DSR Faculty

Neil I. Segil, PhD
Neil I. Segil, PhD
Professor of Stem Cell Biology and Regenerative Medicine
Stem Cell Biology & Regenerative Medicine
BCC 506 1425 San Pablo Street University Park Campus Los Angeles

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1 Elife. 2019 04 29; 8. . View in PubMed

Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs J Vis Exp. 2018 06 01; (136). . View in PubMed

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear Sci Rep. 2017 05 31; 7(1):2497. . View in PubMed

Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance Elife. 2017 07 12; 6. . View in PubMed

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter Development. 2016 Mar 01; 143(5):841-50. . View in PubMed

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates Elife. 2016 12 14; 5. . View in PubMed

Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea Development. 2016 05 01; 143(9):1632. . View in PubMed

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice J Neurosci. 2016 04 27; 36(17):4758-70. . View in PubMed

Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea Development. 2015 Oct 15; 142(20):3529-36. . View in PubMed

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice J Neurosci. 2015 Mar 11; 35(10):4280-6. . View in PubMed

Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear Front Cell Neurosci. 2015; 9:190. . View in PubMed

Nucleocytoplasmic connections and deafness J Clin Invest. 2013 Feb; 123(2):553-5. . View in PubMed

EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals Dev Biol. 2012 Mar 01; 363(1):191-200. . View in PubMed

Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa J Neurosci. 2011 Jun 01; 31(22):8046-58. . View in PubMed

BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea J Neurosci. 2010 Nov 10; 30(45):15044-51. . View in PubMed

Development and regeneration of the inner ear Ann N Y Acad Sci. 2009 Jul; 1170:28-33. . View in PubMed

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti Dev Cell. 2009 Jan; 16(1):58-69. . View in PubMed

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode Development. 2008 Jul; 135(13):2251-61. . View in PubMed

Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development Development. 2007 Dec; 134(24):4405-15. . View in PubMed

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis J Neurosci. 2007 Feb 07; 27(6):1434-44. . View in PubMed

A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development Development. 2006 Aug; 133(15):2817-26. . View in PubMed

Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells Nature. 2006 Jun 22; 441(7096):984-7. . View in PubMed

Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea Brain Res. 2006 May 26; 1091(1):282-8. . View in PubMed

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation Development. 2006 May; 133(9):1767-78. . View in PubMed

Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear J Comp Neurol. 2004 Sep 27; 477(4):412-21. . View in PubMed

In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme Dev Biol. 2004 Aug 15; 272(2):432-47. . View in PubMed

Math1-driven GFP expression in the developing nervous system of transgenic mice Gene Expr Patterns. 2003 Aug; 3(4):389-95. . View in PubMed

Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d Nat Cell Biol. 2003 May; 5(5):422-6. . View in PubMed

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination Development. 2002 May; 129(10):2495-505. . View in PubMed

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice Biochem Biophys Res Commun. 2001 Jun 01; 284(1):142-9. . View in PubMed

p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti Development. 1999 Apr; 126(8):1581-90. . View in PubMed

The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors J Biol Chem. 1997 Nov 21; 272(47):29852-8. . View in PubMed

Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization Genes Dev. 1996 Oct 01; 10(19):2389-400. . View in PubMed

The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase J Biol Chem. 1992 Sep 25; 267(27):19035-8. . View in PubMed

Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity Science. 1991 Dec 20; 254(5039):1814-6. . View in PubMed

Differential phosphorylation of the transcription factor Oct1 during the cell cycle Science. 1991 Aug 30; 253(5023):1022-6. . View in PubMed

Cell-cycle-regulated phosphorylation of the transcription factor Oct-1 Cold Spring Harb Symp Quant Biol. 1991; 56:285-92. . View in PubMed

Development and hormone regulation of androgen receptor levels in the sexually dimorphic larynx of Xenopus laevis Dev Biol. 1989 Jan; 131(1):111-8. . View in PubMed

Enolase isoenzymes in adult and developing Xenopus laevis and characterization of a cloned enolase sequence Biochem J. 1988 Apr 01; 251(1):31-9. . View in PubMed

The nervus terminalis ganglion in Anguilla rostrata: an immunocytochemical and HRP histochemical analysis Brain Res. 1987 Dec 08; 436(1):148-52. . View in PubMed

Androgen-binding levels in a sexually dimorphic muscle of Xenopus laevis Gen Comp Endocrinol. 1987 Apr; 66(1):95-101. . View in PubMed

Pyruvate kinase isozymes in oocytes and embryos from the frog Xenopus laevis Comp Biochem Physiol B. 1987; 88(3):743-9. . View in PubMed

Androgen binding in the brain and electric organ of a mormyrid fish J Comp Physiol A. 1986 Oct; 159(4):535-44. . View in PubMed

Androgen-induced myogenesis and chondrogenesis in the larynx of Xenopus laevis Dev Biol. 1986 Jan; 113(1):135-40. . View in PubMed

Is cerebellar granule cell migration regulated by an internal clock? J Neurosci. 1984 Nov; 4(11):2850-5.. View in PubMed

Secondary lens formation caused by implantation of pituitary into the eyes of the newt, Notophthalmus Dev Biol. 1976 Aug; 52(1):128-40. . View in PubMed

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