DSR Faculty

Andrew P. McMahon, PhD
Andrew P. McMahon, PhD
W.M. Keck Provost and University Professor of Stem Cell Biology and Regenerative Medicine and Biological Sciences;Chair of Stem Cell Biology and Regenerative Medicine;Director, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC
Stem Cell Biology & Regenerative Medicine
BCC 312 1425 San Pablo Street Health Sciences Campus Los Angeles
Professor Andrew (Andy) McMahon is the Chair of the Department of Stem Cell Biology and Regenerative Medicine and Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of the University of Southern California (USC). McMahon joined USC from Harvard University in 2012 as the W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine, and Biological Sciences, and founding chair of the Department of Stem Cell Biology and Regenerative Medicine.

McMahon is a leader in the field of developmental biology. McMahon’s research has provided fundamental insights into the cell interactions driving assembly of multiple organ systems, including the central nervous system, skeleton and kidney. McMahon’s research has identified diverse mechanisms regulating organ development, tissue repair and cancer. Current research focuses on development, injury and repair of the mammalian kidney, to model and treat kidney disease.

McMahon received his bachelor's degree from Oxford University and his PhD from University College London. McMahon completed his postdoctoral research at the California Institute of Technology, then moved to London to start his independent research laboratory in 1984. In 1988, McMahon took up a position as assistant member at the Roche Institute for Molecular Biology, becoming full member and chair of the department in 1992. In 1993, McMahon became a professor of Molecular and Cellular Biology in the Faculty of Arts and Sciences at Harvard University. In a 19-year career at Harvard, McMahon was the Frank B. Baird Jr., Professor of Science, chair of the Department of Cell and Developmental Biology, a founding faculty of the Department of Stem Cells and Regenerative Biology, and principal investigator of the Harvard Stem Cell Institute.

McMahon is an elected fellow of the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the European Molecular Biology Organization and the Royal Society.

Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter iScience. 2019 Sep 26; 20:402-414. . View in PubMed

A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation Nat Commun. 2019 03 11; 10(1):1157. . View in PubMed

Determination of Total Biotin by Liquid Chromatography Coupled with Immunoaffinity Column Cleanup Extraction: Multilaboratory Testing, Final Action 201602. J AOAC Int. 2018 May 01; 101(3):831-842. . View in PubMed

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning J Am Soc Nephrol. 2018 03; 29(3):825-840. . View in PubMed

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney J Am Soc Nephrol. 2018 03; 29(3):806-824. . View in PubMed

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis J Am Soc Nephrol. 2018 03; 29(3):785-805. . View in PubMed

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells Stem Cell Reports. 2018 08 14; 11(2):470-484. . View in PubMed

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants EBioMedicine. 2018 Jan; 27:275-283. . View in PubMed

(Re)Building a Kidney J Am Soc Nephrol. 2017 May; 28(5):1370-1378. . View in PubMed

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry BreakingDev Cell. 2017 03 13; 40(5):439-452. e4. . View in PubMed

An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections PLoS One. 2017; 12(11):e0188413. . View in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development Development. 2017 09 01; 144(17):3177-3188. . View in PubMed

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation PLoS Genet. 2016 Dec; 12(12):e1006533. . View in PubMed

An Emerging Regulatory Landscape for Skeletal Development Trends Genet. 2016 12; 32(12):774-787. . View in PubMed

Development of the Mammalian Kidney Curr Top Dev Biol. 2016; 117:31-64. . View in PubMed

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy Development. 2016 08 15; 143(16):3012-23. . View in PubMed

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1 Elife. 2016 05 05; 5. . View in PubMed

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors Development. 2015 Oct 01; 142(19):3286-93. . View in PubMed

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity J Am Soc Nephrol. 2015 Jan; 26(1):81-94. . View in PubMed

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning Dev Cell. 2014 Nov 24; 31(4):448-60. . View in PubMed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs Nature. 2014 Jul 03; 511(7507):46-51. . View in PubMed

Defining the acute kidney injury and repair transcriptome Semin Nephrol. 2014 Jul; 34(4):404-17. . View in PubMed

Defining kidney biology to understand renal disease Clin J Am Soc Nephrol. 2014 Apr; 9(4):809-11. . View in PubMed

Cell-specific translational profiling in acute kidney injury J Clin Invest. 2014 Mar; 124(3):1242-54. . View in PubMed

A novel site comes into sight Elife. 2013 Dec 03; 2:e01680. . View in PubMed

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis J Clin Invest. 2013 Sep; 123(9):4023-35. . View in PubMed

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers Genesis. 2012 May; 50(5):443-50. . View in PubMed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract Front Neurosci. 2012; 6:130. . View in PubMed

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation Dev Cell. 2011 Jun 14; 20(6):788-801. . View in PubMed

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney Kidney Int. 2011 Feb; 79(3):317-30. . View in PubMed

A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment Biomed Microdevices. 2010 Dec; 12(6):1027-41. . View in PubMed

An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry Curr Biol. 2009 Dec 01; 19(22):1912-7. . View in PubMed

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment Dev Biol. 2009 Aug 15; 332(2):273-86. . View in PubMed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development. 2009 Jan; 136(1):161-71. . View in PubMed

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature Science. 2008 Nov 21; 322(5905):1247-50. . View in PubMed

Atlas of gene expression in the developing kidney at microanatomic resolution Dev Cell. 2008 Nov; 15(5):781-91. . View in PubMed

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb Genes Dev. 2008 Oct 01; 22(19):2651-63. . View in PubMed

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma Cancer Cell. 2008 Aug 12; 14(2):123-34. . View in PubMed

An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo J Am Chem Soc. 2008 Jul 30; 130(30):9925-30. . View in PubMed

Developmental biologyGrasping limb patterning. Science. 2008 Jul 18; 321(5887):350-2. . View in PubMed

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease Genes Dev. 2008 Jun 15; 22(12):1662-76. . View in PubMed

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. . View in PubMed

Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state Dev Biol. 2008 Feb 01; 314(1):112-26. . View in PubMed

A high-resolution anatomical ontology of the developing murine genitourinary tract Gene Expr Patterns. 2007 Jun; 7(6):680-99. . View in PubMed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling Dev Cell. 2007 Jan; 12(1):99-112. . View in PubMed

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway Cancer Res. 2006 Oct 15; 66(20):10171-8. . View in PubMed

Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein J Am Chem Soc. 2006 Jul 12; 128(27):8939-46. . View in PubMed

BMP signaling stimulates cellular differentiation at multiple steps during cartilage development Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. . View in PubMed

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway Nat Genet. 2005 Dec; 37(12):1323-32. . View in PubMed

An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo Nucleic Acids Res. 2005 Oct 12; 33(18):e155. . View in PubMed

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1 Infect Immun. 2005 Oct; 73(10):6981-9. . View in PubMed

Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder Nat Genet. 2005 Oct; 37(10):1082-9. . View in PubMed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell. 2005 May; 8(5):751-64. . View in PubMed

Derivation of embryonic stem-cell lines from human blastocysts N Engl J Med. 2004 Mar 25; 350(13):1353-6. . View in PubMed

Combined activities of hedgehog signaling inhibitors regulate pancreas development Development. 2003 Oct; 130(20):4871-9. . View in PubMed

Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance J Clin Invest. 2003 Aug; 112(4):554-65. . View in PubMed

Branching morphogenesis of the lung: new molecular insights into an old problem Trends Cell Biol. 2003 Feb; 13(2):86-91. . View in PubMed

Developmental roles and clinical significance of hedgehog signaling Curr Top Dev Biol. 2003; 53:1-114. . View in PubMed

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord Genes Dev. 2002 Nov 15; 16(22):2849-64. . View in PubMed

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo Development. 2002 Oct; 129(20):4807-19. . View in PubMed

Cholesterol modification of Hedgehog family proteins J Clin Invest. 2002 Sep; 110(5):591-6. . View in PubMed

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells Nat Neurosci. 2002 Sep; 5(9):831-2. . View in PubMed

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS Development. 2002 May; 129(9):2087-98. . View in PubMed

Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes Mech Dev. 2002 Feb; 111(1-2):75-87. . View in PubMed

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation Development. 2001 Nov; 128(22):4523-34. . View in PubMed

Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv31 and Kv3. 3. J Neurosci. 2001 Sep 01; 21(17):6657-65. . View in PubMed

Developmental biologyVesicles and the spinal cord. Nature. 2001 Jul 12; 412(6843):136-7. . View in PubMed

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1 Cell. 2001 Jun 01; 105(5):599-612. . View in PubMed

Activation of expression of hedgehog target genes in basal cell carcinomas J Invest Dermatol. 2001 May; 116(5):739-42. . View in PubMed

Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives Dev Biol. 2001 Jan 01; 229(1):128-40. . View in PubMed

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling Development. 2000 Apr; 127(7):1337-48. . View in PubMed

A local Wnt-3a signal is required for development of the mammalian hippocampus Development. 2000 Feb; 127(3):457-67. . View in PubMed

Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor Teratology. 1999 Jul; 60(1):22-8. . View in PubMed

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo Development. 1999 Mar; 126(6):1211-23. . View in PubMed

"Cre"-ating mouse mutants-a meeting review on conditional mouse genetics Genes Dev. 1999 Jan 15; 13(2):142-5. . View in PubMed

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth Dev Biol. 1998 Oct 15; 202(2):215-27. . View in PubMed

Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells Brain Res Mol Brain Res. 1998 Feb; 54(1):56-63. . View in PubMed

A 55-kb enhancer is both necessary and sufficient for regulation of Wnt-1 transcription in vivo. Dev Biol. 1997 Dec 15; 192(2):300-9. . View in PubMed

Calbindin-D28k in nerve cell nuclei Neuroscience. 1997 Dec; 81(3):735-43. . View in PubMed

A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo Dev Biol. 1997 Jul 15; 187(2):298-310. . View in PubMed

Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter Dev Biol. 1997 May 15; 185(2):139-47. . View in PubMed

Cell interactions in patterning the mammalian midbrain Cold Spring Harb Symp Quant Biol. 1997; 62:535-44. . View in PubMed

Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization Cytogenet Cell Genet. 1997; 77(3-4):288-9. . View in PubMed

Calbindin-D28K in the nucleus of nerve growth factor-treated PC12 cells Neuroreport. 1996 Nov 04; 7(15-17):2419-22. . View in PubMed

Cell death in the CNS of the Wnt-1 mutant mouse J Neurobiol. 1996 Nov; 31(3):275-82. . View in PubMed

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway Development. 1996 Sep; 122(9):2885-94. . View in PubMed

Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats Biochim Biophys Acta. 1996 May 02; 1306(2-3):147-52. . View in PubMed

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development Genes Dev. 1996 Feb 01; 10(3):313-24. . View in PubMed

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite Genes Dev. 1995 Dec 01; 9(23):2911-22. . View in PubMed

Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties Exp Cell Res. 1995 Oct; 220(2):363-73. . View in PubMed

A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain Mech Dev. 1995 Sep; 53(1):87-96. . View in PubMed

Development of midbrain and anterior hindbrain ocular motoneurons in normal and Wnt-1 knockout mice J Neurobiol. 1995 Aug; 27(4):457-69. . View in PubMed

Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS Development. 1994 Aug; 120(8):2213-24. . View in PubMed

Cell signalling in induction and anterior-posterior patterning of the vertebrate central nervous system Curr Opin Neurobiol. 1993 Feb; 3(1):4-7. . View in PubMed

Cloning developmentally regulated gene families Methods Enzymol. 1993; 225:653-63. . View in PubMed

A new nomenclature for int-1 and related genes: the Wnt gene family Cell. 1991 Jan 25; 64(2):231. . View in PubMed

Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues Development. 1990 Feb; 108(2):281-7. . View in PubMed

A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression Development. 1987 Apr; 99(4):493-500. . View in PubMed

cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin Differentiation. 1987; 34(1):68-78. . View in PubMed

An analysis of the effects of increasing doses of ionizing radiation to the exteriorized rat ovary on follicular development, atresia, and serum gonadotropin levels Am J Obstet Gynecol. 1986 Feb; 154(2):306-9. . View in PubMed

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