CBG Faculty

Chengyu Liang, MD, PhD
Chengyu Liang, MD, PhD
Associate Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
NRT 5507 1450 Biggy Street Health Sciences Campus Los Angeles
Research in my lab is centered on understanding the basic principle of cellular processes including apoptosis and autophagy, cell cycle regulation and genomic stability, as well as intracellular trafficking matrix in the development of cancer and infectious disease. Being a lysosome-dependent quality control mechanism and house-cleaning activity of the cessll, autophagy (Greek for self-eating) has been increasing recognized being essential for cells to maintain homeostasis and also protect the organism against diverse pathogens and cancerous cells.

Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models Hum Mol Genet. 2020 Feb 14. . View in PubMed

UVRAG in autophagy, inflammation, and cancer Autophagy. 2020 02; 16(2):387-388. . View in PubMed

How autophagy is tied to inflammation and cancer Mol Cell Oncol. 2020; 7(2):1717908. . View in PubMed

C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis Autophagy. 2019 Dec 26; 1-16. . View in PubMed

Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models Hum Mol Genet. 2019 Dec 01; 28(23):3940-3953. . View in PubMed

Tumour-Secreted Hsp90a on External Surface of Exosomes Mediates Tumour - Stromal Cell Communication via Autocrine and Paracrine Mechanisms Sci Rep. 2019 Oct 22; 9(1):15108. . View in PubMed

Revisiting the role of autophagy in melanoma Autophagy. 2019 10; 15(10):1843-1844. . View in PubMed

Darkening with UVRAG Autophagy. 2019 02; 15(2):366-367. . View in PubMed

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance Nat Commun. 2019 04 12; 10(1):1693. . View in PubMed

C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner Acta Neuropathol Commun. 2019 03 04; 7(1):32. . View in PubMed

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice Nat Commun. 2019 12 12; 10(1):5681. . View in PubMed

Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus J Virol. 2018 02 15; 92(4). . View in PubMed

Central role of autophagic UVRAG in melanogenesis and the suntan response Proc Natl Acad Sci U S A. 2018 08 14; 115(33):E7728-E7737. . View in PubMed

PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion Mol Cell Biol. 2017 Oct 01; 37(19). . View in PubMed

RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer Nat Commun. 2016 Feb 26; 7:10751. . View in PubMed

Autophagy modulator plays a part in UV protection Autophagy. 2016 09; 12(9):1677-8. . View in PubMed

Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase Mol Cell. 2016 05 19; 62(4):507-19. . View in PubMed

Autophagy interaction with herpes simplex virus type-1 infection Autophagy. 2016; 12(3):451-9. . View in PubMed

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers Nat Commun. 2015 Aug 03; 6:7839. . View in PubMed

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction PLoS Pathog. 2015 Jul; 11(7):e1005060. . View in PubMed

Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication J Virol. 2015 May; 89(10):5308-17. . View in PubMed

Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production Mol Cell. 2015 Apr 02; 58(1):134-46. . View in PubMed

Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer Autophagy. 2015; 11(10):1939-40. . View in PubMed

Novel functions of viral anti-apoptotic factors Nat Rev Microbiol. 2015 Jan; 13(1):7-12. . View in PubMed

MicroRNAs: an emerging player in autophagy ScienceOpen Res. 2015; 2015. . View in PubMed

Viruses customize autophagy protein for efficient viral entry Autophagy. 2014 Jul; 10(7):1355-6. . View in PubMed

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2716-21. . View in PubMed

The intersection of Golgi-ER retrograde and autophagic trafficking Autophagy. 2014 Jan; 10(1):180-1. . View in PubMed

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex Nat Cell Biol. 2013 Oct; 15(10):1206-1219. . View in PubMed

Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking J Cell Sci. 2012 Oct 15; 125(Pt 20):4740-50. . View in PubMed

UVRAG: at the crossroad of autophagy and genomic stability Autophagy. 2012 Sep; 8(9):1392-3. . View in PubMed

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy Dev Cell. 2012 May 15; 22(5):1001-16. . View in PubMed

Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation Cell Host Microbe. 2012 Mar 15; 11(3):264-76. . View in PubMed

Viral FLIPping autophagy for longevity Cell Host Microbe. 2012 Feb 16; 11(2):101-3. . View in PubMed

Measurement of? HV68 infection in mice. J Vis Exp. 2011 Nov 22; (57).. View in PubMed

Anti-autophagic Bcl-2: Not just an innocent bystander Autophagy. 2011 Feb; 7(2):231-2. . View in PubMed

Autophagy genes as tumor suppressors Curr Opin Cell Biol. 2010 Apr; 22(2):226-33. . View in PubMed

Autophagy evasion in herpesviral latency Autophagy. 2010 Jan; 6(1):151-2. . View in PubMed

FLIP-mediated autophagy regulation in cell death control Nat Cell Biol. 2009 Nov; 11(11):1355-62. . View in PubMed

Viral interferon regulatory factors J Interferon Cytokine Res. 2009 Sep; 29(9):621-7. . View in PubMed

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis Semin Cancer Biol. 2008 Dec; 18(6):423-36. . View in PubMed

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16743-8. . View in PubMed

Perturbation of autophagic pathway by hepatitis C virus Autophagy. 2008 Aug; 4(6):830-1. . View in PubMed

Beyond autophagy: the role of UVRAG in membrane trafficking Autophagy. 2008 Aug; 4(6):817-20. . View in PubMed

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking Nat Cell Biol. 2008 Jul; 10(7):776-87. . View in PubMed

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