CBG Faculty

Peter Kuhn

Peter Kuhn

Dean's Professor of Biological Sciences and Professor of Biological Sciences, Medicine, Biomedical Engineering and Aerospace and Mechanical Engineering
Broad CIRM Center
TRF 114A University Park Campus Los Angeles

Phase Ib Study of Enzalutamide with or Without Sorafenib in Patients with Advanced Hepatocellular Carcinoma Oncologist. 2020 Dec; 25(12):e1825-e1836. . View in PubMed

Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes J Am Chem Soc. 2020 Sep 30; 142(39):16704-16715. . View in PubMed

Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic JCO Clin Cancer Inform. 2020 Jun; 4:583-601. . View in PubMed

Liquid Biopsy in Colorectal Carcinoma: Clinical Applications and Challenges Cancers (Basel). 2020 May 27; 12(6). . View in PubMed

Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes Ophthalmic Genet. 2020 12; 41(6):526-532. . View in PubMed

Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Transl Vis Sci Technol. 2020 09; 9(10):30. . View in PubMed

Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Mol Cancer Res. 2020 08; 18(8):1166-1175. . View in PubMed

Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases Clin Pharmacol Ther. 2020 04; 107(4):730-734. . View in PubMed

Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients J Mol Diagn. 2020 03; 22(3):319-337. . View in PubMed

Modeling the Onset of Symptoms of COVID-19 Front Public Health. 2020; 8:473. . View in PubMed

Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis Recent Results Cancer Res. 2020; 215:89-104. . View in PubMed

Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Oncotarget. 2019 Dec 17; 10(66):7016-7030. . View in PubMed

Patient reported outcomes can improve performance status assessment: a pilot study J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. . View in PubMed

Prediction of Bone Metastasis in Inflammatory Breast Cancer Using a Markov Chain Model Oncologist. 2019 10; 24(10):1322-1330. . View in PubMed

Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)Clin Genitourin Cancer. 2019 08; 17(4):241-247. e1. . View in PubMed

Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed

Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients PLoS One. 2019; 14(2):e0210976. . View in PubMed

A new anion exchange purification method for Cu stable isotopes in blood samples Anal Bioanal Chem. 2019 Jan; 411(3):765-776. . View in PubMed

Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer J Transl Med. 2019 08 28; 17(1):294. . View in PubMed

Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed

Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed

Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay Arch Pathol Lab Med. 2018 Feb; 142(2):198-207. . View in PubMed

Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed

Low-dimensional dynamical characterization of human performance of cancer patients using motion data Clin Biomech (BristolAvon). 2018 07; 56:61-69. . View in PubMed

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms J Urol. 2018 06; 199(6):1494-1501. . View in PubMed

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation Clin Transl Sci. 2018 05; 11(3):267-276. . View in PubMed

Development of metastatic brain disease involves progression through lung metastases in EGFR mutated non-small cell lung cancer Converg Sci Phys Oncol. 2017 Sep; 3(3). . View in PubMed

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters Clin Cancer Res. 2017 Apr 01; 23(7):1722-1732. . View in PubMed

Robotic salvage retroperitoneal and pelvic lymph node dissection for 'node-only' recurrent prostate cancer: technique and initial series BJU Int. 2017 09; 120(3):401-408. . View in PubMed

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma JAMA Ophthalmol. 2017 11 01; 135(11):1221-1230. . View in PubMed

A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma Clin Cancer Res. 2016 Jan 01; 22(1):61-8. . View in PubMed

A physical sciences network characterization of circulating tumor cell aggregate transport . 2015 May 15; 308(10):C792-802. . View in PubMed

Fourier-ring descriptor to characterize rare circulating cells from images generated using immunofluorescence microscopy Comput Med Imaging Graph. 2015 Mar; 40:70-87. . View in PubMed

Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients Phys Biol. 2015 Jan 09; 12(1):016008. . View in PubMed

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5 PLoS One. 2015; 10(5):e0127081. . View in PubMed

Entropy, complexity, and Markov diagrams for random walk cancer models Sci Rep. 2014 Dec 19; 4:7558. . View in PubMed

Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer Drug Dev Res. 2014 Sep; 75(6):384-92. . View in PubMed

Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer J Thorac Oncol. 2014 Aug; 9(8):1111-9. . View in PubMed

Adrenal metastases in lung cancer: clinical implications of a mathematical model J Thorac Oncol. 2014 Apr; 9(4):442-6. . View in PubMed

Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction Phys Biol. 2014 Feb; 11(1):016002. . View in PubMed

Physical biology in cancer2. The physical biology of circulating tumor cells. . 2014 Jan 15; 306(2):C80-8. . View in PubMed

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells PLoS One. 2014; 9(8):e101777. . View in PubMed

An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer PLoS One. 2013; 8(7):e67733. . View in PubMed

A physical sciences network characterization of non-tumorigenic and metastatic cells Sci Rep. 2013; 3:1449. . View in PubMed

Circulating tumor cells in non-small cell lung carcinoma J Thorac Dis. 2012 Oct; 4(5):456-8. . View in PubMed

Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease Future Oncol. 2012 Aug; 8(8):989-98. . View in PubMed

Characterization of circulating endothelial cells in acute myocardial infarction Sci Transl Med. 2012 Mar 21; 4(126):126ra33. . View in PubMed

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Phys Biol. 2012 Feb; 9(1):016002. . View in PubMed

High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Phys Biol. 2012 Feb; 9(1):016004. . View in PubMed

Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology Phys Biol. 2012 Feb; 9(1):016005. . View in PubMed

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers Phys Biol. 2012 Feb; 9(1):016003. . View in PubMed

A fluid biopsy as investigating technology for the fluid phase of solid tumors Phys Biol. 2012 Feb; 9(1):010301. . View in PubMed

Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Phys Biol. 2012 Feb; 9(1):016001. . View in PubMed

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient Front Oncol. 2012; 2:72. . View in PubMed

A stochastic Markov chain model to describe lung cancer growth and metastasis PLoS One. 2012; 7(4):e34637. . View in PubMed

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient Front Oncol. 2012; 2:96. . View in PubMed

Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family J Virol. 2010 Mar; 84(6):3059-67. . View in PubMed

Cytomorphology of circulating colorectal tumor cells:a small case series J Oncol. 2010; 2010:861341. . View in PubMed

Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3 J Virol. 2009 Dec; 83(24):12998-3008. . View in PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. . View in PubMed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling J Virol. 2009 Oct; 83(19):10314-8. . View in PubMed

Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans Am J Hum Genet. 2009 Sep; 85(3):328-37. . View in PubMed

Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. . View in PubMed

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5252-7. . View in PubMed

Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold J Virol. 2009 Feb; 83(4):1823-36. . View in PubMed

Enthalpy array analysis of enzymatic and binding reactions Anal Biochem. 2008 Jun 01; 377(1):33-9. . View in PubMed

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 J Virol. 2008 Jun; 82(11):5279-94. . View in PubMed

A specific cholesterol binding site is established by the 28 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. . View in PubMed

C-ME: a 3D community-based, real-time collaboration tool for scientific research and training PLoS One. 2008 Feb 20; 3(2):e1621. . View in PubMed

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. . View in PubMed

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science. 2007 Nov 23; 318(5854):1258-65. . View in PubMed

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus J Virol. 2007 Nov; 81(21):12049-60. . View in PubMed

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression Protein Expr Purif. 2007 Nov; 56(1):85-92. . View in PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol. 2007 Jun; 81(12):6700-8. . View in PubMed

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models J Virol. 2007 Jun; 81(11):5637-48. . View in PubMed

Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex Protein Expr Purif. 2007 May; 53(1):51-62. . View in PubMed

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein J Virol. 2007 Apr; 81(8):3913-21. . View in PubMed

Case study of the morphologic variation of circulating tumor cells Hum Pathol. 2007 Mar; 38(3):514-9. . View in PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 206 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. . View in PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol. 2006 Aug; 80(16):7894-901. . View in PubMed

Crystal structure of TM1367 from Thermotoga maritima at 190 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. . View in PubMed

High speed detection of circulating tumor cells Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. . View in PubMed

In situ data collection and structure refinement from microcapillary protein crystallization J Appl Crystallogr. 2005 Dec; 38(6):900-905. . View in PubMed

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers J Virol. 2005 Aug; 79(15):9665-76. . View in PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena spat 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. . View in PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 280 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. . View in PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 185 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. . View in PubMed

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 165 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. . View in PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 24 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. . View in PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 200-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. . View in PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 210 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. . View in PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 190 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. . View in PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 18 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. . View in PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 160 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. . View in PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 250 A resolution. Proteins. 2004 May 15; 55(3):768-71. . View in PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 175 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. . View in PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 20 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. . View in PubMed

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. . View in PubMed

A low-dimensional deformation model for cancer cells in flow Phys Fluids (1994). 2012 Aug; 24(8):81903. . View in PubMed

Peter Kuhn joined the USC Dana and David Dornsife College of Letters, Arts and Sciences as Dean’s Professor of Biological Sciences in July 2014. Dr. Kuhn also has appointments as Professor of Medicine, Professor of Biomedical Engineering and Professor of Aerospace & Mechanical Engineering, a founding member of the Michelson Center for Convergent Biosciences at USC and is leading CSI-Cancer at USC. He is a scientist, educator and entrepreneur with a career long commitment in personalized medicine and individualized cancer patient care. He is focused on the redesign of cancer care. The first product from technology developed by Dr. Kuhn became available for prostate cancer care in June 2016. Dr. Kuhn’s strategy is to advance our understanding of the human body to improve the human condition for those affected by cancer. His research is shedding new light at how cancer spreads through the body and evolves over time. This new science will lead to a personalized care strategy that is biologically informed and clinically actionable. He is a physicist who trained initially at the Julius Maximilians Universität Würzburg, Germany, before receiving his Masters in Physics at the University of Albany, Albany, NY in 1993 and his Ph.D. in 1995. He then moved to Stanford University where he joined the faculties of Medicine and Accelerator Physics as tenure track Assistant Professor. From 2002 to 2014 he established the Physics Oncology program at The Scripps Research in La Jolla, CA as tenured Associate Professor before joining USC in 2014. He has published over 200 peer scientific articles and patents resulting from his research.
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