Hidekazu Tsukamoto

Hidekazu Tsukamoto

Professor of Pathology
MMR 1333 San Pablo St Health Sciences Campus Los Angeles

Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1ß and IL-17 upregulation in alcoholic hepatitis mice J Mol Med (Berl). 2020 Jul; 98(7):1021-1034. . View in PubMed

Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis J Clin Invest. 2020 Apr 01; 130(4):2129-2145. . View in PubMed

Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. . View in PubMed

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice JCI Insight. 2020 02 13; 5(3). . View in PubMed

Cell Death and Liver Disease Gut Liver. 2020 01 15; 14(1):20-29. . View in PubMed

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science J Gastroenterol. 2019 Mar; 54(3):218-225. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed

Alcoholic liver disease Nat Rev Dis Primers. 2018 08 16; 4(1):16. . View in PubMed

Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases Am J Pathol. 2017 Apr; 187(4):781-797. . View in PubMed

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood Hepatology. 2017 02; 65(2):475-490. . View in PubMed

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Mol Ther. 2017 01 04; 25(1):218-231. . View in PubMed

Alcoholic hepatitis: Translational approaches to develop targeted therapies Hepatology. 2016 10; 64(4):1343-55. . View in PubMed

Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-? 1. Cancer Gene Ther. 2016 08; 23(8):266-77.. View in PubMed

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese J Lipid Res. 2016 06; 57(6):1017-28. . View in PubMed

A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution Front Physiol. 2016; 7:579. . View in PubMed

ALPD 2015, Preface Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. . View in PubMed

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice J Neuroimmunol. 2015 Aug 15; 285:169-79. . View in PubMed

Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Pancreas. 2015 Aug; 44(6):882-7. . View in PubMed

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells J Hepatol. 2015 Feb; 62(2):388-97. . View in PubMed

Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells Hepatology. 2014 Mar; 59(3):1118-29. . View in PubMed

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice Hepatology. 2013 Jul; 58(1):108-19. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Epigenetic regulation of miR-34a expression in alcoholic liver injury Am J Pathol. 2012 Sep; 181(3):804-17. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Epigenetic cell fate regulation of hepatic stellate cells Hepatol Res. 2011 Jul; 41(7):675-82. . View in PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology. 2011 Jan; 53(1):96-105. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. . View in PubMed

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology. 2010 Mar; 51(3):986-95. . View in PubMed

Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 2010 Mar; 51(3):932-41. . View in PubMed

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed

Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol. 2009 Oct 15; 183(8):5232-43. . View in PubMed

"Second hit" models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed

Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas. 2009 Mar; 38(2):e47-52. . View in PubMed

C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene Oncogene. 2008 Dec 04; 27(53):6749-60. . View in PubMed

Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. . View in PubMed

Expression of carboxylesterase and lipase genes in rat liver cell-types Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. . View in PubMed

Fat paradox of steatohepatitis J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. . View in PubMed

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. . View in PubMed

Conceptual importance of identifying alcoholic liver disease as a lifestyle disease J Gastroenterol. 2007 Aug; 42(8):603-9. . View in PubMed

A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem. 2007 Apr 27; 282(17):12928-39. . View in PubMed

Epigenetic mechanism of stellate cell trans-differentiation J Hepatol. 2007 Feb; 46(2):352-3. . View in PubMed

Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. . View in PubMed

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. . View in PubMed

A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease Ann Rheum Dis. 2006 Apr; 65(4):508-14. . View in PubMed

Fat paradox in liver disease Keio J Med. 2005 Dec; 54(4):190-2. . View in PubMed

Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. . View in PubMed

A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease Addict Behav. 2005 Mar; 30(3):465-73. . View in PubMed

Adipogenic transcriptional regulation of hepatic stellate cells J Biol Chem. 2005 Feb 11; 280(6):4959-67. . View in PubMed

Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption Gastroenterology. 2004 May; 126(5):1387-99. . View in PubMed

Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed

Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. . View in PubMed

Aberrant HS1 molecule in a patient with systemic lupus erythematosus Genes Immun. 2003 Mar; 4(2):122-31. . View in PubMed

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001 Alcohol. 2002 Oct; 28(2):117-28. . View in PubMed

Alcoholic liver disease (ALD): a new domain for prevention efforts Subst Use Misuse. 2002; 37(14):1887-904. . View in PubMed

Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis Arthritis Rheum. 2001 Dec; 44(12):2819-27. . View in PubMed

Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E420-9. . View in PubMed

Defect of lck in a patient with common variable immunodeficiency Int J Mol Med. 2001 Jun; 7(6):609-14. . View in PubMed

Current concepts in the pathogenesis of alcoholic liver injury FASEB J. 2001 Jun; 15(8):1335-49. . View in PubMed

Alcohol and retinoids Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):207S-217S. . View in PubMed

Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. . View in PubMed

Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology. 2000 Nov; 32(5):1008-17. . View in PubMed

Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. . View in PubMed

Cyp2e1 and ALD Hepatology. 2000 Jul; 32(1):154-6. . View in PubMed

Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. . View in PubMed

Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. . View in PubMed

Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology. 1999 Sep; 117(3):706-16. . View in PubMed

Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat Hepatology. 1999 Jul; 30(1):209-14. . View in PubMed

Cytokine regulation of hepatic stellate cells in liver fibrosis Alcohol Clin Exp Res. 1999 May; 23(5):911-6. . View in PubMed

Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS J Pharm Sci. 1998 Nov; 87(11):1308-15. . View in PubMed

Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells J Biol Chem. 1998 Jan 02; 273(1):302-8. . View in PubMed

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis Am J Physiol. 1997 Mar; 272(3 Pt 1):G589-96. . View in PubMed

A new type of major aminopeptidase in bovine brain Biochem Mol Med. 1996 Dec; 59(2):161-8. . View in PubMed

Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA J Neurochem. 1996 Oct; 67(4):1335-43. . View in PubMed

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells Hepatology. 1996 Sep; 24(3):670-6. . View in PubMed

Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA J Clin Invest. 1996 Jun 15; 97(12):2823-32. . View in PubMed

Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA J Immunol. 1996 Jun 15; 156(12):4901-8. . View in PubMed

Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart Free Radic Res. 1996 May; 24(5):361-7. . View in PubMed

Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation Am J Physiol. 1996 Apr; 270(4 Pt 1):G581-6. . View in PubMed

Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease Hepatology. 1995 Oct; 22(4 Pt 1):1304-9. . View in PubMed

Experimental liver cirrhosis induced by alcohol and iron J Clin Invest. 1995 Jul; 96(1):620-30. . View in PubMed

Bispecific antibody-mediated cytotoxicity by CD4+ and CD8(+)-activated T cells generated from leukemia patients after allogeneic bone marrow transplantation Bone Marrow Transplant. 1995 Feb; 15(2):193-8. . View in PubMed

Fatty Liver, Hepatitus, and Cirrhosis in Sub-Human Primates Fed Ethanol Alcohol Health Res World. 1995; 19(1):42-43. . View in PubMed

[A case of nodular regenerative hyperplasia (NRH) of the liver associated with recurrent hepatic encephalopathy due to splenorenal shunt] Nihon Shokakibyo Gakkai Zasshi. 1994 Jun; 91(6):1136-40. . View in PubMed

Evolution of intragastric ethanol infusion model Alcohol. 1993 Nov-Dec; 10(6):437-41. . View in PubMed

Dietary modulation of alcohol-induced pancreatic injury Alcohol. 1993 Nov-Dec; 10(6):481-4. . View in PubMed

Experimental models of hepatic fibrosis: a review Semin Liver Dis. 1990 Feb; 10(1):56-65. . View in PubMed

Animal models for alcoholic liver disease Hepatology. 1989 Nov; 10(5):898-9. . View in PubMed

Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells Liver. 1989 Apr; 9(2):71-8. . View in PubMed

[Abnormal cholecystokinin-acinar function coupling in atrophied pancreatic acini from rats fed ethanol and a high-fat diet] Arukoru Kenkyuto Yakubutsu Ison. 1988 Dec; 23(4):332-50. . View in PubMed

Ethanol-induced liver fibrosis in rats fed high fat diet Hepatology. 1986 Sep-Oct; 6(5):814-22. . View in PubMed

Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat Alcohol Clin Exp Res. 1986; 10(6 Suppl):13S-19S. . View in PubMed

Comparison of tyrosine phosphorylation of proteins by membrane fractions from mouse liver, Ehrlich ascites tumor and MH134 hepatoma FEBS Lett. 1985 May 06; 184(1):60-4. . View in PubMed

Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats Alcohol Clin Exp Res. 1985 Jan-Feb; 9(1):31-7. . View in PubMed

[Studies on the direct extraction method for determination of lead in blood by atomic absorption spectrophotometry (author's transl)] Rinsho Byori. 1978 Jul; 26(7):611-4. . View in PubMed

Activation and isolation of mitochondrial adenosine triphosphatase by ultrasonic irradiation Acta Med Okayama. 1970 Feb; 24(1):49-64. . View in PubMed

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