. . View in PubMed

Approaches to complex pathways in molecular epidemiology: summary of a special conference of the American Association for Cancer Research Cancer Res. 2008 Dec 15; 68(24):10028-30. . View in PubMed

Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1021-30. . View in PubMed

Design considerations in a sib-pair study of linkage for susceptibility loci in cancer BMC Med Genet. 2008 Jul 10; 9:64. . View in PubMed

Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study J Natl Cancer Inst. 2008 Jan 02; 100(1):32-40. . View in PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed

Multistage sampling for latent variable models Lifetime Data Anal. 2007 Dec; 13(4):565-81. . View in PubMed

Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty Health Phys. 2007 Oct; 93(4):326-7; author reply 327-8. . View in PubMed

Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al Ann Epidemiol. 2007 Jul; 17(7):511-3. . View in PubMed

Dissecting effects of complex mixtures: who's afraid of informative priors? Epidemiology. 2007 Mar; 18(2):186-90.. View in PubMed

Bayesian model averaging in time-series studies of air pollution and mortality J Toxicol Environ Health A. 2007 Feb 01; 70(3-4):311-5. . View in PubMed

Bayesian hierarchical modeling of means and covariances of gene expression data within families BMC Proc. 2007; 1 Suppl 1:S111. . View in PubMed

Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15 Genet Epidemiol. 2007; 31 Suppl 1:S96-102. . View in PubMed

An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna Eur J Hum Genet. 2006 Dec; 14(12):1238-9. . View in PubMed

BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50 Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1863-70. . View in PubMed

High-volume "-omics" technologies and the future of molecular epidemiology Epidemiology. 2006 Sep; 17(5):490-1. . View in PubMed

No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1565-7. . View in PubMed

Optimal two-stage genotyping designs for genome-wide association scans Genet Epidemiol. 2006 May; 30(4):356-68. . View in PubMed

Are we ready for genome-wide association studies? Cancer Epidemiol Biomarkers Prev. 2006 Apr; 15(4):595-8.. View in PubMed

Recent developments in genomewide association scans: a workshop summary and review Am J Hum Genet. 2005 Sep; 77(3):337-45. . View in PubMed

Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study Radiat Res. 2005 Jun; 163(6):698-9. . View in PubMed

BRCA1 variants in a family study of African-American and Latina women Hum Genet. 2005 May; 116(6):497-506. . View in PubMed

A three-level model for binary time-series data: the effects of air pollution on school absences in the Southern California Children's Health Study Stat Med. 2005 Apr 15; 24(7):1103-15. . View in PubMed

Breast cancer risks for BRCA1/2 carriers Science. 2004 Dec 24; 306(5705):2187-91; author reply 2187-91. . View in PubMed

Lung cancer etiology: independent and joint effects of genetics, tobacco, and arsenic JAMA. 2004 Dec 22; 292(24):3026-9. . View in PubMed

Case-sibling gene-association studies for diseases with variable age at onset Stat Med. 2004 Dec 15; 23(23):3697-712. . View in PubMed

SNPs, haplotypes, and cancer: applications in molecular epidemiology Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):681-7. . View in PubMed

Commentary: the concept of 'Mendelian Randomization' Int J Epidemiol. 2004 Feb; 33(1):21-5. . View in PubMed

Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits BMC Genet. 2003 Dec 31; 4 Suppl 1:S3. . View in PubMed

Segregation and linkage analysis for longitudinal measurements of a quantitative trait BMC Genet. 2003 Dec 31; 4 Suppl 1:S21. . View in PubMed

Bayesian modeling of complex metabolic pathways Hum Hered. 2003; 56(1-3):83-93. . View in PubMed

Bayesian spatial modeling of haplotype associations Hum Hered. 2003; 56(1-3):32-40. . View in PubMed

Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals Hum Hered. 2003; 55(4):179-90. . View in PubMed

Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):505-12.. View in PubMed

A two-stage model for multiple time series data of counts Biostatistics. 2002 Mar; 3(1):21-32. . View in PubMed

Genetic epidemiology with a capital "E" Genet Epidemiol. 2000 Dec; 19(4):289-300. . View in PubMed

My primary research interest has been in the development of statistical methods for genetic and environmental epidemiology, with wide involvement in numerous studies in both areas. My statistical contributions include methods for analysis of nested case-control studies, approaches to modeling exposure-time-response relationships and interaction effects, exposure modeling and measurement error, and the use of Markov chain Monte Carlo (MCMC) methods and Generalized Estimating Equations (GEE) methods in genetics.On the environmental side, I have been particularly active in air pollution and radiation carcinogenesis. I was one of the founding investigators of the Southern California Children’s Health Study, a major cohort study of the health effects of air pollution on schoolchildren’s lung development. I have also collaborated on studies of cancer in residents downwind of the Nevada Test Site, uranium miners, medical irradiation, and the atomic bomb survivors. I was a member of President Clinton’s Advisory Committee on Human Radiation Experiments, as well as the National Academy of Sciences Committee on the Biological Effects of Ionizing Radiation (BEIR V), and radiation advisory committees for numerous other governmental agencies. Other environmental activities include studies of asbestos, malathion spraying in California, electromagnetic fields, and air pollution; I am a Co-Director of the Southern California Environmental Health Research Center.On the genetic side, I have numerous publications in the area of statistical genetics and am collaborating on family studies of breast and colon cancer, pathway based modeling, several genome-wide association studies, next generation sequencing, and epigenetics. I chaired organizing committees for the Genetic Analysis Workshop, and am a Past President of the International Genetic Epidemiology Society.I have authored two textbooks: Statistical Methods in Genetic Epidemiology (Oxford University Press, 2003) and Statistical Methods in Environmental Epidemiology (Oxford University Press, 2009).I feel that these three broad areas of interest make me uniquely qualified to address methodological challenges in studying gene-environment interactions.
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