Sarah Hamm-Alvarez, PhD

Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC’s School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.

• American Association of Pharmaceutical Scientists: Fellow, 2014
• Higher Education Resource Services (HERS) Representative, 2010-2011
• USC School of Pharmacy: Gavin S. Herbert Professor of Pharmaceutical Sciences, 2004-2015
• USC School of Pharmacy: John A. Biles Professor of Pharmaceutical Sciences, 2003
• Linneaus University, Kalmar Sweden: Doctor of Philosophy, honoris causa, 2003
• American Heart Association: Initial Investigatorship, 1994-1996
• Duke University: Muscular Dystrophy Association Postdoctoral Fellow, 1991-1993

• The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):1. . View in PubMed
• Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren’s syndrome Biomaterials. 2022 04; 283:121441. . View in PubMed
• Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye Exp Biol Med (Maywood). 2022 03; 247(6):519-526. . View in PubMed
• Cathepsin S is a novel target for age-related dry eye Exp Eye Res. 2022 01; 214:108895. . View in PubMed
• Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism Front Immunol. 2022; 13:833254. . View in PubMed
• Intracellular Dynamin Elastin-like Polypeptides Assemble into Rodlike, Spherical, and Reticular Dynasomes Biomacromolecules. 2022 01 10; 23(1):265-275. . View in PubMed
• Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells Int J Mol Sci. 2021 Feb 05; 22(4). . View in PubMed
• Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway Exp Eye Res. 2021 10; 211:108760. . View in PubMed
• Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren’s Syndrome Biomacromolecules. 2021 03 08; 22(3):1102-1114. . View in PubMed
• Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium Int J Mol Sci. 2020 Aug 26; 21(17). . View in PubMed
• A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye Int J Mol Sci. 2020 Apr 15; 21(8). . View in PubMed
• Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease Eye Contact Lens. 2020 Mar; 46 Suppl 2:S70-S83. . View in PubMed
• Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption Transl Vis Sci Technol. 2020 07; 9(8):23. . View in PubMed
• Tears – more to them than meets the eye: why tears are a good source of biomarkers in Parkinson’s disease Biomark Med. 2020 02; 14(2):151-163. . View in PubMed
• Caveolin elastin-like polypeptide fusions mediate temperature-dependent assembly of caveolar microdomains ACS Biomater Sci Eng. 2020 01 13; 6(1):198-204. . View in PubMed
• Small RNA Deep Sequencing Identifies a Unique miRNA Signature Released in Serum Exosomes in a Mouse Model of Sjögren’s Syndrome Front Immunol. 2020; 11:1475. . View in PubMed
• Application of advances in endocytosis and membrane trafficking to drug delivery Adv Drug Deliv Rev. 2020; 157:118-141. . View in PubMed
• Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model Sci Rep. 2020 01 29; 10(1):1455. . View in PubMed
• PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease Am J Respir Crit Care Med. 2019 Jul 01; 200(1):6-8. . View in PubMed
• Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren’s Syndrome Biomarkers. 2019 Feb; 24(1):91-102. . View in PubMed
• Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson’s disease patients from healthy controls Biomark Med. 2019 12; 13(17):1447-1457. . View in PubMed
• Oligomeric a-synuclein is increased in basal tears of Parkinson’s patients Biomark Med. 2019 08; 13(11):941-952. . View in PubMed
• Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome Sci Rep. 2019 07 02; 9(1):9559. . View in PubMed
• Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide Bioconjug Chem. 2019 09 18; 30(9):2358-2372. . View in PubMed
• Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease Mol Pharm. 2019 07 01; 16(7):3024-3039. . View in PubMed
• Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells Int J Mol Sci. 2018 Nov 09; 19(11). . View in PubMed
• NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis Exp Eye Res. 2018 11; 176:243-251. . View in PubMed
• A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren’s syndrome J Control Release. 2018 12 28; 292:183-195. . View in PubMed
• Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients Sci Rep. 2018 07 23; 8(1):11044. . View in PubMed
• Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren’s syndrome animal models Sci Rep. 2018 07 02; 8(1):9919. . View in PubMed
• PLoS One. 2017; 12(9):e0184781. . View in PubMed
• Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome Stem Cells Int. 2017; 2017:3134543. . View in PubMed
• Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren’s Syndrome Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. . View in PubMed
• Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines J Control Release. 2016 10 28; 240:93-108. . View in PubMed
• Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren’s Syndrome Am J Physiol Cell Physiol. 2016 06 01; 310(11):C942-54. . View in PubMed
• Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification J Proteomics Bioinform. 2015 Nov; 8(11):260-265. . View in PubMed
• Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland J Control Release. 2015 Jun 28; 208:2-13. . View in PubMed
• A thermo-responsive protein treatment for dry eyes J Control Release. 2015 Feb 10; 199:156-67. . View in PubMed
• Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. . View in PubMed
• Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. . View in PubMed
• Tear cathepsin S as a candidate biomarker for Sjögren’s syndrome Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. . View in PubMed
• A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren’s syndrome J Control Release. 2013 Nov 10; 171(3):269-79. . View in PubMed
• Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms Nanomedicine. 2013 Aug; 9(6):786-94. . View in PubMed
• Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. . View in PubMed
• Analyzing live cellularity in the human trabecular meshwork Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. . View in PubMed
• Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. . View in PubMed
• A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains Biomacromolecules. 2012 Nov 12; 13(11):3439-44. . View in PubMed
• In situ autofluorescence visualization of human trabecular meshwork structure Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. . View in PubMed
• Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells Cytotechnology. 2012 Mar; 64(2):149-56. . View in PubMed
• The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice PLoS One. 2012; 7(2):e31616. . View in PubMed
• Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site PLoS One. 2012; 7(2):e31789. . View in PubMed
• Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain J Control Release. 2011 Oct 30; 155(2):218-26. . View in PubMed
• Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways J Control Release. 2011 Oct 30; 155(2):134-43. . View in PubMed
• A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. . View in PubMed
• Polystyrene nanoparticle trafficking across MDCK-II Nanomedicine. 2011 Oct; 7(5):588-94. . View in PubMed
• Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21. . View in PubMed
• Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers Int J Nanomedicine. 2011; 6:2849-57. . View in PubMed
• Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. . View in PubMed
• Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. . View in PubMed
• Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells ACS Nano. 2010 May 25; 4(5):2735-47. . View in PubMed
• Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. . View in PubMed
• Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren’s syndrome-like exocrinopathy Exp Eye Res. 2010 Feb; 90(2):223-37. . View in PubMed
• Mitochondrial medicine and therapeutics, Part IIPreface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. . View in PubMed
• Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland Exp Eye Res. 2009 Sep; 89(3):319-32. . View in PubMed
• Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol Exp Eye Res. 2009 Mar; 88(3):467-78. . View in PubMed
• Quantitative second harmonic generation imaging of cartilage damage Cell Tissue Bank. 2008 Dec; 9(4):299-307. . View in PubMed
• Mitochondrial medicine and mitochondrion-based therapeutics Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. . View in PubMed
• Site-specific labeling of enveloped viruses with quantum dots for single virus tracking ACS Nano. 2008 Aug; 2(8):1553-62. . View in PubMed
• The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28. . View in PubMed
• Polystyrene nanoparticle trafficking across alveolar epithelium Nanomedicine. 2008 Jun; 4(2):139-45. . View in PubMed
• Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. . View in PubMed
• Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren’s syndrome Matrix Biol. 2008 Jan; 27(1):53-66. . View in PubMed
• Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21. . View in PubMed
• Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells Exp Eye Res. 2007 Dec; 85(6):749-61. . View in PubMed
• Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability Ann Thorac Surg. 2007 May; 83(5):1641-50. . View in PubMed
• Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. . View in PubMed
• Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini J Virol. 2006 Dec; 80(23):11833-51. . View in PubMed
• Current status of gene delivery and gene therapy in lacrimal gland using viral vectors Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. . View in PubMed
• Integrin adhesion in regulation of lacrimal gland acinar cell secretion Exp Eye Res. 2006 Sep; 83(3):543-53. . View in PubMed
• Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis Exp Eye Res. 2006 Jul; 83(1):84-96. . View in PubMed
• Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer Gene Ther. 2006 May; 13(10):821-36. . View in PubMed
• Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice Curr Eye Res. 2006 Jan; 31(1):13-22. . View in PubMed
• Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development Exp Eye Res. 2006 Jan; 82(1):33-45. . View in PubMed
• Intracellular trafficking of nonviral vectors Gene Ther. 2005 Dec; 12(24):1734-51. . View in PubMed
• Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. . View in PubMed
• Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. . View in PubMed
• Mucosal immunity and self-tolerance in the ocular surface system Ocul Surf. 2005 Oct; 3(4):182-92. . View in PubMed
• The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway Gene Ther. 2005 Feb; 12(3):225-37. . View in PubMed
• Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation Scand J Immunol. 2005 Jan; 61(1):36-50. . View in PubMed
• Stable transfection of MDCK cells with epitope-tagged human PepT1 Pharm Res. 2004 Nov; 21(11):1970-3. . View in PubMed
• Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation Exp Eye Res. 2004 Nov; 79(5):665-75. . View in PubMed
• Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network Exp Eye Res. 2004 Jun; 78(6):1093-106. . View in PubMed
• Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland Gene Ther. 2004 Jun; 11(12):970-81. . View in PubMed
• Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells J Cell Physiol. 2004 Apr; 199(1):108-25. . View in PubMed
• Modulation of secretory functions in epithelia by adenovirus capsid proteins J Control Release. 2003 Dec 05; 93(2):129-40. . View in PubMed
• Actin microfilaments et al–the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. . View in PubMed
• Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist Scand J Immunol. 2003 Nov; 58(5):550-65. . View in PubMed
• Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells Mol Biol Cell. 2003 Nov; 14(11):4397-413. . View in PubMed
• Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. . View in PubMed
• Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. . View in PubMed
• Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. . View in PubMed
• Epidermal growth factor traffic in lacrimal acinar cells Adv Exp Med Biol. 2002; 506(Pt A):213-7. . View in PubMed
• Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells Adv Exp Med Biol. 2002; 506(Pt A):199-205. . View in PubMed
• M3 receptor autoimmunity: losing tolerance to a familiar protein Adv Exp Med Biol. 2002; 506(Pt A):51-8. . View in PubMed
• Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system Exp Eye Res. 2002 Jan; 74(1):7-22. . View in PubMed
• Etk/Bmx activation modulates barrier function in epithelial cells Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1657-68. . View in PubMed
• Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases Cell Motil Cytoskeleton. 2000 Dec; 47(4):253-68. . View in PubMed
• Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton Biochem Biophys Res Commun. 2000 Nov 02; 277(3):525-30. . View in PubMed
• Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini Curr Eye Res. 2000 May; 20(5):373-83. . View in PubMed
• Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1 J Control Release. 1999 Nov 01; 62(1-2):129-40. . View in PubMed
• Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function Biochem J. 1999 Aug 15; 342 ( Pt 1):1-6. . View in PubMed
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• Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney Physiol Rev. 1998 Oct; 78(4):1109-29. . View in PubMed
• Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1) Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. . View in PubMed
• A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments J Cell Sci. 1998 Jul; 111 ( Pt 13):1841-52. . View in PubMed
• Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells J Cell Sci. 1998 May; 111 ( Pt 9):1267-76. . View in PubMed
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• MacKay, John
• Okamoto, Curtis