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Shahab Asgharzadeh, MD

Associate Professor of Pediatrics and Pathology

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Phone +1 323 361 8643
Email sasgharzadeh@chla.usc.edu
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Publications

  • Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children’s Oncology Group Trial ANBL12P1Transplant Cell Ther. 2021 06; 27(6):490. e1-490. e8. . View in PubMed
  • Ultra-High Dose Vitamin D in Pediatric Hematopoietic Stem Cell Transplantation: A Nonrandomized Controlled TrialTransplant Cell Ther. 2021 12; 27(12):1001. e1-1001. e9. . View in PubMed
  • ALK upregulates POSTN and WNT signaling to drive neuroblastoma Cell Rep. 2024 Mar 05; 43(3):113927. . View in PubMed
  • AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis Oncogene. 2024 Feb 27. . View in PubMed
  • KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children’s Oncology Group J Immunother Cancer. 2023 02; 11(2). . View in PubMed
  • Anti-CCL2 antibody combined with etoposide prolongs survival in a minimal residual disease mouse model of neuroblastoma Sci Rep. 2023 11 14; 13(1):19915. . View in PubMed
  • Impact of Genomic and Clinical Factors on Outcome of Children =18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN Amplification: A Children’s Oncology Group (COG) Report Clin Cancer Res. 2023 04 14; 29(8):1546-1556. . View in PubMed
  • Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma Br J Cancer. 2022 11; 127(11):2006-2015. . View in PubMed
  • Expression of neuroblastoma-related genes in bone marrow at end of high-risk neuroblastoma therapy Pediatr Blood Cancer. 2022 09; 69(9):e29719. . View in PubMed
  • Anti-disialoganglioside antibody internalization by neuroblastoma cells as a mechanism of immunotherapy resistance Cancer Immunol Immunother. 2022 Jan; 71(1):153-164. . View in PubMed
  • Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-ß/IL-6 pathway in neuroblastoma Oncoimmunology. 2022; 11(1):2146860. . View in PubMed
  • Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection Front Immunol. 2022; 13:831103. . View in PubMed
  • Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma Nat Commun. 2021 01 21; 12(1):511. . View in PubMed
  • Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma Oncoimmunology. 2021 01 04; 10(1):1838140. . View in PubMed
  • Revised Neuroblastoma Risk Classification System: A Report From the Children’s Oncology Group J Clin Oncol. 2021 10 10; 39(29):3229-3241. . View in PubMed
  • A genome-wide association study on medulloblastoma J Neurooncol. 2020 Apr; 147(2):309-315. . View in PubMed
  • Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma Genome Res. 2020 09; 30(9):1228-1242. . View in PubMed
  • Multi-site reproducibility of a human immunophenotyping assay in whole blood and peripheral blood mononuclear cells preparations using CyTOF technology coupled with Maxpar Pathsetter, an automated data analysis system Cytometry B Clin Cytom. 2020 03; 98(2):146-160. . View in PubMed
  • Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children’s Oncology Group J Clin Oncol. 2020 07 01; 38(19):2160-2169. . View in PubMed
  • Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens J Neurooncol. 2019 Nov; 145(2):375-383. . View in PubMed
  • Enhancing Natural Killer and CD8+ T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8+ T Cells with HLA-E Monospecific Monoclonal Antibodies Monoclon Antib Immunodiagn Immunother. 2019 Apr; 38(2):38-59. . View in PubMed
  • Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 11; 18(6):659-670. . View in PubMed
  • Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Cancer Res. 2019 05 01; 79(9):2208-2219. . View in PubMed
  • Rare MYC-amplified Neuroblastoma With Large Cell Histology Pediatr Dev Pathol. 2018 Sep-Oct; 21(5):461-466. . View in PubMed
  • MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children’s oncology group Oncotarget. 2018 Jan 19; 9(5):6416-6432. . View in PubMed
  • Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma Cancer Discov. 2018 05; 8(5):582-599. . View in PubMed
  • Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma Clin Cancer Res. 2018 11 15; 24(22):5673-5684. . View in PubMed
  • Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients J Natl Cancer Inst. 2018 10 01; 110(10):1084-1093. . View in PubMed
  • Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC Oncotarget. 2017 Oct 31; 8(53):91516-91529. . View in PubMed
  • Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383. . View in PubMed
  • TGFßR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch1418) with Natural Killer Cells. Clin Cancer Res. 2017 Feb 01; 23(3):804-813. . View in PubMed
  • NK Cell-derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells J Immunother. 2017 09; 40(7):265-276. . View in PubMed
  • Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells Cancer Res. 2017 09 15; 77(18):5142-5157. . View in PubMed
  • MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma Cancer Lett. 2016 Feb 28; 371(2):214-24. . View in PubMed
  • BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma PLoS One. 2016; 11(6):e0156907. . View in PubMed
  • More than the genes, the tumor microenvironment in neuroblastoma Cancer Lett. 2016 09 28; 380(1):304-14. . View in PubMed
  • Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy Neuro Oncol. 2016 Jan; 18(1):126-31. . View in PubMed
  • A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis Cancer Cell. 2015 Nov 09; 28(5):599-609. . View in PubMed
  • CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus Cancer Res. 2015 Aug 01; 75(15):3155-66. . View in PubMed
  • Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy J Natl Cancer Inst. 2015 Jul; 107(7). . View in PubMed
  • Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group study Br J Cancer. 2015 Jun 30; 113(1):57-63. . View in PubMed
  • Comparison of RNA-seq and microarray-based models for clinical endpoint prediction Genome Biol. 2015 Jun 25; 16:133. . View in PubMed
  • Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration Exp Cell Res. 2015 May 15; 334(1):78-89. . View in PubMed
  • Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers Clin Cancer Res. 2015 Apr 15; 21(8):1904-15. . View in PubMed
  • Tumor-associated macrophages in SHH subgroup of medulloblastomas Clin Cancer Res. 2015 Mar 15; 21(6):1457-65. . View in PubMed
  • Pediatric brain tumor cell lines J Cell Biochem. 2015 Feb; 116(2):218-24. . View in PubMed
  • Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations Nat Genet. 2015 08; 47(8):864-71. . View in PubMed
  • Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia Front Oncol. 2015; 5:191. . View in PubMed
  • MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival Cancer Res. 2014 Nov 01; 74(21):5999-6009. . View in PubMed
  • PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas Clin Cancer Res. 2014 Feb 15; 20(4):827-36. . View in PubMed
  • Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling PLoS One. 2014; 9(10):e108818. . View in PubMed
  • Trends in childhood brain tumor incidence, 1973-2009 J Neurooncol. 2013 Nov; 115(2):153-60. . View in PubMed
  • Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells Clin Immunol. 2013 Oct; 149(1):55-64. . View in PubMed
  • Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFß1 Cancer Immunol Immunother. 2013 Oct; 62(10):1637-48. . View in PubMed
  • Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells J Immunother. 2013 Jun; 36(5):319-29. . View in PubMed
  • The genetic landscape of high-risk neuroblastoma Nat Genet. 2013 Mar; 45(3):279-84. . View in PubMed
  • Copy number variation signature to predict human ancestry BMC Bioinformatics. 2012 Dec 27; 13:336. . View in PubMed
  • Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma Oncogene. 2012 Nov 15; 31(46):4859-67. . View in PubMed
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma J Clin Oncol. 2012 Oct 01; 30(28):3525-32. . View in PubMed
  • IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity J Clin Invest. 2012 Jun; 122(6):2221-33. . View in PubMed
  • Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity Cancer Res. 2012 Apr 15; 72(8):2068-78. . View in PubMed
  • Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors Stem Cells. 2012 Apr; 30(4):697-708. . View in PubMed
  • Neuroblastoma: issues in transplantation Biol Blood Marrow Transplant. 2012 Jan; 18(1 Suppl):S92-100. . View in PubMed
  • TARGETgene: a tool for identification of potential therapeutic targets in cancer PLoS One. 2012; 7(8):e43305. . View in PubMed
  • Bioinformatics for copy number variation data Methods Mol Biol. 2011; 719:235-49. . View in PubMed
  • NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome Cell. 2010 Jul 23; 142(2):218-29. . View in PubMed
  • Prognostic impact of gene expression-based classification for neuroblastoma J Clin Oncol. 2010 Jul 20; 28(21):3506-15. . View in PubMed
  • Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning Bioinformatics. 2010 Mar 15; 26(6):807-13. . View in PubMed
  • Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages J Clin Invest. 2009 Jun; 119(6):1524-36. . View in PubMed
  • Common variations in BARD1 influence susceptibility to high-risk neuroblastoma Nat Genet. 2009 Jun; 41(6):718-23. . View in PubMed
  • Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA Bioinformatics. 2009 May 15; 25(10):1223-30. . View in PubMed
  • ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome Cancer Cell. 2009 Apr 07; 15(4):328-40. . View in PubMed
  • An integrated cross-platform prognosis study on neuroblastoma patients Genomics. 2008 Oct; 92(4):195-203. . View in PubMed
  • Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors Pediatr Blood Cancer. 2008 Aug; 51(2):235-40. . View in PubMed
  • Chromosome 6p22 locus associated with clinically aggressive neuroblastoma N Engl J Med. 2008 Jun 12; 358(24):2585-93. . View in PubMed
  • Sparse representation and Bayesian detection of genome copy number alterations from microarray data Bioinformatics. 2008 Feb 01; 24(3):309-18. . View in PubMed
  • Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience Pediatr Blood Cancer. 2008 Feb; 50(2):312-8. . View in PubMed
  • Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue Pediatr Blood Cancer. 2007 Jul; 49(1):34-40. . View in PubMed
  • Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification J Natl Cancer Inst. 2006 Sep 06; 98(17):1193-203. . View in PubMed
  • Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2 J Exp Med. 2004 May 03; 199(9):1213-21. . View in PubMed

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