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Jing-Hsiung James Ou, PhD

Interim Chair and Professor of Molecular Microbiology & Immunology, Fletcher Jones Foundation Chair in Molecular Microbiology and Immunology

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Phone +1 323 442 1720
Email jamesou@usc.edu
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Overview

The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.

Publications

  • Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages PLoS Pathog. 2024 Mar 11; 20(3):e1012079. . View in PubMed
  • Regulation of Mitochondrial Metabolism by Hepatitis B Virus Viruses. 2023 Nov 30; 15(12). . View in PubMed
  • Regulation of hepatitis B virus replication by autophagic membranes Autophagy. 2023 04; 19(4):1357-1358. . View in PubMed
  • ß-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy Front Immunol. 2023; 14:1204907. . View in PubMed
  • Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome Cell Rep. 2023 08 29; 42(8):112990. . View in PubMed
  • Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1ß to downregulate PPARa and FOXO3 Cell Rep. 2022 Jul 05; 40(1):111068. . View in PubMed
  • Biographical Feature: James HStrauss, Jr. (1938-2021). J Virol. 2022 May 11; 96(9):e0015522. . View in PubMed
  • Pathogenicity and virulence of Hepatitis B virus Virulence. 2022 12; 13(1):258-296. . View in PubMed
  • Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model STAR Protoc. 2022 06 17; 3(2):101364. . View in PubMed
  • Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1ß to downregulate PPARa and FOXO3 Cell Rep. 2022 01 25; 38(4):110284. . View in PubMed
  • Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2201927119. . View in PubMed
  • Hepatitis B virus e antigen and viral persistence Curr Opin Virol. 2021 Dec; 51:158-163. . View in PubMed
  • Regulators of liver cancer stem cells World J Stem Cells. 2021 Aug 26; 13(8):1127-1133. . View in PubMed
  • Autophagy in HCV Replication and Protein Trafficking Int J Mol Sci. 2021 Jan 22; 22(3). . View in PubMed
  • Mechanisms of Hepatitis B Virus-Induced Hepatocarcinogenesis Recent Results Cancer Res. 2021; 217:47-70. . View in PubMed
  • Hepatitis C Virus Induces the Ubiquitin-Editing Enzyme A20 via Depletion of the Transcription Factor Upstream Stimulatory Factor 1 To Support Its Replication mBio. 2019 Jul 23; 10(4). . View in PubMed
  • Hepatitis B Virus-Specific T Cells as a Biomarker for Discontinuation of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B Hepatology. 2019 Mar; 69(3):1342-1344. . View in PubMed
  • Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance J Virol. 2019 04 15; 93(8). . View in PubMed
  • Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy J Virol. 2018 Jul 15; 92(14). . View in PubMed
  • Regulation of Autophagy by Hepatitis C Virus for Its Replication DNA Cell Biol. 2018 Apr; 37(4):287-290. . View in PubMed
  • Mitophagy and hepatic cancer stem cells Autophagy. 2018; 14(4):715-716. . View in PubMed
  • Autophagy and mitophagy in hepatocarcinogenesis Mol Cell Oncol. 2018; 5(2):e1405142. . View in PubMed
  • Mechanisms of Hepatitis B Virus Persistence Trends Microbiol. 2018 Jan; 26(1):33-42. . View in PubMed
  • New insight into the role of autophagy in tumorigenesis Cell Stress. 2017 Dec 04; 1(3):136-138. . View in PubMed
  • Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem CellsMol Cell. 2017 Oct 19; 68(2):281-292. e5. . View in PubMed
  • Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication J Virol. 2017 Oct 15; 91(20). . View in PubMed
  • HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication PLoS Pathog. 2017 Sep; 13(9):e1006609. . View in PubMed
  • Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response Viruses. 2017 Aug 12; 9(8). . View in PubMed
  • Partial Hepatectomy and Castration of HBV Transgenic Mice Methods Mol Biol. 2017; 1540:259-266. . View in PubMed
  • Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6 J Virol. 2016 Dec 01; 90(23):10928-10935. . View in PubMed
  • Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission Immunity. 2016 05 17; 44(5):1204-14. . View in PubMed
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy. 2016; 12(1):1-222. . View in PubMed
  • Hepatitis C virus and autophagy Biol Chem. 2015 Nov; 396(11):1215-22. . View in PubMed
  • Autophagy, a double-edged sword in hepatocarcinogenesis Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. . View in PubMed
  • Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis Cell Death Differ. 2015 Jun; 22(6):1025-34. . View in PubMed
  • TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. 2015 May; 11(5):e1004937. . View in PubMed
  • Technical standards for hepatitis B virus X protein (HBx) research Hepatology. 2015 Apr; 61(4):1416-24. . View in PubMed
  • Oncogenic viruses and cancer Virol Sin. 2015 Apr; 30(2):83-4. . View in PubMed
  • Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma Virol Sin. 2015 Apr; 30(2):85-91. . View in PubMed
  • HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication PLoS Pathog. 2015 Mar; 11(3):e1004764. . View in PubMed
  • Virus control goes epigenetic PLoS Pathog. 2014 Sep; 10(9):e1004370. . View in PubMed
  • Functions of autophagy in normal and diseased liver Autophagy. 2013 Aug; 9(8):1131-58. . View in PubMed
  • Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry J Biol Chem. 2012 Dec 07; 287(50):41922-30. . View in PubMed
  • Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice J Virol. 2012 Sep; 86(18):9599-605. . View in PubMed
  • Replication of hepatitis C virus RNA on autophagosomal membranes J Biol Chem. 2012 May 25; 287(22):18036-43. . View in PubMed
  • Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells Mol Biotechnol. 2012 May; 51(1):1-8. . View in PubMed
  • Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy. 2012 Apr; 8(4):445-544. . View in PubMed
  • Enhancement of hepatitis B virus replication by androgen and its receptor in mice J Virol. 2012 Feb; 86(4):1904-10. . View in PubMed
  • Hepatitis C virus translation preferentially depends on active RNA replication PLoS One. 2012; 7(8):e43600. . View in PubMed
  • Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. 2012; 7(5):e36818. . View in PubMed
  • Autophagy required for hepatitis B virus replication in transgenic mice J Virol. 2011 Dec; 85(24):13453-6. . View in PubMed
  • IFN-a/ß and autophagy: tug-of-war between HCV and the host Autophagy. 2011 Nov; 7(11):1394-6. . View in PubMed
  • Inhibition of RIG-I-mediated signaling by Kaposi’s sarcoma-associated herpesvirus-encoded deubiquitinase ORF64 J Virol. 2011 Oct; 85(20):10899-904. . View in PubMed
  • Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Hepatology. 2011 Jul; 54(1):109-21. . View in PubMed
  • Effects of interferon-a/ß on HBV replication determined by viral load PLoS Pathog. 2011 Jul; 7(7):e1002159. . View in PubMed
  • The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway PLoS One. 2011; 6(7):e22979. . View in PubMed
  • Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury PLoS One. 2011; 6(10):e26240. . View in PubMed
  • Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. 2010 Dec 01; 185(11):6985-98. . View in PubMed
  • Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo J Virol. 2010 Sep; 84(18):9326-31. . View in PubMed
  • c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed
  • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription Sci Transl Med. 2010 May 19; 2(32):32ra35. . View in PubMed
  • Autophagy by hepatitis B virus and for hepatitis B virus Autophagy. 2010 May; 6(4):548-9. . View in PubMed
  • The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4383-8. . View in PubMed
  • Autophagy in viral replication and pathogenesis Mol Cells. 2010 Jan; 29(1):1-7. . View in PubMed
  • Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. . View in PubMed
  • PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis Autophagy. 2009 Feb; 5(2):244-6. . View in PubMed
  • Ubiquitin-independent degradation of hepatitis C virus F protein J Virol. 2009 Jan; 83(2):612-21. . View in PubMed
  • Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response Hepatology. 2008 Oct; 48(4):1054-61. . View in PubMed
  • Beyond autophagy: the role of UVRAG in membrane trafficking Autophagy. 2008 Aug; 4(6):817-20. . View in PubMed
  • Perturbation of autophagic pathway by hepatitis C virus Autophagy. 2008 Aug; 4(6):830-1. . View in PubMed
  • Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc J Biomed Sci. 2008 Jul; 15(4):417-25. . View in PubMed
  • Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein Virology. 2007 Jul 05; 363(2):454-61. . View in PubMed
  • Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology. 2007 Jan; 45(1):16-21. . View in PubMed
  • Redox modulation of the hepatitis C virus replication complex is calcium dependent Free Radic Biol Med. 2006 Nov 01; 41(9):1488-98. . View in PubMed
  • [Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population] Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. . View in PubMed
  • Mechanisms of liver injuryIII. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. . View in PubMed
  • Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein Virology. 2005 Nov 10; 342(1):150-8. . View in PubMed
  • Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein J Virol. 2004 Jul; 78(13):6908-14. . View in PubMed
  • The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo J Virol. 2004 Apr; 78(7):3797-802. . View in PubMed
  • Phosphorylation analysis of hepatitis B virus core protein in mammalian cells Methods Mol Med. 2004; 95:227-33. . View in PubMed
  • Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells Hepatology. 2004 Jan; 39(1):81-9. . View in PubMed
  • Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice Methods Mol Med. 2004; 95:295-302. . View in PubMed
  • A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis Lett Appl Microbiol. 2004; 39(5):407-12. . View in PubMed
  • [Horizontal gene transfer] Yi Chuan. 2003 Sep; 25(5):623-7. . View in PubMed
  • The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice J Hepatol. 2003 Aug; 39(2):262-8. . View in PubMed
  • Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway J Virol. 2003 Jul; 77(14):7707-12. . View in PubMed
  • Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4 J Biol Chem. 2003 Mar 14; 278(11):9353-60. . View in PubMed
  • Triple decoding of hepatitis C virus RNA by programmed translational frameshifting Mol Cell Biol. 2003 Mar; 23(5):1489-97. . View in PubMed
  • Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum J Virol. 2003 Jan; 77(2):1578-83. . View in PubMed
  • Membrane topology of the hepatitis C virus NS2 protein J Biol Chem. 2002 Sep 06; 277(36):33228-34. . View in PubMed
  • Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C Virology. 2002 Aug 15; 300(1):20-30. . View in PubMed
  • Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins J Virol. 2002 Jun; 76(12):5875-81. . View in PubMed
  • Enhancement of hepatitis B virus replication by its X protein in transgenic mice J Virol. 2002 Mar; 76(5):2579-84. . View in PubMed
  • Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase J Biol Chem. 2001 Dec 21; 276(51):47993-9. . View in PubMed
  • Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor J Virol. 2001 Sep; 75(18):8400-6. . View in PubMed
  • Transitional cell carcinoma in dialysis patients Eur Urol. 2000 Jan; 37(1):90-4. . View in PubMed
  • Activation of p53 tumor suppressor by hepatitis C virus core protein Virology. 1999 Nov 10; 264(1):134-41. . View in PubMed
  • Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation J Virol. 1999 Feb; 73(2):1239-44. . View in PubMed
  • Expression and Dimerization of Hepatitis C Virus Core Protein in Ecoli. Methods Mol Med. 1999; 19:325-30. . View in PubMed
  • Molecular biology of hepatitis B virus e antigen J Gastroenterol Hepatol. 1997 Oct; 12(9-10):S178-87. . View in PubMed
  • Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication J Gen Virol. 1997 Aug; 78 ( Pt 8):2055-65. . View in PubMed
  • Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor J Virol. 1997 Feb; 71(2):1301-9. . View in PubMed
  • Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter Virology. 1997 Jan 20; 227(2):515-8. . View in PubMed
  • Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication J Virol. 1996 Sep; 70(9):5845-51. . View in PubMed
  • Interaction between hepatitis C virus core protein and E1 envelope protein J Virol. 1996 Aug; 70(8):5177-82. . View in PubMed
  • Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22 Arch Virol. 1996; 141(3-4):425-38. . View in PubMed
  • Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter Virology. 1995 Dec 01; 214(1):198-206. . View in PubMed
  • Differential subcellular localization of hepatitis C virus core gene products Virology. 1995 Nov 10; 213(2):455-61. . View in PubMed
  • Detection of Cellular Proteins and Viral Core Protein Interacting with the 5′ Untranslated Region of Hepatitis C Virus RNA J Biomed Sci. 1995 Aug; 2(3):227-236. . View in PubMed
  • Key role of a CCAAT element in regulating hepatitis B virus surface protein expression Virology. 1995 Feb 01; 206(2):1155-8. . View in PubMed
  • Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs J Virol. 1995 Feb; 69(2):1025-9. . View in PubMed
  • Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3 Virology. 1994 Nov 15; 205(1):127-32. . View in PubMed
  • Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. . View in PubMed
  • Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment J Clin Microbiol. 1994 Sep; 32(9):2235-41. . View in PubMed
  • Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution Virology. 1994 Feb 15; 199(1):124-31. . View in PubMed
  • Cell cycle regulation of nuclear localization of hepatitis B virus core protein Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6459-63. . View in PubMed
  • Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation Mol Cell Biol. 1993 Jan; 13(1):443-8. . View in PubMed
  • Brefeldin A as a regulator of grp78 gene expression in mammalian cells J Biol Chem. 1992 Apr 05; 267(10):7128-33. . View in PubMed
  • Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex J Virol. 1992 Feb; 66(2):914-21. . View in PubMed
  • Characterization of the hepatitis B virus EnhI enhancer and X promoter complex J Virol. 1991 Dec; 65(12):6686-92. . View in PubMed
  • Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment J Virol. 1991 Sep; 65(9):5080-3. . View in PubMed
  • Phosphorylation of hepatitis B virus precore and core proteins J Virol. 1991 May; 65(5):2327-31. . View in PubMed

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