CBG Faculty

Stephen B Gruber, MD, PhD, MPH
Stephen B Gruber, MD, PhD, MPH
Professor of Medicine and Preventive Medicine;Jane & Kris Popovich Chair in Cancer Research
NTT 4436 Health Sciences Campus Los Angeles
Stephen B. Gruber, M.D., Ph.D., M.P.H., Director of the USC Norris Comprehensive Cancer Center, is a Professor of Medicine at the Keck School of Medicine of the University of Southern California, and the H. Leslie Hoffman and Elaine S. Hoffman Chair in Cancer Research.

Dr. Gruber is a board certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

Dr. Gruber obtained his Bachelor’s Degree from the University of Pennsylvania in 1984 and subsequently a Master of Public Health Degree from Yale University in 1986. After completing his Doctorate Degree in Epidemiology at Yale in 1988, Dr. Gruber enrolled in the University of Pennsylvania Medical School and obtained his Medical Degree in 1992, where he also completed his internship and residency. He completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at the University of Michigan.

He has received a variety of honors and awards and is the author of 158 peer-reviewed publications, many in very high quality journals attesting to his standing in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology.

Association of American Cancer Institute: Board of Directors, 2015

Collaborative Group of the Americas on Inherited Colorectal Cancer : Lifetime Achievement Award, 2013

USC: H. Leslie and Elaine S. Hoffman Cancer Research Chair, 2012

University of Michigan: League of Research Excellence, 2011

American Society of Clinical Investigation: Elected Member, 2003

: Jerome Conn Award for Excellence in Research, 2000

: Penn Pearls Teaching Award, 1994

: Alfred Stengel Memorial Prize, 1992

: Penn Medical Scholar, 1989-1992

National Institute of Health: Cancer Training Grant, 1986-1988

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 Jan; 51(1):76-87. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2018 Dec 03. . View in PubMed

Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma Matrix Biol. 2018 Dec; 74:52-61. . View in PubMed

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster Nat Chem. 2018 Aug; 10(8):873-880. . View in PubMed

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster Nat Chem. 2018 Jun 18. . View in PubMed

Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma Matrix Biol. 2018 Jun 06. . View in PubMed

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative Am J Hum Genet. 2018 May 17. . View in PubMed

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors Gastroenterology. 2018 Feb 17. . View in PubMed

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic FactorsGastroenterology. 2018 06; 154(8):2152-2164. e19. . View in PubMed

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative Am J Hum Genet. 2018 06 07; 102(6):1048-1061. . View in PubMed

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies PLoS One. 2018; 13(1):e0190324. . View in PubMed

Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma J Invest Dermatol. 2017 Dec; 137(12):2588-2598. . View in PubMed

Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma JAMA Dermatol. 2017 Oct 01; 153(10):1026-1031. . View in PubMed

Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma J Invest Dermatol. 2017 12; 137(12):2588-2598. . View in PubMed

Cross-Cancer Analysis Reveals Novel Pleiotropic Associations-Response Cancer Res. 2017 11 01; 77(21):6045-6046. . View in PubMed

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses PLoS Med. 2016 Sep; 13(9):e1002118. . View in PubMed

Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways J Natl Cancer Inst. 2016 Jul; 108(7). . View in PubMed

A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer Cancer Genet. 2016 Mar; 209(3):75-81. . View in PubMed

Coffee Consumption and the Risk of Colorectal Cancer Cancer Epidemiol Biomarkers Prev. 2016 04; 25(4):634-9. . View in PubMed

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Cancer Res. 2016 09 01; 76(17):5103-14. . View in PubMed

A Germline Variant on Chromosome 4q311 Associates with Susceptibility to Developing Colon Cancer Metastasis. PLoS One. 2016; 11(1):e0146435. . View in PubMed

A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer Cancer Epidemiol Biomarkers Prev. 2016 Jan; 25(1):193-200. . View in PubMed

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer J Natl Cancer Inst. 2015 Nov; 107(11). . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma JAMA Oncol. 2015 Jun; 1(3):359-68. . View in PubMed

A model to determine colorectal cancer risk using common genetic susceptibility lociGastroenterology. 2015 Jun; 148(7):1330-9. e14. . View in PubMed

A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype J Med Genet. 2015 May; 52(5):348-52. . View in PubMed

Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study JAMA Dermatol. 2014 Dec; 150(12):1306-314. . View in PubMed

A novel colorectal cancer risk locus at 4q322 identified from an international genome-wide association study. Carcinogenesis. 2014 Nov; 35(11):2512-9. . View in PubMed

An oncocytic adrenal tumour in a patient with Birt-Hogg-Dubé syndrome Clin Endocrinol (Oxf). 2014 Jun; 80(6):925-7. . View in PubMed

Clinical application of bilateral high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging of the breast at 7 T Eur Radiol. 2014 Apr; 24(4):913-20. . View in PubMed

Cumulative exposure to medical radiation for children requiring surgery for congenital heart diseaseJ Pediatr. 2014 Apr; 164(4):789-794. e10. . View in PubMed

[Data for epidemiological research on ageing in GermanyOpportunities and limitations of existing datasets: results of the second workshop of the working group Epidemiology of Ageing within the German Society for Epidemiology (DGEpi)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Oct; 56(10):1425-31. . View in PubMed

Distinct molecular features of colorectal cancer in Ghana Cancer Epidemiol. 2013 Oct; 37(5):556-61. . View in PubMed

Adrenocortical carcinoma is a lynch syndrome-associated cancer J Clin Oncol. 2013 Aug 20; 31(24):3012-8. . View in PubMed

Combined contrast-enhanced magnetic resonance and diffusion-weighted imaging reading adapted to the "Breast Imaging Reporting and Data System" for multiparametric 3-T imaging of breast lesions Eur Radiol. 2013 Jul; 23(7):1791-802. . View in PubMed

Elevated risk of prostate cancer among men with Lynch syndrome J Clin Oncol. 2013 May 10; 31(14):1713-8. . View in PubMed


Contemporary outcomes of surgical ventricular septal defect closure J Thorac Cardiovasc Surg. 2013 Mar; 145(3):641-7. . View in PubMed

Common MUTYH mutations and colorectal cancer risk in multiethnic populations Fam Cancer. 2012 Sep; 11(3):329-35. . View in PubMed

Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort Breast Cancer Res Treat. 2012 Jun; 133(3):1125-30. . View in PubMed

An American founder mutation in MLH1 Int J Cancer. 2012 May 01; 130(9):2088-95. . View in PubMed

Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas Ann Surg Oncol. 2012 Mar; 19(3):1024-33. . View in PubMed

A pilot study of microsatellite instability and endometrial cancer survival in white and African American women Int J Gynecol Pathol. 2012 Jan; 31(1):66-72. . View in PubMed

Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome Biometrics. 2011 Dec; 67(4):1627-37. . View in PubMed

Adiponectin gene and risk of colorectal cancer Br J Cancer. 2011 Aug 09; 105(4):562-4. . View in PubMed

Clinical implications of UGT1A1*28 genotype testing in colorectal cancer patients Cancer. 2011 Jul 15; 117(14):3156-62. . View in PubMed

Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome Clin Genet. 2011 Jun; 79(6):512-22. . View in PubMed

AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome Am J Med Genet A. 2011 Apr; 155A(4):898-902. . View in PubMed

Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers Cancer Epidemiol Biomarkers Prev. 2011 Mar; 20(3):522-9. . View in PubMed

[Functional and molecular imaging of breast tumors] Radiologe. 2010 Nov; 50(11):1030-8. . View in PubMed

A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome Genet Epidemiol. 2010 Nov; 34(7):756-68. . View in PubMed

Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis Breast Cancer Res Treat. 2010 Nov; 124(2):441-51. . View in PubMed

Case-control studies of gene-environment interaction: Bayesian design and analysis Biometrics. 2010 Sep; 66(3):934-48. . View in PubMed

Allele-specific expression of APC in adenomatous polyposis familiesGastroenterology. 2010 Aug; 139(2):439-47, 447. e1. . View in PubMed

CYP24A1 splice variants--implications for the antitumorigenic actions of 1,25-(OH)2D3 in colorectal cancer J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):76-9. . View in PubMed

Common variation in ISL1 confers genetic susceptibility for human congenital heart disease PLoS One. 2010 May 26; 5(5):e10855. . View in PubMed

A case-control study of levothyroxine and the risk of colorectal cancer J Natl Cancer Inst. 2010 Apr 21; 102(8):568-72. . View in PubMed

Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome Gastroenterology. 2009 Nov; 137(5):1621-7. . View in PubMed

Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome J Clin Oncol. 2009 Aug 20; 27(24):3981-6. . View in PubMed

Emerging molecular technologies for identifying the risk of second cancers Cancer Prev Res (Phila). 2009 Jul; 2(7):605-7. . View in PubMed

Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation Head Neck. 2009 May; 31(5):689-94. . View in PubMed

Breast cancer characteristics at diagnosis and survival among Arab-American women compared to European- and African-American women Breast Cancer Res Treat. 2009 Mar; 114(2):339-46. . View in PubMed

Anticipation in lynch syndrome: still waiting for the answer J Clin Oncol. 2009 Jan 20; 27(3):326-7. . View in PubMed

Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer Am J Surg Pathol. 2008 Nov; 32(11):1661-6. . View in PubMed

Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction Stat Med. 2008 Jul 10; 27(15):2756-83. . View in PubMed

Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR) Hum Mutat. 2008 Jun; 29(6):852-60. . View in PubMed

Dietary intake of carotenoid isomers in Israel Int J Vitam Nutr Res. 2007 Nov; 77(6):398-405. . View in PubMed

Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer JAMA. 2007 Jun 06; 297(21):2410-1. . View in PubMed

CDKN2A germline mutations in individuals with cutaneous malignant melanoma J Invest Dermatol. 2007 May; 127(5):1234-43. . View in PubMed

APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2325-7. . View in PubMed

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes Ann Surg Oncol. 2006 Oct; 13(10):1296-321. . View in PubMed

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway Nat Cell Biol. 2006 Oct; 8(10):1053-63. . View in PubMed

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes J Clin Oncol. 2006 Oct 01; 24(28):4642-60. . View in PubMed

BRAF and NRAS mutations in spitzoid melanocytic lesions Mod Pathol. 2006 Oct; 19(10):1324-32. . View in PubMed

Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and normal left ventricle J Thorac Cardiovasc Surg. 2006 Aug; 132(2):260-3. . View in PubMed

BRAF and NRAS mutations in melanoma and melanocytic nevi Melanoma Res. 2006 Aug; 16(4):267-73. . View in PubMed

A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma Int J Epidemiol. 2006 Jun; 35(3):756-64. . View in PubMed

Colorectal Cancer Screening Clinical Practice Guidelines J Natl Compr Canc Netw. 2006 Apr; 4(4):384-420. . View in PubMed

APC I1307K and the risk of prostate cancer Cancer Epidemiol Biomarkers Prev. 2006 Mar; 15(3):468-73. . View in PubMed

Colorectal polyps in carriers of the APC I1307K polymorphism Dis Colon Rectum. 2005 Dec; 48(12):2317-21. . View in PubMed

CDX2 polymorphisms, RNA expression, and risk of colorectal cancer Cancer Res. 2005 Jul 01; 65(13):5488-92. . View in PubMed

CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium Gastroenterology. 2005 Apr; 128(4):946-61. . View in PubMed

Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data BMC Bioinformatics. 2005 Feb 10; 6:26. . View in PubMed

Endometrial cancer: socioeconomic status and racial/ethnic differences in stage at diagnosis, treatment, and survival Am J Public Health. 2004 Dec; 94(12):2104-11. . View in PubMed

Familial aggregation of melanoma risks in a large population-based sample of melanoma cases Cancer Causes Control. 2004 Nov; 15(9):957-65. . View in PubMed

[Not Available] Strahlenther Onkol. 2004 Jun; 180 Suppl 1:5-87. . View in PubMed

EGF gene polymorphism and the risk of incident primary melanoma Cancer Res. 2004 Apr 15; 64(8):2668-72. . View in PubMed

BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer J Natl Cancer Inst. 2004 Jan 07; 96(1):15-21. . View in PubMed

Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework Am J Pathol. 2003 Nov; 163(5):1985-95. . View in PubMed

A twofold increase in BRCA mutation related prostate cancer among Ashkenazi Israelis is not associated with distinctive histopathology J Med Genet. 2003 Oct; 40(10):787-92. . View in PubMed

Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas Clin Cancer Res. 2003 Aug 01; 9(8):3065-72. . View in PubMed

Degree of hypomyelination and magnetic resonance spectroscopy findings in patients with Pelizaeus Merzbacher phenotype Neuropediatrics. 2003 Jun; 34(3):127-36. . View in PubMed

BLM heterozygosity and the risk of colorectal cancer Science. 2002 Sep 20; 297(5589):2013. . View in PubMed

Cancer risks in BRCA1 carriers: time for the next generation of studies J Natl Cancer Inst. 2002 Sep 18; 94(18):1344-5. . View in PubMed

Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies Nat Genet. 2001 Aug; 28(4):361-4. . View in PubMed

Assay for Detecting the I1307K Susceptibility Allele within the Adenomatous Polyposis ColiGene Methods Mol Med. 2001; 49:263-70. . View in PubMed

Effects of acute and chronic electroconvulsive stimuli on cAMP and cGMP efflux in the rat striatum and hippocampus Eur Neuropsychopharmacol. 2000 Dec; 10(6):495-500. . View in PubMed

Analysis of masked mutations in familial adenomatous polyposis Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2322-6. . View in PubMed

Cancer risk in collagenous colitis Inflamm Bowel Dis. 1999 Feb; 5(1):40-3. . View in PubMed

Cancer, crash sites, and the new genetics of neoplasia Gastroenterology. 1999 Jan; 116(1):210-2. . View in PubMed

A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins Virology. 1998 Oct 10; 250(1):9-18. . View in PubMed

APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis Gut. 1997 Apr; 40(4):521-5. . View in PubMed

A population-based study of endometrial cancer and familial risk in younger womenCancer and Steroid Hormone Study Group. Cancer Epidemiol Biomarkers Prev. 1996 Jun; 5(6):411-7. . View in PubMed

Effects of sex on differences in awareness, treatment, and control of high blood pressure Am J Prev Med. 1988 Nov-Dec; 4(6):315-26. . View in PubMed

A case of erythroblastosis fetalis caused by isoimmunization with the agglutinogen B J Pediatr. 1946 Oct; 29(4):518. . View in PubMed

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