Faculty

Aaron Nagiel, MD, PhD
Aaron Nagiel, MD, PhD
Assistant Professor of Ophthalmology
Pediatrics
4640 West Sunset Boulevard Off Campus Los Angeles
The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

https://www.chla.org/research/nagiel-laboratory

: Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship, 2016-2019

: Ooops. Something went wrong., 2016-2019

: Ronald G. Michels Fellowship Foundation Award, 2016-2017

: Ooops. Something went wrong., 2016-2017

Jules Stein Eye Institute: Excellence in Research Award, 2016

Jules Stein Eye Institute: Ooops. Something went wrong., 2016

: Heed Ophthalmic Foundation Fellowship, 2015-2016

: Ooops. Something went wrong., 2015-2016

Jules Stein Eye Institute: Pepose-Saltzman Young Investigator ARVO Award, 2014-2015

Jules Stein Eye Institute: Ooops. Something went wrong., 2014-2015

Jules Stein Eye Institute: Ooops. Something went wrong., 2014

: Heed Foundation Residents Retreat Participant, 2014

: Ooops. Something went wrong., 2014

Jules Stein Eye Institute: Excellence in Research Award, 2014

: ARVO National Eye Institute Travel Grant, 2014

Jules Stein Eye Institute: Robert E. Christensen Research Award, 2013

Jules Stein Eye Institute: Ooops. Something went wrong., 2013

The Rockefeller University: Sumi Koide Travel Fellowship, 2010

The Rockefeller University: Ooops. Something went wrong., 2010

: Finalist, Paul and Daisy Soros Fellowship for New Americans, 2006

: Ooops. Something went wrong., 2006

: Ooops. Something went wrong., 2001-2003

: John Harvard Scholarship, 2001-2003

Harvard University: Ooops. Something went wrong., 2001

Harvard University: Detur Prize, 2001

Diagnostic and Therapeutic Challenges Retina. 2019 Jul 30. . View in PubMed

Correspondence Retina. 2019 Jan; 39(1):e4. . View in PubMed

Correspondence Retina. 2018 Nov 07. . View in PubMed

Practice Patterns of Endophthalmitis Treatment: An International Survey of Retina Specialists Ophthalmol Retina. 2018 Sep; 2(9):979-980. . View in PubMed

Endoscopy for Pediatric Retinal Disease Asia Pac J Ophthalmol (Phila). 2018 May 30. . View in PubMed

Gene therapy for RPE65-mediated retinal dystrophies Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. . View in PubMed

Endoscopy for Pediatric Retinal Disease Asia Pac J Ophthalmol (Phila). 2018 May-Jun; 7(3):200-207. . View in PubMed

EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY Retina. 2018 Apr; 38(4):748-754. . View in PubMed

PERIPAPILLARY PACHYCHOROID SYNDROME Retina. 2018 09; 38(9):1652-1667. . View in PubMed

SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S87-S91. . View in PubMed

Retina. 2017 Nov 10. . View in PubMed

Retina. 2017 Nov 10. . View in PubMed

SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS Retin Cases Brief Rep. 2017 Oct 12. . View in PubMed

VITRECTOMY-ASSISTED BIOPSY FOR MOLECULAR PROGNOSTICATION OF CHOROIDAL MELANOMA 2 MM OR LESS IN THICKNESS WITH A 27-GAUGE CUTTER Retina. 2017 Jul; 37(7):1377-1382. . View in PubMed

Am J Ophthalmol. 2017 Feb; 174:85-94. . View in PubMed

Am J Ophthalmol. 2017 Feb; 174:85-94. . View in PubMed

Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. . View in PubMed

Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. . View in PubMed

Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. . View in PubMed

Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. . View in PubMed

Retina. 2016 Apr; 36(4):660-78. . View in PubMed

Retina. 2016 Apr; 36(4):660-78. . View in PubMed

Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. . View in PubMed

Isolated Zygomycetes Endophthalmitis: A Case Report Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. . View in PubMed

Isolated Zygomycetes Endophthalmitis: A Case Report Ophthal Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. . View in PubMed

JAMA Ophthalmol. 2015 Jun; 133(6):629-30. . View in PubMed

JAMA Ophthalmol. 2015 Jun; 133(6):629-30. . View in PubMed

Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography Retina. 2015 Apr; 35(4):638-47. . View in PubMed

Retin Cases Brief Rep. 2015; 9(4):269-72. . View in PubMed

Retin Cases Brief Rep. 2015; 9(4):269-72. . View in PubMed

Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomographyAm J Ophthalmol. 2013 Nov; 156(5):981-988. e2. . View in PubMed

Retinopathy of prematurity residency trainingOphthalmology. 2012 Dec; 119(12):2644-5. e1-2. . View in PubMed

Arch Ophthalmol. 2012 Dec; 130(12):1605-8. . View in PubMed

Arch Ophthalmol. 2012 Dec; 130(12):1605-8. . View in PubMed

Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. . View in PubMed

Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. . View in PubMed

Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. . View in PubMed

Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. . View in PubMed

J Neurosci. 2008 Aug 20; 28(34):8442-53. . View in PubMed

J Neurosci. 2008 Aug 20; 28(34):8442-53. . View in PubMed

Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells J Biol Chem. 2004 Sep 24; 279(39):40659-69. . View in PubMed

Powered by SC CTSI

Affiliated Faculty at UPC