Faculty

Cheng-Ming Chuong, MD, PhD
Cheng-Ming Chuong, MD, PhD
Professor of Pathology;Director of Graduate Programs
Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles

Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin Exp Dermatol. 2019 Feb 08. . View in PubMed

Instructive role of melanocytes during pigment pattern formation of the avian skin Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6884-6890. . View in PubMed

Comprehensive molecular and cellular studies suggest avian scutate scales are secondarily derived from feathers, and more distant from reptilian scales Sci Rep. 2018 Nov 13; 8(1):16766. . View in PubMed

Epidermal Darwinism and Competitive Equilibrium within the Epidermis Cell Stem Cell. 2018 Nov 01; 23(5):627-629. . View in PubMed

Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage colouration Gigascience. 2018 Sep 06. . View in PubMed

Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling Nat Commun. 2018 Apr 09; 9(1):1345. . View in PubMed

Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage coloration Gigascience. 2018 10 01; 7(10). . View in PubMed

Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks Nat Commun. 2018 12 18; 9(1):5377. . View in PubMed

Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling Nat Commun. 2018 04 09; 9(1):1345. . View in PubMed

Getting to the Core of the Dermal Papilla J Invest Dermatol. 2017 Nov; 137(11):2250-2253. . View in PubMed

Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10930-10935. . View in PubMed

Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in BudgerigarsCell. 2017 Oct 05; 171(2):427-439. e21. . View in PubMed

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme Nat Commun. 2017 Jan 20; 8:ncomms14139. . View in PubMed

Getting to the Core of the Dermal Papilla J Invest Dermatol. 2017 11; 137(11):2250-2253. . View in PubMed

Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10930-10935. . View in PubMed

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme Nat Commun. 2017 01 20; 8:ncomms14139. . View in PubMed

Corrigendum: Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 11 14; 6:31257. . View in PubMed

Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 05 23; 6:26436. . View in PubMed

Evolution and functional significance of derived sternal ossification patterns in ornithothoracine birds J Evol Biol. 2015 Aug; 28(8):1550-67. . View in PubMed

Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Dev Dyn. 2015 Aug; 244(8):905-20. . View in PubMed

Feather on the Cap of Medicine J Invest Dermatol. 2015 Jul; 135(7):1719-1721. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin BMC Genomics. 2015 Jan 23; 16:22. . View in PubMed

Development, regeneration, and evolution of feathers Annu Rev Anim Biosci. 2015; 3:169-95. . View in PubMed

An integrative approach to understanding bird origins Science. 2014 Dec 12; 346(6215):1253293. . View in PubMed

Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15114-9. . View in PubMed

Defining dermal adipose tissue Exp Dermatol. 2014 Sep; 23(9):629-31. . View in PubMed

Genomic organization, transcriptomic analysis, and functional characterization of avian a- and ß-keratins in diverse feather forms Genome Biol Evol. 2014 Aug 24; 6(9):2258-73. . View in PubMed

Dkk2/Frzb in the dermal papillae regulates feather regeneration Dev Biol. 2014 Mar 15; 387(2):167-78. . View in PubMed

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis J Invest Dermatol. 2014 Jan; 134(1):24-32. . View in PubMed

Environmental reprogramming and molecular profiling in reconstitution of human hair follicles Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19658-9. . View in PubMed

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):E2106-15. . View in PubMed

Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1351-6. . View in PubMed

Feather regeneration as a model for organogenesis Dev Growth Differ. 2013 Jan; 55(1):139-48. . View in PubMed

Homology and Potential Cellular and Molecular Mechanisms for the Development of Unique Feather Morphologies in Early Birds Geosciences (Basel). 2012 Sep 14; 2(3):157-177. . View in PubMed

From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis Differentiation. 2011 Jun; 81(5):307-14. . View in PubMed

A simplified procedure to reconstitute hair-producing skin Tissue Eng Part C Methods. 2011 Apr; 17(4):391-400. . View in PubMed

In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr; 3(4):388-407. . View in PubMed

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2 Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. . View in PubMed

Building complex tissues: high-throughput screening for molecules required in hair engineering J Invest Dermatol. 2009 Apr; 129(4):815-7. . View in PubMed

Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity Int J Dev Biol. 2009; 53(5-6):857-68. . View in PubMed

Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface Am J Pathol. 2008 Nov; 173(5):1339-48. . View in PubMed

Complex hair cycle domain patterns and regenerative hair waves in living rodents J Invest Dermatol. 2008 May; 128(5):1071-80. . View in PubMed

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration Nature. 2008 Jan 17; 451(7176):340-4. . View in PubMed

Defining hair follicles in the age of stem cell bioengineering J Invest Dermatol. 2007 Sep; 127(9):2098-100. . View in PubMed

An integrated gene regulatory network controls stem cell proliferation in teeth PLoS Biol. 2007 Jun; 5(6):e159. . View in PubMed

Developmental biologyThe Turing model comes of molecular age. Science. 2006 Dec 01; 314(5804):1397-8. . View in PubMed

Distinct mechanisms underlie pattern formation in the skin and skin appendages Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. . View in PubMed

Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis Curr Top Dev Biol. 2006; 72:237-74. . View in PubMed

Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers Mech Dev. 2004 Feb; 121(2):157-71. . View in PubMed

Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models Int J Dev Biol. 2004; 48(2-3):117-35. . View in PubMed

Evo-Devo of amniote integuments and appendages Int J Dev Biol. 2004; 48(2-3):249-70. . View in PubMed

A mouthful of epithelial-mesenchymal interactions J Invest Dermatol. 2003 Dec; 121(6):vii-viii. . View in PubMed

Development and evolution of the amniote integument: current landscape and future horizon J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):1-11. . View in PubMed

Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):42-56. . View in PubMed

'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation Development. 2003 Jan; 130(2):379-89. . View in PubMed

Homeobox genes, fetal wound healing, and skin regional specificity J Invest Dermatol. 2003 Jan; 120(1):9-11. . View in PubMed

D-RNAi (messenger RNA-antisense DNA interference) as a novel defense system against cancer and viral infections Curr Cancer Drug Targets. 2001 Nov; 1(3):241-7. . View in PubMed

Eur J Dermatol. 2001 Jul-Aug; 11(4):286-92. . View in PubMed

Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval Kaohsiung J Med Sci. 2001 Jun; 17(7):351-7. . View in PubMed

A Novel mRNA-cDNA interference phenomenon for silencing bcl-2 expression in human LNCaP cells Biochem Biophys Res Commun. 2001 Mar 02; 281(3):639-44. . View in PubMed

Conservation of early odontogenic signaling pathways in Aves Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10044-9. . View in PubMed

Evo-devo of feathers and scales: building complex epithelial appendages Curr Opin Genet Dev. 2000 Aug; 10(4):449-56. . View in PubMed

Dynamic expression of lunatic fringe during feather morphogenesis: a switch from medial-lateral to anterior-posterior asymmetry Mech Dev. 2000 Mar 01; 91(1-2):351-4. . View in PubMed

beta-catenin in epithelial morphogenesis: conversion of part of avian foot scales into feather buds with a mutated beta-catenin Dev Biol. 2000 Mar 01; 219(1):98-114. . View in PubMed

Avian integument provides multiple possibilities to analyse different phases of skin appendage morphogenesis J Investig Dermatol Symp Proc. 1999 Dec; 4(3):333-7. . View in PubMed

Early events in skin appendage formation: induction of epithelial placodes and condensation of dermal mesenchyme J Investig Dermatol Symp Proc. 1999 Dec; 4(3):302-6. . View in PubMed

In vivo analysis of cancerous gene expression by RNA-polymerase chain reaction Nucleic Acids Res. 1999 Dec 01; 27(23):4585-9. . View in PubMed

Generation of full-length cDNA library from single human prostate cancer cells Biotechniques. 1999 Sep; 27(3):410-2, 414. . View in PubMed

Epidermal dysplasia and abnormal hair follicles in transgenic mice overexpressing homeobox gene MSX-2 J Invest Dermatol. 1999 Aug; 113(2):230-7. . View in PubMed

Lineage and pluripotentiality of epithelial precursor cells in developing chicken skin Biochem Cell Biol. 1998; 76(6):1069-77. . View in PubMed

Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen J Cell Sci. 1997 Nov; 110 ( Pt 21):2691-701. . View in PubMed

Expression of two Ig family adhesion molecules in the murine hair cycle: DCC in the bulge epithelia and NCAM in the follicular papilla J Invest Dermatol. 1997 Nov; 109(5):672-8. . View in PubMed

Isolation and characterization of chicken beta-catenin Gene. 1997 Sep 01; 196(1-2):201-7. . View in PubMed

Asymmetric expression of Notch/Delta/Serrate is associated with the anterior-posterior axis of feather buds Dev Biol. 1997 Aug 01; 188(1):181-7. . View in PubMed

Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis J Cell Physiol. 1997 Feb; 170(2):153-65. . View in PubMed

FGF induces new feather buds from developing avian skin J Invest Dermatol. 1996 Dec; 107(6):797-803. . View in PubMed

Early events during avian skin appendage regeneration: dependence on epithelial-mesenchymal interaction and order of molecular reappearance J Invest Dermatol. 1996 Oct; 107(4):639-46. . View in PubMed

cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog Biochem Biophys Res Commun. 1996 Feb 06; 219(1):180-5. . View in PubMed

Homeobox genes Msx-1 and Msx-2 are associated with induction and growth of skin appendages J Invest Dermatol. 1995 May; 104(5):711-9. . View in PubMed

cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction Dev Biol. 1994 Aug; 164(2):383-97. . View in PubMed

Effect of in ovo retinoic acid exposure on forebrain neural crest: in vitro analysis reveals up-regulation of N-CAM and loss of mesenchymal phenotype Dev Dyn. 1994 Jun; 200(2):89-102. . View in PubMed

Asymmetric patterns of gap junctional communication in developing chicken skin Development. 1993 Sep; 119(1):85-96. . View in PubMed

Design of compact multiple cloning sites Biotechniques. 1993 Aug; 15(2):208, 210-2, 214. . View in PubMed

Adhesion molecules in skeletogenesis: IINeural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis. J Cell Physiol. 1993 Aug; 156(2):399-411. . View in PubMed

Adhesion molecules and homeoproteins in the phenotypic determination of skin appendages J Invest Dermatol. 1993 Jul; 101(1 Suppl):10S-15S. . View in PubMed

Activin enhances chondrogenesis of limb bud cells: stimulation of precartilaginous mesenchymal condensations and expression of NCAM Dev Biol. 1993 Feb; 155(2):545-57. . View in PubMed

Adhesion molecules in skeletogenesis: ITransient expression of neural cell adhesion molecules (NCAM) in osteoblasts during endochondral and intramembranous ossification. J Bone Miner Res. 1992 Dec; 7(12):1435-46. . View in PubMed

Adhesion molecules in skin development: morphogenesis of feather and hair Ann N Y Acad Sci. 1991 Dec 26; 642:263-80. . View in PubMed

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing Am J Pathol. 1991 Feb; 138(2):427-40. . View in PubMed

Gradients of homeoproteins in developing feather buds Development. 1990 Dec; 110(4):1021-30. . View in PubMed

Differential roles of multiple adhesion molecules in cell migration: granule cell migration in cerebellum Experientia. 1990 Sep 15; 46(9):892-9. . View in PubMed

Adhesion molecules (N-CAM and tenascin) in embryonic development and tissue regeneration J Craniofac Genet Dev Biol. 1990; 10(2):147-61. . View in PubMed

Alterations in the Xenopus retinotectal projection by antibodies to Xenopus N-CAM Dev Biol. 1988 Sep; 129(1):217-30. . View in PubMed

Expression of cell adhesion molecules during embryonic inductionIII. Development of the otic placode. Dev Biol. 1987 Jan; 119(1):217-30. . View in PubMed

Antibodies to liver cell adhesion molecule perturb inductive interactions and alter feather pattern and structure Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8235-9. . View in PubMed

Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions J Cell Biol. 1986 Jul; 103(1):145-58. . View in PubMed

Differential distribution of cell adhesion molecules during histogenesis of the chick nervous system J Neurosci. 1986 Mar; 6(3):739-58. . View in PubMed

Expression sequences of cell adhesion molecules Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6942-6. . View in PubMed

Expression of cell-adhesion molecules in embryonic inductionI. Morphogenesis of nestling feathers. J Cell Biol. 1985 Sep; 101(3):1009-26. . View in PubMed

Expression of cell-adhesion molecules in embryonic inductionII. Morphogenesis of adult feathers. J Cell Biol. 1985 Sep; 101(3):1027-43. . View in PubMed

Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6881-5. . View in PubMed

Alterations in neural cell adhesion molecules during development of different regions of the nervous system J Neurosci. 1984 Sep; 4(9):2354-68. . View in PubMed

Alteration of the retinotectal map in Xenopus by antibodies to neural cell adhesion molecules Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4222-6. . View in PubMed

Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice Proc Natl Acad Sci U S A. 1982 Nov; 79(22):7036-40. . View in PubMed

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Affiliated Faculty at UPC