Faculty
My laboratory will focus on utilizing patient derived induced pluripotent stem cells (iPSC) and state-of-the-art gene editing technologies, such as CRISPR, to a) model and study mechanisms of lung disease development and b) investigate approaches for tissue regeneration and stem cell mediated repair of the airway epithelium.
American Thoracic Society: ATS Assembly on Respiratory Cell and Molecular Biology Carol Basbaum Award , 2017
British Council: British Councils Alumni Award for Professional Achievement in the USA Finalist, 2017
American Physiology Society: Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award, 2014
American Heart Association : Finalist, Cournand and Comroe Young Investigator Award, 2009
House of Commons: Finalist, Britain's Top Young Researcher in Biosciences and Medicine, 2005
Blockade of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the tricyclic antidepressant clomipramine J Pharmacol Sci. 2018 May; 137(1):61-66. . View in PubMed
The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels Life Sci. 2018 Mar 15; 197:46-55. . View in PubMed
Inhibition of the voltage-dependent K+ current by the class Ic antiarrhythmic drug flecainide in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2018 12; 45(12):1286-1292. . View in PubMed
Inhibition of the Voltage-Dependent K+ Current by the Tricyclic Antidepressant Desipramine in Rabbit Coronary Arterial Smooth Muscle Cells Cardiovasc Toxicol. 2018 06; 18(3):252-260. . View in PubMed
Inhibitory effect of the tricyclic antidepressant amitriptyline on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2018 02; 45(2):205-212. . View in PubMed
CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed
Establishment of the early cilia preassembly protein complex during motile ciliogenesis Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1221-E1228. . View in PubMed
The vasorelaxant effect of mitiglinide via activation of voltage-dependent K+ channels and SERCA pump in aortic smooth muscle Life Sci. 2017 Nov 01; 188:1-9. . View in PubMed
The PPARa activator fenofibrate inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Eur J Pharmacol. 2017 Oct 05; 812:155-162. . View in PubMed
The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. . View in PubMed
Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration Cell Stem Cell. 2017 12 07; 21(6):712-714. . View in PubMed
Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells J Biosci. 2016 Dec; 41(4):659-666. . View in PubMed
The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. . View in PubMed
Alterations of voltage-dependent K(+) channels in the mesenteric artery during the early and chronic phases of diabetes Clin Exp Pharmacol Physiol. 2016 09; 43(9):808-17. . View in PubMed
The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle Vascul Pharmacol. 2016 09; 84:38-46. . View in PubMed
Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells Pharmacology. 2016; 98(5-6):220-227. . View in PubMed
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs Cell Rep. 2015 Sep 01; 12(9):1385-90. . View in PubMed
Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs Cell Stem Cell. 2015 Apr 02; 16(4):367-72. . View in PubMed
W-7 inhibits voltage-dependent K(+) channels independent of calmodulin activity in rabbit coronary arterial smooth muscle cells Eur J Pharmacol. 2015 Mar 05; 750:14-9. . View in PubMed
The Effects of the Selective Serotonin Reuptake Inhibitor Fluvoxamine on Voltage-Dependent K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells Biol Pharm Bull. 2015; 38(8):1208-13. . View in PubMed
Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. . View in PubMed
Side-effects of protein kinase inhibitors on ion channels J Biosci. 2013 Dec; 38(5):937-49. . View in PubMed
Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension Physiol Rep. 2013 Dec 01; 1(7):e00190. . View in PubMed
Human models for smooth muscle cell differentiationFocus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C287-8. . View in PubMed
Regulation of ca(2+) signaling in pulmonary hypertension Korean J Physiol Pharmacol. 2013 Feb; 17(1):1-8. . View in PubMed
Animal models of pulmonary hypertension: Rho kinase inhibition Prog Biophys Mol Biol. 2012 Aug; 109(3):67-75. . View in PubMed
"Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cellsFocus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". Am J Physiol Cell Physiol. 2012 Jul 15; 303(2):C113-4. . View in PubMed
PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C405-11. . View in PubMed
Identification of functional progenitor cells in the pulmonary vasculature Pulm Circ. 2012 Jan-Mar; 2(1):84-100. . View in PubMed
Direct effect of protein kinase C inhibitors on cardiovascular ion channels BMB Rep. 2011 Sep; 44(9):559-65. . View in PubMed
Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines Stem Cells. 2011 Jul; 29(7):1158-64. . View in PubMed
Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling Compr Physiol. 2011 Jul; 1(3):1555-602. . View in PubMed
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant Mol Pharmacol. 2011 Mar; 79(3):381-8. . View in PubMed
Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels Pulm Circ. 2011 Jan 01; 1(1):48-71. . View in PubMed
Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats Prog Biophys Mol Biol. 2010 Sep; 103(1):88-94. . View in PubMed
Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101. . View in PubMed
Idiopathic pulmonary arterial hypertension Dis Model Mech. 2010 May-Jun; 3(5-6):268-73. . View in PubMed
Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension Am J Physiol Cell Physiol. 2010 May; 298(5):C1217-25. . View in PubMed
Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension Am J Physiol Lung Cell Mol Physiol. 2010 Apr; 298(4):L548-57. . View in PubMed
Patho-, physiological roles of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells J Smooth Muscle Res. 2010; 46(2):89-105. . View in PubMed
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76. . View in PubMed
Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells Ann N Y Acad Sci. 2009 Oct; 1177:101-11. . View in PubMed
Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8. . View in PubMed
Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L979-86. . View in PubMed
Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation Am J Physiol Lung Cell Mol Physiol. 2009 Mar; 296(3):L347-60. . View in PubMed
Fine tuning I(CRAC): the interactions of STIM-1 and Orai J Physiol. 2009 Jan 15; 587(1):15-6. . View in PubMed
Bringing down the ROS: a new therapeutic approach for PPHN Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L976-8. . View in PubMed
Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1048-55. . View in PubMed
Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L648-57. . View in PubMed
Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L61-70. . View in PubMed
Regulation of pulmonary vasoconstriction by agonists and caveolae Exp Lung Res. 2008 May; 34(4):195-208. . View in PubMed
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling Circulation. 2008 Jan 01; 117(1):61-9. . View in PubMed
Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L952-9. . View in PubMed
Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells Am J Physiol Cell Physiol. 2007 Sep; 293(3):C928-37. . View in PubMed
