CBG Faculty

Phase Ib Study of Enzalutamide with or Without Sorafenib in Patients with Advanced Hepatocellular Carcinoma Oncologist. 2020 Dec; 25(12):e1825-e1836. . View in PubMed

Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes J Am Chem Soc. 2020 Sep 30; 142(39):16704-16715. . View in PubMed

Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic JCO Clin Cancer Inform. 2020 Jun; 4:583-601. . View in PubMed

Liquid Biopsy in Colorectal Carcinoma: Clinical Applications and Challenges Cancers (Basel). 2020 May 27; 12(6). . View in PubMed

Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes Ophthalmic Genet. 2020 12; 41(6):526-532. . View in PubMed

Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Transl Vis Sci Technol. 2020 09; 9(10):30. . View in PubMed

Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Mol Cancer Res. 2020 08; 18(8):1166-1175. . View in PubMed

Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases Clin Pharmacol Ther. 2020 04; 107(4):730-734. . View in PubMed

Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients J Mol Diagn. 2020 03; 22(3):319-337. . View in PubMed

Modeling the Onset of Symptoms of COVID-19 Front Public Health. 2020; 8:473. . View in PubMed

Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis Recent Results Cancer Res. 2020; 215:89-104. . View in PubMed

Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Oncotarget. 2019 Dec 17; 10(66):7016-7030. . View in PubMed

Patient reported outcomes can improve performance status assessment: a pilot study J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. . View in PubMed

Prediction of Bone Metastasis in Inflammatory Breast Cancer Using a Markov Chain Model Oncologist. 2019 10; 24(10):1322-1330. . View in PubMed

Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)Clin Genitourin Cancer. 2019 08; 17(4):241-247. e1. . View in PubMed

Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed

Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients PLoS One. 2019; 14(2):e0210976. . View in PubMed

A new anion exchange purification method for Cu stable isotopes in blood samples Anal Bioanal Chem. 2019 Jan; 411(3):765-776. . View in PubMed

Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer J Transl Med. 2019 08 28; 17(1):294. . View in PubMed

Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed

Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed

Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay Arch Pathol Lab Med. 2018 Feb; 142(2):198-207. . View in PubMed

Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed

Low-dimensional dynamical characterization of human performance of cancer patients using motion data Clin Biomech (BristolAvon). 2018 07; 56:61-69. . View in PubMed

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms J Urol. 2018 06; 199(6):1494-1501. . View in PubMed

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation Clin Transl Sci. 2018 05; 11(3):267-276. . View in PubMed

Development of metastatic brain disease involves progression through lung metastases in EGFR mutated non-small cell lung cancer Converg Sci Phys Oncol. 2017 Sep; 3(3). . View in PubMed

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters Clin Cancer Res. 2017 Apr 01; 23(7):1722-1732. . View in PubMed

Robotic salvage retroperitoneal and pelvic lymph node dissection for 'node-only' recurrent prostate cancer: technique and initial series BJU Int. 2017 09; 120(3):401-408. . View in PubMed

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma JAMA Ophthalmol. 2017 11 01; 135(11):1221-1230. . View in PubMed

A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma Clin Cancer Res. 2016 Jan 01; 22(1):61-8. . View in PubMed

A physical sciences network characterization of circulating tumor cell aggregate transport . 2015 May 15; 308(10):C792-802. . View in PubMed

Fourier-ring descriptor to characterize rare circulating cells from images generated using immunofluorescence microscopy Comput Med Imaging Graph. 2015 Mar; 40:70-87. . View in PubMed

Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients Phys Biol. 2015 Jan 09; 12(1):016008. . View in PubMed

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5 PLoS One. 2015; 10(5):e0127081. . View in PubMed

Entropy, complexity, and Markov diagrams for random walk cancer models Sci Rep. 2014 Dec 19; 4:7558. . View in PubMed

Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer Drug Dev Res. 2014 Sep; 75(6):384-92. . View in PubMed

Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer J Thorac Oncol. 2014 Aug; 9(8):1111-9. . View in PubMed

Adrenal metastases in lung cancer: clinical implications of a mathematical model J Thorac Oncol. 2014 Apr; 9(4):442-6. . View in PubMed

Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction Phys Biol. 2014 Feb; 11(1):016002. . View in PubMed

Physical biology in cancer2. The physical biology of circulating tumor cells. . 2014 Jan 15; 306(2):C80-8. . View in PubMed

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells PLoS One. 2014; 9(8):e101777. . View in PubMed

An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer PLoS One. 2013; 8(7):e67733. . View in PubMed

A physical sciences network characterization of non-tumorigenic and metastatic cells Sci Rep. 2013; 3:1449. . View in PubMed

Circulating tumor cells in non-small cell lung carcinoma J Thorac Dis. 2012 Oct; 4(5):456-8. . View in PubMed

Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease Future Oncol. 2012 Aug; 8(8):989-98. . View in PubMed

Characterization of circulating endothelial cells in acute myocardial infarction Sci Transl Med. 2012 Mar 21; 4(126):126ra33. . View in PubMed

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Phys Biol. 2012 Feb; 9(1):016002. . View in PubMed

High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Phys Biol. 2012 Feb; 9(1):016004. . View in PubMed

Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology Phys Biol. 2012 Feb; 9(1):016005. . View in PubMed

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers Phys Biol. 2012 Feb; 9(1):016003. . View in PubMed

A fluid biopsy as investigating technology for the fluid phase of solid tumors Phys Biol. 2012 Feb; 9(1):010301. . View in PubMed

Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Phys Biol. 2012 Feb; 9(1):016001. . View in PubMed

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient Front Oncol. 2012; 2:72. . View in PubMed

A stochastic Markov chain model to describe lung cancer growth and metastasis PLoS One. 2012; 7(4):e34637. . View in PubMed

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient Front Oncol. 2012; 2:96. . View in PubMed

Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family J Virol. 2010 Mar; 84(6):3059-67. . View in PubMed

Cytomorphology of circulating colorectal tumor cells:a small case series J Oncol. 2010; 2010:861341. . View in PubMed

Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3 J Virol. 2009 Dec; 83(24):12998-3008. . View in PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. . View in PubMed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling J Virol. 2009 Oct; 83(19):10314-8. . View in PubMed

Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans Am J Hum Genet. 2009 Sep; 85(3):328-37. . View in PubMed

Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. . View in PubMed

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5252-7. . View in PubMed

Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold J Virol. 2009 Feb; 83(4):1823-36. . View in PubMed

Enthalpy array analysis of enzymatic and binding reactions Anal Biochem. 2008 Jun 01; 377(1):33-9. . View in PubMed

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 J Virol. 2008 Jun; 82(11):5279-94. . View in PubMed

A specific cholesterol binding site is established by the 28 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. . View in PubMed

C-ME: a 3D community-based, real-time collaboration tool for scientific research and training PLoS One. 2008 Feb 20; 3(2):e1621. . View in PubMed

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. . View in PubMed

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science. 2007 Nov 23; 318(5854):1258-65. . View in PubMed

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus J Virol. 2007 Nov; 81(21):12049-60. . View in PubMed

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression Protein Expr Purif. 2007 Nov; 56(1):85-92. . View in PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol. 2007 Jun; 81(12):6700-8. . View in PubMed

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models J Virol. 2007 Jun; 81(11):5637-48. . View in PubMed

Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex Protein Expr Purif. 2007 May; 53(1):51-62. . View in PubMed

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein J Virol. 2007 Apr; 81(8):3913-21. . View in PubMed

Case study of the morphologic variation of circulating tumor cells Hum Pathol. 2007 Mar; 38(3):514-9. . View in PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 206 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. . View in PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol. 2006 Aug; 80(16):7894-901. . View in PubMed

Crystal structure of TM1367 from Thermotoga maritima at 190 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. . View in PubMed

High speed detection of circulating tumor cells Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. . View in PubMed

In situ data collection and structure refinement from microcapillary protein crystallization J Appl Crystallogr. 2005 Dec; 38(6):900-905. . View in PubMed

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers J Virol. 2005 Aug; 79(15):9665-76. . View in PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena spat 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. . View in PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 280 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. . View in PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 185 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. . View in PubMed

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 165 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. . View in PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 24 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. . View in PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 200-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. . View in PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 210 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. . View in PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 190 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. . View in PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 18 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. . View in PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 160 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. . View in PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 250 A resolution. Proteins. 2004 May 15; 55(3):768-71. . View in PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 175 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. . View in PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 20 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. . View in PubMed

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. . View in PubMed

A low-dimensional deformation model for cancer cells in flow Phys Fluids (1994). 2012 Aug; 24(8):81903. . View in PubMed